Overview
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
5.8
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B-12 (as Cyanocobalamin)
2,500 mcg
104,167%
Top Medical Research Studies
7
We explored how vitamin B12 affects spinal fractures in patients with osteoporosis, a condition that significantly increases the risk of these injuries. Our investigation involved 105 participants diagnosed with osteoporosis. We assessed clinical data alongside blood levels of several vitamins, including vitamin B12, to understand their connection to spinal fractures.
Our analysis revealed a substantial relationship between elevated vitamin B12 levels and the incidence of spinal fractures. We found that not only was there a notable association with spinal fractures, but higher vitamin B12 was also linked to a shorter time before a recurrence of fractures occurred. These findings suggest that as vitamin B12 levels rise, the risk for spinal fractures in osteoporosis patients increases, which indicates a potentially serious concern for these individuals.
While vitamin B9 also showed some association, it was vitamin B12 that stood out in both our logistic regression analyses. Overall, our results suggest that monitoring and perhaps addressing vitamin B12 levels could be crucial for managing patients’ health and preventing further complications from osteoporosis.
Our analysis revealed a substantial relationship between elevated vitamin B12 levels and the incidence of spinal fractures. We found that not only was there a notable association with spinal fractures, but higher vitamin B12 was also linked to a shorter time before a recurrence of fractures occurred. These findings suggest that as vitamin B12 levels rise, the risk for spinal fractures in osteoporosis patients increases, which indicates a potentially serious concern for these individuals.
While vitamin B9 also showed some association, it was vitamin B12 that stood out in both our logistic regression analyses. Overall, our results suggest that monitoring and perhaps addressing vitamin B12 levels could be crucial for managing patients’ health and preventing further complications from osteoporosis.
Read More
7
We examined how vitamin B-12 affects bone health, particularly in relation to osteoporosis, by looking at a group of 93 healthy postmenopausal Chinese-Singaporean women. The study focused on measuring bone density and strength as well as the women’s levels of vitamin B-12 and folate.
What we found was intriguing. Women with higher levels of circulating folate tended to have better bone mineral density (BMD), while those with greater levels of vitamin B-12 displayed stronger bones overall. This indicates a potential positive relationship between these vitamins and bone strength, particularly suggesting that vitamin B-12 could play a role in promoting bone health among postmenopausal women.
Nevertheless, while these results are promising, they also suggest more research is needed. We should explore whether improving the intake of these vitamins could help reduce the risk of osteoporosis and fractures. In our study, we didn’t find any direct intervention that confirms vitamin B-12 alone successfully treats osteoporosis, but the associations encourage further investigation into how dietary adjustments might benefit bone health.
What we found was intriguing. Women with higher levels of circulating folate tended to have better bone mineral density (BMD), while those with greater levels of vitamin B-12 displayed stronger bones overall. This indicates a potential positive relationship between these vitamins and bone strength, particularly suggesting that vitamin B-12 could play a role in promoting bone health among postmenopausal women.
Nevertheless, while these results are promising, they also suggest more research is needed. We should explore whether improving the intake of these vitamins could help reduce the risk of osteoporosis and fractures. In our study, we didn’t find any direct intervention that confirms vitamin B-12 alone successfully treats osteoporosis, but the associations encourage further investigation into how dietary adjustments might benefit bone health.
Read More
5
We conducted a two-year study to explore how low-dose B-vitamin supplementation, particularly focusing on vitamin B12, impacts bone health in adults aged 50 and older. Our participants were divided into two groups: one received the B-vitamin combination, which included folic acid, B12, B6, and riboflavin, while the other group was given a placebo. All participants received vitamin D as well, ensuring they had the same base level of this important nutrient.
Throughout the study, we measured bone mineral density (BMD) using advanced imaging techniques. Interestingly, the overall results showed that B-vitamin supplementation did not significantly prevent bone density loss; both groups experienced a decline in BMD by about 1%. However, we found that participants with lower baseline levels of B12 experienced less bone loss when they received B-vitamin supplementation compared to those who did not. This suggests that improving B-vitamin status, particularly in individuals with lower B12, could have specific benefits for maintaining bone health.
Although the intervention did not affect BMD for everyone, the findings highlight the potential importance of B12 for those at risk. We believe this study opens doors for further research on how necessary nutrients like B12 can support bone health, especially in older adults.
Throughout the study, we measured bone mineral density (BMD) using advanced imaging techniques. Interestingly, the overall results showed that B-vitamin supplementation did not significantly prevent bone density loss; both groups experienced a decline in BMD by about 1%. However, we found that participants with lower baseline levels of B12 experienced less bone loss when they received B-vitamin supplementation compared to those who did not. This suggests that improving B-vitamin status, particularly in individuals with lower B12, could have specific benefits for maintaining bone health.
Although the intervention did not affect BMD for everyone, the findings highlight the potential importance of B12 for those at risk. We believe this study opens doors for further research on how necessary nutrients like B12 can support bone health, especially in older adults.
Read More
Most Useful Reviews
8.8
Boosts bone health
B12 vitamins help produce red blood cells and prevent anaemia. They improve bone health and lower the risk of osteoporosis, while also boosting energy levels. Additionally, B12 aids in protecting the brain against dementia.
Read More
7.5
Supports bone health
The price is reasonable. This company faces criticism for not registering its products as non-GMO. The effect is beneficial if there's no absorption issue, particularly in the elderly; a deficiency of pepsin in the stomach means pills won't work. In such cases, B12 injections are necessary. Vitamin B12 supports nerves and blood cells. It's essential for daily health, aiding in red blood cell formation, maintaining nerve cell health, and helping DNA production. Deficiency leads to noticeable symptoms. It's advisable to take B12 with folic acid. Nutritionists highlight its importance for mood regulation and mental health, as B12 contributes to neurotransmitter production. This may explain its potential benefits for those with depression or anxiety. B12 also supports healthy fetal development and helps prevent osteoporosis.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
5.8
- All Researches
7
We explored how vitamin B12 affects spinal fractures in patients with osteoporosis, a condition that significantly increases the risk of these injuries. Our investigation involved 105 participants diagnosed with osteoporosis. We assessed clinical data alongside blood levels of several vitamins, including vitamin B12, to understand their connection to spinal fractures.
Our analysis revealed a substantial relationship between elevated vitamin B12 levels and the incidence of spinal fractures. We found that not only was there a notable association with spinal fractures, but higher vitamin B12 was also linked to a shorter time before a recurrence of fractures occurred. These findings suggest that as vitamin B12 levels rise, the risk for spinal fractures in osteoporosis patients increases, which indicates a potentially serious concern for these individuals.
While vitamin B9 also showed some association, it was vitamin B12 that stood out in both our logistic regression analyses. Overall, our results suggest that monitoring and perhaps addressing vitamin B12 levels could be crucial for managing patients’ health and preventing further complications from osteoporosis.
Our analysis revealed a substantial relationship between elevated vitamin B12 levels and the incidence of spinal fractures. We found that not only was there a notable association with spinal fractures, but higher vitamin B12 was also linked to a shorter time before a recurrence of fractures occurred. These findings suggest that as vitamin B12 levels rise, the risk for spinal fractures in osteoporosis patients increases, which indicates a potentially serious concern for these individuals.
While vitamin B9 also showed some association, it was vitamin B12 that stood out in both our logistic regression analyses. Overall, our results suggest that monitoring and perhaps addressing vitamin B12 levels could be crucial for managing patients’ health and preventing further complications from osteoporosis.
Read More
7
We examined how vitamin B-12 affects bone health, particularly in relation to osteoporosis, by looking at a group of 93 healthy postmenopausal Chinese-Singaporean women. The study focused on measuring bone density and strength as well as the women’s levels of vitamin B-12 and folate.
What we found was intriguing. Women with higher levels of circulating folate tended to have better bone mineral density (BMD), while those with greater levels of vitamin B-12 displayed stronger bones overall. This indicates a potential positive relationship between these vitamins and bone strength, particularly suggesting that vitamin B-12 could play a role in promoting bone health among postmenopausal women.
Nevertheless, while these results are promising, they also suggest more research is needed. We should explore whether improving the intake of these vitamins could help reduce the risk of osteoporosis and fractures. In our study, we didn’t find any direct intervention that confirms vitamin B-12 alone successfully treats osteoporosis, but the associations encourage further investigation into how dietary adjustments might benefit bone health.
What we found was intriguing. Women with higher levels of circulating folate tended to have better bone mineral density (BMD), while those with greater levels of vitamin B-12 displayed stronger bones overall. This indicates a potential positive relationship between these vitamins and bone strength, particularly suggesting that vitamin B-12 could play a role in promoting bone health among postmenopausal women.
Nevertheless, while these results are promising, they also suggest more research is needed. We should explore whether improving the intake of these vitamins could help reduce the risk of osteoporosis and fractures. In our study, we didn’t find any direct intervention that confirms vitamin B-12 alone successfully treats osteoporosis, but the associations encourage further investigation into how dietary adjustments might benefit bone health.
Read More
5
We conducted a two-year study to explore how low-dose B-vitamin supplementation, particularly focusing on vitamin B12, impacts bone health in adults aged 50 and older. Our participants were divided into two groups: one received the B-vitamin combination, which included folic acid, B12, B6, and riboflavin, while the other group was given a placebo. All participants received vitamin D as well, ensuring they had the same base level of this important nutrient.
Throughout the study, we measured bone mineral density (BMD) using advanced imaging techniques. Interestingly, the overall results showed that B-vitamin supplementation did not significantly prevent bone density loss; both groups experienced a decline in BMD by about 1%. However, we found that participants with lower baseline levels of B12 experienced less bone loss when they received B-vitamin supplementation compared to those who did not. This suggests that improving B-vitamin status, particularly in individuals with lower B12, could have specific benefits for maintaining bone health.
Although the intervention did not affect BMD for everyone, the findings highlight the potential importance of B12 for those at risk. We believe this study opens doors for further research on how necessary nutrients like B12 can support bone health, especially in older adults.
Throughout the study, we measured bone mineral density (BMD) using advanced imaging techniques. Interestingly, the overall results showed that B-vitamin supplementation did not significantly prevent bone density loss; both groups experienced a decline in BMD by about 1%. However, we found that participants with lower baseline levels of B12 experienced less bone loss when they received B-vitamin supplementation compared to those who did not. This suggests that improving B-vitamin status, particularly in individuals with lower B12, could have specific benefits for maintaining bone health.
Although the intervention did not affect BMD for everyone, the findings highlight the potential importance of B12 for those at risk. We believe this study opens doors for further research on how necessary nutrients like B12 can support bone health, especially in older adults.
Read More
4
We investigated how vitamin B12 influences osteoporosis, especially in cases linked to high homocysteine levels, alongside taurine. Through molecular docking techniques and laboratory experiments, we discovered that taurine and homocysteine interact with PPARγ, a crucial protein in bone health.
Vitamin B12 showed some positive effects on bone health; however, it didn't perform as strongly as taurine. We noticed that while vitamin B12 contributes beneficially, it can't fully counteract the damaging impact of hyperhomocysteinemia on bone. The study highlighted that taurine, particularly when combined with vitamin B12, exhibited greater effectiveness against osteoporosis.
In conclusion, while vitamin B12 has its merits in promoting bone health, taurine appears to play a more significant role. This suggests that further exploration into taurine's mechanisms could be valuable for developing treatments for osteoporosis.
Vitamin B12 showed some positive effects on bone health; however, it didn't perform as strongly as taurine. We noticed that while vitamin B12 contributes beneficially, it can't fully counteract the damaging impact of hyperhomocysteinemia on bone. The study highlighted that taurine, particularly when combined with vitamin B12, exhibited greater effectiveness against osteoporosis.
In conclusion, while vitamin B12 has its merits in promoting bone health, taurine appears to play a more significant role. This suggests that further exploration into taurine's mechanisms could be valuable for developing treatments for osteoporosis.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Boosts bone health
B12 vitamins help produce red blood cells and prevent anaemia. They improve bone health and lower the risk of osteoporosis, while also boosting energy levels. Additionally, B12 aids in protecting the brain against dementia.
Read More
7.5
Supports bone health
The price is reasonable. This company faces criticism for not registering its products as non-GMO. The effect is beneficial if there's no absorption issue, particularly in the elderly; a deficiency of pepsin in the stomach means pills won't work. In such cases, B12 injections are necessary. Vitamin B12 supports nerves and blood cells. It's essential for daily health, aiding in red blood cell formation, maintaining nerve cell health, and helping DNA production. Deficiency leads to noticeable symptoms. It's advisable to take B12 with folic acid. Nutritionists highlight its importance for mood regulation and mental health, as B12 contributes to neurotransmitter production. This may explain its potential benefits for those with depression or anxiety. B12 also supports healthy fetal development and helps prevent osteoporosis.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Adhish M, Manjubala I. Integrative in-silico and in-vitro analysis of taurine and vitamin B12 in modulating PPARγ and Wnt signaling in hyperhomocysteinemia-induced osteoporosis. Biol Direct. 2024;19:141. doi:10.1186/s13062-024-00581-z
- Li Z, Zheng R, Xue H, Zhu H. Vitamin B12 as a novel risk biomarker of spinal fractures. Medicine (Baltimore). 2022;101:e30796. doi:10.1097/MD.0000000000030796
- Clements M, Heffernan M, Ward M, Hoey L, Doherty LC, et al. A 2-Year Randomized Controlled Trial With Low-Dose B-Vitamin Supplementation Shows Benefits on Bone Mineral Density in Adults With Lower B12 Status. J Bone Miner Res. 2022;37:2443. doi:10.1002/jbmr.4709
- Kalimeri M, Leek F, Wang NX, Koh HR, Roy NC, et al. Folate and Vitamin B-12 Status Is Associated With Bone Mineral Density and Hip Strength of Postmenopausal Chinese-Singaporean Women. JBMR Plus. 2020;4:e10399. doi:10.1002/jbm4.10399
