Infographics 
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
USERS' SCORE
Moderately Good
Based on 619 Reviews
7.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Pantothenic Acid (as d-Calcium Pantothenate)
500 mg
10,000%
Calcium (as d-Calcium Pantothenate)
49 mg
4%
Top Medical Research Studies
7
We examined oral nutraceuticals as a treatment for acne through a thorough review of clinical trials. After evaluating over 2580 abstracts, we found that specifically, vitamins B5 and D, along with probiotics and certain botanical extracts, may offer some benefits, such as reduced lesion counts.
However, it’s important to note that while adverse effects were generally rare, some gastrointestinal issues were reported with zinc therapy. Overall, while the findings are promising, more extensive research is needed to truly understand the effectiveness of these treatments.
However, it’s important to note that while adverse effects were generally rare, some gastrointestinal issues were reported with zinc therapy. Overall, while the findings are promising, more extensive research is needed to truly understand the effectiveness of these treatments.
Read More
4
We explored the role of extracellular calcium and 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) in the functioning of sebaceous glands, with a focus on their implications for acne treatment. In our study, we looked at how different concentrations of calcium affect the morphology, cell count, and lipid production of SZ95 sebocytes, both in controlled lab conditions and in clinical observations of acne patients.
Our findings revealed that when exposed to low levels of calcium, there was an increase in lipogenesis—this means the cells produced more lipids or oils. However, as we raised the extracellular calcium levels, we noted that the number of sebocytes increased, and their shape became more like epithelial cells, while lipid production decreased. Importantly, low calcium also led to a decrease in E-cadherin, a protein vital for cell adherence, which seemed to correlate with increased cell detachment and apoptosis, or cell death.
We also noted that 1,25(OH)2D3 appears to suppress oil production while simultaneously triggering autophagy, a process that helps cells clean out damaged components. In the clinical study involving acne patients, we observed no significant abnormalities in serum calcium levels, but younger patients had lower 1,25(OH)2D3 levels than older individuals.
This suggests that both calcium and vitamin D have a role in acne development, but there wasn't a clear, standalone benefit of calcium treatment for managing acne. Instead, the combination of increased calcium and decreased vitamin D might contribute to the problems seen in younger patients with acne. Overall, our research highlights the complex interplay between these nutrients and sebaceous gland function, offering important insights for potential acne therapies.
Our findings revealed that when exposed to low levels of calcium, there was an increase in lipogenesis—this means the cells produced more lipids or oils. However, as we raised the extracellular calcium levels, we noted that the number of sebocytes increased, and their shape became more like epithelial cells, while lipid production decreased. Importantly, low calcium also led to a decrease in E-cadherin, a protein vital for cell adherence, which seemed to correlate with increased cell detachment and apoptosis, or cell death.
We also noted that 1,25(OH)2D3 appears to suppress oil production while simultaneously triggering autophagy, a process that helps cells clean out damaged components. In the clinical study involving acne patients, we observed no significant abnormalities in serum calcium levels, but younger patients had lower 1,25(OH)2D3 levels than older individuals.
This suggests that both calcium and vitamin D have a role in acne development, but there wasn't a clear, standalone benefit of calcium treatment for managing acne. Instead, the combination of increased calcium and decreased vitamin D might contribute to the problems seen in younger patients with acne. Overall, our research highlights the complex interplay between these nutrients and sebaceous gland function, offering important insights for potential acne therapies.
Read More
8
We examined how calcium treatment influences sebum production, particularly in relation to acne. Sebocytes, the cells in our skin that produce oil, were treated with calcium, and we confirmed increased lipid production using well-established techniques. This response is important because excessive sebum is a key factor in acne development.
Our findings showed that calcium not only increased the overall sebum output but also stepped up the levels of several key regulators involved in the lipogenesis process. Notably, we observed that calcium treatment boosted the expression of proteins like SREBP1, which plays a crucial role in managing lipid levels in skin cells.
We also discovered that the transcription factor KLF4 was elevated with calcium treatment. This raised a fascinating question: could KLF4 be enhancing lipid production? To test this, we overexpressed KLF4 in sebocytes, and indeed found that it further stimulated the expression of lipid-producing proteins and increased overall lipid production.
In conclusion, our study sheds light on the significant role of calcium in sebum production and highlights KLF4 as a promising new regulator in this process. These insights may open doors for developing more effective acne treatments by targeting sebum production pathways.
Our findings showed that calcium not only increased the overall sebum output but also stepped up the levels of several key regulators involved in the lipogenesis process. Notably, we observed that calcium treatment boosted the expression of proteins like SREBP1, which plays a crucial role in managing lipid levels in skin cells.
We also discovered that the transcription factor KLF4 was elevated with calcium treatment. This raised a fascinating question: could KLF4 be enhancing lipid production? To test this, we overexpressed KLF4 in sebocytes, and indeed found that it further stimulated the expression of lipid-producing proteins and increased overall lipid production.
In conclusion, our study sheds light on the significant role of calcium in sebum production and highlights KLF4 as a promising new regulator in this process. These insights may open doors for developing more effective acne treatments by targeting sebum production pathways.
Read More
Most Useful Reviews
9
Effective for acne
177 people found this helpful
For the harmony of the figure and the skin, vitamin B5 is indispensable for managing mental and physical stress. Few realise that pantothenic acid, alongside lecithin, produces a considerable amount of acetylcholine, which supports brain function and liver health. Importantly for those with acne, vitamin B5 exhibits anti-inflammatory properties, alleviating breakouts even before critical days. The product has shown no side effects; although the capsules are somewhat large, they are easy to swallow. I believe it’s a good value product for health.
Read More
9
Improves acne treatment
64 people found this helpful
I take pantothenic acid for its numerous benefits, especially for my skin. I noticed that when I started taking it, the acne and other inflammations decreased significantly. It's essential for the adrenal glands and helps balance hormone production. I encourage others to give it a try for health and prevention. If my review was helpful, please like it.
Read More
9
Reduced sebum secretion
39 people found this helpful
I'm taking this for acne and have noticed a decrease in sebum secretion. I take it twice daily, and there's a noticeable difference in the amount of sebum produced. I feel that consistent use over two months will yield even better results!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
- All Researches
9
We explored the effectiveness of combining microfocused ultrasound with a calcium hydroxylapatite dermal filler for treating acne scars. This approach was evaluated in a group of healthy adults aged 35-55, who had moderate to severe facial scars from acne.
During the treatment, ultrasound was applied in a cross-hatch pattern to stimulate the skin, followed by injections of a diluted calcium hydroxylapatite filler mixed with lidocaine for comfort. The results were assessed 90 days later, focusing on changes in scar severity and overall satisfaction of the subjects.
The findings revealed significant improvement in acne scars, particularly in those with severe scarring. The majority of participants reported being satisfied with their results, and no adverse side effects were noted. While calcium hydroxylapatite alone was not isolated in this study, its combination with ultrasound showed promising results for reducing scar visibility.
During the treatment, ultrasound was applied in a cross-hatch pattern to stimulate the skin, followed by injections of a diluted calcium hydroxylapatite filler mixed with lidocaine for comfort. The results were assessed 90 days later, focusing on changes in scar severity and overall satisfaction of the subjects.
The findings revealed significant improvement in acne scars, particularly in those with severe scarring. The majority of participants reported being satisfied with their results, and no adverse side effects were noted. While calcium hydroxylapatite alone was not isolated in this study, its combination with ultrasound showed promising results for reducing scar visibility.
Read More
8
We examined how calcium treatment influences sebum production, particularly in relation to acne. Sebocytes, the cells in our skin that produce oil, were treated with calcium, and we confirmed increased lipid production using well-established techniques. This response is important because excessive sebum is a key factor in acne development.
Our findings showed that calcium not only increased the overall sebum output but also stepped up the levels of several key regulators involved in the lipogenesis process. Notably, we observed that calcium treatment boosted the expression of proteins like SREBP1, which plays a crucial role in managing lipid levels in skin cells.
We also discovered that the transcription factor KLF4 was elevated with calcium treatment. This raised a fascinating question: could KLF4 be enhancing lipid production? To test this, we overexpressed KLF4 in sebocytes, and indeed found that it further stimulated the expression of lipid-producing proteins and increased overall lipid production.
In conclusion, our study sheds light on the significant role of calcium in sebum production and highlights KLF4 as a promising new regulator in this process. These insights may open doors for developing more effective acne treatments by targeting sebum production pathways.
Our findings showed that calcium not only increased the overall sebum output but also stepped up the levels of several key regulators involved in the lipogenesis process. Notably, we observed that calcium treatment boosted the expression of proteins like SREBP1, which plays a crucial role in managing lipid levels in skin cells.
We also discovered that the transcription factor KLF4 was elevated with calcium treatment. This raised a fascinating question: could KLF4 be enhancing lipid production? To test this, we overexpressed KLF4 in sebocytes, and indeed found that it further stimulated the expression of lipid-producing proteins and increased overall lipid production.
In conclusion, our study sheds light on the significant role of calcium in sebum production and highlights KLF4 as a promising new regulator in this process. These insights may open doors for developing more effective acne treatments by targeting sebum production pathways.
Read More
8
We explored the effectiveness of calcium hydroxylapatite as a treatment for moderate to severe atrophic acne scars. In a carefully structured study, twenty women with noticeable acne scars were treated with calcium hydroxylapatite alone and also in combination with high-intensity microfocused ultrasound (HIFU).
Our assessments showed promising results. After just one month, those who received the calcium treatment noted an improvement in their skin texture and wrinkles when compared to those who received a placebo. By three and six months, every participant in the study reported an improvement in their acne scars.
However, it's important to highlight that while the calcium treatment was indeed effective, adding HIFU did not provide any additional benefits beyond the results seen from calcium alone. This suggests that while calcium hydroxylapatite stands out as a solid option for tackling acne scars, pairing it with HIFU doesn’t necessarily enhance its effectiveness.
Our assessments showed promising results. After just one month, those who received the calcium treatment noted an improvement in their skin texture and wrinkles when compared to those who received a placebo. By three and six months, every participant in the study reported an improvement in their acne scars.
However, it's important to highlight that while the calcium treatment was indeed effective, adding HIFU did not provide any additional benefits beyond the results seen from calcium alone. This suggests that while calcium hydroxylapatite stands out as a solid option for tackling acne scars, pairing it with HIFU doesn’t necessarily enhance its effectiveness.
Read More
8
We explored how calcium may impact skin health, particularly in relation to acne. The study utilized an innovative screening method to identify effective exfoliating agents, focusing on amino acids like carnitine and serine. While the results highlighted these agents as effective in enhancing skin exfoliation, the study also noted the role of calcium.
However, it’s important to clarify that while calcium was mentioned, the study did not specifically isolate its effects on acne treatment. The agents tested showed effective results in improving the skin's turnover rate, hinting at potential benefits for various skin issues, including dullness and minor acne.
Ultimately, while the research signifies the promise of calcium in skincare, it stops short of stating it as a proven treatment for acne. For now, the focus remains on agents like carnitine and serine, which could support healthier skin through enhanced exfoliation.
However, it’s important to clarify that while calcium was mentioned, the study did not specifically isolate its effects on acne treatment. The agents tested showed effective results in improving the skin's turnover rate, hinting at potential benefits for various skin issues, including dullness and minor acne.
Ultimately, while the research signifies the promise of calcium in skincare, it stops short of stating it as a proven treatment for acne. For now, the focus remains on agents like carnitine and serine, which could support healthier skin through enhanced exfoliation.
Read More
7
We examined oral nutraceuticals as a treatment for acne through a thorough review of clinical trials. After evaluating over 2580 abstracts, we found that specifically, vitamins B5 and D, along with probiotics and certain botanical extracts, may offer some benefits, such as reduced lesion counts.
However, it’s important to note that while adverse effects were generally rare, some gastrointestinal issues were reported with zinc therapy. Overall, while the findings are promising, more extensive research is needed to truly understand the effectiveness of these treatments.
However, it’s important to note that while adverse effects were generally rare, some gastrointestinal issues were reported with zinc therapy. Overall, while the findings are promising, more extensive research is needed to truly understand the effectiveness of these treatments.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 619 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective for acne
177 people found this helpful
For the harmony of the figure and the skin, vitamin B5 is indispensable for managing mental and physical stress. Few realise that pantothenic acid, alongside lecithin, produces a considerable amount of acetylcholine, which supports brain function and liver health. Importantly for those with acne, vitamin B5 exhibits anti-inflammatory properties, alleviating breakouts even before critical days. The product has shown no side effects; although the capsules are somewhat large, they are easy to swallow. I believe it’s a good value product for health.
Read More
9
Improves acne treatment
64 people found this helpful
I take pantothenic acid for its numerous benefits, especially for my skin. I noticed that when I started taking it, the acne and other inflammations decreased significantly. It's essential for the adrenal glands and helps balance hormone production. I encourage others to give it a try for health and prevention. If my review was helpful, please like it.
Read More
9
Reduced sebum secretion
39 people found this helpful
I'm taking this for acne and have noticed a decrease in sebum secretion. I take it twice daily, and there's a noticeable difference in the amount of sebum produced. I feel that consistent use over two months will yield even better results!
Read More
9
No more cystic acne
36 people found this helpful
No more cystic acne on my face and back! I'm restocking my B5 again. Previously, I had breakouts on these areas, but B5 significantly helped reduce them. I've been taking it for years and will continue as part of my acne maintenance regimen.
Read More
9
Clears skin effectively
20 people found this helpful
Helps to keep the skin clean; all acne goes away.
Read More
Frequently Asked Questions
9
Great for bad skin
4 people found this helpful
B5 is a water-soluble vitamin, so any excess is flushed out. If you have bad skin or acne, this is fantastic! After taking 4-6 daily, I saw a significant change in just two weeks. Although I'm still dealing with scars, I use it for prevention. The product is affordable, and I highly recommend it.
9
Significant acne reduction
11 people found this helpful
After trying various treatments, pantothenic acid worked wonders for my greasy skin and acne. Within three weeks, my acne noticeably improved. I recommend this to anyone struggling with acne!
9
Reduced sebum secretion
39 people found this helpful
I'm taking this for acne and have noticed a decrease in sebum secretion. I take it twice daily, and there's a noticeable difference in the amount of sebum produced. I feel that consistent use over two months will yield even better results!
9
Significant acne reduction
3 people found this helpful
It works incredibly well for acne! I typically don't review products, but after using this, I feel compelled to. At 21, I never experienced acne, but after starting whey protein, I developed a multitude of spots. I tried various treatments, including salicylic acid and benzoyl peroxide, but none cleared my face completely. After four months of experimentation, I began taking Pantothenic Acid, and it worked wonders for my acne. My face became clear within a month, although I still have some hyperpigmentation, which I hope will fade with time. I will continue to use this, as I noticed acne tends to return if you stop. Furthermore, reducing dairy significantly aided my situation.
9
No more cystic acne
36 people found this helpful
No more cystic acne on my face and back! I'm restocking my B5 again. Previously, I had breakouts on these areas, but B5 significantly helped reduce them. I've been taking it for years and will continue as part of my acne maintenance regimen.
10
No new acne
6 people found this helpful
I've been taking three pills (1.5g) twice daily and haven't experienced any new acne since starting my regimen. It's been remarkably effective.
9
Scar colour improvement
8 people found this helpful
I've been taking this for about a week. Surprisingly, the colour of my acne scars is improving. I couldn't believe the change in my skin; it's obviously effective for acne problems.
9
Reduced hormonal acne
7 people found this helpful
I began taking pantothenic acid upon learning about its effects on hormonal acne. I take two pills every morning; it truly made a considerable difference. I've seen fewer inflamed and irritated blemishes since starting my routine, and when I omitted it for a short period, my acne returned. It’s definitely essential in my regimen!
9
Effective for acne
5 people found this helpful
Great product! It has really helped my acne. Just a tip: don’t take it simultaneously with biotin.
9
Oily skin improvement
4 people found this helpful
My acne frequency has diminished considerably. Previously, I had excessive oil, needing to wipe my face frequently. However, since incorporating B5 alongside a vitamin complex last year, my skin's oiliness has decreased substantially, changing how I manage skin care. While I’ve experienced some dryness, I improve hydration with a mist.
8
Enhanced skin condition
8 people found this helpful
I struggled with hormonal acne for years, particularly around my jawline and neck, which I found embarrassing. After trying various supplements without success, I discovered a YouTube channel that featured B5. I decided to give it a go, taking between 5 to 10 pills daily since January 3rd. I've noticed a significant improvement in my skin condition.
9
Highly effective for acne
10 people found this helpful
I'm amazed at how well these work for controlling my acne. Starting with one a day, I'm now taking two and have seen a significant reduction in my hormonal acne and scars. I couldn't be happier and would definitely recommend them.
8
We examined how calcium treatment influences sebum production, particularly in relation to acne. Sebocytes, the cells in our skin that produce oil, were treated with calcium, and we confirmed increased lipid production using well-established techniques. This response is important because excessive sebum is a key factor in acne development.
Our findings showed that calcium not only increased the overall sebum output but also stepped up the levels of several key regulators involved in the lipogenesis process. Notably, we observed that calcium treatment boosted the expression of proteins like SREBP1, which plays a crucial role in managing lipid levels in skin cells.
We also discovered that the transcription factor KLF4 was elevated with calcium treatment. This raised a fascinating question: could KLF4 be enhancing lipid production? To test this, we overexpressed KLF4 in sebocytes, and indeed found that it further stimulated the expression of lipid-producing proteins and increased overall lipid production.
In conclusion, our study sheds light on the significant role of calcium in sebum production and highlights KLF4 as a promising new regulator in this process. These insights may open doors for developing more effective acne treatments by targeting sebum production pathways.
Our findings showed that calcium not only increased the overall sebum output but also stepped up the levels of several key regulators involved in the lipogenesis process. Notably, we observed that calcium treatment boosted the expression of proteins like SREBP1, which plays a crucial role in managing lipid levels in skin cells.
We also discovered that the transcription factor KLF4 was elevated with calcium treatment. This raised a fascinating question: could KLF4 be enhancing lipid production? To test this, we overexpressed KLF4 in sebocytes, and indeed found that it further stimulated the expression of lipid-producing proteins and increased overall lipid production.
In conclusion, our study sheds light on the significant role of calcium in sebum production and highlights KLF4 as a promising new regulator in this process. These insights may open doors for developing more effective acne treatments by targeting sebum production pathways.
8
We explored how calcium may impact skin health, particularly in relation to acne. The study utilized an innovative screening method to identify effective exfoliating agents, focusing on amino acids like carnitine and serine. While the results highlighted these agents as effective in enhancing skin exfoliation, the study also noted the role of calcium.
However, it’s important to clarify that while calcium was mentioned, the study did not specifically isolate its effects on acne treatment. The agents tested showed effective results in improving the skin's turnover rate, hinting at potential benefits for various skin issues, including dullness and minor acne.
Ultimately, while the research signifies the promise of calcium in skincare, it stops short of stating it as a proven treatment for acne. For now, the focus remains on agents like carnitine and serine, which could support healthier skin through enhanced exfoliation.
However, it’s important to clarify that while calcium was mentioned, the study did not specifically isolate its effects on acne treatment. The agents tested showed effective results in improving the skin's turnover rate, hinting at potential benefits for various skin issues, including dullness and minor acne.
Ultimately, while the research signifies the promise of calcium in skincare, it stops short of stating it as a proven treatment for acne. For now, the focus remains on agents like carnitine and serine, which could support healthier skin through enhanced exfoliation.
4
We explored the role of extracellular calcium and 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) in the functioning of sebaceous glands, with a focus on their implications for acne treatment. In our study, we looked at how different concentrations of calcium affect the morphology, cell count, and lipid production of SZ95 sebocytes, both in controlled lab conditions and in clinical observations of acne patients.
Our findings revealed that when exposed to low levels of calcium, there was an increase in lipogenesis—this means the cells produced more lipids or oils. However, as we raised the extracellular calcium levels, we noted that the number of sebocytes increased, and their shape became more like epithelial cells, while lipid production decreased. Importantly, low calcium also led to a decrease in E-cadherin, a protein vital for cell adherence, which seemed to correlate with increased cell detachment and apoptosis, or cell death.
We also noted that 1,25(OH)2D3 appears to suppress oil production while simultaneously triggering autophagy, a process that helps cells clean out damaged components. In the clinical study involving acne patients, we observed no significant abnormalities in serum calcium levels, but younger patients had lower 1,25(OH)2D3 levels than older individuals.
This suggests that both calcium and vitamin D have a role in acne development, but there wasn't a clear, standalone benefit of calcium treatment for managing acne. Instead, the combination of increased calcium and decreased vitamin D might contribute to the problems seen in younger patients with acne. Overall, our research highlights the complex interplay between these nutrients and sebaceous gland function, offering important insights for potential acne therapies.
Our findings revealed that when exposed to low levels of calcium, there was an increase in lipogenesis—this means the cells produced more lipids or oils. However, as we raised the extracellular calcium levels, we noted that the number of sebocytes increased, and their shape became more like epithelial cells, while lipid production decreased. Importantly, low calcium also led to a decrease in E-cadherin, a protein vital for cell adherence, which seemed to correlate with increased cell detachment and apoptosis, or cell death.
We also noted that 1,25(OH)2D3 appears to suppress oil production while simultaneously triggering autophagy, a process that helps cells clean out damaged components. In the clinical study involving acne patients, we observed no significant abnormalities in serum calcium levels, but younger patients had lower 1,25(OH)2D3 levels than older individuals.
This suggests that both calcium and vitamin D have a role in acne development, but there wasn't a clear, standalone benefit of calcium treatment for managing acne. Instead, the combination of increased calcium and decreased vitamin D might contribute to the problems seen in younger patients with acne. Overall, our research highlights the complex interplay between these nutrients and sebaceous gland function, offering important insights for potential acne therapies.
References
- Shields A, Ly S, Wafae B, Chang YF, Manjaly P, et al. Safety and Effectiveness of Oral Nutraceuticals for Treating Acne: A Systematic Review. JAMA Dermatol. 2023;159:1373. 10.1001/jamadermatol.2023.3949
- Li X, Zeng X, Kim D, Jiang J, Wei F, et al. Krüppel-like factor 4 (KLF4) facilitates lipid production in immortalized human sebocytes via regulating the expression of SREBP1. Biochem Biophys Res Commun. 2023;667:146. 10.1016/j.bbrc.2023.05.043
- Antonino A, Francesco A. Prospective and randomized comparative study of calcium hydroxylapatite vs calcium hydroxylapatite plus HIFU in treatment of moderate-to-severe acne scars. J Cosmet Dermatol. 2021;20:53. 10.1111/jocd.13472
- Ahn B, Lee SH, Kim JH, Goh A, Park SG, et al. Identification and validation of amino acid-based mild exfoliating agents through a de novo screening method. J Cosmet Dermatol. 2019;18:1404. 10.1111/jocd.12871
- Casabona G. Combined use of microfocused ultrasound and a calcium hydroxylapatite dermal filler for treating atrophic acne scars: A pilot study. J Cosmet Laser Ther. 2018;20:301. 10.1080/14764172.2017.1406606
- Zouboulis CC, Seltmann H, Abdel-Naser MB, Hossini AM, Menon GK, et al. Effects of Extracellular Calcium and 1,25 dihydroxyvitamin D3 on Sebaceous Gland Cells In vitro and In vivo. Acta Derm Venereol. 2017;97:313. 10.2340/00015555-2525
