Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.5
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.9
Supplement Facts
Serving Size: 1 Softgel
Serving Per Container: 120
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Top Medical Research Studies
9
We conducted a study to see how coenzyme Q10 (CoQ10) supplementation impacts migraine symptoms and inflammation. This randomized double-blind trial involved 45 non-menopausal women with episodic migraines.
Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.
Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.
Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
Read More
8
We investigated whether coenzyme Q10 (CoQ10) could help reduce migraines. By examining five studies with 346 participants, we learned that CoQ10 may not significantly cut down on the number of attacks or their severity.
However, it appears to decrease the number of migraine days and duration each month. This suggests that while CoQ10 may not be a cure-all, it could help those suffering from migraines find some relief. Further research will be necessary to confirm these findings.
However, it appears to decrease the number of migraine days and duration each month. This suggests that while CoQ10 may not be a cure-all, it could help those suffering from migraines find some relief. Further research will be necessary to confirm these findings.
Read More
8
Co-Q10 potentially benefits migraine patients
We investigated how Coenzyme Q10 (Co-Q10) affects migraine symptoms in a well-structured clinical trial. Over the course of 12 weeks, 84 women aged 18 to 50 diagnosed with episodic migraines participated in a randomized, double-blind study, where they received either Co-Q10 (400 mg/day) or a placebo.
Upon analyzing the results, we observed some promising outcomes. Participants who took Co-Q10 experienced a significant reduction in malondialdehyde (MDA) levels, an indicator of oxidative stress. Additionally, there was a noteworthy increase in high-density lipoprotein cholesterol (HDL-C) levels, which is beneficial for overall heart health. We also noted a decrease in body fat percentage among those receiving Co-Q10.
However, while some improvements were documented, Co-Q10 did not show a significant effect on total antioxidant capacity or other lipid profile measures like low-density lipoprotein cholesterol and triglycerides. Therefore, while Co-Q10 may hold potential for enhancing certain health aspects in migraine sufferers, its overall impact on migraine management and other related parameters remains mixed.
Upon analyzing the results, we observed some promising outcomes. Participants who took Co-Q10 experienced a significant reduction in malondialdehyde (MDA) levels, an indicator of oxidative stress. Additionally, there was a noteworthy increase in high-density lipoprotein cholesterol (HDL-C) levels, which is beneficial for overall heart health. We also noted a decrease in body fat percentage among those receiving Co-Q10.
However, while some improvements were documented, Co-Q10 did not show a significant effect on total antioxidant capacity or other lipid profile measures like low-density lipoprotein cholesterol and triglycerides. Therefore, while Co-Q10 may hold potential for enhancing certain health aspects in migraine sufferers, its overall impact on migraine management and other related parameters remains mixed.
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Most Useful Reviews
9
Decreases migraines
1 people found this helpful
This CoQ10 is of great quality, offering better absorption with its technology. I take it consistently as it is excellent for health, and I've noticed a significant reduction in my daughter's migraines since she started using it. We ensure to take it with oily foods for enhanced absorption. Although the softgel is a bit large, the results are outstanding.
Read More
7.5
Reduces migraines
I trust the Jarrow brand for its reliability. CoQ10 appears beneficial for cardiovascular health, particularly in older individuals, and it has also reduced my migraines. Initially, it made me a bit sleepy, so I take it at night now.
Read More
0
Causes migraines
I developed a migraine after taking this product. While some might find it suitable, I often manage with soy supplements without issues. However, this particular product triggered a migraine for me. Additionally, the capsule has a bitter and nauseating taste, leading me to decide against purchasing it again.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.5
- All Researches
9
Nano-curcumin and CoQ10 reduce migraines
We explored how the combination of nano-curcumin and coenzyme Q10 (CoQ10) affects migraine symptoms and patients' quality of life. In a double-blind, placebo-controlled study involving 100 participants, we assessed the impacts on headache frequency, severity, and duration over eight weeks.
Our findings were promising: the group taking both nano-curcumin and CoQ10 showed significant improvements compared to those receiving the placebo or single supplements alone. Remarkably, this combination enhanced migraine-specific scores without any reported side effects. Overall, it highlights the potential benefits of these supplements in managing migraine.
Our findings were promising: the group taking both nano-curcumin and CoQ10 showed significant improvements compared to those receiving the placebo or single supplements alone. Remarkably, this combination enhanced migraine-specific scores without any reported side effects. Overall, it highlights the potential benefits of these supplements in managing migraine.
Read More
9
CoQ10 and L-carnitine aid migraines
We explored the impact of Coenzyme Q10 in combination with L-carnitine on migraine symptoms in a well-structured trial involving 56 participants aged 20-40. Over eight weeks, subjects received these supplements or a placebo.
Our findings show a substantial improvement in migraine-related aspects, including a decrease in headache severity, duration, and frequency, alongside lower serum lactate levels. This suggests that these supplements could be beneficial for those suffering from migraines.
Our findings show a substantial improvement in migraine-related aspects, including a decrease in headache severity, duration, and frequency, alongside lower serum lactate levels. This suggests that these supplements could be beneficial for those suffering from migraines.
Read More
9
We conducted a study to see how coenzyme Q10 (CoQ10) supplementation impacts migraine symptoms and inflammation. This randomized double-blind trial involved 45 non-menopausal women with episodic migraines.
Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.
Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.
Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
Read More
9
We explored the effects of a daily supplement containing coenzyme Q10, feverfew, and magnesium on migraine prevention. In our observational study, which included adult migraine sufferers, participants took the supplement for three months after a one-month baseline phase.
Results revealed a significant reduction in migraine days, dropping from an average of 4.9 days to 1.3 days by the third month. Additionally, 75% of participants experienced at least a 50% reduction in migraine frequency.
The treatment was well tolerated and also appeared to improve anxiety and depressive symptoms, enhancing overall quality of life.
Results revealed a significant reduction in migraine days, dropping from an average of 4.9 days to 1.3 days by the third month. Additionally, 75% of participants experienced at least a 50% reduction in migraine frequency.
The treatment was well tolerated and also appeared to improve anxiety and depressive symptoms, enhancing overall quality of life.
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9
We aimed to explore how a nutraceutical combination of Ginkgolide B, Coenzyme Q10, Riboflavin, and Magnesium could help children with neurofibromatosis type 1 manage migraine without aura. Over six months, 18 school-aged children took this supplement twice a day and kept journals tracking their migraine symptoms.
Remarkably, we observed significant reductions in frequency, intensity, duration, and overall migraine-related disability. Our findings reveal that this nutraceutical blend may effectively alleviate migraine symptoms for these children, marking a promising step forward in managing headaches associated with NF1.
Remarkably, we observed significant reductions in frequency, intensity, duration, and overall migraine-related disability. Our findings reveal that this nutraceutical blend may effectively alleviate migraine symptoms for these children, marking a promising step forward in managing headaches associated with NF1.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Decreases migraines
1 people found this helpful
This CoQ10 is of great quality, offering better absorption with its technology. I take it consistently as it is excellent for health, and I've noticed a significant reduction in my daughter's migraines since she started using it. We ensure to take it with oily foods for enhanced absorption. Although the softgel is a bit large, the results are outstanding.
Read More
7.5
Reduces migraines
I trust the Jarrow brand for its reliability. CoQ10 appears beneficial for cardiovascular health, particularly in older individuals, and it has also reduced my migraines. Initially, it made me a bit sleepy, so I take it at night now.
Read More
0
Causes migraines
I developed a migraine after taking this product. While some might find it suitable, I often manage with soy supplements without issues. However, this particular product triggered a migraine for me. Additionally, the capsule has a bitter and nauseating taste, leading me to decide against purchasing it again.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Sazali S, Badrin S, Norhayati MN, Idris NS. Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis. BMJ Open. 2021;11:e039358. 10.1136/bmjopen-2020-039358
- Lisicki M, Schoenen J. Metabolic treatments of migraine. Expert Rev Neurother. 2020;20:295. 10.1080/14737175.2020.1729130
- Parohan M, Sarraf P, Javanbakht MH, Foroushani AR, Ranji-Burachaloo S, et al. The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial. Nutr Neurosci. 2021;24:317. 10.1080/1028415X.2019.1627770
- Moscano F, Guiducci M, Maltoni L, Striano P, Ledda MG, et al. An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache. Ital J Pediatr. 2019;45:36. 10.1186/s13052-019-0624-z
- Parohan M, Sarraf P, Javanbakht MH, Ranji-Burachaloo S, Djalali M. Effect of coenzyme Q10 supplementation on clinical features of migraine: a systematic review and dose-response meta-analysis of randomized controlled trials. Nutr Neurosci. 2020;23:868. 10.1080/1028415X.2019.1572940
- Hajihashemi P, Askari G, Khorvash F, Reza Maracy M, Nourian M. The effects of concurrent Coenzyme Q10, L-carnitine supplementation in migraine prophylaxis: A randomized, placebo-controlled, double-blind trial. Cephalalgia. 2019;39:648. 10.1177/0333102418821661
- Zeng Z, Li Y, Lu S, Huang W, Di W. Efficacy of CoQ10 as supplementation for migraine: A meta-analysis. Acta Neurol Scand. 2019;139:284. 10.1111/ane.13051
- Dahri M, Tarighat-Esfanjani A, Asghari-Jafarabadi M, Hashemilar M. Oral coenzyme Q10 supplementation in patients with migraine: Effects on clinical features and inflammatory markers. Nutr Neurosci. 2019;22:607. 10.1080/1028415X.2017.1421039
- Guilbot A, Bangratz M, Ait Abdellah S, Lucas C. A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study. BMC Complement Altern Med. 2017;17:433. 10.1186/s12906-017-1933-7
- Shoeibi A, Olfati N, Soltani Sabi M, Salehi M, Mali S, et al. Effectiveness of coenzyme Q10 in prophylactic treatment of migraine headache: an open-label, add-on, controlled trial. Acta Neurol Belg. 2017;117:103. 10.1007/s13760-016-0697-z
- Gaul C, Diener HC, Danesch U. Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial. J Headache Pain. 2015;16:516. 10.1186/s10194-015-0516-6
- Carotenuto M, Esposito M. Nutraceuticals safety and efficacy in migraine without aura in a population of children affected by neurofibromatosis type I. Neurol Sci. 2013;34:1905. 10.1007/s10072-013-1403-z
- Pringsheim T, Davenport W, Mackie G, Worthington I, Aubé M, et al. Canadian Headache Society guideline for migraine prophylaxis. Can J Neurol Sci. 2012;39:S1.
- Slater SK, Nelson TD, Kabbouche MA, LeCates SL, Horn P, et al. A randomized, double-blinded, placebo-controlled, crossover, add-on study of CoEnzyme Q10 in the prevention of pediatric and adolescent migraine. Cephalalgia. 2011;31:897. 10.1177/0333102411406755
- Schiapparelli P, Allais G, Castagnoli Gabellari I, Rolando S, Terzi MG, et al. Non-pharmacological approach to migraine prophylaxis: part II. Neurol Sci. 2010;31 Suppl 1:S137. 10.1007/s10072-010-0307-4
- Tavasoli A, Rezazadeh M, Kachuei M. Eyebrow bleeding as a rare migraine symptom: a case report. Ann Med Surg (Lond). 2024;86:7377. 10.1097/MS9.0000000000002655
- Hajhashemy Z, Golpour-Hamedani S, Eshaghian N, Sadeghi O, Khorvash F, et al. Practical supplements for prevention and management of migraine attacks: a narrative review. Front Nutr. 2024;11:1433390. 10.3389/fnut.2024.1433390
- Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Espada-Rubio S, Agúndez JAG. Oxidative Stress and Migraine. Mol Neurobiol. 2024;61:8344. 10.1007/s12035-024-04114-7
- Hannigan IP, Rosengren SM, Di Tanna GL, Watson SRD, Welgampola MS. Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study. Intern Med J. 2024;54:916. 10.1111/imj.16314
- Dahri M, Sarafan Sadeghi A, Pahlavani N, Nattagh-Eshtivani E, Hashemilar M, et al. The Effects of Coenzyme Q10 Supplementation on Oxidative Status and Lipid Profile in Migraine Patients: A Randomized Double-Blinded Controlled Clinical Trial. Clin Nutr Res. 2023;12:257. 10.7762/cnr.2023.12.4.257
- Ebrahimi A, Kamyab A, Hosseini S, Ebrahimi S, Ashkani-Esfahani S. Involvement of Coenzyme Q10 in Various Neurodegenerative and Psychiatric Diseases. Biochem Res Int. 2023;2023:5510874. 10.1155/2023/5510874
- Stearns SA, Xun H, Haddad A, Rinkinen J, Bustos VP, et al. Therapeutic Options for Migraines in the Microsurgical Patient: A Scoping Review. Plast Reconstr Surg. 2024;153:988e. 10.1097/PRS.0000000000010861
- Yaghini O, Hoseini N, Ghazavi MR, Mansouri V, Nasiri J, et al. A Comparative Study on the Efficacy of Coenzyme Q10 and Amitriptyline in the Prophylactic Treatment of Migraine Headaches in Children: A Randomized Controlled Trial. Adv Biomed Res. 2022;11:43. 10.4103/abr.abr_235_20
- Ariyanfar S, Razeghi Jahromi S, Togha M, Ghorbani Z. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep. 2022;26:193. 10.1007/s11916-022-01019-9
- Grech O, Mollan SP, Wakerley BR, Fulton D, Lavery GG, et al. The Role of Metabolism in Migraine Pathophysiology and Susceptibility. Life (Basel). 2021;11. 10.3390/life11050415
- Kaur K, Hernandez V, Al Hajaj SW, Ebrahim AM, Razack M, et al. The Efficacy of Herbal Supplements and Nutraceuticals for Prevention of Migraine: Can They Help?. Cureus. 2021;13:e14868. 10.7759/cureus.14868
- Vikelis M, Dermitzakis EV, Vlachos GS, Soldatos P, Spingos KC, et al. Open Label Prospective Experience of Supplementation with a Fixed Combination of Magnesium, Vitamin B2, Feverfew, Andrographis Paniculata and Coenzyme Q10 for Episodic Migraine Prophylaxis. J Clin Med. 2020;10. 10.3390/jcm10010067
- Onofri A, Necozione S, Tozzi E. Complementary and alternative medicine (CAM) in headache of children and adolescents: open-label Italian study. Clin Ter. 2020;171:e393. 10.7417/CT.2020.2246
