Last update
3/18/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.8
USERS' SCORE
Moderately Good
Based on 19 Reviews
7.8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Milk Thistle Extract(Silybum marianum) (Fruit/Seed)(Standardized to 240 mg Silymarin Flavonoids - equivalent 80%)
300 mg
**
Dandelion Root (Taraxacum officinale)
100 mg
**
Artichoke (Cynara scolymus) (Leaf)
50 mg
**
Top Medical Research Studies
9
We examined how silibinin, a compound found in milk thistle, affects allergic asthma in a mouse model. Our findings showed that silibinin significantly helped reduce airway inflammation and hyperresponsiveness, mainly by targeting the NF-κB pathway. This suggests that silibinin might offer protective benefits against allergic airway conditions by moderating inflammatory responses. While our research found promising results in mice, further studies are necessary to confirm its effectiveness in human asthma treatment.
Read More
9
We explored the effects of silibinin on allergies by studying its impact on antibody production and T-cell responses in mice sensitized to ovalbumin. The mice received either no treatment or different doses of silibinin before being exposed to the allergen.
Our findings revealed that silibinin significantly reduced the levels of IgE antibodies, which are responsible for allergic reactions. Conversely, it boosted levels of IgG(2a), an antibody that can help fight off allergens.
Silibinin also shifted the immune response towards a balance that favors Th1 cells, which may provide a beneficial effect against allergies.
Our findings revealed that silibinin significantly reduced the levels of IgE antibodies, which are responsible for allergic reactions. Conversely, it boosted levels of IgG(2a), an antibody that can help fight off allergens.
Silibinin also shifted the immune response towards a balance that favors Th1 cells, which may provide a beneficial effect against allergies.
Read More
8
Silybine shows potential against allergies
We observed the effects of silybine, a key component derived from Silybum marianum seeds, on allergic reactions in rats. The study revealed that silybine can lower blood pressure and inhibit the severe responses associated with anaphylactic shock.
Notably, it appears to stabilize mast cell membranes, preventing the release of histamine—a major player in allergic reactions. However, while these findings are promising, it remains unclear how these effects translate to humans suffering from allergies.
Notably, it appears to stabilize mast cell membranes, preventing the release of histamine—a major player in allergic reactions. However, while these findings are promising, it remains unclear how these effects translate to humans suffering from allergies.
Read More
Most Useful Reviews
9
Effective support
64 people found this helpful
My husband suffered from seasonal allergies each spring, with watery and itchy eyes, and a runny nose. Over-the-counter antihistamines did nothing. Following a recommendation, I took a liver support regimen before the flowering season began, including silymarin and quercetin, alongside an antihistamine diet. It worked! Supporting the liver is crucial in managing allergies.
Read More
9
No more allergies
32 people found this helpful
I cleanse my liver annually, which has eliminated my severe springtime allergies. Previously, I was housebound during this season, and antihistamines like Cetrin were ineffective. After starting liver support with Burdock and Milk Thistle, my allergy symptoms ceased within days. I can finally breathe freely!
Read More
7.5
Skin improvement
17 people found this helpful
This supplement, mainly composed of milk thistle, detoxifies the liver and aids in filtering the body. I've found it particularly effective during seasonal allergies, noting improvements in my skin condition. While the taste is not pleasant, the benefits are noteworthy and make it worthwhile.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.8
- All Researches
9
We examined how silibinin, a compound found in milk thistle, affects allergic asthma in a mouse model. Our findings showed that silibinin significantly helped reduce airway inflammation and hyperresponsiveness, mainly by targeting the NF-κB pathway. This suggests that silibinin might offer protective benefits against allergic airway conditions by moderating inflammatory responses. While our research found promising results in mice, further studies are necessary to confirm its effectiveness in human asthma treatment.
Read More
9
We explored the effects of silibinin on allergies by studying its impact on antibody production and T-cell responses in mice sensitized to ovalbumin. The mice received either no treatment or different doses of silibinin before being exposed to the allergen.
Our findings revealed that silibinin significantly reduced the levels of IgE antibodies, which are responsible for allergic reactions. Conversely, it boosted levels of IgG(2a), an antibody that can help fight off allergens.
Silibinin also shifted the immune response towards a balance that favors Th1 cells, which may provide a beneficial effect against allergies.
Our findings revealed that silibinin significantly reduced the levels of IgE antibodies, which are responsible for allergic reactions. Conversely, it boosted levels of IgG(2a), an antibody that can help fight off allergens.
Silibinin also shifted the immune response towards a balance that favors Th1 cells, which may provide a beneficial effect against allergies.
Read More
9
We explored how silymarin, a natural compound from milk thistle, impacts UV light-induced immune suppression and oxidative stress. Testing on mice showed that silymarin treatment significantly enhanced the skin's immune response, reducing harmful leukocyte infiltration and lowering levels of immunosuppressive cytokines.
Notably, silymarin also decreased the production of reactive oxygen species and nitric oxide linked to skin damage. Our findings suggest that silymarin could be a promising candidate for developing skincare products or sunscreens aimed at preventing skin cancer.
Notably, silymarin also decreased the production of reactive oxygen species and nitric oxide linked to skin damage. Our findings suggest that silymarin could be a promising candidate for developing skincare products or sunscreens aimed at preventing skin cancer.
Read More
8
Silybine shows potential against allergies
We observed the effects of silybine, a key component derived from Silybum marianum seeds, on allergic reactions in rats. The study revealed that silybine can lower blood pressure and inhibit the severe responses associated with anaphylactic shock.
Notably, it appears to stabilize mast cell membranes, preventing the release of histamine—a major player in allergic reactions. However, while these findings are promising, it remains unclear how these effects translate to humans suffering from allergies.
Notably, it appears to stabilize mast cell membranes, preventing the release of histamine—a major player in allergic reactions. However, while these findings are promising, it remains unclear how these effects translate to humans suffering from allergies.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 19 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective support
64 people found this helpful
My husband suffered from seasonal allergies each spring, with watery and itchy eyes, and a runny nose. Over-the-counter antihistamines did nothing. Following a recommendation, I took a liver support regimen before the flowering season began, including silymarin and quercetin, alongside an antihistamine diet. It worked! Supporting the liver is crucial in managing allergies.
Read More
9
No more allergies
32 people found this helpful
I cleanse my liver annually, which has eliminated my severe springtime allergies. Previously, I was housebound during this season, and antihistamines like Cetrin were ineffective. After starting liver support with Burdock and Milk Thistle, my allergy symptoms ceased within days. I can finally breathe freely!
Read More
7.5
Skin improvement
17 people found this helpful
This supplement, mainly composed of milk thistle, detoxifies the liver and aids in filtering the body. I've found it particularly effective during seasonal allergies, noting improvements in my skin condition. While the taste is not pleasant, the benefits are noteworthy and make it worthwhile.
Read More
9
Allergy assistant
5 people found this helpful
SILIMARIN is an essential hepatoprotector in my home. I take it once or twice yearly, and it's invaluable for dealing with allergies and poisoning. I suffer from skin allergies, and this supplement has been my go-to remedy for managing my condition.
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0
Caused hives reaction
3 people found this helpful
This product caused me to break out in hives within three days. My vet recommended milk thistle for my dog’s high liver results. I thought I would try it but woke up with hives after taking it. I’ve not had allergies for years, so I suspect it’s related to this product.
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Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Choi YH, Jin GY, Guo HS, Piao HM, Li Lc, et al. Silibinin attenuates allergic airway inflammation in mice. Biochem Biophys Res Commun. 2012;427:450. 10.1016/j.bbrc.2012.07.112
- Kuo FH, Jan TR. Silibinin attenuates antigen-specific IgE production through the modulation of Th1/Th2 balance in ovalbumin-sensitized BALB/c mice. Phytomedicine. 2009;16:271. 10.1016/j.phymed.2008.07.006
- Katiyar SK. Treatment of silymarin, a plant flavonoid, prevents ultraviolet light-induced immune suppression and oxidative stress in mouse skin. Int J Oncol. 2002;21:1213. PubMed
- Lecomte J. [General pharmacologic properties of silybine and silymarine in the rat]. Arch Int Pharmacodyn Ther. 1975;214:165. PubMed
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