Last update
3/11/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
USERS' SCORE
Good
Based on 14 Reviews
8
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Acetyl-L-Carnitine (from 1,250 mg Acetyl-L-Carnitine HCl)
1 g (1,000 mg)
**
Top Medical Research Studies
7
We investigated the effects of acetyl-L-carnitine (ALCAR) on anxiety-like behaviors in rats, using a systematic approach with control groups. Our findings revealed that chronic doses of 50 and 75 mg/kg significantly reduced anxiety, while doses of 10 and 100 mg/kg showed no effect. In an interesting twist, an acute dose of 100 mg/kg led to increased anxiety. This suggests a complex relationship where ALCAR may work differently depending on the dosage and timing. More research is needed to clarify how ALCAR influences anxiety in these cases.
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8
ALC shows promise for anxiety treatment
We evaluated how acetyl-L-carnitine (ALC) can influence anxiety-like behaviors in zebrafish under stress. Using a protocol that simulated unpredictable chronic stress, we saw that the fish exhibited increased anxiety and oxidative stress.
Remarkably, after ALC treatment, these anxiety-like behaviors and signs of oxidative damage were significantly reduced in the stressed group. However, ALC showed negligible effects on the control animals.
Although our findings highlight ALC’s potential as a neuroprotective agent for stress-related psychiatric disorders, more research is necessary to fully understand how it works and confirm its effectiveness.
Remarkably, after ALC treatment, these anxiety-like behaviors and signs of oxidative damage were significantly reduced in the stressed group. However, ALC showed negligible effects on the control animals.
Although our findings highlight ALC’s potential as a neuroprotective agent for stress-related psychiatric disorders, more research is necessary to fully understand how it works and confirm its effectiveness.
Read More
8
We explored how acetyl-l-carnitine (LAC) treatment affects anxiety linked to stress. In our study, mice experiencing chronic stress showed structural changes in the medial amygdala, a brain area crucial for anxiety responses.
We introduced LAC shortly before the stress period ended, and we saw some promising results. Treatment with LAC improved social interaction and reduced passive behaviors in stressful situations, indicating enhanced resilience. However, while LAC influenced some brain structures positively, it did not entirely reverse stress-related changes in all neuron types.
We introduced LAC shortly before the stress period ended, and we saw some promising results. Treatment with LAC improved social interaction and reduced passive behaviors in stressful situations, indicating enhanced resilience. However, while LAC influenced some brain structures positively, it did not entirely reverse stress-related changes in all neuron types.
Read More
Most Useful Reviews
9
Reduced social fear
8 people found this helpful
Six stars out of five! This is the best supplement I've used so far. It significantly reduces stress and improves mood, making it ideal for anyone facing social anxiety or fear of public speaking.
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9
Helps with multiple issues
I have AuDHD and various autoimmune problems; taking one daily helps ease my anxiety, depression, and obsessive thoughts. It works well, especially in conjunction with NAC and L-Theanine.
Read More
7.5
Energy and clarity boost
406 people found this helpful
Do you lack energy or clarity? I have Fibromyalgia with chronic fatigue and often spend days in bed. After researching ALC, I began a regimen that gave me great energy, clarity, and mood improvement. I had a rash once but adjusted my dosage. Now, I take three capsules daily and no longer break out. While I still have lazy days, my overall energy has increased, which has changed my life. I recommend ALC to anyone with fatigue, memory issues, anxiety, or low moods.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
- All Researches
9
We checked how acetyl-L-carnitine (ALC) affects patients with minimal hepatic encephalopathy (MHE), a condition that can lower quality of life. Through a rigorous, randomized, double-blind study with 67 participants, half received ALC while the other half got a placebo for 90 days.
By the end, those on ALC reported notable improvements in energy and mental health, correlating with lower anxiety and depression levels. This suggests that ALC could be a valuable treatment option for enhancing well-being in patients facing this challenging condition.
By the end, those on ALC reported notable improvements in energy and mental health, correlating with lower anxiety and depression levels. This suggests that ALC could be a valuable treatment option for enhancing well-being in patients facing this challenging condition.
Read More
8
ALC shows promise for anxiety treatment
We evaluated how acetyl-L-carnitine (ALC) can influence anxiety-like behaviors in zebrafish under stress. Using a protocol that simulated unpredictable chronic stress, we saw that the fish exhibited increased anxiety and oxidative stress.
Remarkably, after ALC treatment, these anxiety-like behaviors and signs of oxidative damage were significantly reduced in the stressed group. However, ALC showed negligible effects on the control animals.
Although our findings highlight ALC’s potential as a neuroprotective agent for stress-related psychiatric disorders, more research is necessary to fully understand how it works and confirm its effectiveness.
Remarkably, after ALC treatment, these anxiety-like behaviors and signs of oxidative damage were significantly reduced in the stressed group. However, ALC showed negligible effects on the control animals.
Although our findings highlight ALC’s potential as a neuroprotective agent for stress-related psychiatric disorders, more research is necessary to fully understand how it works and confirm its effectiveness.
Read More
8
We explored how acetyl-l-carnitine (LAC) treatment affects anxiety linked to stress. In our study, mice experiencing chronic stress showed structural changes in the medial amygdala, a brain area crucial for anxiety responses.
We introduced LAC shortly before the stress period ended, and we saw some promising results. Treatment with LAC improved social interaction and reduced passive behaviors in stressful situations, indicating enhanced resilience. However, while LAC influenced some brain structures positively, it did not entirely reverse stress-related changes in all neuron types.
We introduced LAC shortly before the stress period ended, and we saw some promising results. Treatment with LAC improved social interaction and reduced passive behaviors in stressful situations, indicating enhanced resilience. However, while LAC influenced some brain structures positively, it did not entirely reverse stress-related changes in all neuron types.
Read More
8
Antidepressant and carnitine effective
We examined how combining acetyl-L-carnitine with modern antidepressants affects anxiety and depression in elderly patients. In our study involving two groups of older individuals, we compared those receiving solo antidepressant treatment to those receiving a combination with carnitine over eight weeks.
The results showed that the combination therapy led to quicker improvements in anxiety and other symptoms, while also causing fewer side effects. Thus, we recommend this approach for better managing depression in older adults.
The results showed that the combination therapy led to quicker improvements in anxiety and other symptoms, while also causing fewer side effects. Thus, we recommend this approach for better managing depression in older adults.
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8
We analyzed randomized controlled trials to see how effective different treatments for persistent depressive disorder are.
Our study included data from over 8,000 patients across multiple interventions, including medications, psychotherapy, and combinations of both.
Notably, acetyl-l-carnitine showed significant effectiveness, with an odds ratio that indicates it performs better than a placebo.
However, while various treatments stand out, we also found important differences in their acceptability and effectiveness.
Our study included data from over 8,000 patients across multiple interventions, including medications, psychotherapy, and combinations of both.
Notably, acetyl-l-carnitine showed significant effectiveness, with an odds ratio that indicates it performs better than a placebo.
However, while various treatments stand out, we also found important differences in their acceptability and effectiveness.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced social fear
8 people found this helpful
Six stars out of five! This is the best supplement I've used so far. It significantly reduces stress and improves mood, making it ideal for anyone facing social anxiety or fear of public speaking.
Read More
9
Helps with multiple issues
I have AuDHD and various autoimmune problems; taking one daily helps ease my anxiety, depression, and obsessive thoughts. It works well, especially in conjunction with NAC and L-Theanine.
Read More
7.5
Energy and clarity boost
406 people found this helpful
Do you lack energy or clarity? I have Fibromyalgia with chronic fatigue and often spend days in bed. After researching ALC, I began a regimen that gave me great energy, clarity, and mood improvement. I had a rash once but adjusted my dosage. Now, I take three capsules daily and no longer break out. While I still have lazy days, my overall energy has increased, which has changed my life. I recommend ALC to anyone with fatigue, memory issues, anxiety, or low moods.
Read More
9
Increased motivation
13 people found this helpful
This product worked for me as I dealt with issues of poor energy, motivation, and anxiety. Now I feel much better after dietary changes and stopping smoking and caffeine. Whatever it is, don’t give up!
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7.5
Improved conversation confidence
1 people found this helpful
I have ADHD and struggle with severe anxiety and fatigue that affect my daily communication. After taking these supplements, I found myself able to engage in conversations without anxiety. I'm more focused and energetic now. It's been a subtle yet significant improvement compared to other options.
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Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- McIlwrath SL, Starr ME, High AE, Saito H, Westlund KN. Effect of acetyl-L-carnitine on hypersensitivity in acute recurrent caerulein-induced pancreatitis and microglial activation along the brain's pain circuitry. World J Gastroenterol. 2021;27:794. 10.3748/wjg.v27.i9.794
- Nasca C, Menard C, Hodes G, Bigio B, Pena C, et al. Multidimensional Predictors of Susceptibility and Resilience to Social Defeat Stress. Biol Psychiatry. 2019;86:483. 10.1016/j.biopsych.2019.06.030
- Marcon M, Mocelin R, de Oliveira DL, da Rosa Araujo AS, Herrmann AP, et al. Acetyl-L-carnitine as a putative candidate for the treatment of stress-related psychiatric disorders: Novel evidence from a zebrafish model. Neuropharmacology. 2019;150:145. 10.1016/j.neuropharm.2019.03.024
- Lau T, Bigio B, Zelli D, McEwen BS, Nasca C. Stress-induced structural plasticity of medial amygdala stellate neurons and rapid prevention by a candidate antidepressant. Mol Psychiatry. 2017;22:227. 10.1038/mp.2016.68
- Gavrilova SI, Kalyn YB, Safarova TP, Yakovleva OB, Sheshenin VS, et al. [Optimization of the efficacy and safety of antidepressant therapy in patients of a geriatric psychiatric unit]. Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115:24. 10.17116/jnevro20151156124-32
- Kriston L, von Wolff A, Westphal A, Hölzel LP, Härter M. Efficacy and acceptability of acute treatments for persistent depressive disorder: a network meta-analysis. Depress Anxiety. 2014;31:621. 10.1002/da.22236
- Malaguarnera M, Bella R, Vacante M, Giordano M, Malaguarnera G, et al. Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy. Scand J Gastroenterol. 2011;46:750. 10.3109/00365521.2011.565067
- Levine J, Kaplan Z, Pettegrew JW, McClure RJ, Gershon S, et al. Effect of intraperitoneal acetyl-L-carnitine (ALCAR) on anxiety-like behaviours in rats. Int J Neuropsychopharmacol. 2005;8:65. PubMed
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