Last update
3/18/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5
USERS' SCORE
Good
Based on 2 Reviews
8
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Acetyl-L-Carnitine (from 1,250 mg Acetyl-L-Carnitine HCl)
1 g (1,000 mg)
**
Top Medical Research Studies
2
We conducted a robust study comparing acetyl-l-carnitine to a placebo for preventing migraines.
In a triple-blind, crossover design, 72 participants aged 18-65 received either the treatment or placebo for 12 weeks.
Unfortunately, our findings showed no significant differences in headache days between the two groups, meaning acetyl-l-carnitine did not prove effective as a preventive measure for migraines.
In a triple-blind, crossover design, 72 participants aged 18-65 received either the treatment or placebo for 12 weeks.
Unfortunately, our findings showed no significant differences in headache days between the two groups, meaning acetyl-l-carnitine did not prove effective as a preventive measure for migraines.
Read More
8
We looked into how various metabolic factors relate to migraines in patients with patent foramen ovale (PFO). Our study involved 11 PFO patients undergoing surgery and 11 healthy controls.
We found notable differences in certain metabolites like acetylcarnitine and dopamine between the groups. After the surgery, PFO patients experienced significant reductions in headache frequency and severity.
However, while their headaches improved, other migraine symptoms didn't change significantly. Overall, the surgery showed promise in alleviating migraines associated with PFO.
We found notable differences in certain metabolites like acetylcarnitine and dopamine between the groups. After the surgery, PFO patients experienced significant reductions in headache frequency and severity.
However, while their headaches improved, other migraine symptoms didn't change significantly. Overall, the surgery showed promise in alleviating migraines associated with PFO.
Read More
Most Useful Reviews
7.5
Notable improvements
3 people found this helpful
We frequently host the entire family. Acetyl-L-Carnitine is the best form for absorption. A teenager with disabilities and migraines takes this supplement along with a basic protocol, and the improvements are noticeable over the year.
Read More
2
Energy boost
The product is okay for me, although it does trigger migraines. On the positive side, it provides energy, as many reviews suggest. When I'm utterly drained, the pill is quite helpful. However, I can only take it every two days; if I take it daily, I end up with a strong migraine. I've experimented with different methods of taking it because I appreciate the effect of the medication, yet the migraines persist.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5
- All Researches
8
We looked into how various metabolic factors relate to migraines in patients with patent foramen ovale (PFO). Our study involved 11 PFO patients undergoing surgery and 11 healthy controls.
We found notable differences in certain metabolites like acetylcarnitine and dopamine between the groups. After the surgery, PFO patients experienced significant reductions in headache frequency and severity.
However, while their headaches improved, other migraine symptoms didn't change significantly. Overall, the surgery showed promise in alleviating migraines associated with PFO.
We found notable differences in certain metabolites like acetylcarnitine and dopamine between the groups. After the surgery, PFO patients experienced significant reductions in headache frequency and severity.
However, while their headaches improved, other migraine symptoms didn't change significantly. Overall, the surgery showed promise in alleviating migraines associated with PFO.
Read More
2
We conducted a robust study comparing acetyl-l-carnitine to a placebo for preventing migraines.
In a triple-blind, crossover design, 72 participants aged 18-65 received either the treatment or placebo for 12 weeks.
Unfortunately, our findings showed no significant differences in headache days between the two groups, meaning acetyl-l-carnitine did not prove effective as a preventive measure for migraines.
In a triple-blind, crossover design, 72 participants aged 18-65 received either the treatment or placebo for 12 weeks.
Unfortunately, our findings showed no significant differences in headache days between the two groups, meaning acetyl-l-carnitine did not prove effective as a preventive measure for migraines.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Notable improvements
3 people found this helpful
We frequently host the entire family. Acetyl-L-Carnitine is the best form for absorption. A teenager with disabilities and migraines takes this supplement along with a basic protocol, and the improvements are noticeable over the year.
Read More
2
Energy boost
The product is okay for me, although it does trigger migraines. On the positive side, it provides energy, as many reviews suggest. When I'm utterly drained, the pill is quite helpful. However, I can only take it every two days; if I take it daily, I end up with a strong migraine. I've experimented with different methods of taking it because I appreciate the effect of the medication, yet the migraines persist.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Tuerxun P, Liu J, Aisaiti A, Shen G, Gong P, et al. Preliminary exploration of metabolomics mechanisms in patients with patent foramen ovale and migraine. J Oral Facial Pain Headache. 2024;38:111. 10.22514/jofph.2024.044
- Hagen K, Brenner E, Linde M, Gravdahl GB, Tronvik EA, et al. Acetyl-l-carnitine versus placebo for migraine prophylaxis: A randomized, triple-blind, crossover study. Cephalalgia. 2015;35:987. 10.1177/0333102414566817
Data last updated:
