Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.6
USERS' SCORE
Good
Based on 3 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
L-Carnitine (Carnipure®)(from 1,493 mg L-Carnitine Tartrate)
1 g (1,000 mg)
**
Top Medical Research Studies
9
We explored the effects of L-carnitine on patients suffering from cystic acne who were undergoing isotretinoin therapy. This study involved 230 patients, all treated with a standard isotretinoin dosage. When they began to experience muscular symptoms, we examined the role of L-carnitine supplementation. Half of the patients received L-carnitine, while the other half received a placebo.
The results were encouraging for those on L-carnitine. Patients who received the supplement reported a notable improvement in muscle pain and discomfort within just a week. Additionally, their liver enzyme levels returned to normal, along with an increase in carnitine levels. In contrast, the placebo group continued to struggle with muscle symptoms, highlighting the potential benefits of L-carnitine for these patients. For those who did not experience muscle issues initially, we observed decreases in carnitine blood levels and elevation in liver enzymes, indicating an overall systemic effect from isotretinoin.
While these findings are promising, they call for further investigation to confirm the benefits of L-carnitine supplementation for patients undergoing isotretinoin therapy.
The results were encouraging for those on L-carnitine. Patients who received the supplement reported a notable improvement in muscle pain and discomfort within just a week. Additionally, their liver enzyme levels returned to normal, along with an increase in carnitine levels. In contrast, the placebo group continued to struggle with muscle symptoms, highlighting the potential benefits of L-carnitine for these patients. For those who did not experience muscle issues initially, we observed decreases in carnitine blood levels and elevation in liver enzymes, indicating an overall systemic effect from isotretinoin.
While these findings are promising, they call for further investigation to confirm the benefits of L-carnitine supplementation for patients undergoing isotretinoin therapy.
Read More
9
Our exploration focused on the impact of l-carnitine in treating acne, aiming to understand how it influences key factors like exfoliation, lipogenesis (the production of fats), bacterial growth, and inflammation.
Through our analysis, we noted that while l-carnitine shows potential in these areas, the study also investigated other treatments concurrently. This approach made it challenging to isolate l-carnitine's effects definitively, as multiple factors could play a role in the overall treatment outcomes.
Ultimately, the results suggested that while l-carnitine might contribute to some improvement, any significant benefit in acne treatment wasn't clearly established. We are left with important insights but also recognize the need for further research to pinpoint l-carnitine's specific contributions.
Through our analysis, we noted that while l-carnitine shows potential in these areas, the study also investigated other treatments concurrently. This approach made it challenging to isolate l-carnitine's effects definitively, as multiple factors could play a role in the overall treatment outcomes.
Ultimately, the results suggested that while l-carnitine might contribute to some improvement, any significant benefit in acne treatment wasn't clearly established. We are left with important insights but also recognize the need for further research to pinpoint l-carnitine's specific contributions.
Read More
9
IPL therapy with L-carnitine effective
We explored the effectiveness of a unique combination treatment for acne that includes intense pulsed light (IPL) therapy along with a special cream containing licochalcone A, L-carnitine, and decanediol. The study included 29 volunteers aged between 21 and 39, who were experiencing mild to severe facial acne. By using a split-face approach, we applied IPL therapy combined with the active cream on one side of their faces while the other side received the therapy with a placebo cream.
Our findings revealed that the acne treatment was significantly more effective when combined with the active formulation. Not only did subjects experience a noticeable reduction in acne, but they also saw improvements in post-inflammatory hyperpigmentation. This suggests that combining L-carnitine with IPL therapy contributes positively to acne treatment outcomes. Overall, this combination appears to be a safe and effective option for those struggling with moderate to severe acne.
Our findings revealed that the acne treatment was significantly more effective when combined with the active formulation. Not only did subjects experience a noticeable reduction in acne, but they also saw improvements in post-inflammatory hyperpigmentation. This suggests that combining L-carnitine with IPL therapy contributes positively to acne treatment outcomes. Overall, this combination appears to be a safe and effective option for those struggling with moderate to severe acne.
Read More
Most Useful Reviews
7.5
Supports acne treatment
2nd time buying. L-carnitine is an important amino acid that supports fat metabolism. Among its many benefits, it assists with my facial acne. It’s essential for me.
Read More
6
Improves acne treatment
Used as part of an acne treatment and skin improvement regimen, it accelerates fluid excretion.
Read More
7.5
Enhances acne control
A must-have! I take this with vitamin B5 (pantothenic acid) which has greatly helped with both my acne and energy levels.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.6
- All Researches
9
Our exploration focused on the impact of l-carnitine in treating acne, aiming to understand how it influences key factors like exfoliation, lipogenesis (the production of fats), bacterial growth, and inflammation.
Through our analysis, we noted that while l-carnitine shows potential in these areas, the study also investigated other treatments concurrently. This approach made it challenging to isolate l-carnitine's effects definitively, as multiple factors could play a role in the overall treatment outcomes.
Ultimately, the results suggested that while l-carnitine might contribute to some improvement, any significant benefit in acne treatment wasn't clearly established. We are left with important insights but also recognize the need for further research to pinpoint l-carnitine's specific contributions.
Through our analysis, we noted that while l-carnitine shows potential in these areas, the study also investigated other treatments concurrently. This approach made it challenging to isolate l-carnitine's effects definitively, as multiple factors could play a role in the overall treatment outcomes.
Ultimately, the results suggested that while l-carnitine might contribute to some improvement, any significant benefit in acne treatment wasn't clearly established. We are left with important insights but also recognize the need for further research to pinpoint l-carnitine's specific contributions.
Read More
9
We investigated the potential of L-carnitine combined with salicylic acid, referred to as IP-BHA, and magnolol to combat acne effectively. Traditional salicylic acid has been useful for acne treatment due to its ability to reduce skin cell buildup and kill bacteria. However, we aimed to enhance its performance and reduce skin irritation, especially at neutral pH levels.
Through our research, we found that the combination of IP-BHA and magnolol significantly improved anti-acne effects. Notably, magnolol demonstrated robust antibacterial activity against Cutibacterium acnes, surpassing that of a widely used antibiotic, clindamycin. When paired with IP-BHA, the antibacterial effectiveness increased by 2.5 times, showcasing the strength of their combined properties.
We also observed the duo's positive impact on reducing lipogenesis triggered by testosterone, while independent treatment showed minimal effects. Additionally, inflammatory markers linked to C. acnes were completely inhibited when using both IP-BHA and magnolol together. These powerful ingredients not only help in exfoliating the skin but also soothe inflammation linked to acne.
Our study highlights that the ionic pair of L-carnitine and salicylic acid can be effective against acne while remaining gentle on the skin. The findings suggest promising opportunities for using IP-BHA and magnolol as a treatment option for improving inflammatory acne conditions.
Through our research, we found that the combination of IP-BHA and magnolol significantly improved anti-acne effects. Notably, magnolol demonstrated robust antibacterial activity against Cutibacterium acnes, surpassing that of a widely used antibiotic, clindamycin. When paired with IP-BHA, the antibacterial effectiveness increased by 2.5 times, showcasing the strength of their combined properties.
We also observed the duo's positive impact on reducing lipogenesis triggered by testosterone, while independent treatment showed minimal effects. Additionally, inflammatory markers linked to C. acnes were completely inhibited when using both IP-BHA and magnolol together. These powerful ingredients not only help in exfoliating the skin but also soothe inflammation linked to acne.
Our study highlights that the ionic pair of L-carnitine and salicylic acid can be effective against acne while remaining gentle on the skin. The findings suggest promising opportunities for using IP-BHA and magnolol as a treatment option for improving inflammatory acne conditions.
Read More
We evaluated the effectiveness of a moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid for preventing acne relapse during the maintenance phase in Thai patients with mild to moderate acne. In a controlled clinical trial, after an initial treatment with a combination of adapalene and benzoyl peroxide, patients who saw significant improvement were split into two groups.
Each group applied either the moisturizer or a vehicle lotion without active ingredients to different sides of their faces for 12 weeks. By looking at acne lesion counts and the overall severity of acne, we observed that the treatment group using the active moisturizer had notably fewer lesions after the trial period.
Importantly, we found no significant differences in skin dryness or irritation between the groups, suggesting the product was well-tolerated. The inclusion of L-carnitine in the moisturizer seems to contribute positively to reducing acne lesions and preventing new ones during this maintenance phase, even if we cannot determine its isolated effects due to the combination method used in the study.
Each group applied either the moisturizer or a vehicle lotion without active ingredients to different sides of their faces for 12 weeks. By looking at acne lesion counts and the overall severity of acne, we observed that the treatment group using the active moisturizer had notably fewer lesions after the trial period.
Importantly, we found no significant differences in skin dryness or irritation between the groups, suggesting the product was well-tolerated. The inclusion of L-carnitine in the moisturizer seems to contribute positively to reducing acne lesions and preventing new ones during this maintenance phase, even if we cannot determine its isolated effects due to the combination method used in the study.
Read More
9
L-Carnitine benefits mild acne treatment
We conducted a study to assess how a daily routine involving Licochalcone A, Salicylic acid, and L-Carnitine can improve mild facial acne. Over eight weeks, 91 adults applied a fluid with Licochalcone A, Salicylic acid, and L-Carnitine in the morning and a cream with Licochalcone A and Hydroxy-Complex 10% at night.
Our effectiveness measurements used the Global Acne Grading System (GAGS) and counted comedones (clogged pores) and papules (small raised bumps). By the four-week mark, we observed a statistically significant decrease in GAGS scores, along with a 41% reduction in comedones and a 45% decrease in papules. Additionally, there was a notable drop in sebum production by about 47%.
By the end of the eight-week treatment period, these positive trends persisted, showcasing further reductions of 64% in GAGS scores and 71% in both comedones and papules. This suggests that the combination regimen we explored—featuring L-Carnitine as a key ingredient—presents a promising option for those dealing with mild acne, offering a pleasant approach to skin care.
Our effectiveness measurements used the Global Acne Grading System (GAGS) and counted comedones (clogged pores) and papules (small raised bumps). By the four-week mark, we observed a statistically significant decrease in GAGS scores, along with a 41% reduction in comedones and a 45% decrease in papules. Additionally, there was a notable drop in sebum production by about 47%.
By the end of the eight-week treatment period, these positive trends persisted, showcasing further reductions of 64% in GAGS scores and 71% in both comedones and papules. This suggests that the combination regimen we explored—featuring L-Carnitine as a key ingredient—presents a promising option for those dealing with mild acne, offering a pleasant approach to skin care.
Read More
9
IPL therapy with L-carnitine effective
We explored the effectiveness of a unique combination treatment for acne that includes intense pulsed light (IPL) therapy along with a special cream containing licochalcone A, L-carnitine, and decanediol. The study included 29 volunteers aged between 21 and 39, who were experiencing mild to severe facial acne. By using a split-face approach, we applied IPL therapy combined with the active cream on one side of their faces while the other side received the therapy with a placebo cream.
Our findings revealed that the acne treatment was significantly more effective when combined with the active formulation. Not only did subjects experience a noticeable reduction in acne, but they also saw improvements in post-inflammatory hyperpigmentation. This suggests that combining L-carnitine with IPL therapy contributes positively to acne treatment outcomes. Overall, this combination appears to be a safe and effective option for those struggling with moderate to severe acne.
Our findings revealed that the acne treatment was significantly more effective when combined with the active formulation. Not only did subjects experience a noticeable reduction in acne, but they also saw improvements in post-inflammatory hyperpigmentation. This suggests that combining L-carnitine with IPL therapy contributes positively to acne treatment outcomes. Overall, this combination appears to be a safe and effective option for those struggling with moderate to severe acne.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Supports acne treatment
2nd time buying. L-carnitine is an important amino acid that supports fat metabolism. Among its many benefits, it assists with my facial acne. It’s essential for me.
Read More
6
Improves acne treatment
Used as part of an acne treatment and skin improvement regimen, it accelerates fluid excretion.
Read More
7.5
Enhances acne control
A must-have! I take this with vitamin B5 (pantothenic acid) which has greatly helped with both my acne and energy levels.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- How KN, Ho WC, Sundaran M, Wan Ahmal Kammal WSL, Lim PY, et al. Efficacy and Tolerability of a Sunscreen Containing Licochalcone a and L-Carnitine as an Adjunct to Retinoids in the Management of Acne and Post-Acne Pigmentation Among Malaysian Patients. Clin Cosmet Investig Dermatol. 2023;16:3719. doi:10.2147/CCID.S422898
- Correction to Anti-acne activity of carnitine salicylate and magnolol through the regulation of exfoliation, lipogenesis, bacterial growth and inflammation. Skin Res Technol. 2023;29:e13406. doi:10.1111/srt.13451
- Kwon KC, Won JG, Kim MS, Shin YW, Park SW, et al. Anti-acne activity of carnitine salicylate and magnolol through the regulation of exfoliation, lipogenesis, bacterial growth and inflammation. Skin Res Technol. 2023;29:e13406. doi:10.1111/srt.13406
- Wongtada C, Pewlong P, Asawanonda P, Noppakun N, Pongpamorn P, et al. Influence of moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid on facial skin lipidome among seborrhea participants. J Cosmet Dermatol. 2022;21:7081. doi:10.1111/jocd.15381
- Kulthanan K, Trakanwittayarak S, Tuchinda P, Chularojanamontri L, Limphoka P, et al. A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population. Biomed Res Int. 2020;2020:2857812. doi:10.1155/2020/2857812
- Dall'Oglio F, Fabbrocini G, Tedeschi A, Donnarumma M, Chiodini P, et al. Licochalcone A in Combination with Salicylic Acid as Fluid Based and Hydroxy-Complex 10% Cream for the Treatment of Mild Acne: A Multicenter Prospective Trial. Clin Cosmet Investig Dermatol. 2019;12:961. doi:10.2147/CCID.S206935
- Wanitphakdeedecha R, Tavechodperathum N, Tantrapornpong P, Suphatsathienkul P, Techapichetvanich T, et al. Acne treatment efficacy of intense pulsed light photodynamic therapy with topical licochalcone A, l-carnitine, and decanediol: A spilt-face, double-blind, randomized controlled trial. J Cosmet Dermatol. 2020;19:78. doi:10.1111/jocd.13178
- Chularojanamontri L, Tuchinda P, Kulthanan K, Varothai S, Winayanuwattikun W. A double-blinded, randomized, vehicle-controlled study to access skin tolerability and efficacy of an anti-inflammatory moisturizer in treatment of acne with 0.1% adapalene gel. J Dermatolog Treat. 2016;27:140. doi:10.3109/09546634.2015.1079298
- Angelova-Fischer I, Rippke F, Fischer TW, Neufang G, Zillikens D. A double-blind, randomized, vehicle-controlled efficacy assessment study of a skin care formulation for improvement of mild to moderately severe acne. J Eur Acad Dermatol Venereol. 2013;27 Suppl 2:6. doi:10.1111/jdv.12168
- Georgala S, Schulpis KH, Georgala C, Michas T. L-carnitine supplementation in patients with cystic acne on isotretinoin therapy. J Eur Acad Dermatol Venereol. 1999;13:205.
