Last update
4/17/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Milk Thistle Extract(Silybum marianum) (Fruit/Seed)(Standardized to 240 mg Silymarin Flavonoids - equivalent 80%)
300 mg
**
Dandelion Root (Taraxacum officinale)
100 mg
**
Artichoke (Cynara scolymus) (Leaf)
50 mg
**
Top Medical Research Studies
8
In our exploration, we found that silibinin, a key component of silymarin derived from milk thistle, shows promising effects on osteoporosis treatment. Through in vitro studies involving murine osteoblast and macrophage cells, silibinin not only boosted bone formation by promoting the growth and mineralization of bone cells but also helped inhibit the harmful activity of osteoclasts, which are responsible for bone resorption.
Although these findings are encouraging, it’s essential to note that further research is needed to confirm its efficacy and potential for use in clinical settings.
Although these findings are encouraging, it’s essential to note that further research is needed to confirm its efficacy and potential for use in clinical settings.
Read More
9
We explored how silymarin (SIL) could work as an alternative treatment for osteoporosis in ovariectomized (OVX) rats. During a 12-week study, we compared its effects with those of ethinylestradiol (EE).
Both SIL and EE helped protect bone density, but SIL had milder effects on the uterus and did not significantly lower levels of certain bone markers like osteocalcin.
While SIL showed promise in promoting bone health, its overall impact was not as strong as that of EE, suggesting a need for further research in humans.
Both SIL and EE helped protect bone density, but SIL had milder effects on the uterus and did not significantly lower levels of certain bone markers like osteocalcin.
While SIL showed promise in promoting bone health, its overall impact was not as strong as that of EE, suggesting a need for further research in humans.
Read More
8
Silymarin shows potential for osteoporosis
We examined how silymarin, the key compound found in milk thistle, might help treat osteoporosis. This review highlights its potent antioxidant properties and potential to enhance bone formation, particularly in postmenopausal women who are at higher risk for fractures.
Our findings suggest that silymarin may improve bone health by increasing bone density and encouraging healing after fractures in models. While promising, silymarin’s effectiveness and any potential side effects need further investigation before becoming a recommended treatment.
Our findings suggest that silymarin may improve bone health by increasing bone density and encouraging healing after fractures in models. While promising, silymarin’s effectiveness and any potential side effects need further investigation before becoming a recommended treatment.
Read More
Most Useful Reviews
9
Improves liver function
My doctor recommended silymarin to protect and restore my liver. After using 100 capsules, my liver function improved significantly, and my acne cleared up. This is likely the best silymarin available; I will order more for my parents to support their osteoporosis prevention.
Read More
7.5
Liver health benefits
California Gold Nutrition's Silymarin Complex is a blend of effective herbs for liver health. Milk thistle is renowned for its protective qualities, particularly against liver diseases and osteoporosis complications. This product also supports detoxification and overall liver support. I recommend taking one capsule daily with meals.
Read More
7.5
Good for osteoporosis
I took this supplement to protect my liver and manage osteoporosis. It is a beneficial product with multiple health advantages, and I recommend it.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
- All Researches
9
We explored how silymarin (SIL) could work as an alternative treatment for osteoporosis in ovariectomized (OVX) rats. During a 12-week study, we compared its effects with those of ethinylestradiol (EE).
Both SIL and EE helped protect bone density, but SIL had milder effects on the uterus and did not significantly lower levels of certain bone markers like osteocalcin.
While SIL showed promise in promoting bone health, its overall impact was not as strong as that of EE, suggesting a need for further research in humans.
Both SIL and EE helped protect bone density, but SIL had milder effects on the uterus and did not significantly lower levels of certain bone markers like osteocalcin.
While SIL showed promise in promoting bone health, its overall impact was not as strong as that of EE, suggesting a need for further research in humans.
Read More
8
Effect of ZnO-NPs on osteoporosis
We investigated the impact of foliar spraying with zinc oxide nanoparticles (ZnO-NPs) on a specific plant known for its silymarin content.
By applying these nanoparticles, we saw an increase in the beneficial compounds silybin (A+B), enhancing the plant’s growth and medicinal properties. This method also positively influenced the plants' ability to combat osteoporosis.
In tests, extracts from these treated plants showed potential to improve bone health in rats suffering from osteoporosis, including stimulating bone formation and reducing bone resorption.
By applying these nanoparticles, we saw an increase in the beneficial compounds silybin (A+B), enhancing the plant’s growth and medicinal properties. This method also positively influenced the plants' ability to combat osteoporosis.
In tests, extracts from these treated plants showed potential to improve bone health in rats suffering from osteoporosis, including stimulating bone formation and reducing bone resorption.
Read More
8
Silymarin shows potential for osteoporosis
We examined how silymarin, the key compound found in milk thistle, might help treat osteoporosis. This review highlights its potent antioxidant properties and potential to enhance bone formation, particularly in postmenopausal women who are at higher risk for fractures.
Our findings suggest that silymarin may improve bone health by increasing bone density and encouraging healing after fractures in models. While promising, silymarin’s effectiveness and any potential side effects need further investigation before becoming a recommended treatment.
Our findings suggest that silymarin may improve bone health by increasing bone density and encouraging healing after fractures in models. While promising, silymarin’s effectiveness and any potential side effects need further investigation before becoming a recommended treatment.
Read More
8
We investigated how milk thistle extract (MTE), rich in silymarin, impacts osteoporosis in mice after ovariectomy, simulating postmenopausal conditions.
Over eight weeks, we observed that MTE and its key component, silibinin, positively influenced bone density and reduced bone loss associated with estrogen deficiency.
Our findings suggest MTE can enhance bone formation and limit bone resorption, comparable to traditional estrogen treatments. This positions MTE as a promising option for addressing bone health in postmenopausal individuals.
Over eight weeks, we observed that MTE and its key component, silibinin, positively influenced bone density and reduced bone loss associated with estrogen deficiency.
Our findings suggest MTE can enhance bone formation and limit bone resorption, comparable to traditional estrogen treatments. This positions MTE as a promising option for addressing bone health in postmenopausal individuals.
Read More
8
In our exploration, we found that silibinin, a key component of silymarin derived from milk thistle, shows promising effects on osteoporosis treatment. Through in vitro studies involving murine osteoblast and macrophage cells, silibinin not only boosted bone formation by promoting the growth and mineralization of bone cells but also helped inhibit the harmful activity of osteoclasts, which are responsible for bone resorption.
Although these findings are encouraging, it’s essential to note that further research is needed to confirm its efficacy and potential for use in clinical settings.
Although these findings are encouraging, it’s essential to note that further research is needed to confirm its efficacy and potential for use in clinical settings.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improves liver function
My doctor recommended silymarin to protect and restore my liver. After using 100 capsules, my liver function improved significantly, and my acne cleared up. This is likely the best silymarin available; I will order more for my parents to support their osteoporosis prevention.
Read More
7.5
Liver health benefits
California Gold Nutrition's Silymarin Complex is a blend of effective herbs for liver health. Milk thistle is renowned for its protective qualities, particularly against liver diseases and osteoporosis complications. This product also supports detoxification and overall liver support. I recommend taking one capsule daily with meals.
Read More
7.5
Good for osteoporosis
I took this supplement to protect my liver and manage osteoporosis. It is a beneficial product with multiple health advantages, and I recommend it.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Fahad Almulhim B, Sherif FE, Younis NS, Safwat Y, Khattab S. Foliar spraying with zinc oxide nanoparticles enhances the anti-osteoporotic efficacy of the fruit extracts of L. by stimulating silybin production. Front Plant Sci. 2024;15:1421485. 10.3389/fpls.2024.1421485
- Mohd Fozi NF, Mazlan M, Shuid AN, Isa Naina M. Milk thistle: a future potential anti-osteoporotic and fracture healing agent. Curr Drug Targets. 2013;14:1659. PubMed
- Kim JL, Kim YH, Kang MK, Gong JH, Han SJ, et al. Antiosteoclastic activity of milk thistle extract after ovariectomy to suppress estrogen deficiency-induced osteoporosis. Biomed Res Int. 2013;2013:919374. 10.1155/2013/919374
- Kim JL, Kang SW, Kang MK, Gong JH, Lee ES, et al. Osteoblastogenesis and osteoprotection enhanced by flavonolignan silibinin in osteoblasts and osteoclasts. J Cell Biochem. 2012;113:247. 10.1002/jcb.23351
- El-Shitany NA, Hegazy S, El-Desoky K. Evidences for antiosteoporotic and selective estrogen receptor modulator activity of silymarin compared with ethinylestradiol in ovariectomized rats. Phytomedicine. 2010;17:116. 10.1016/j.phymed.2009.05.012
