Overview
Top Medical Research Studies
Our findings revealed that when exposed to low levels of calcium, there was an increase in lipogenesis—this means the cells produced more lipids or oils. However, as we raised the extracellular calcium levels, we noted that the number of sebocytes increased, and their shape became more like epithelial cells, while lipid production decreased. Importantly, low calcium also led to a decrease in E-cadherin, a protein vital for cell adherence, which seemed to correlate with increased cell detachment and apoptosis, or cell death.
We also noted that 1,25(OH)2D3 appears to suppress oil production while simultaneously triggering autophagy, a process that helps cells clean out damaged components. In the clinical study involving acne patients, we observed no significant abnormalities in serum calcium levels, but younger patients had lower 1,25(OH)2D3 levels than older individuals.
This suggests that both calcium and vitamin D have a role in acne development, but there wasn't a clear, standalone benefit of calcium treatment for managing acne. Instead, the combination of increased calcium and decreased vitamin D might contribute to the problems seen in younger patients with acne. Overall, our research highlights the complex interplay between these nutrients and sebaceous gland function, offering important insights for potential acne therapies.
Our findings showed that calcium not only increased the overall sebum output but also stepped up the levels of several key regulators involved in the lipogenesis process. Notably, we observed that calcium treatment boosted the expression of proteins like SREBP1, which plays a crucial role in managing lipid levels in skin cells.
We also discovered that the transcription factor KLF4 was elevated with calcium treatment. This raised a fascinating question: could KLF4 be enhancing lipid production? To test this, we overexpressed KLF4 in sebocytes, and indeed found that it further stimulated the expression of lipid-producing proteins and increased overall lipid production.
In conclusion, our study sheds light on the significant role of calcium in sebum production and highlights KLF4 as a promising new regulator in this process. These insights may open doors for developing more effective acne treatments by targeting sebum production pathways.
During the treatment, ultrasound was applied in a cross-hatch pattern to stimulate the skin, followed by injections of a diluted calcium hydroxylapatite filler mixed with lidocaine for comfort. The results were assessed 90 days later, focusing on changes in scar severity and overall satisfaction of the subjects.
The findings revealed significant improvement in acne scars, particularly in those with severe scarring. The majority of participants reported being satisfied with their results, and no adverse side effects were noted. While calcium hydroxylapatite alone was not isolated in this study, its combination with ultrasound showed promising results for reducing scar visibility.
Most Useful Reviews
Medical Researches
- All Researches
During the treatment, ultrasound was applied in a cross-hatch pattern to stimulate the skin, followed by injections of a diluted calcium hydroxylapatite filler mixed with lidocaine for comfort. The results were assessed 90 days later, focusing on changes in scar severity and overall satisfaction of the subjects.
The findings revealed significant improvement in acne scars, particularly in those with severe scarring. The majority of participants reported being satisfied with their results, and no adverse side effects were noted. While calcium hydroxylapatite alone was not isolated in this study, its combination with ultrasound showed promising results for reducing scar visibility.
Our findings showed that calcium not only increased the overall sebum output but also stepped up the levels of several key regulators involved in the lipogenesis process. Notably, we observed that calcium treatment boosted the expression of proteins like SREBP1, which plays a crucial role in managing lipid levels in skin cells.
We also discovered that the transcription factor KLF4 was elevated with calcium treatment. This raised a fascinating question: could KLF4 be enhancing lipid production? To test this, we overexpressed KLF4 in sebocytes, and indeed found that it further stimulated the expression of lipid-producing proteins and increased overall lipid production.
In conclusion, our study sheds light on the significant role of calcium in sebum production and highlights KLF4 as a promising new regulator in this process. These insights may open doors for developing more effective acne treatments by targeting sebum production pathways.
Our assessments showed promising results. After just one month, those who received the calcium treatment noted an improvement in their skin texture and wrinkles when compared to those who received a placebo. By three and six months, every participant in the study reported an improvement in their acne scars.
However, it's important to highlight that while the calcium treatment was indeed effective, adding HIFU did not provide any additional benefits beyond the results seen from calcium alone. This suggests that while calcium hydroxylapatite stands out as a solid option for tackling acne scars, pairing it with HIFU doesn’t necessarily enhance its effectiveness.
However, it’s important to clarify that while calcium was mentioned, the study did not specifically isolate its effects on acne treatment. The agents tested showed effective results in improving the skin's turnover rate, hinting at potential benefits for various skin issues, including dullness and minor acne.
Ultimately, while the research signifies the promise of calcium in skincare, it stops short of stating it as a proven treatment for acne. For now, the focus remains on agents like carnitine and serine, which could support healthier skin through enhanced exfoliation.
Our findings revealed that when exposed to low levels of calcium, there was an increase in lipogenesis—this means the cells produced more lipids or oils. However, as we raised the extracellular calcium levels, we noted that the number of sebocytes increased, and their shape became more like epithelial cells, while lipid production decreased. Importantly, low calcium also led to a decrease in E-cadherin, a protein vital for cell adherence, which seemed to correlate with increased cell detachment and apoptosis, or cell death.
We also noted that 1,25(OH)2D3 appears to suppress oil production while simultaneously triggering autophagy, a process that helps cells clean out damaged components. In the clinical study involving acne patients, we observed no significant abnormalities in serum calcium levels, but younger patients had lower 1,25(OH)2D3 levels than older individuals.
This suggests that both calcium and vitamin D have a role in acne development, but there wasn't a clear, standalone benefit of calcium treatment for managing acne. Instead, the combination of increased calcium and decreased vitamin D might contribute to the problems seen in younger patients with acne. Overall, our research highlights the complex interplay between these nutrients and sebaceous gland function, offering important insights for potential acne therapies.
User Reviews
- All Reviews
- Positive Reviews
- Negative Reviews
Frequently Asked Questions
Acne is a common skin condition that affects people of all ages, though it's especially prevalent among teenagers and young adults. It occurs when hair follicles become clogged with oil and dead skin cells, leading to the formation of pimples, blackheads, and cysts. The main factors contributing to acne include excess oil production, hormonal changes, and the presence of bacteria on the skin. Acne can manifest in various forms, from mild cases with just a few breakouts to more severe forms that can cause significant inflammation and scarring.
Treatment for acne varies depending on its severity and can range from over-the-counter topical treatments like benzoyl peroxide and salicylic acid to prescription medications including retinoids and antibiotics. Lifestyle adjustments, such as maintaining a balanced diet and proper skin hygiene, may also contribute to managing and reducing breakouts. Despite being a common skin issue, the psychological impact of acne should not be underestimated, as it can affect self-esteem and overall quality of life.
Vitamin B refers to a group of eight essential water-soluble vitamins that play a vital role in various physiological functions in the body. These vitamins include B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate, or folic acid), and B12 (cobalamin). Each of these vitamins contributes to key processes such as energy metabolism, red blood cell formation, cognitive function, and the synthesis of DNA. Because they are water-soluble, any excess amounts are not stored in the body and can be lost through urine, making regular dietary intake important.
Foods rich in B vitamins include whole grains, meat, eggs, dairy products, legumes, seeds, nuts, and dark leafy greens. Deficiencies can lead to a host of health issues, including fatigue, anemia, cognitive decline, and skin problems. Supplements are available and can be beneficial, especially for individuals with specific dietary restrictions, such as vegetarians or those with certain medical conditions that affect nutrient absorption. Always consult a healthcare professional before starting any new supplement regimen to assess individual needs and avoid potential negative interactions.
Vitamin B, particularly in its various forms, has shown potential benefits for skin health, but its efficacy in treating acne specifically can vary. Vitamin B3, also known as niacinamide, has gained attention in dermatology for its anti-inflammatory properties and the ability to regulate oil production in the skin. Studies suggest that niacinamide can help reduce the appearance of acne and improve the overall texture and tone of the skin. Additionally, it may assist in minimizing post-acne marks, providing a dual benefit for those dealing with this persistent skin condition.
On the other hand, some forms of Vitamin B, like B12 and biotin, have been reported in anecdotal accounts to exacerbate acne in some individuals. It’s crucial to monitor how your skin responds when incorporating any new supplement into your regimen. Moreover, while vitamins can contribute positively to skin health, they should not replace established acne treatments. It's always wise to consult a dermatologist for personalized advice and a comprehensive approach to managing acne.
Based on user reviews, the time it takes to see results from pantothenic acid supplementation for acne can vary, but many users report noticeable improvements within approximately two to four weeks. For instance, one user experienced a significant reduction in oiliness and acne after just three weeks of taking 7g daily (Read Review). Another reviewer experienced substantial skin clarity changes after about a month of consistent use, calling it a “miracle pill” (Read Review).
However, some users note that while initial improvements can occur within weeks, achieving full clarity may take longer. For instance, one user reported it took them over six months to completely clear their cystic acne (Read Review). Another mentioned seeing noticeable improvements only after about two months (Read Review). Overall, while many users do see benefits relatively quickly, the timeline for optimal results may differ by individual circumstances.
Calcium's potential role in treating acne has been explored through various studies, yielding a mix of results. One study found that calcium treatment significantly increased lipid production in sebocytes, the oil-producing cells in the skin, suggesting that calcium could play a pivotal role in managing sebum levels, which are crucial in acne development [1]. This research highlights calcium's ability to regulate important proteins involved in lipogenesis, indicating a potential pathway for acne treatment targeting sebum production.
However, other studies have indicated that while calcium can influence skin health and sebum production, it does not provide conclusive evidence as a standalone treatment for acne. For example, another research pointed out that while calcium showed promise in assisting with skin exfoliation, it did not isolate its effects as a direct treatment for acne [3]. Furthermore, a study focusing on calcium and vitamin D revealed that low levels of calcium might not effectively combat acne, indicating a more complex interaction involving these nutrients [5]. Thus, while calcium shows potential in acne-related research, more comprehensive studies are needed to establish its efficacy as a definitive treatment option.
Based on user reviews, there is a notable trend of individuals experiencing significant improvements in their acne symptoms after taking pantothenic acid. Many users report noticing a marked reduction in oiliness and acne within a few weeks. For instance, one user mentioned a substantial decrease in oiliness and a quicker healing of acne after just three weeks of taking 7g daily (Read Review). Another reviewer found that after a couple of months, they enjoyed clear skin for the first time in years, describing the supplement as a "miracle pill" (Read Review).
Users also report varying degrees of success with the supplement over different time frames. Some noted complete acne clearance after several months of use (Read Review), while others experienced notable improvements in overall skin texture and reduction in acne frequency after just a couple of weeks (Read Review). However, it is essential to keep in mind that individual results can vary widely, and factors like dosage, consistency, and dietary habits may influence outcomes.
Based on user reviews, there are several positive reports regarding the combination of pantothenic acid with other supplements for managing acne. One user indicated notable improvements while taking pantothenic acid alongside Zinc picolinate and a zinc cream, noting a drastic reduction in acne severity within a short period of six weeks (Read Review). This suggests that integrating pantothenic acid with zinc supplements can enhance its effectiveness in clearing up acne.
Additionally, another user highlighted that after incorporating pantothenic acid into their routine, their skin’s overall condition improved significantly. They had previously suffered from back acne and saw marked improvements after consistently using the supplement for a month (Read Review). These experiences indicate that combining pantothenic acid with other treatments may lead to better outcomes for individuals battling acne, though results may vary individually.
Users reported varying doses of Vitamin B5 (pantothenic acid) to effectively treat acne, often highlighting that higher doses provided better results. For instance, one user mentioned taking 7g daily and experiencing a significant improvement in oiliness and acne after only three weeks (Read Review). Another user recommended starting with 4 tablets daily, gradually adjusting the dose over time based on results (Read Review). Many reviewers indicated that they found success with a range of dosages, from 2.5g taken twice a day (Read Review) to as much as 25 capsules daily in some cases (Read Review).
Overall, users highlighted that while starting with a higher dosage was often beneficial, they could taper their intake as their skin improved. For example, one user emphasized that after starting with 10-12g/day, they only required 3-6g/day to maintain clear skin (Read Review). This suggests that individuals may need to experiment with their dosage to find the most effective amount for their own skin condition.
Our findings showed that calcium not only increased the overall sebum output but also stepped up the levels of several key regulators involved in the lipogenesis process. Notably, we observed that calcium treatment boosted the expression of proteins like SREBP1, which plays a crucial role in managing lipid levels in skin cells.
We also discovered that the transcription factor KLF4 was elevated with calcium treatment. This raised a fascinating question: could KLF4 be enhancing lipid production? To test this, we overexpressed KLF4 in sebocytes, and indeed found that it further stimulated the expression of lipid-producing proteins and increased overall lipid production.
In conclusion, our study sheds light on the significant role of calcium in sebum production and highlights KLF4 as a promising new regulator in this process. These insights may open doors for developing more effective acne treatments by targeting sebum production pathways.
However, it’s important to clarify that while calcium was mentioned, the study did not specifically isolate its effects on acne treatment. The agents tested showed effective results in improving the skin's turnover rate, hinting at potential benefits for various skin issues, including dullness and minor acne.
Ultimately, while the research signifies the promise of calcium in skincare, it stops short of stating it as a proven treatment for acne. For now, the focus remains on agents like carnitine and serine, which could support healthier skin through enhanced exfoliation.
Our findings revealed that when exposed to low levels of calcium, there was an increase in lipogenesis—this means the cells produced more lipids or oils. However, as we raised the extracellular calcium levels, we noted that the number of sebocytes increased, and their shape became more like epithelial cells, while lipid production decreased. Importantly, low calcium also led to a decrease in E-cadherin, a protein vital for cell adherence, which seemed to correlate with increased cell detachment and apoptosis, or cell death.
We also noted that 1,25(OH)2D3 appears to suppress oil production while simultaneously triggering autophagy, a process that helps cells clean out damaged components. In the clinical study involving acne patients, we observed no significant abnormalities in serum calcium levels, but younger patients had lower 1,25(OH)2D3 levels than older individuals.
This suggests that both calcium and vitamin D have a role in acne development, but there wasn't a clear, standalone benefit of calcium treatment for managing acne. Instead, the combination of increased calcium and decreased vitamin D might contribute to the problems seen in younger patients with acne. Overall, our research highlights the complex interplay between these nutrients and sebaceous gland function, offering important insights for potential acne therapies.
References
- Li X, Zeng X, Kim D, Jiang J, Wei F, et al. Krüppel-like factor 4 (KLF4) facilitates lipid production in immortalized human sebocytes via regulating the expression of SREBP1. Biochem Biophys Res Commun. 2023;667:146. doi:10.1016/j.bbrc.2023.05.043
- Antonino A, Francesco A. Prospective and randomized comparative study of calcium hydroxylapatite vs calcium hydroxylapatite plus HIFU in treatment of moderate-to-severe acne scars. J Cosmet Dermatol. 2021;20:53. doi:10.1111/jocd.13472
- Ahn B, Lee SH, Kim JH, Goh A, Park SG, et al. Identification and validation of amino acid-based mild exfoliating agents through a de novo screening method. J Cosmet Dermatol. 2019;18:1404. doi:10.1111/jocd.12871
- Casabona G. Combined use of microfocused ultrasound and a calcium hydroxylapatite dermal filler for treating atrophic acne scars: A pilot study. J Cosmet Laser Ther. 2018;20:301. doi:10.1080/14764172.2017.1406606
- Zouboulis CC, Seltmann H, Abdel-Naser MB, Hossini AM, Menon GK, et al. Effects of Extracellular Calcium and 1,25 dihydroxyvitamin D3 on Sebaceous Gland Cells In vitro and In vivo. Acta Derm Venereol. 2017;97:313. doi:10.2340/00015555-2525
