Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Pantothenic Acid (Vitamin B-5) (From Calcium Pantothenate)
500 mg
10,000%
Calcium (From Calcium Pantothenate)
45 mg
3%
Top Medical Research Studies
9
We looked into how Vitamin B2 supplementation might help with migraines, focusing on its potential to reduce the number of migraine days, duration, frequency, and pain scores.
Using systematic reviews and meta-analyses, we explored data from multiple reliable databases. Our findings reveal that taking 400 mg of Vitamin B2 daily for three months can significantly cut down on migraine days, duration, frequency, and pain levels.
So, if you're seeking alternatives to pharmaceuticals, Vitamin B2 could be a beneficial option to consider.
Using systematic reviews and meta-analyses, we explored data from multiple reliable databases. Our findings reveal that taking 400 mg of Vitamin B2 daily for three months can significantly cut down on migraine days, duration, frequency, and pain levels.
So, if you're seeking alternatives to pharmaceuticals, Vitamin B2 could be a beneficial option to consider.
Read More
9
We evaluated the effectiveness of riboflavin in young patients suffering from migraines through a retrospective study involving 42 children and adolescents aged six to 18.
After treatment, we observed a significant decrease in headache frequency, intensity, and duration. Patients reported fewer days missed from school and reduced usage of acute medications.
Our findings suggest riboflavin is a safe, affordable, and effective option for preventing migraines in pediatric patients.
After treatment, we observed a significant decrease in headache frequency, intensity, and duration. Patients reported fewer days missed from school and reduced usage of acute medications.
Our findings suggest riboflavin is a safe, affordable, and effective option for preventing migraines in pediatric patients.
Read More
7
We explored the use of vitamin B2, also known as riboflavin, for preventing migraines in adults. The findings suggest that riboflavin can be beneficial, with minimal side effects reported. However, there’s insufficient evidence to recommend it for children.
Coenzyme Q10 showed some promise as well, though with less compelling evidence overall. Other nutraceuticals like feverfew and magnesium may have varying levels of effectiveness but come with cautions about safety and dosage.
Overall, while riboflavin stands out as a possible preventive measure, further research is necessary to establish its full potential.
Coenzyme Q10 showed some promise as well, though with less compelling evidence overall. Other nutraceuticals like feverfew and magnesium may have varying levels of effectiveness but come with cautions about safety and dosage.
Overall, while riboflavin stands out as a possible preventive measure, further research is necessary to establish its full potential.
Read More
Most Useful Reviews
8.8
Reduced migraines
The quality of both the packaging and the ingredients is commendable. I take it alongside vitamin B12 for better digestibility, and I've noticed that my migraines have decreased significantly.
Read More
4.8
Ineffective treatment
It was average. I tried it to prevent period migraines, but it actually didn't help.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.7
- All Researches
9
We assessed the potential benefits of alpha-lipoic acid (ALA) as a preventive treatment for adolescent migraines in a clinical trial involving 60 participants.
Those who received ALA alongside flunarizine showed a significant decrease in migraine frequency, with an impressive responder rate of 80% compared to 33.3% in the control group.
Other improvements included reduced severity of migraine attacks and better scores in quality of life assessments.
Overall, adding ALA appears to enhance outcomes for adolescents suffering from migraines.
Those who received ALA alongside flunarizine showed a significant decrease in migraine frequency, with an impressive responder rate of 80% compared to 33.3% in the control group.
Other improvements included reduced severity of migraine attacks and better scores in quality of life assessments.
Overall, adding ALA appears to enhance outcomes for adolescents suffering from migraines.
Read More
9
We looked into how Vitamin B2 supplementation might help with migraines, focusing on its potential to reduce the number of migraine days, duration, frequency, and pain scores.
Using systematic reviews and meta-analyses, we explored data from multiple reliable databases. Our findings reveal that taking 400 mg of Vitamin B2 daily for three months can significantly cut down on migraine days, duration, frequency, and pain levels.
So, if you're seeking alternatives to pharmaceuticals, Vitamin B2 could be a beneficial option to consider.
Using systematic reviews and meta-analyses, we explored data from multiple reliable databases. Our findings reveal that taking 400 mg of Vitamin B2 daily for three months can significantly cut down on migraine days, duration, frequency, and pain levels.
So, if you're seeking alternatives to pharmaceuticals, Vitamin B2 could be a beneficial option to consider.
Read More
9
We evaluated the effectiveness of riboflavin in young patients suffering from migraines through a retrospective study involving 42 children and adolescents aged six to 18.
After treatment, we observed a significant decrease in headache frequency, intensity, and duration. Patients reported fewer days missed from school and reduced usage of acute medications.
Our findings suggest riboflavin is a safe, affordable, and effective option for preventing migraines in pediatric patients.
After treatment, we observed a significant decrease in headache frequency, intensity, and duration. Patients reported fewer days missed from school and reduced usage of acute medications.
Our findings suggest riboflavin is a safe, affordable, and effective option for preventing migraines in pediatric patients.
Read More
8
We explored how genetic factors related to folate metabolism might be connected to migraines in children. In this study, 54 children aged 7 to 18 with migraines were compared to 115 healthy peers.
Interestingly, the rare 677TT genotype was found more frequently among those with migraines, indicating a potential link to higher homocysteine levels and folate deficiency. Moreover, we noted that treating these children with Cortexin led to significant improvements in their symptoms, including reduced headaches and fatigue.
Interestingly, the rare 677TT genotype was found more frequently among those with migraines, indicating a potential link to higher homocysteine levels and folate deficiency. Moreover, we noted that treating these children with Cortexin led to significant improvements in their symptoms, including reduced headaches and fatigue.
Read More
8
We reviewed the impact of dietary supplements on migraines, especially focusing on Vitamin B. Our findings revealed that nutrients like vitamin B, magnesium, and Coenzyme Q10 play vital roles in energy metabolism and may help alleviate migraine symptoms.
Notably, a daily intake of 400 milligrams of riboflavin over three months resulted in a remarkable 50% reduction in migraine attacks for many users. Additionally, vitamin D and Omega-3 have also shown promise in reducing migraine occurrences, suggesting that these supplements could serve as a cost-effective approach for migraine prevention.
Notably, a daily intake of 400 milligrams of riboflavin over three months resulted in a remarkable 50% reduction in migraine attacks for many users. Additionally, vitamin D and Omega-3 have also shown promise in reducing migraine occurrences, suggesting that these supplements could serve as a cost-effective approach for migraine prevention.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Reduced migraines
The quality of both the packaging and the ingredients is commendable. I take it alongside vitamin B12 for better digestibility, and I've noticed that my migraines have decreased significantly.
Read More
4.8
Ineffective treatment
It was average. I tried it to prevent period migraines, but it actually didn't help.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Strozenko LA, Ponomaryov VS, Sanina OO, Lobanov YF. [The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children]. Zh Nevrol Psikhiatr Im S S Korsakova. 2025;125:47. doi:10.17116/jnevro202512501147
- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. doi:10.1007/s11916-025-01358-3
- Puliappadamb HM, Satpathy AK, Mishra BR, Maiti R, Jena M. Evaluation of Safety and Efficacy of Add-on Alpha-Lipoic Acid on Migraine Prophylaxis in an Adolescent Population: A Randomized Controlled Trial. J Clin Pharmacol. 2023;63:1398. doi:10.1002/jcph.2331
- Li H, Krall JR, Frankenfeld C, Slavin M. Nutritional intake of riboflavin (vitamin B2) and migraine: a cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES) 2001-2004. Nutr Neurosci. 2023;26:1068. doi:10.1080/1028415X.2022.2126760
- Li D, Guo Y, Xia M, Zhang J, Zang W. Dietary intake of thiamine and riboflavin in relation to severe headache or migraine: A cross-sectional survey. Headache. 2022;62:1133. doi:10.1111/head.14384
- Liu H, Wang L, Chen C, Dong Z, Yu S. Association between Dietary Niacin Intake and Migraine among American Adults: National Health and Nutrition Examination Survey. Nutrients. 2022;14. doi:10.3390/nu14153052
- Ariyanfar S, Razeghi Jahromi S, Togha M, Ghorbani Z. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep. 2022;26:193. doi:10.1007/s11916-022-01019-9
- Matin H, Taghian F, Chitsaz A. Artificial intelligence analysis to explore synchronize exercise, cobalamin, and magnesium as new actors to therapeutic of migraine symptoms: a randomized, placebo-controlled trial. Neurol Sci. 2022;43:4413. doi:10.1007/s10072-021-05843-6
- Yamanaka G, Suzuki S, Morishita N, Takeshita M, Kanou K, et al. Experimental and Clinical Evidence of the Effectiveness of Riboflavin on Migraines. Nutrients. 2021;13. doi:10.3390/nu13082612
- Chen YS, Lee HF, Tsai CH, Hsu YY, Fang CJ, et al. Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis. Nutr Neurosci. 2022;25:1801. doi:10.1080/1028415X.2021.1904542
- Das R, Qubty W. Retrospective Observational Study on Riboflavin Prophylaxis in Child and Adolescent Migraine. Pediatr Neurol. 2021;114:5. doi:10.1016/j.pediatrneurol.2020.09.009
- Yamanaka G, Suzuki S, Takeshita M, Go S, Morishita N, et al. Effectiveness of low-dose riboflavin as a prophylactic agent in pediatric migraine. Brain Dev. 2020;42:523. doi:10.1016/j.braindev.2020.04.002
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. doi:10.1111/ane.13251
- Togha M, Razeghi Jahromi S, Ghorbani Z, Martami F, Seifishahpar M. Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study. Headache. 2019;59:1492. doi:10.1111/head.13618
- Moscano F, Guiducci M, Maltoni L, Striano P, Ledda MG, et al. An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache. Ital J Pediatr. 2019;45:36. doi:10.1186/s13052-019-0624-z
- Nattagh-Eshtivani E, Sani MA, Dahri M, Ghalichi F, Ghavami A, et al. The role of nutrients in the pathogenesis and treatment of migraine headaches: Review. Biomed Pharmacother. 2018;102:317. doi:10.1016/j.biopha.2018.03.059
- Ilik F, Ertem DH, Ilik MK. [Management of migraine without aura in adolescents: The experience of flunarizine use in a Turkish cohort]. Ideggyogy Sz. 2025;78:122. doi:10.18071/isz.77.0122
- Ma C, Zhu C, Zhang Y, Yu M, Song Y, et al. Gastrodin alleviates NTG-induced migraine-like pain via inhibiting succinate/HIF-1α/TRPM2 signaling pathway in trigeminal ganglion. Phytomedicine. 2024;125:155266. doi:10.1016/j.phymed.2023.155266
- Carcel C, Haghdoost F, Shen J, Nanda P, Bai Y, et al. The effect of blood pressure lowering medications on the prevention of episodic migraine: A systematic review and meta-analysis. Cephalalgia. 2023;43:3331024231183166. doi:10.1177/03331024231183166
