NOW Supplements, Zinc 50 mg

Khajeh M, Hassanizadeh S, Pourteymour Fard Tabrizi F, Hassanizadeh R, Vajdi M, et al. Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients with Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis. Biol Trace Elem Res. 2024;202:4877. doi:10.1007/s12011-024-04059-x

Zinc improves cholesterol levels

We explored how zinc supplementation affects cholesterol levels and body composition in patients with type 2 diabetes. By reviewing data from nineteen randomized controlled trials, involving 1,357 participants, we uncovered significant findings regarding lipid profiles.

Our results revealed that zinc supplementation leads to reduced levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). Specifically, we noted reductions of 17.41 mg/dL in triglycerides, 19.60 mg/dL in total cholesterol, and 8.80 mg/dL in LDL-C. Furthermore, we observed an increase in high-density lipoprotein cholesterol (HDL-C) by 4.82 mg/dL, which is often termed "good" cholesterol.

While zinc appears to positively influence cholesterol levels, it's interesting to note that it did not have a significant impact on body weight. The body mass index (BMI) did show a slight decrease of 0.53 kg/m², but overall body weight remained unchanged.

In conclusion, our findings suggest that zinc supplementation could be a beneficial strategy for improving cholesterol levels in individuals with type 2 diabetes, thus contributing positively to their overall health and well-being.

9.5

Stopped hair loss

Most Useful Review

My husband and I took zinc during our family's bout with CROWN, as vitamins are crucial for recovery. We noticed excessive hair loss and brittle nails, but after three weeks on zinc, both issues resolved. The results were impressive, as my hair stopped falling out and my nails became stronger. However, we were advised to avoid long-term zinc usage beyond two months to prevent copper depletion. Overall, we are thrilled with the effectiveness of zinc in improving our hair and nail health amidst our illness.

Sleep Apnea details

Zinc protects heart function in OSA

Chen TI, Chen MY. Zinc Is Indispensable in Exercise-Induced Cardioprotection against Intermittent Hypoxia-Induced Left Ventricular Function Impairment in Rats. PLoS One. 2016;11:e0168600. doi:10.1371/journal.pone.0168600

We explored how zinc affects heart function in the context of obstructive sleep apnea (OSA), specifically focusing on cases of intermittent hypoxia (IH). In a detailed study using male rats, researchers set up different groups: a control group and one that underwent 10 weeks of exercise training. Half of the rats in both groups were exposed to IH conditions to simulate the effects of sleep apnea.

The results were eye-opening. Rats that experienced IH showed notable impairment in their heart's left ventricular function, characterized by reduced ejection fraction and increased inflammation. However, when treated with zinc, these negative effects were significantly countered. Notably, those who exercised and received zinc treatment displayed improved heart function and antioxidant capabilities compared to their counterparts that did not receive zinc.

On the flip side, exercise alone did not provide the same protective benefits when zinc was absent. The findings suggest that zinc is essential not only for the heart's protection against the damaging effects of IH but also enhances the benefits of physical exercise. This research indicates the importance of zinc in potentially managing heart health in individuals suffering from sleep apnea.

9.5

Longer sleep duration

Most Useful Review

I consumed zinc at 50mg daily alongside 2000mg of collagen. My atopic dermatitis symptoms improved significantly, and I can now enjoy uninterrupted sleep for 6 hours at a time, a stark contrast to the 2-3 hours I endured previously due to intense itching.

Ulcer details

Hayashi A, Taki Y, Arai K, Sato S, Higashizono K, et al. Esophageal ulcer related to zinc deficiency following a total gastrectomy. Nutrition. 2023;110:111999. doi:10.1016/j.nut.2023.111999

Based on 16 Researches

Zinc helps heal esophageal ulcers

We delved into an interesting case of a 76-year-old man who developed severe esophageal ulcers, likely due to zinc deficiency following a total gastrectomy. His symptoms included sore throat, heartburn, and difficulty swallowing.

After the diagnosis of zinc deficiency, he began oral zinc treatment. Remarkably, this led to significant symptom relief and visible healing of the ulcers during follow-up imaging. Impressively, he has maintained his zinc supplementation for five years without any recurrence of symptoms. This unique case shines a light on the potential role of zinc in ulcer healing.

No recurrence noted

Most Useful Review

Lasting Effects I went to the hospital due to severe mouth ulcers, and a blood test revealed a zinc deficiency. I took prescribed medication for two weeks but switched to zinc tablets due to the cost. After six months of this, my blood tests showed normal zinc levels, and my mouth ulcers have not returned, so I am feeling the benefits.

Abscess details

Zinc is a man's best friend! I have severe spots on my face, with inflammation featuring an abscess, yet the abscess is hardly noticeable and resembles typical spots, especially beneath the eyes. Although I am well past my teenage years, I struggled with acne that no treatment alleviated. After starting ZINC for my health, I was astonished to find that, within a week, the spots began to diminish on their own, filling me with immense joy. Upon further reading about zinc, it became clear this is the remedy I needed; ZINC is indeed fantastic!

Anxiety details

Zinc may alleviate anxiety symptoms

Based on 8 Researches

Azargoonjahromi A. A systematic review of the association between zinc and anxiety. Nutr Rev. 2024;82:612. doi:10.1093/nutrit/nuad076

We explored the connection between zinc intake and anxiety in adults through a systematic review of nine original studies. Two of these studies looked at how zinc consumption impacts anxiety, while the other seven focused on the relationship between serum zinc levels and anxiety symptoms. Our analysis included studies published in English within peer-reviewed journals, ensuring a solid foundation for understanding this potential link.

What we discovered was quite illuminating. The data indicated that individuals experiencing anxiety often had lower levels of zinc in their serum compared to those who did not suffer from anxiety. Additionally, we observed an inverse association between zinc intake and anxiety levels. This suggests that higher consumption of zinc may contribute to reduced anxiety symptoms.

In conclusion, the evidence points towards zinc playing a positive role in treating anxiety, although we acknowledge some limitations in the available studies. This means zinc supplementation could be a beneficial strategy for those looking to manage their anxiety, but more research is needed to confirm these findings and understand the underlying mechanisms better.

9.5

Improved energy

Most Useful Review

Now zinc is wonderful! It arrived in 9 days in Brazil, which is excellent as deliveries can take up to 15 days without charge. I’ve been taking 50mg daily to boost my immunity. The cost benefit is fantastic as it lasts nearly a year, and I have used Now products for six years. Since starting zinc, I’ve noticed improvements in my hair and feel shinier, with my anxiety markedly decreased. I have more energy for daily tasks, and I started to feel the effects within 2 weeks. I hope this helps you!

Arthritis details

Hasan M, Yadav P, Ansari MA, Ali S, Khan HA. Therapeutic Dose of Zinc Aspartate and Zinc Citrate Attenuates Disease Activity Indices in Rheumatoid Arthritis. Biol Trace Elem Res. 2024. doi:10.1007/s12011-024-04439-3

Zinc alleviates arthritis symptoms

We explored the effects of zinc supplements—specifically zinc aspartate and zinc citrate—on reducing the symptoms of rheumatoid arthritis. In our study, we induced arthritis in male Wistar rats using a collagen-related method and then treated the rats with these zinc compounds over a four-week period. Our objective was to evaluate how these compounds could impact the disease's severity and markers associated with rheumatoid arthritis.

The results were quite promising. Both zinc aspartate and zinc citrate, administered at a therapeutic dose of 50 mg of elemental zinc per day, showed a significant reduction in the clinical symptoms associated with arthritis. Furthermore, these compounds displayed antibacterial properties against Escherichia coli, which is notable since rheumatoid arthritis patients often suffer from increased sensitivity to bacterial infections.

Importantly, we found no adverse effects on liver or kidney function in the rats that received the zinc treatment. This highlights the potential of zinc compounds not only as anti-inflammatory agents but also as preventive measures against microbial growth that can complicate rheumatoid arthritis.

9.5

Remarkable improvement

Most Useful Review

My father struggled to get around due to arthritis and eventually needed a walker. After taking this vitamin daily for two weeks, he could walk unaided. My husband also takes this vitamin; whenever he feels unwell, he takes it and within 24 hours, he feels normal again.

Brain Tumor details

Zinc aids in glioblastoma treatment

Gujaran TV, Easwaran VB, Sankhe R, Bakthavatchalam P, Dsouza HS, et al. Ketogenic diet with oxyresveratrol and zinc inhibits glioblastoma and restores memory function and motor coordination. Oncol Res. 2025;33:381. doi:10.32604/or.2024.049538

We evaluated the potential of zinc in combination with a ketogenic diet and oxyresveratrol in fighting glioblastoma, a highly aggressive brain tumor. Through a series of carefully designed experiments, we examined how these treatments affect tumor growth and overall brain function.

In our study, we induced brain tumors in Wistar rats and then applied our treatment regimen. We tracked various outcomes, including tumor size, proliferation rates, memory function, and motor coordination. By assessing glucose and ketone levels, we gained insights into the metabolic changes occurring as a result of the treatments.

The findings suggested that zinc played a supportive role alongside the ketogenic diet and oxyresveratrol in reducing tumor growth. Moreover, these treatments appeared to enhance memory and motor coordination, indicating a multi-faceted benefit. Overall, this progression offered valuable information about the role of diet and supplementary compounds in battling aggressive brain tumors like glioblastoma.

8.3

Improves focus

Most Useful Review

This zinc supplement features impressive packaging and composition, primarily strengthening immunity and supporting skin, hair, and hormonal balance. It enhances memory and brain function, improving focus and concentration. Additionally, it accelerates wound healing, making it a well-rounded product for overall health.

Pneumonia details

Zinc is a vital nutrient that supports the functioning of various organ systems. It is crucial for the immune, nervous, and endocrine systems. It enhances immunity and can help prevent new coronary pneumonia. Additionally, zinc plays a crucial role in neutralising free radicals and supports healthy ageing. This dosage is ideal, and the ingredients are sufficient.

Polycystic Ovary Syndrome details

Miraculous cycle restoration

I took it as directed by a gynaecologist to restore my cycle. I have Polycystic ovary syndrome and without taking COCs, my periods came every 4-5 months. My doctor believes that filling the body with necessary vitamins helps the reproductive system work on its own, and yes, it worked! In addition to zinc, I took magnesium, calcium, L-tyrosine, aloe, Omega 3, vitamin D, selenium, kelp iodine, and folate. It was miraculous when menstruation began naturally after 45 days of vitamins! I now feel improved energy, better sleep, a perfect complexion, and no weight gain, unlike before.

Psoriasis details

Zinc conditioner benefits scalp psoriasis

Yu C, Yu N, Jiang X, Gao X, Lv S, et al. Efficacy and safety of supramolecular active zinc in the treatment of scalp psoriasis: a multicentre, randomized, observed-blind, parallel-group, placebo- and active-controlled noninferiority trial. Clin Exp Dermatol. 2023;48:1138. doi:10.1093/ced/llad168

We delved into the effectiveness of a zinc-based hair conditioner specifically designed for treating scalp psoriasis. This study was a well-structured clinical trial involving 211 participants, where individuals were divided into three groups: those receiving the specialized zinc treatment, a placebo, and a control group given calcipotriol ointment. Remarkably, the trial was multicenter and observed-blind, which adds credibility to the findings.

Our results revealed that the zinc conditioner led to a 39% disease control rate after four weeks, compared to 25% for the placebo and 37% for the calcipotriol ointment group. This means that the zinc treatment significantly outperformed the placebo while being on par with the active control variant. In essence, those using the zinc product experienced better management of their scalp psoriasis than those using a non-active alternative.

Overall, our findings highlight that a supramolecular active zinc antidandruff formulation is not just effective for treating scalp psoriasis but also helps in maintaining results over time and potentially preventing future flare-ups. This offers a promising new avenue for patients seeking relief from this chronic condition.

8.8

Boosts immune system

Most Useful Review

I have been taking it for over a year on and off, and it's excellent for stimulating both my immune system and skin. Zinc helps with my psoriasis. When I was hospitalised with coronavirus in 2020, the doctor advised me to continue taking it alongside vitamin D3.

Rash details

Excellent zinc! I've been taking this for several months, switching from Solgar without noticing differences in effectiveness. The price is significantly lower. After a month, my oily skin improved notably (less fat, few pimples). After three months, my nails became stronger, and new hair growth was evident. Zinc solved my long-term problem with rashes on my face and neck! I now see nearly no pimples, and healing is quick without scarring. Highly recommended!

Acne details

Yee BE, Richards P, Sui JY, Marsch AF. Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis. Dermatol Ther. 2020;33:e14252. doi:10.1111/dth.14252

Based on 16 Researches

Zinc effective for acne treatment

We explored how zinc affects acne through a systematic review and meta-analysis that looked at two main questions. First, we wanted to know if there are differences in zinc levels between people with acne and those without. Second, we examined how effective zinc treatments are for managing acne.

Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.

Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!

8.8

Significant improvement noted

Most Useful Review

After a month of taking zinc, I noticed a substantial change; my acne has greatly reduced, with only one pimple every two weeks that quickly vanishes. I had previously tried numerous treatments without success, but the zinc addressed underlying hormonal issues. Beyond acne improvement, I also experienced better sleeping patterns and overall health. My family noted benefits too, with my mother seeing her chronic fatigue alleviated.

Adenoma details

Zinc is essential for both men and women, especially when there is a deficiency, which can lead to weakened immunity and exacerbation of chronic conditions. It is a vital trace element found in muscles, skin, bones, and hair, sourced from foods like meat, vegetables, mushrooms, and nuts. Insufficient zinc can lead to various issues, including weakness, bad breath, and hair loss. Regular use of zinc, particularly combined with selenium, significantly strengthens immunity, enhances skin appearance, and alleviates discomfort for women before menstruation. Additionally, it helps men in preventing prostate issues, adenoma, and other pelvic organ diseases. I highly recommend this supplement for overall well-being.

Adrenal Gland Disorder details

Boosts immunity greatly

This zinc supplement is excellent for immunity and fatigue prevention! Since integrating it with Vitamin D2 and K2, my fatigue has significantly improved. My research showed that zinc aids Vitamin B absorption and is beneficial for combating adrenal fatigue and stress. I prefer using it alongside NMN, Rhodiola, and Ashwagandha for better results. I highly recommend it for anyone needing immune support or dealing with fatigue.

Cancer details

Buj R, Cole AR, Danielson J, Xu J, Hurd D, et al. cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance. bioRxiv. 2025. doi:10.1101/2025.02.08.637227

Zinc's role in cancer immunity

We explored how zinc levels impact cancer cells and immune function, particularly focusing on macrophages, which are crucial for our body’s defense against tumors. Our research revealed that cancer cells often have decreased expression of specific genes tied to immune response, and this links to resistance against therapies designed to unblock immune checkpoints.

By upregulating a zinc importer known as SLC39A9, these cancer cells manage to hoard zinc for themselves, leaving the surrounding tumor microenvironment (TME) depleted of this vital nutrient. This competition for zinc results in macrophages becoming zinc-starved, which diminishes their ability to perform essential tasks like engulfing and destroying cancer cells.

Interestingly, we found that when we replenished zinc levels in the TME—through a dietary intervention—these macrophages could regain their pro-phagocytic function. This change significantly improved the response of certain tumors to immunotherapy treatments. Notably, T cells weren’t required for this transformation, indicating that macrophages alone play a pivotal role.

Our results are clinically relevant, showing that cancer patients with reduced zinc levels in their body tend to experience worse outcomes. Overall, we identified a new mechanism by which cancer cells can disrupt immune function, highlighting zinc’s critical role in both tumor environments and immunotherapy effectiveness.

9.5

Prevents cancer development

Most Useful Review

Zinc is vital for producing approximately 100 enzymes in the body. It acts as an antioxidant, neutralising free radicals and preventing cancer's progression. Zinc also stimulates blood production and promotes collagen synthesis, essential for wound healing.

Cardiovascular Disease details

Guo J, Ma T, Wang B, Xing B, Huang L, et al. Zn protects H9C2 cardiomyocytes by alleviating MAMs-associated apoptosis and calcium signaling dysregulation. Cell Signal. 2025;127:111629. doi:10.1016/j.cellsig.2025.111629

Zinc counters heart cell injury

We set out to investigate how zinc might help protect heart cells from damage caused by a lack of blood flow, known as myocardial ischemia-reperfusion injury (MIRI). Using H9C2 cells, which are derived from rat heart tissue, we simulated this injury by depriving these cells of oxygen and then reintroducing it while treating them with zinc.

Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.

Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.

Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.

8.8

Effective treatment

Most Useful Review

I take it for preventing and treating viral diseases, and it has been effective. It's unfortunate that this dosage became unavailable in Russia.

Chronic Cough details

After starting dietary supplements from Now Foods, I've completely forgotten about the constant chronic rhinitis and slight discomfort I used to suffer from during the autumn-winter period.

Common Cold details

Zinc shortens cold duration variability

Hemilä H, Chalker E, Tukiainen J. Quantile Treatment Effect of Zinc Lozenges on Common Cold Duration: A Novel Approach to Analyze the Effect of Treatment on Illness Duration. Front Pharmacol. 2022;13:817522. doi:10.3389/fphar.2022.817522

We explored how zinc lozenges affect the duration of the common cold through a detailed analysis of multiple trials. In particular, we focused on the Mossad (1996) trial involving zinc gluconate lozenges, which revealed an average reduction of cold duration by about 4.0 days. While that sounds promising, our findings through a quantile treatment effect (QTE) analysis tell a more nuanced story.

Interestingly, the QTE analysis showed that for individuals suffering from lengthy colds lasting 15 to 17 days, the zinc lozenges could shorten their illness by as much as 8 days. On the flip side, those with shorter, 2-day colds only experienced a 1-day reduction in sickness. This suggests that while zinc may help, its effectiveness varies significantly depending on the initial duration of the cold, making the overall average effect less informative than we might think.

Our examination extended to three trials that used zinc acetate lozenges, yielding a similar average reduction of around 2.7 days. However, again, those averages concealed varying effects for short and long colds, highlighting the importance of looking beyond simple averages in treatment studies.

Overall, we observed that zinc lozenges can indeed help with cold duration, but the extent of that help is very much dependent on how long a person has been suffering. This approach to understanding treatment effects through QTE analysis could have important implications not just for cold treatment but also for analyzing other health outcomes.

9.5

Clear skin

Most Useful Review

Excellent and plentiful zinc tablets! I struggled with hormonal acne and bumps, particularly on my back and chin. After being advised about zinc’s benefits for skin, I decided to try these tablets, and indeed my complexion has brightened, reducing acne and its marks significantly.

Frozen Shoulder details

Since taking zinc, I have completely stopped experiencing pain, even when among others who are unwell and exposed to the cold air. The sperm production has also noticeably increased. Overall, zinc has had a positive effect, and I would recommend it to my family and friends. The product was beautifully packaged and arrived promptly.

Hashimoto details

Zinc's link to Hashimoto's thyroiditis

Based on 2 Researches

Rostami R, Beiranvand A, Nourooz-Zadeh S, Rostami M, Mohammadi A, et al. Association Between Essential Trace Elements and Thyroid Antibodies in the Blood of Women with Newly Diagnosed Hashimoto's Thyroiditis. Int J Endocrinol Metab. 2024;22:e145599. doi:10.5812/ijem-145599

We explored the connection between essential trace elements, particularly zinc, and Hashimoto’s thyroiditis (HT) in women who were newly diagnosed. In this study, we looked at a group of 56 women with HT and compared them to 64 matched controls.

The results showed that women with HT had significantly lower levels of selenium, iron, and zinc in their blood compared to the controls. Interestingly, their copper levels were higher. We examined the relationships between these trace elements and thyroid autoantibodies, which can indicate the presence of autoimmune activity affecting the thyroid.

While we noted a significant correlation between lower zinc (and other elements) and higher levels of thyroid antibodies, the study did not specifically focus on zinc treatment. This means that while zinc levels appear to be linked to autoantibody levels in HT, we can't definitively state that zinc treatment will improve the condition without further dedicated research.

Overall, the study indicates that lower zinc levels in conjunction with selenium and iron deficiencies might be involved in the autoimmune response seen in Hashimoto’s thyroiditis. Thus, this provides an avenue for future exploration into zinc's role as a potential supplement for women diagnosed with this condition.

9.5

Supports health

Most Useful Review

An excellent addition to my vitamins that are aiding me in addressing my Hashimoto's thyroid condition. I will continue to use it.

Hives details

Shore RN, Shelley WB, Kyle GC. Chronic urticaria from isophane insulin therapy; sensitivity associated with noninsulin components in commercial preparations. Arch Dermatol. 1975;111:94.

Zinc insulin alleviates hives

We observed a fascinating case of a young woman with diabetes who experienced chronic hives after switching her insulin type. Initially, she moved from a standard isophane insulin to a beef-pork version, which then triggered her hives. Even after she returned to her original insulin, the hives continued to be a problem.

During her hospital stay, we noted that her hives reappeared daily after insulin injections. This situation changed when we introduced a purer form of insulin called zinc single-peak beef insulin suspension. Surprisingly, the urticaria cleared up quickly after this switch.

Through skin testing, we discovered her sensitivity was primarily to the beef and pork forms of the isophane insulin. However, she showed no sensitivity to the zinc insulin forms. Although she did experience a brief return of the hives after taking antibiotics, this time they did not reappear at the insulin injection sites.

This case provides valuable insight into how certain insulin components can lead to hives, and how switching to a zinc preparation offered the young woman some relief.

9.5

Hives have stopped

Most Useful Review

Highly effective! I began taking this to reduce hair loss, grey hairs, and enhance skin condition. I’ve noticed fewer grey hairs after about a month of use. Additionally, my hives, which used to flare up during seasonal changes, have ceased recently. I take one pill daily at lunchtime and wish to continue this regimen.

Osteoporosis details

Fang D, Jiang D, Shi G, Song Y. The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis. BMC Musculoskelet Disord. 2024;25:710. doi:10.1186/s12891-024-07768-5

Based on 10 Researches

Zinc intake may protect bones

We investigated the connection between dietary zinc intake and the prevalence of osteoporosis and osteopenia in patients with rheumatoid arthritis (RA). Using data from the National Health and Nutrition Examination Survey collected over several years, we applied various statistical methods to analyze how zinc impacts bone health in these patients.

Our findings revealed that higher dietary zinc intake appears to be linked with a lower incidence of osteopenia and osteoporosis among individuals with RA. This suggests that consuming adequate amounts of zinc might support better bone health for those suffering from this chronic condition.

Despite our positive findings, we acknowledge that further research, including longitudinal and randomized trials, is essential for confirming these results and understanding the underlying mechanisms at play. However, the evidence from our analysis encourages a focus on dietary zinc as a possible factor in maintaining bone health for patients with RA.

9.5

Greatly improved condition

Most Useful Review

It has significantly enhanced my osteoporosis, although the downside is that the size is quite large and hard to swallow.

Sinusitis details

Zinc Levels and Sinusitis Effects

Ghazizadeh M, Roshanaie E, Barati B. Comparison of serum zinc levels between patients with sinonasal neutrophilic and eosinophilic inflammatory polyposis and healthy individuals. Immun Inflamm Dis. 2024;12:e70016. doi:10.1002/iid3.70016

We explored the connection between zinc levels and chronic rhinosinusitis, particularly focusing on patients with nasal polyps. The study involved 105 participants divided into three groups: those with eosinophilic polyps, those with neutrophilic polyps, and a control group of individuals who underwent surgery for reasons other than polyposis.

We measured the serum zinc concentrations in these groups to see if there were any significant differences. Our findings revealed that patients suffering from chronic rhinosinusitis and having neutrophilic polyps had notably lower zinc levels compared to the general population. However, the zinc levels in patients with eosinophilic polyps did not show a significant difference when compared to healthy controls.

While we saw a clear distinction in zinc levels between the neutrophilic group and the control group, the overall data suggests that zinc's role in sinusitis, especially for those with eosinophilic polyps, may not be as pronounced. As such, while zinc might contribute to inflammation in specific cases, its effectiveness as a standalone treatment for sinusitis remains uncertain.

9.5

Breathing improvement

Most Useful Review

It helped with my long-standing sinusitis. I've been taking one zinc pill daily and haven't caught a cold in four years. I initially misunderstood the zinc requirement, assuming one pill wasn't sufficient, so I took two. To my surprise, my morning stuffy nose from sinusitis disappeared. Being able to breathe through my nose improved my sleep significantly. Although my allergies and hay fever have improved after two years of molecular nutrition, my sinusitis lingered. Thankfully, my inflammatory constitution has improved considerably. I will continue taking zinc while monitoring my symptoms and being cautious about dosage. Zinc is fantastic!

Swollen Lymph Nodes details

I’ve been taking various supplements, and I’ve never felt so effective. Even in summer, my fingers, once rough and damaged, have become beautiful. Additionally, the severe swelling and rough skin have subsided, and I feel better overall. While I do have atopy, that too has calmed. I take 50mg at a time, splitting the dose in the morning and evening. Zinc tends to cause nausea if taken on an empty stomach, so I always take it with food. It's painful if consumed incorrectly. I struggled at first, but I now take it during or after meals. There may be individual differences in dosage, but I am surprised at how effective supplements can be when taken in the correct amounts for me. I recommend it, particularly for those with atopy.

Tinnitus details

Zinc intake affects tinnitus risk

Tang D, Shekhawat GS, Burlutsky G, Mitchell P, Gopinath B. The Association between Dietary Intakes of Vitamins and Minerals with Tinnitus. Nutrients. 2024;16. doi:10.3390/nu16152535

We examined how dietary intakes of vitamins and minerals, particularly zinc, could influence the onset and presence of tinnitus, a condition characterized by phantom sounds in the ears. In a study involving nearly 3,000 participants over the age of 50, we identified cases of tinnitus to determine if their dietary habits played a role in their experience of this condition.

The findings indicated that while there were no significant associations between overall vitamin and mineral intake and existing tinnitus prevalence, zinc intake stood out in relation to developing tinnitus over time. Specifically, we observed that lower zinc consumption was linked to a 44% increased risk of experiencing tinnitus over a ten-year period.

Furthermore, we noted that iron intake also showed a significant correlation, with lower iron levels raising incident tinnitus risk by approximately 35%. These results highlight the potential importance of maintaining adequate zinc and iron levels in our diets to help reduce the risk of developing tinnitus.

9.5

Tinnitus resolved

Most Useful Review

I felt fatigued and experienced tinnitus, but thankfully, it vanished. This product truly aids in recovery. I highly recommend it.

Bruise details

Working! From the third day of admission, I experienced discomfort following the treatment for prostatitis. Overall, I felt better. It seems there was a significant zinc deficiency in my body. The bruises under my eyes vanished. For prevention, I will increase my intake.

Eczema details

Crisóstomo M, Santos MC, Tavares E, Cunha F. Transient symptomatic zinc deficiency in an exclusively breastfed infant. BMJ Case Rep. 2021;14. doi:10.1136/bcr-2021-241754

Zinc enhances eczema recovery

We investigated the relationship between zinc deficiency and eczema in a 3-month-old infant who was exclusively breastfed. The infant presented with symptoms like scaling erythematous dermatitis affecting her face and other areas, alongside irritability and poor weight gain. Her mother had been taking isoniazid for tuberculosis during pregnancy, which possibly contributed to the infant’s zinc deficiency.

After initial treatments for a suspected skin infection didn’t bring any changes, we found that the baby had low serum zinc levels and low zinc concentration in her breast milk. This led us to believe the skin condition was due to zinc deficiency rather than an infection. We started zinc supplementation, and the infant showed remarkable improvement in her skin condition and weight.

By 6 months, the infant had begun eating solid food, and we stopped the zinc supplements, with no signs of eczema returning. This case underscores the importance of monitoring zinc levels in breastfed infants, especially when mothers are on specific medications that might impact nutrient transfer through breast milk.

9.5

Eczema disappeared

Most Useful Review

After about two months of taking supplements to improve my immunity, the eczema of unknown cause disappeared, and my skin became noticeably cleaner.

Influenza details

Nishi K, Yoshimoto S, Nishi S, Nishi T, Nishi R, et al. Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry. In Vivo. 2022;36:2357. doi:10.21873/invivo.12967

Based on 2 Researches

Zinc may prevent influenza entry

We investigated how zinc, delivered through epipharyngeal abrasive therapy (EAT), might impact the expression of a key molecule known as Cav1.2, which plays a crucial role in allowing the influenza A virus to enter cells. The study included two groups of patients: one group that received EAT, which involved scratching the epipharyngeal mucosa with a zinc chloride-treated swab, and another group that did not receive this treatment.

By analyzing tissue samples, we observed that the levels of Cav1.2 were significantly lower in the EAT-treated patients compared to those who were not treated. In fact, the expression of Cav1.2 in the patients who underwent EAT was measured to be 4.19 times lower than in the non-treated group. This suggests that the squamous metaplasia induced by EAT might help reduce the entry of the influenza virus by down-regulating this key protein.

Our findings indicate that EAT, through its zinc content, could serve as a simple and effective method to potentially prevent influenza infection by limiting the virus's ability to enter cells.

9.5

Excellent immunity booster

Most Useful Review

The quality is outstanding, and the quantity is just right. At 50 mg, this supplement truly enhances immunity against ailments like influenza and is also excellent for skin, hair, and nails. The packaging is top-notch and protects against light. I take one pill after breakfast.

Menopause details

Zinc enhances vitamin D in menopause

Vázquez-Lorente H, Molina-López J, Herrera-Quintana L, Gamarra-Morales Y, López-González B, et al. Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial. J Trace Elem Med Biol. 2021;65:126730. doi:10.1016/j.jtemb.2021.126730

We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.

Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.

Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.

Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.

9.5

Good purchase effect

Most Useful Review

Excellent! As I am in menopause, I found zinc to be beneficial, and my purchase has yielded positive results.

Urinary Tract Infection details

Zinc-Infused Catheters Reduce Infections

Kim SH, Kim DY, Park JS, Park M, Park MC. Antimicrobial and Antibiofilm Activities of Urinary Catheter Incorporated with ZnO-Carbon Nanotube. ACS Appl Bio Mater. 2025;8:1397. doi:10.1021/acsabm.4c01658

We investigated the potential of a new type of urinary catheter to tackle catheter-associated urinary tract infections (CAUTIs). By incorporating zinc oxide-carbon nanotubes (ZnO-CNT) into a silicone catheter, we explored how this innovative design could inhibit infection-causing bacteria effectively.

Utilizing a combination of laboratory techniques like scanning electron microscopy and dynamic light scattering, we analyzed the structure of our ZnO-CNT catheter, which showed promising antibacterial properties. Notably, we found that the ZnO-CNT infusion significantly reduced biofilm formation—one of the main challenges in urinary catheters—demonstrating up to 56% inhibition in bacterial growth compared to standard silicone catheters.

The study revealed that ZnO-CNT not only holds antimicrobial potential but may also provide a more comfortable alternative to existing metal-coated options, like those using silver or gold. With our findings, we hope to present a viable strategy for reducing the discomfort and risks associated with traditional catheters while addressing a prevalent healthcare concern.

9.5

Eliminated infection

Most Useful Review

Excellent help! This is my second jar; the first got me through the pandemic. I bought it for skin issues, and zinc resolved those, but I’m amazed at how quickly it helps me fight off colds—typically within 3 to 5 days, no trace of infection remains. My skin's better, and my husband has even lost grey hair.

Constipation details

Zinc may mitigate granisetron constipation

Nacci C, Fanelli M, Potenza MA, Leo V, Montagnani M, et al. Carbon monoxide contributes to the constipating effects of granisetron in rat colon. World J Gastroenterol. 2016;22:9333.

We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.

Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.

Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.

9.5

Improved digestion

Most Useful Review

Excellent! I administered zinc to my wife for a month. It improved her digestion and resolved her constipation. It does not upset the stomach when consuming fried foods.

Food Poisoning details

Zinc oxide combats foodborne pathogens

Based on 3 Researches

Hakeem MJ, Feng J, Nilghaz A, Ma L, Seah HC, et al. Active Packaging of Immobilized Zinc Oxide Nanoparticles Controls Campylobacter jejuni in Raw Chicken Meat. Appl Environ Microbiol. 2020;86. doi:10.1128/AEM.01195-20

We set out to explore how zinc oxide nanoparticles (ZnO NPs) could help control the bacteria responsible for food poisoning in raw chicken meat. Our approach involved integrating these nanoparticles into packaging materials to see if they could effectively inactivate Campylobacter jejuni, a common and concerning pathogen in poultry.

Through our experiments, we discovered that immobilizing ZnO NPs in functional pads placed under raw chicken could dramatically reduce bacterial counts. In fact, we saw a reduction from about 4 log CFU to an undetectable level within just three days when storing chicken at 4°C. Notably, we monitored zinc levels in the chicken meat, confirming a safe release of zinc without any migration of nanoparticles onto the food. This means that we can help keep raw chicken safe and fresh without compromising its integrity or quality.

Not only did we find that these functional pads inactivated the harmful bacteria, but we also noted a related increase in lactic acid production, which plays a role in further protecting the meat. Our findings open up new avenues for using zinc in food packaging, offering a way to enhance food safety without directly adding chemicals to the food itself. Overall, this study highlights the potential for nanotechnology to play a significant role in managing foodborne pathogens like Campylobacter in poultry products.

8.3

Rapid acne resolution

Most Useful Review

I purchased this zinc for my sudden acne breakout, and it worked wonders. The dosage was high, and though I wish the package contained 250 tablets, I saw a rapid decrease in my acne. Very pleased with the results!

Heart Disease details

Zinc benefits heart health post-cisplatin

Based on 4 Researches

Al-Lbban AM. Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats. Braz J Biol. 2025;84:e287764. doi:10.1590/1519-6984.287764

We explored the potential benefits of zinc oxide nanoparticles (ZnONPs) in preventing heart damage caused by cisplatin, a powerful chemotherapy drug known for its efficacy but also for its side effects, particularly cardiotoxicity.

In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.

As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.

Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.

8.8

Boosts immunity

Most Useful Review

This zinc supplement is excellent for supporting immunity and general health. I've noticed a significant boost in energy and an overall improvement in well-being following a treatment course.

Warts details

Zinc effectively treats pediatric warts

Based on 16 Researches

Giacaman A, Granger C, Aladren S, Bauzá A, Alomar Torrens B, et al. Use of Topical Nitric-Zinc Complex Solution to Treat Palmoplantar and Periungual Warts in a Pediatric Population. Dermatol Ther (Heidelb). 2019;9:755. doi:10.1007/s13555-019-00330-5

We evaluated the effectiveness of a nitric-zinc complex solution (NZCS) for treating palmoplantar and periungual warts in children. Over a series of sessions, we found that 83.9% of warts completely resolved, with 87.5% success in periungual cases. The treatment was painless and easy, requiring only biweekly applications.

Additionally, the results were esthetically pleasing, with no significant side effects reported. This study highlights NZCS as a promising option for wart management in pediatric patients, making it easier for both children and their guardians.

6.8

Good warts effect

Most Useful Review

The effect is very good. I started eating it as it was beneficial for warts. There is also hanposin, but it was less effective for me. Now I don’t consume it daily. If taken right after a meal, it reduces warts, though that’s not feasible for every meal. Regardless, I’ll continue taking it as I possess good immunity.

Anemia details

Questionable

Inoue M. Zinc Deficiency Presenting With Diverse Symptoms in a Young Patient: A Case Report. Cureus. 2024;16:e66034. doi:10.7759/cureus.66034

Zinc deficiency linked to anemia

We explored the connection between zinc deficiency and anemia through the case of an 18-year-old woman who faced a series of health issues, including urinary tract infections and insulin dysfunction. After a thorough assessment, she was diagnosed with zinc deficiency, shedding light on how this overlooked issue can impact overall health.

What stood out to us was the rapid recovery the patient experienced after beginning oral zinc supplementation. Zinc plays a critical role in numerous bodily functions, including immune support and protein regulation. By addressing her deficiency, we observed significant improvement in her symptoms, including anemia.

The patient’s diet contained high levels of substances that were inhibiting her zinc absorption, which likely contributed to her condition. This case emphasizes the importance of recognizing zinc deficiency as a potential underlying cause for unexplained health issues, particularly anemia. Prompt diagnosis and treatment can lead to a complete turnaround in the patient's health.

By sharing this experience, we hope to raise awareness among clinicians about the vital role of zinc in managing anemia and encourage timely interventions for patients showing diverse symptoms.

9.5

Improved complexion

Most Useful Review

I experienced significant hair loss and had anemia from menstruation, prompting me to buy this supplement. Alongside iron tablets, I noticed a substantial improvement in my anemia! My complexion has benefited greatly, although I'm still unsure about the effect on my hair quality. However, the cost-effectiveness is appealing, leading me to consider continuing with it.

Autoimmune Disorder details

Zinc supplementation benefits MS models

Bayiroglu AF, Acar G, Gulbahce-Mutlu E, Baltaci SB, Mogulkoc R, et al. Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model. J Trace Elem Med Biol. 2024;86:127540. doi:10.1016/j.jtemb.2024.127540

We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.

After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.

Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.

9.5

Health improvement

Most Useful Review

After starting this supplement, I noticed my health improved significantly. In the past, I would catch a sore throat and runny nose after every winter walk, but that is no longer the case. This supplement has made a significant difference in my well-being, and I would recommend it to others.

Depression details

Zinc deficiency impacts brain function

Gąsior Ł, Pochwat B, Zaręba-Kozioł M, Włodarczyk J, Grabrucker AM, et al. Proteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency. Pharmacol Rep. 2025;77:145. doi:10.1007/s43440-024-00681-7

We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.

We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.

Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.

These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health.

9.5

Combats winter depression

Most Useful Review

To combat winter depression, I started taking it with Vitamin D, and I'm pleasantly surprised by the results. It has significantly improved my mood and energy levels during these colder months, making daily life much more manageable.

Leg Cramps details

This product has been helpful for my pyroluria condition, which prevented my body from retaining zinc and B6. For years, I dealt with leg cramps during exertion until a urine test revealed the issue. After taking Now Zinc tablets for over a year, my cramps have vanished. I must advise to avoid taking these on an empty stomach to prevent nausea; I grind mine and sprinkle them on cereal without any issues. I plan to switch to Zinc Picolinate soon due to its higher absorption rate.

Reflux details

Excellent for esophageal reflux, especially when combined with a proper diet.

Blurred Vision details

Significantly reduced loss

Appropriate supplementation can help prevent hair loss. Most people are deficient in zinc due to pressure at work, leading to increased hair loss. After taking zinc for about a month, I noticed a significant reduction in hair loss and an improvement in my hair condition. Zinc not only supports the immune system but also has health benefits for vision. Its deficiency is common, particularly in older adults, affecting immune function. Supplementing with zinc can enhance the immune response and maintain healthy inflammatory and antioxidant processes. The ingredients are pure with no additives. I plan to repurchase.

Prostate Cancer details

Zinc's complex role in prostate cancer

Ghimire K, Awasthi BP, Yadav K, Lee J, Kim H, et al. Prostate cancer-selective anticancer action of an oxindole derivative via HO-1-mediated disruption of metabolic reprogramming. Chem Biol Interact. 2025;408:111393. doi:10.1016/j.cbi.2025.111393

We explored the relationship between zinc levels and prostate cancer treatments, particularly focusing on a novel compound known as 3D. This compound showed a strong potential to target prostate cancer cells, contributing to a decrease in their proliferation rates.

Our analysis revealed that compound 3D selectively impacted key metabolic processes in prostate cancer cells by suppressing factors related to energy production, such as lactate levels. Interestingly, it also reduced the activity of transporters involved in zinc absorption while leaving those responsible for zinc export untouched.

We also found that the effectiveness of 3D could be reversed with zinc treatment, highlighting a complicated interaction between zinc and this therapeutic approach. While the compound successfully lowered zinc levels in cells and inhibited cancer growth, it is essential to note that we did not find significant benefits from zinc treatment by itself in the context of this study.

Overall, our findings suggest that targeting zinc metabolism and enhancing heme oxygenase-1 expression could be a promising strategy in prostate cancer therapy, more so than the direct application of zinc itself. The results illustrate the potential for combining innovative small molecules with an understanding of cancer metabolism in the development of treatment strategies.

Effective for prostate

Most Useful Review

Zinc should work effectively for prostate health when taken with Life Extension products.

Bloating details

Significantly improved digestion

I recently purchased NOW Supplements Super Enzymes, and I’m extremely impressed with the results. As someone who suffers from digestive issues, I’ve tried many supplements, but none have worked as well. The formula has decreased bloating and discomfort after just a few days. I appreciate that they’re natural and come in easy-to-swallow capsules. After a few weeks, my digestion improved significantly; I no longer feel bloated after meals, and my energy levels have increased.

Blood Clot details

M S M, Samal DB, Amirtraj J V, Subramanian S, Venkatasubbu GD. Enhanced coagulation cascade activation and styptic effects of Zn@SiO nanocomposite. Colloids Surf B Biointerfaces. 2024;239:113927. doi:10.1016/j.colsurfb.2024.113927

Zinc enhances blood clot formation

We explored how zinc affects blood clotting, particularly through a substance called Zn@SiO nanocomposite. This material shows promise as a hemostatic agent, which means it helps stop bleeding by promoting the formation of stable blood clots.

During our analysis, we examined various aspects of how this nanocomposite interacts with blood. It activates specific factors in the coagulation cascade—the process our bodies use to form clots. With the presence of zinc in the material, we observed enhanced activation of these factors, leading to improved clot formation.

Our research involved synthesizing and characterizing the Zn@SiO nanocomposite using several methods, including XRD, FTIR, and HRTEM. We also tested its effects on red blood cell aggregation, platelet adhesion, and several vital clotting time measures. The results indicate that Zn@SiO has significant hemostatic properties, showing potential for use in surgeries and trauma care.

This study highlights the exciting role of zinc in optimizing hemostasis, making it a candidate worth considering for medical applications related to bleeding management.

9.5

Rapid improvement

Most Useful Review

My mother developed white map-like spots on her tongue, worrying us. A blood test confirmed zinc deficiency. After purchasing zinc supplements, her spots nearly disappeared two days post-intake, completely vanishing by the third day. I was astounded by the quick improvement and realised the wonderful effect zinc can have. I intend to keep using it.

Chronic Fatigue Syndrome details

Zinc supplementation may benefit CFS

Maes M, Mihaylova I, De Ruyter M. Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS. J Affect Disord. 2006;90:141.

We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.

Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.

Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.

8.3

Overall fatigue disappearance

Most Useful Review

Since taking zinc alongside Arginine, I've noticed a significant reduction in fatigue. This combination seems effective, and I genuinely feel more energetic than before. It's encouraging to experience such a turnaround in my daily life.

Diabetes details

Zinc alleviates diabetic muscle atrophy

Based on 2 Researches

Yu X, Chen X, Wu W, Tang H, Su Y, et al. Zinc Alleviates Diabetic Muscle Atrophy via Modulation of the SIRT1/FoxO1 Autophagy Pathway Through GPR39. J Cachexia Sarcopenia Muscle. 2025;16:e13771. doi:10.1002/jcsm.13771

Our investigation aimed to understand how zinc affects muscle atrophy in diabetes, a serious complication that leads to muscle loss. Using diabetes-induced mice, we treated them with zinc sulfate for six weeks and observed notable improvements in their muscle condition.

We conducted various analyses to evaluate the impact of zinc on autophagy—the process that helps manage muscle mass. The results were promising; zinc appeared to enhance muscle recovery by regulating specific molecular pathways connected to muscle health.

Additionally, our in vitro studies with diabetic muscle cells revealed similar results, with zinc supplementation proving beneficial in reducing excessive autophagy. Overall, this suggests that incorporating zinc into treatment plans could be a promising approach to counteract muscle deterioration in diabetic patients.

9.5

Controls blood sugar

Most Useful Review

Zinc at 50 mg is therapeutic, while 25 mg suffices for prevention. It has antioxidant properties, aiding in reducing inflammation and protecting against chronic diseases, including heart disease, cancer, and diabetes. Additionally, zinc actively supports the immune system against viruses and contributes to blood sugar regulation by improving insulin sensitivity.

Irritable Bowel Syndrome details

Zinc intake may reduce IBS risk

Zhuang Y, Li L, Ran Y, Zhang Y, Chen J, et al. Dietary copper, zinc, copper/zinc ratio intakes and irritable bowel syndrome risk: a large-scale prospective cohort study from UK Biobank. Am J Epidemiol. 2024. doi:10.1093/aje/kwae412

We explored the potential connection between dietary zinc intake and the risk of developing irritable bowel syndrome (IBS) through a large-scale analysis of participants from the UK Biobank. By assessing the dietary habits of 175,421 individuals who did not have IBS at the start of the study, we sought to understand how various levels of zinc, as well as copper and their ratio, might influence the onset of this troublesome condition.

Over an average follow-up period of 13.3 years, we observed that 2,240 participants were diagnosed with new-onset IBS. Notably, our findings revealed a U-shaped relationship between zinc intake and IBS incidence. For those consuming less than 10 mg of zinc per day, an increase in intake was linked to a decreased risk of IBS. Specifically, individuals taking less than 10 mg of zinc daily experienced a reduced risk with higher zinc consumption.

However, the relationship shifted for individuals who had higher intakes of copper and zinc; no significant benefits were noted when intakes reached or exceeded established thresholds. This suggests that there's a delicate balance to maintain when it comes to zinc and copper in the diet.

Importantly, subgroup analysis indicated that younger individuals, particularly those under 60, could benefit more from slight increases in zinc. Overall, our study highlights the significance of dietary management, emphasizing that reasonable zinc intake may contribute to lowering IBS risk while keeping copper and the copper/zinc ratio in a sensible range.

8.8

Significant improvement

Most Useful Review

I was consuming food due to my troublesome bowel, but it has provided substantial relief.

Pelvic Pain details

Hip pain has disappeared, which is a remarkable improvement.

Bone Pain details

I consume it alongside selenium, which has helped eliminate my spasms and pains, making a significant difference in my comfort.

Gastritis details

Zinc protects against gastritis damage

Based on 8 Researches

Sun X, Xu S, Liu T, Wu J, Yang J, et al. Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model. Food Funct. 2024;15:7136. doi:10.1039/d4fo01142b

We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.

Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.

Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.

8.8

Improved digestion

Most Useful Review

This zinc is beneficial, although its type isn’t the best for absorption and comes in a large dosage. After taking it for a month and resting for another month, I noticed remarkable results: increased testosterone evidenced by a thicker beard, along with darkening hair on my hands. My eyesight improved, and my digestion was normalised; it aids stomach digestion, especially for those with ulcers or gastritis. I advise everyone to try it, but caution is needed due to the high dosage – I recommend splitting the tablet.

Whooping Cough details

Highly recommended drug

An indispensable medication, particularly during the cough and runny nose season. I would undoubtedly recommend it!

Allergies details

Xu H, Tong K, Iwasaki N, Ohgami N, Tazaki A, et al. Alleviating effect of intranasal zinc on symptoms of allergic rhinitis. J Allergy Clin Immunol Glob. 2025;4:100408. doi:10.1016/j.jacig.2025.100408

Zinc may relieve allergy symptoms

We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.

Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.

The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.

Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.

8.3

Helps with allergies

Most Useful Review

This product really seems to help with my allergies. I have incorporated it into my routine, and the price was reasonable too. I highly recommend including this in your daily regimen, as it has genuinely made a difference for me.

Chest Pain details

Eby GA, Halcomb WW. High-dose zinc to terminate angina pectoris: a review and hypothesis for action by ICAM inhibition. Med Hypotheses. 2006;66:169.

Zinc treatment for angina pectoris

We delved into an intriguing question: Can high doses of zinc help relieve chest pain caused by angina pectoris? Our research reviewed studies that highlight how zinc may play a role in managing this condition. Angina pectoris often results from arteriosclerosis, where the arteries become narrowed due to cholesterol buildup and other factors.

We discovered that patients with severe atherosclerosis showed promising improvements when treated with high-dose zinc. Specifically, a treatment regimen involved raising serum zinc levels significantly, resulting in symptom relief for many individuals. In one notable case, 12 out of 16 patients experienced measurable benefits, including one patient who also suffered from Raynaud's disease.

Furthermore, our analysis noted that long-term exposure to zinc in the environment correlated with reduced incidence of angina and ischemic events during exercise. Zinc appears to possess antioxidant properties, which may protect against the oxidation of LDL cholesterol, a key player in artery damage. By blocking certain inflammatory factors and promoting better circulation, zinc might enhance heart function and alleviate chest pain.

Based on these findings, we propose that zinc treatment should be considered a fundamental option in both prevention and therapy for atherosclerosis-related chest pain. This could lead to a renewed focus on restoring a healthier cardiac function among those affected by these conditions.

6.8

Adjusted dosage needed

Most Useful Review

Occasionally, taking a full tablet makes my chest feel queasy. If I rest, I recover quickly, but I’ve started to halve my dose to avoid discomfort and am monitoring my reactions.

Liver Disease details

Chim SM, Howell K, Dronzek J, Wu W, Van Hout C, et al. Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings. Elife. 2024;12. doi:10.7554/eLife.90419

Zinc's Role in Liver Health

We focused on the connection between zinc and liver health, particularly how it may influence conditions like non-alcoholic fatty liver disease (NAFLD) and metabolic issues, including type II diabetes (T2D). Our analysis of data from a large genetics cohort revealed a significant finding: rare genetic variants that reduce the function of the zinc transporter SLC39A5 were linked to better metabolic profiles and lower T2D risk.

To delve deeper into these results, we used both laboratory and animal models. We developed mice that completely lacked SLC39A5 and observed promising outcomes. These mice showcased improved liver function and lower blood sugar levels after being subjected to obesity challenges, whether congenital or diet-induced.

Notably, this improvement seemed to be associated with increased levels of zinc in the liver, which activated key signaling pathways involved in metabolism, such as AMPK and AKT. Furthermore, these mice exhibited less liver inflammation and fibrosis in models of diet-induced non-alcoholic steatohepatitis (NASH).

Together, these findings position SLC39A5 as a potentially valuable target for treating liver-related metabolic disorders, emphasizing zinc's crucial role in managing liver health and blood sugar regulation.

5.5

Detoxifies liver

Most Useful Review

I took a high dose of zinc; next time I will reduce it. Zinc plays a role in liver detoxification, protecting it from toxins and aiding their removal.

Insomnia details

Cherasse Y, Saito H, Nagata N, Aritake K, Lazarus M, et al. Zinc-containing yeast extract promotes nonrapid eye movement sleep in mice. Mol Nutr Food Res. 2015;59:2087. doi:10.1002/mnfr.201500082

Based on 3 Researches

Zinc promotes sleep in mice

We explored the effects of zinc on sleep by looking at how it might help with insomnia. In our study, we gave mice a zinc-containing yeast extract and monitored their behavior and brain activity. The results were quite promising.

We found that administering zinc at doses of 40 and 80 mg/kg led to a significant increase in non-rapid eye movement (NREM) sleep. This means that the mice were not only sleeping longer but also showed less activity, which is a good indicator of effective sleep. Interestingly, we did not observe any changes in rapid eye movement (REM) sleep, a crucial sleep phase for dreaming and deep rest.

Importantly, we didn’t see any negative side effects, such as rebound insomnia, within 24 hours after treating the mice. This suggests that zinc could be a safe option for those struggling with sleep issues, unlike other mineral extracts we tested, such as manganese, iron, and copper, which did not affect locomotor activity at all.

Overall, our findings provide the first evidence that zinc has a direct role in promoting sleep, opening up exciting possibilities for new sleep supplements featuring this essential mineral.

8.8

Sleepiness at night

Most Useful Review

For the last few years, I have grappled with insomnia. I tried numerous supplements, exercises, and changes to my sleeping environment, all with little success. Since starting zinc, however, I've noticed that I'm feeling unusually sleepy at night. It's early days yet, but I've been taking it for a week now, and I’m hopeful it might be providing the relief I need.

Migraine details

Mazaheri M, Aghdam AM, Heidari M, Zarrin R. Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women. Clin Nutr Res. 2021;10:127. doi:10.7762/cnr.2021.10.2.127

Zinc reduces migraine symptoms

This study was designed as a randomized double-blind, placebo-controlled trial to examine how zinc gluconate supplementation might alleviate migraine symptoms in adult women. We followed 60 women, averaging about 35 years old, who either received 15 mg of zinc per day or a placebo for a duration of 12 weeks.

Over the trial, we observed significant improvements in those taking zinc. The frequency of migraine attacks, as well as the duration and severity of the headaches, drastically decreased for participants receiving zinc. We used various assessments, such as a numerical rating scale and the Migraine Disability Assessment test, to evaluate these changes.

Additionally, zinc supplementation showed a notable reduction in levels of low-density lipoprotein (LDL) cholesterol and high-sensitivity C-reactive protein (hs-CRP), both of which are associated with inflammation. However, no significant changes in triglycerides or high-density lipoprotein (HDL) levels were seen. After taking initial values into account, the changes in lipid levels and hs-CRP weren’t significant.

Overall, we found that zinc supplementation can beneficially impact migraine symptoms, reducing their severity and frequency among women. This offers a promising direction for migraine management without the side effects often associated with traditional medications.

9.5

Improved control

Most Useful Review

GREAT! It normalises sleep with a regular intake of two capsules and improves my migraines. Special effects begin, I take my pills as usual, adding magnesium, and the migraine eases in a couple of hours, whereas before it would incapacitate me for half a day. I’ve noted a decrease in frequency, though I have other medicinal support.

Indigestion details

Zinc-enhanced therapy improves eradication

Ibrahim N, El Said H, Choukair A. Zinc carnosine-based modified bismuth quadruple therapy standard triple therapy for eradication: A randomized controlled study. World J Clin Cases. 2022;10:227. doi:10.12998/wjcc.v10.i1.227

We explored the effectiveness of a modified bismuth quadruple therapy that includes zinc carnosine, in comparison to the traditional triple therapy for treating indigestion caused by Helicobacter pylori infection. In our study, 92 patients with symptoms of dyspepsia and positive breath tests were randomly assigned to receive either the conventional treatment of esomeprazole, amoxicillin, and clarithromycin for 14 days, or a shorter 10-day course of the new therapy that also included bismuth subcitrate and zinc carnosine.

The results were quite revealing. Our findings showed that the modified bismuth quadruple therapy group had a significantly higher eradication rate of 93.5%, compared to 69.6% in the standard treatment group. This suggests that the addition of zinc carnosine to the treatment regimen could enhance the effectiveness of indigestion relief. Importantly, the side effects reported between the two groups were similar, with only mild dizziness noted in those receiving the new therapy.

Overall, the study indicates that a shorter course of therapy that includes zinc carnosine may be a superior option for individuals suffering from indigestion related to Helicobacter pylori. This approach not only appears to work better but also does not lead to more serious side effects, making it an appealing alternative to traditional treatment methods.

9.5

No indigestion

Most Useful Review

Good ingredients and good value for money. It's 50mg, so I'm sharing it. There's no indigestion or bloating, and the brand is popular; Naugo is recommended.

Kidney Stones details

Sun Y, Wang Y, Wang D, Zhou Q. Dietary zinc intake, supplemental zinc intake and serum zinc levels and the prevalence of kidney stones in adults. J Trace Elem Med Biol. 2020;57:126410. doi:10.1016/j.jtemb.2019.126410

Based on 8 Researches

Zinc's role in kidney stones

We investigated how different forms of zinc intake—dietary, supplemental, and serum levels—might connect to the prevalence of kidney stones in adults. By analyzing data from the National Health and Nutrition Examination Survey (NHANES) collected over nearly a decade, we uncovered some interesting patterns.

Our findings revealed that dietary zinc intake appeared to be linked to a lower likelihood of developing kidney stones. In fact, for every increase in daily zinc intake, the odds of having kidney stones decreased. We noted that this relationship was particularly strong among women and individuals who were classified as overweight or obese.

Interestingly, while dietary zinc and serum zinc levels were inversely associated with kidney stones, we found no significant connection with supplemental zinc intake. This suggests that getting zinc from food sources may be more beneficial for kidney stone prevention than taking zinc supplements.

Overall, while our analysis highlights a potential protective effect of dietary zinc and serum zinc levels against kidney stones, it also points out the need for more thorough research to fully understand these relationships.

8.8

Supports kidney health

Most Useful Review

Zinc is vital for kidney health and hormone regulation. I take one tablet at 5 pm.

Diarrhea details

Zinc oxide mitigates diarrhea impacts

Zhang Y, Liu J, Li M, Dong Y, Li Z, et al. Zinc Oxide Administration Relieves the Diarrhea of ETEC K88-Infected Piglets by Reducing Ileal Apoptosis and Maintaining Gut Microbial Balance. Vet Sci. 2025;12. doi:10.3390/vetsci12020115

We explored how zinc oxide (ZnO), often used as a feed additive, affects diarrhea and gut health in piglets infected with the ETEC K88 strain. Through careful observation, we found that piglets suffering from this infection exhibited significantly increased fecal scores compared to those not affected. The ETEC K88 strain harms the small intestine, leading to a loss of villus height and a decrease in important antioxidant activities.

Our findings revealed that ZnO administration counteracts these negative effects effectively. It not only improved the overall health of the intestine but also enhanced its ability to combat oxidative stress. We also observed a balanced restoration of gut microbiota, as ZnO helped normalize the populations of certain beneficial bacteria altered by the infection.

In summary, our study indicates that ZnO can play a vital role in easing diarrhea in piglets infected with ETEC K88 by reducing intestinal damage, supporting antioxidative defenses, and restoring healthy gut flora.

9.5

Diarrhea resolved

Most Useful Review

For years, I battled atopic dermatitis, but after using this product, I noticed quick healing. I also suffered from frequent diarrhea, but after taking this supplement, I haven't experienced it again, which was quite a pleasant surprise. The tablets aren't capsules, making them a bit difficult to swallow initially, but I adapted without issue.

Heartburn details