Last update
3/31/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 5 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Zinc (from 405 mg Zinc Gluconate)
50 mg
455%
Top Medical Research Studies
8
We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
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Most Useful Reviews
9
Improved digestion
14 people found this helpful
Excellent! I administered zinc to my wife for a month. It improved her digestion and resolved her constipation. It does not upset the stomach when consuming fried foods.
Read More
10
Constipation resolved
I observed a good effect; my condition improved and constipation disappeared completely.
Read More
7.5
Consistent bowel movements
This is an excellent product for constipation. I've noticed a significant improvement; I previously had bowel movements only once a week, but now I go every day.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved digestion
14 people found this helpful
Excellent! I administered zinc to my wife for a month. It improved her digestion and resolved her constipation. It does not upset the stomach when consuming fried foods.
Read More
10
Constipation resolved
I observed a good effect; my condition improved and constipation disappeared completely.
Read More
7.5
Consistent bowel movements
This is an excellent product for constipation. I've noticed a significant improvement; I previously had bowel movements only once a week, but now I go every day.
Read More
7.5
Supports digestion
Excellent! Apple Cider Vinegar 5% unfiltered helps with digestion, prevents constipation, detoxifies the liver, and helps with weight loss. It can also dissolve fat and produce enzymes.
Read More
0
Causes constipation
I often get constipation. I'm unsure of its effectiveness, but it makes my stools hard and leads to constipation when I take it, so I won't use it again.
Read More
Frequently Asked Questions
9
Improved digestion
14 people found this helpful
Excellent! I administered zinc to my wife for a month. It improved her digestion and resolved her constipation. It does not upset the stomach when consuming fried foods.
10
Constipation resolved
I observed a good effect; my condition improved and constipation disappeared completely.
7.5
Consistent bowel movements
This is an excellent product for constipation. I've noticed a significant improvement; I previously had bowel movements only once a week, but now I go every day.
0
Causes constipation
I often get constipation. I'm unsure of its effectiveness, but it makes my stools hard and leads to constipation when I take it, so I won't use it again.
7.5
Supports digestion
Excellent! Apple Cider Vinegar 5% unfiltered helps with digestion, prevents constipation, detoxifies the liver, and helps with weight loss. It can also dissolve fat and produce enzymes.
8
We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
References
- Nacci C, Fanelli M, Potenza MA, Leo V, Montagnani M, et al. Carbon monoxide contributes to the constipating effects of granisetron in rat colon. World J Gastroenterol. 2016;22:9333. PubMed
