Last update
3/13/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.5
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Acetyl-L-Carnitine (from 1,250 mg Acetyl-L-Carnitine HCl)
1 g (1,000 mg)
**
Top Medical Research Studies
8
We examined how acetyl-L-carnitine influences hypothyroidism, particularly focusing on its impact on liver mitochondria. In our study, we measured the amount of messenger RNA for cytochrome oxidase subunit I in the livers of hypothyroid rats.
After treating the rats with acetyl-L-carnitine, we observed a significant increase in the mRNA levels just three hours post-treatment. This improvement in gene expression suggests that acetyl-L-carnitine may promote mitochondrial function even in altered metabolic states.
Interestingly, even rats that were pre-treated with T3, a thyroid hormone, showed similar positive effects when administered acetyl-L-carnitine. These findings lend further support to the idea that acetyl-L-carnitine can stimulate important processes in mitochondria, especially under conditions like hypothyroidism.
After treating the rats with acetyl-L-carnitine, we observed a significant increase in the mRNA levels just three hours post-treatment. This improvement in gene expression suggests that acetyl-L-carnitine may promote mitochondrial function even in altered metabolic states.
Interestingly, even rats that were pre-treated with T3, a thyroid hormone, showed similar positive effects when administered acetyl-L-carnitine. These findings lend further support to the idea that acetyl-L-carnitine can stimulate important processes in mitochondria, especially under conditions like hypothyroidism.
Read More
Most Useful Reviews
9
Feeling better
I started taking this on my endocrinologist's advice for hypothyroidism, and I feel significantly better now.
Read More
2
Dopamine overload
3 people found this helpful
Warning: This supplement may lead to dopamine overload in some individuals – it triggered a severe depressive and anxious episode for me, which I managed with 5-HTP. It can also affect thyroid function and lead to symptoms of hypothyroidism, which I am currently experiencing. Note that ALCAR has a long half-life of 28.9 - 35.9 hours, resulting in quick accumulation in the body.
Read More
7.5
Increased energy
1 people found this helpful
Excellent! While some individuals may not respond well to hypothyroidism, I appreciate it as it boosts my energy levels. The size is also convenient to consume.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
We examined how acetyl-L-carnitine influences hypothyroidism, particularly focusing on its impact on liver mitochondria. In our study, we measured the amount of messenger RNA for cytochrome oxidase subunit I in the livers of hypothyroid rats.
After treating the rats with acetyl-L-carnitine, we observed a significant increase in the mRNA levels just three hours post-treatment. This improvement in gene expression suggests that acetyl-L-carnitine may promote mitochondrial function even in altered metabolic states.
Interestingly, even rats that were pre-treated with T3, a thyroid hormone, showed similar positive effects when administered acetyl-L-carnitine. These findings lend further support to the idea that acetyl-L-carnitine can stimulate important processes in mitochondria, especially under conditions like hypothyroidism.
After treating the rats with acetyl-L-carnitine, we observed a significant increase in the mRNA levels just three hours post-treatment. This improvement in gene expression suggests that acetyl-L-carnitine may promote mitochondrial function even in altered metabolic states.
Interestingly, even rats that were pre-treated with T3, a thyroid hormone, showed similar positive effects when administered acetyl-L-carnitine. These findings lend further support to the idea that acetyl-L-carnitine can stimulate important processes in mitochondria, especially under conditions like hypothyroidism.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Feeling better
I started taking this on my endocrinologist's advice for hypothyroidism, and I feel significantly better now.
Read More
2
Dopamine overload
3 people found this helpful
Warning: This supplement may lead to dopamine overload in some individuals – it triggered a severe depressive and anxious episode for me, which I managed with 5-HTP. It can also affect thyroid function and lead to symptoms of hypothyroidism, which I am currently experiencing. Note that ALCAR has a long half-life of 28.9 - 35.9 hours, resulting in quick accumulation in the body.
Read More
7.5
Increased energy
1 people found this helpful
Excellent! While some individuals may not respond well to hypothyroidism, I appreciate it as it boosts my energy levels. The size is also convenient to consume.
Read More
7.5
Necessary supplement
I came across a physician's blog stating that this is an essential supplement for individuals with hypothyroidism due to their slow metabolism. L-carnitine enhances energy in cells, and I intend to start taking it.
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6
Slight improvement
Magnificent! I have hypothyroidism and decided to try this supplement after hearing praise for it. I have only been on it for a month and am noticing a slight improvement regarding symptoms of hypothyroidism. I will take a test soon for more reassurance.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Gadaleta MN, Petruzzella V, Fracasso F, Fernandez-Silva P, Cantatore P. Acetyl-L-carnitine increases cytochrome oxidase subunit I mRNA content in hypothyroid rat liver. FEBS Lett. 1990;277:191. PubMed
Data last updated:
