Last update
5/25/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.9
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Milk Thistle Extract(Silybum marianum) (Fruit/Seed)(Standardized to 240 mg Silymarin Flavonoids - equivalent 80%)
300 mg
**
Dandelion Root (Taraxacum officinale)
100 mg
**
Artichoke (Cynara scolymus) (Leaf)
50 mg
**
Top Medical Research Studies
8
Silybine lowers blood pressure in rats
We examined how silybine, the active ingredient in Silybum marianum, impacts blood pressure based on research conducted on normal albino rats. We found that even at low doses, silybine effectively lowers systemic blood pressure without causing increased vascular permeability.
Interestingly, it also helps counteract anaphylactic shocks and stabilize cell membranes, preventing histamine release. However, further studies are needed to fully understand its potential effects on hypertension in humans.
Interestingly, it also helps counteract anaphylactic shocks and stabilize cell membranes, preventing histamine release. However, further studies are needed to fully understand its potential effects on hypertension in humans.
Read More
9
We explored how silybin, a compound from Silybum marianum, affects blood pressure and vascular function. Our research included molecular docking experiments and measurements of calcium concentrations to understand its interaction with TRPV4 channels in small arteries.
We found that in mice with high salt-induced hypertension, silybin effectively lowered systolic blood pressure and improved blood vessel response. This suggests silybin could play a role in promoting better vascular health and preventing related cardiovascular issues.
We found that in mice with high salt-induced hypertension, silybin effectively lowered systolic blood pressure and improved blood vessel response. This suggests silybin could play a role in promoting better vascular health and preventing related cardiovascular issues.
Read More
8
We explored the effects of milk thistle cold press oil, derived from Silybum marianum, on obesity-related hypertension in mice. In this study, mice fed a high-fat diet were treated with the oil for the last eight weeks.
The results showed that the oil significantly reduced hypertension, obesity, and hyperglycemia, while also improving markers of inflammation and liver fibrosis. These findings suggest that milk thistle oil may be a helpful natural treatment for managing symptoms related to metabolic syndrome, including hypertension.
The results showed that the oil significantly reduced hypertension, obesity, and hyperglycemia, while also improving markers of inflammation and liver fibrosis. These findings suggest that milk thistle oil may be a helpful natural treatment for managing symptoms related to metabolic syndrome, including hypertension.
Read More
Most Useful Reviews
2
No effect noted
I tried Milk Thistle for my isolated diastolic hypertension, but I noticed no effect. The only remedy that worked for me was Rwolfia Serpentina (Indian Snakeroot).
Read More
7.5
Blood pressure stabilised
I purchased this because of reviews suggesting it can improve hypertension and diabetes. I've only just started taking it, but my blood pressure has stabilised. I'm eager for my next appointment.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
- All Researches
9
We explored how silybin, a compound from Silybum marianum, affects blood pressure and vascular function. Our research included molecular docking experiments and measurements of calcium concentrations to understand its interaction with TRPV4 channels in small arteries.
We found that in mice with high salt-induced hypertension, silybin effectively lowered systolic blood pressure and improved blood vessel response. This suggests silybin could play a role in promoting better vascular health and preventing related cardiovascular issues.
We found that in mice with high salt-induced hypertension, silybin effectively lowered systolic blood pressure and improved blood vessel response. This suggests silybin could play a role in promoting better vascular health and preventing related cardiovascular issues.
Read More
8
We explored the effects of milk thistle cold press oil, derived from Silybum marianum, on obesity-related hypertension in mice. In this study, mice fed a high-fat diet were treated with the oil for the last eight weeks.
The results showed that the oil significantly reduced hypertension, obesity, and hyperglycemia, while also improving markers of inflammation and liver fibrosis. These findings suggest that milk thistle oil may be a helpful natural treatment for managing symptoms related to metabolic syndrome, including hypertension.
The results showed that the oil significantly reduced hypertension, obesity, and hyperglycemia, while also improving markers of inflammation and liver fibrosis. These findings suggest that milk thistle oil may be a helpful natural treatment for managing symptoms related to metabolic syndrome, including hypertension.
Read More
8
Silybine lowers blood pressure in rats
We examined how silybine, the active ingredient in Silybum marianum, impacts blood pressure based on research conducted on normal albino rats. We found that even at low doses, silybine effectively lowers systemic blood pressure without causing increased vascular permeability.
Interestingly, it also helps counteract anaphylactic shocks and stabilize cell membranes, preventing histamine release. However, further studies are needed to fully understand its potential effects on hypertension in humans.
Interestingly, it also helps counteract anaphylactic shocks and stabilize cell membranes, preventing histamine release. However, further studies are needed to fully understand its potential effects on hypertension in humans.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
2
No effect noted
I tried Milk Thistle for my isolated diastolic hypertension, but I noticed no effect. The only remedy that worked for me was Rwolfia Serpentina (Indian Snakeroot).
Read More
7.5
Blood pressure stabilised
I purchased this because of reviews suggesting it can improve hypertension and diabetes. I've only just started taking it, but my blood pressure has stabilised. I'm eager for my next appointment.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Wen X, Peng Y, Zheng B, Yang S, Han J, et al. Silybin induces endothelium-dependent vasodilation via TRPV4 channels in mouse mesenteric arteries. Hypertens Res. 2022;45:1954. 10.1038/s41440-022-01000-4
- Shen HH, Alex R, Bellner L, Raffaele M, Licari M, et al. Milk thistle seed cold press oil attenuates markers of the metabolic syndrome in a mouse model of dietary-induced obesity. J Food Biochem. 2020;44:e13522. 10.1111/jfbc.13522
- Lecomte J. [General pharmacologic properties of silybine and silymarine in the rat]. Arch Int Pharmacodyn Ther. 1975;214:165. PubMed
