We examined how the papaya preparation Caricol® impacts digestive issues like bloating and constipation in a double-blind placebo-controlled study. Participants with chronic digestive complaints took either Caricol® or a placebo for 40 days.

While we noticed significant improvements in symptoms of constipation and bloating for some participants, these benefits didn’t continue after the washout phase. Unfortunately, the treatment showed no lasting effect on heartburn. Overall, Caricol® may help some digestive issues but the benefits seem temporary.

Panic attack relief

Most Useful Review

20 people found this helpful

My Life Saver. I’ve suffered from chronic gastritis with constant bloating, burping, fatigue, and nausea. This caused anxiety. After research, I tried these tablets. Within two days, I felt relief after being in hospital three times for gastric symptoms. Thankfully, I discovered these tablets; I take three after meals. They taste fruity and minty; they’re chewable! My symptoms are gone. Thank you for these; I've saved a fortune!

Updated: Mar 2026

We analyzed the effectiveness of the papaya preparation Caricol® in treating digestive disorders, including heartburn, using a double-blind placebo-controlled design. Participants with chronic digestive issues took either Caricol® or a placebo for 40 days.

While we observed significant improvements in symptoms like constipation and bloating among early returnees, results for heartburn did not reach statistical significance due to a small sample size. Thus, while Caricol® supports digestive health, it may not effectively alleviate heartburn symptoms specifically.

Heartburn-free now

Most Useful Review

7 people found this helpful

Finally, something that helps! I have suffered from Acid Reflux almost daily for the past three years. During the night, I would wake up in pain and reach for TUMS to get back to sleep. I know relying on TUMS often isn't good for me. A friend suggested taking Papaya Enzyme, and after a week of using this product, I’ve been heartburn-free! Occasionally, I sense heartburn about to strike, but it never reaches discomfort level. I'm thrilled with my results and have reordered already!

Updated: Mar 2026

High Cholesterol details

Effective nutrient absorption

Most Useful Review

This improved digestive supplement is a fantastic aid for inefficient digestion, featuring 100% natural enzymes. Each serving contains delicious papaya fruit and renowned enzymes such as papain and bromelain, promoting proper nutrient absorption and aiding digestion. Added peppermint and chlorophyll enhance the taste and freshen breath. Overall, it’s a high-quality and highly effective product.

Updated: Apr 2025

Back Pain details

7 people found this helpful

Finally, something that truly helps! I've dealt with acid reflux daily for three years, often relying on TUMS that couldn’t be a long-term solution. After hearing about Papaya Enzyme at a dinner, I decided to give it a try. In just a week of use, I am completely heartburn-free! I no longer wake in pain, and even if I sense heartburn developing, it's quickly alleviated. I'm thoroughly impressed and have reordered.

Updated: Apr 2025

Blood Clot details

Excellent! This medication positively influences metabolism. It cleans blood vessels, lowers cholesterol levels, and helps prevent blood clotting.

Updated: Apr 2025

Celiac details

No bloating experienced

Most Useful Review

These enzymes are my go-to for every meal, especially when my family experiences stomach discomfort from something we've eaten. They work excellently to aid digestion of gluten, lactose, casein, and any other troublesome elements. I usually take stomach acid pills at the beginning of the meal and these at the end to ensure proper handling. They work wonderfully—no pain, discomfort, or bloating! My entire family enjoys their taste.

Updated: Apr 2025

Gastritis details

This product perfectly addresses the challenges of food digestion for my daughter, who has gastritis.

Updated: Apr 2025

Indigestion details

26 people found this helpful

Excellent! I came across this in someone's reviews – thank you! These tablets help alleviate heaviness in the stomach associated with eating and indigestion. I purchased them in Hungary, and they taste lovely. Without these wonderful tablets, I wouldn't be as enthusiastic about the Hungarian cuisine! They work perfectly. I often rely on them and even assist my colleagues. The white tablets are medium-sized, with a pleasant, slightly minty taste. After taking them, I quickly feel a clean and comfortable stomach again. They’ve frequently helped colleagues with their stomach troubles too. Everyone keeps asking what sort of miracle these pills are!

Updated: Apr 2025

Nausea details

20 people found this helpful

I've suffered with chronic gastritis for years, which included constant fatigue and nausea. After using these tablets for just two days, I felt a significant relief, preventing any further trips to the hospital for gastric symptoms.

Updated: Mar 2026

Cardiovascular Disease details

3 people found this helpful

The American Health Chewable Super Papaya Enzyme Plus tablets are a delightful way to ease my stomach post-meal.

Updated: Apr 2025

Flu details

SCIENTIFIC SCORE

Likely Very Effective

Based on 4 Researches

Promising vaccine approach for influenza

Carignan D, Thérien A, Rioux G, Paquet G, Gagné ML, et al. Engineering of the PapMV vaccine platform with a shortened M2e peptide leads to an effective one dose influenza vaccine. Vaccine. 2015;33:7245. doi:10.1016/j.vaccine.2015.10.123

We explored a new vaccine approach using papaya mosaic virus particles fused with a short influenza peptide. This innovative structure showed promise in generating strong immune responses after just one dose in mice. The results indicated that vaccinated mice were significantly protected from the flu, suggesting that this could pave the way for an effective, broadly protective vaccine. While the study used mouse models, the findings could provide insights into future influenza vaccine development.

No more heartburn

Most Useful Review

7 people found this helpful

I've suffered from acid reflux for the past three years, which has been rather bothersome. During the night, I would awaken in pain and reach for TUMS to settle down. A friend suggested papaya enzyme, and since starting it a week ago, I'm now heartburn-free! I no longer wake in discomfort, and this product has truly been life-changing.

Updated: Mar 2026

Swollen Lymph Nodes details

8 people found this helpful

Good composition without sugar. After a month of use, I noticed that my body began to respond more calmly, and the swelling was alleviated. I found myself eating less than before; despite someone claiming their appetite increased, mine actually decreased. My diet became healthier, focusing more on vegetables and fruits. I have been prescribed to take 8 pieces a day by my gynaecologist for 2 months. The heaviness in my stomach is now a thing of the past, and my portion sizes have reduced by half. I have lost 2 kg in a month.

Updated: Apr 2025

Yeast Infection details

4 people found this helpful

I find these digestive enzymes quite delightful and adjustable in dosage, making them very beneficial. Due to a Helicobacter pylori infection that led to atrophic gastritis, I realised my digestive capability was compromised after years of gastric acid issues. I’ve started actively using digestive enzymes alongside other supplements. So far, I feel in great shape and my stomach is doing well. After discontinuing absorption-blocking supplements, I noticed my metabolism slightly increased, making weight gain more difficult. Now, I feel hungrier and my cravings for sweets have vanished, showing promising signs in dealing with my condition.

Updated: Apr 2025

Cancer details

Benefits digestion, cancer

Most Useful Review

2 people found this helpful

A natural and excellent product, with a very appropriate and abundant quantity. Papaya offers great benefits for digestion, fighting cancer, infections, and ulcers. After placing my trust in God Almighty, I found this product to be particularly special. I wish everyone could benefit from it, and may you all remain well.

Updated: Apr 2025

Constipation details

Papaya shows limited digestive benefits

Muss C, Mosgoeller W, Endler T. Papaya preparation (Caricol®) in digestive disorders. Neuro Endocrinol Lett. 2013;34:38.

We explored the impact of Caricol®, a papaya preparation, on digestive issues, particularly constipation. In a double-blind, placebo-controlled study, volunteers suffering from chronic indigestion took either Caricol® or a placebo for 40 days.

Although participants reported significant improvements in constipation and bloating, these benefits did not persist after a washout phase. There was no substantial effect on heartburn due to the limited number of cases. Overall, while Caricol® showed promise, its long-term efficacy remains uncertain.

Excellent product

Most Useful Review

3 people found this helpful

My fitness friend recommended this. Having dealt with chronic constipation and weeks without a bowel movement, this product has been outstanding for me, making me regular without causing the diarrhoea typical with laxatives.

Updated: Apr 2025

Gastroesophageal Reflux Disease details

1 people found this helpful

Super Enzymes are simply the best. They have been an absolute lifesaver; I have suffered with Gastroesophageal Reflux Disease for 30 years and have issues breaking down proteins. Consequently, I avoid certain foods. However, with these Super Papaya Enzymes, I can enjoy meals again. I take three after a high protein meal and experience no problems at all. These enzymes are truly worth their weight in gold for anyone who struggles to break down proteins.

Updated: Mar 2026

Heart Attack details

Super Papaya Enzyme, combined with Fennel Seed, effectively prevents my heartburn. I no longer need over-the-counter antacids, and I love the minty freshness it leaves.

Updated: Mar 2026

Irritable Bowel Syndrome details

It tastes great, and I have seen benefits from taking it. My bowel movements have returned to normal, and the tablet dissolves well, making it a pleasant after-meal treat.

Updated: Mar 2026

Food Poisoning details

SCIENTIFIC SCORE

Likely Very Effective

Papaya extract’s effect on S. aureus

Handayani L, Faridah DN, Kusumaningrum HD. Staphylococcal enterotoxin A gene-carrying Staphylococcus aureus isolated from foods and its control by crude alkaloid from papaya leaves. J Food Prot. 2014;77:1992. doi:10.4315/0362-028X.JFP-13-483

We investigated how a crude alkaloid extract from papaya leaves impacts Staphylococcus aureus, the bacteria responsible for food poisoning through its harmful enterotoxin A.

We discovered that this extract significantly inhibits the growth of the bacteria and reduces the production of enterotoxin A. When tested, the extract led to a notable decrease in enterotoxin expression.

Although the papaya extract showed promise, it's essential to conduct further research to better understand its practical applications in food safety settings.