Last update
5/6/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Likely Ineffective
Based on 1 Research
4
USERS' SCORE
Good
Based on 28 Reviews
8.5
Supplement Facts
Serving Size: 3 tablets
Amount Per Serving
%DV
Protease (4,800 USP)
3 mg
**
Bromelain (0.2 GDU)
3 mg
**
Alpha Amylase (120 DU)
3 mg
**
Cellulase Enzyme (9 ACU)
94.5 mg
**
Papain (90,000 USP)
45 mg
**
Lipase (12 USP)
1.5 mg
**
Papaya Fruit
15 mg
**
Sodium Copper Chlorophyllin (Chlorophyll)
1.5 mg
**
Top Medical Research Studies
4
Papaya treatment shows mixed results
We analyzed the effectiveness of the papaya preparation Caricol® in treating digestive disorders, including heartburn, using a double-blind placebo-controlled design. Participants with chronic digestive issues took either Caricol® or a placebo for 40 days.
While we observed significant improvements in symptoms like constipation and bloating among early returnees, results for heartburn did not reach statistical significance due to a small sample size. Thus, while Caricol® supports digestive health, it may not effectively alleviate heartburn symptoms specifically.
While we observed significant improvements in symptoms like constipation and bloating among early returnees, results for heartburn did not reach statistical significance due to a small sample size. Thus, while Caricol® supports digestive health, it may not effectively alleviate heartburn symptoms specifically.
Read More
Most Useful Reviews
10
Heartburn-free now
7 people found this helpful
Finally, something that helps! I have suffered from Acid Reflux almost daily for the past three years. During the night, I would wake up in pain and reach for TUMS to get back to sleep. I know relying on TUMS often isn't good for me. A friend suggested taking Papaya Enzyme, and after a week of using this product, I’ve been heartburn-free! Occasionally, I sense heartburn about to strike, but it never reaches discomfort level. I'm thrilled with my results and have reordered already!
Read More
10
Amazing for GERD
6 people found this helpful
This product works fantastically for heartburn and GERD symptoms, far better for one's health than Tums!
Read More
10
Quick heartburn relief
4 people found this helpful
Super for heartburn and acid reflux! This stuff is incredible, and more people should be aware of it. One night, my husband suffered from heartburn during the night, so I gave him some, and in the morning, he asked what magic I had given him. It’s best used daily for prevention, but it also works quickly and on-the-spot when needed. Whenever I’ve offered it to someone at my house experiencing heartburn, they’ve asked what it is so they can get some for themselves!
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Ineffective
Based on 1 Research
4
- All Researches
4
Papaya treatment shows mixed results
We analyzed the effectiveness of the papaya preparation Caricol® in treating digestive disorders, including heartburn, using a double-blind placebo-controlled design. Participants with chronic digestive issues took either Caricol® or a placebo for 40 days.
While we observed significant improvements in symptoms like constipation and bloating among early returnees, results for heartburn did not reach statistical significance due to a small sample size. Thus, while Caricol® supports digestive health, it may not effectively alleviate heartburn symptoms specifically.
While we observed significant improvements in symptoms like constipation and bloating among early returnees, results for heartburn did not reach statistical significance due to a small sample size. Thus, while Caricol® supports digestive health, it may not effectively alleviate heartburn symptoms specifically.
Read More
User Reviews
USERS' SCORE
Good
Based on 28 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
10
Heartburn-free now
7 people found this helpful
Finally, something that helps! I have suffered from Acid Reflux almost daily for the past three years. During the night, I would wake up in pain and reach for TUMS to get back to sleep. I know relying on TUMS often isn't good for me. A friend suggested taking Papaya Enzyme, and after a week of using this product, I’ve been heartburn-free! Occasionally, I sense heartburn about to strike, but it never reaches discomfort level. I'm thrilled with my results and have reordered already!
Read More
10
Amazing for GERD
6 people found this helpful
This product works fantastically for heartburn and GERD symptoms, far better for one's health than Tums!
Read More
10
Quick heartburn relief
4 people found this helpful
Super for heartburn and acid reflux! This stuff is incredible, and more people should be aware of it. One night, my husband suffered from heartburn during the night, so I gave him some, and in the morning, he asked what magic I had given him. It’s best used daily for prevention, but it also works quickly and on-the-spot when needed. Whenever I’ve offered it to someone at my house experiencing heartburn, they’ve asked what it is so they can get some for themselves!
Read More
10
Natural heartburn relief
3 people found this helpful
I really love this product! It's a much better alternative to chemicals and it truly works for heartburn, acid reflux, and GERD.
Read More
9
Natural remedy
3 people found this helpful
This product has nearly eradicated my heartburn. After finding that standard antacids didn't work, I started taking these plant-based enzymes after meals. They taste pleasant and are highly effective.
Read More
Frequently Asked Questions
8
Heartburn remedy
I have suffered from heartburn for years, but these pills work well. While the dosage is three lozenges, I usually take only one or two daily.
4
Papaya treatment shows mixed results
We analyzed the effectiveness of the papaya preparation Caricol® in treating digestive disorders, including heartburn, using a double-blind placebo-controlled design. Participants with chronic digestive issues took either Caricol® or a placebo for 40 days.
While we observed significant improvements in symptoms like constipation and bloating among early returnees, results for heartburn did not reach statistical significance due to a small sample size. Thus, while Caricol® supports digestive health, it may not effectively alleviate heartburn symptoms specifically.
While we observed significant improvements in symptoms like constipation and bloating among early returnees, results for heartburn did not reach statistical significance due to a small sample size. Thus, while Caricol® supports digestive health, it may not effectively alleviate heartburn symptoms specifically.
References
- Muss C, Mosgoeller W, Endler T. Papaya preparation (Caricol®) in digestive disorders. Neuro Endocrinol Lett. 2013;34:38. PubMed
