Last update
3/24/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.3
Supplement Facts
Serving Size: 1 Vegetarian Tablet
Amount Per Serving
%DV
Vitamin C (as Ester-C® Calcium Ascorbate)
1,000 mg (1 g)
1,111%
Calcium (as Ester-C® Calcium Ascorbate)
110 mg
8%
Citrus Bioflavonoids ComplexCitrus Bioflavonoids (Citrus sinensis) (fruit), Sweet Orange, Tangerine, Lime, Lemon, Acerola, Rutin, Hesperidin Complex (Citrus spp.) (fruit), Naturally Occurring Vitamin C Metabolites
200 mg
**
Top Medical Research Studies
9
We delved into how vitamin C might influence cancer treatment, focusing on its effects on the immune system. Our findings revealed that vitamin C directly modifies certain proteins, leading to a new type of protein change called vitcylation. This process specifically affects a protein known as STAT1.
By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.
Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.
By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.
Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.
Read More
7
Novel nanoparticle system demonstrates enhanced cancer-fighting potential
We designed a specialized nanoparticle system combining copper-doped metal-organic frameworks with calcium ascorbate (a form of vitamin C) to fight cancer more effectively. The system is wrapped in hyaluronic acid, which acts like a homing beacon to target tumors.
Once inside tumor cells, the nanoparticles release calcium ascorbate, which generates hydrogen peroxide—a powerful cancer-fighting molecule. At the same time, the released copper works to strip away glutathione, a natural defense that cancer cells use to protect themselves. This one-two punch creates toxic hydroxyl radicals that damage cancer cells while reducing their ability to survive.
Our tests showed this approach significantly enhanced cancer cell death compared to traditional methods, suggesting a promising new strategy for more effective chemodynamic therapy.
Once inside tumor cells, the nanoparticles release calcium ascorbate, which generates hydrogen peroxide—a powerful cancer-fighting molecule. At the same time, the released copper works to strip away glutathione, a natural defense that cancer cells use to protect themselves. This one-two punch creates toxic hydroxyl radicals that damage cancer cells while reducing their ability to survive.
Our tests showed this approach significantly enhanced cancer cell death compared to traditional methods, suggesting a promising new strategy for more effective chemodynamic therapy.
Read More
Most Useful Reviews
9
Immunity-boosting effects
The most favourite vitamin C, as its effectiveness is clinically proven. It has a powerful dosage that the whole family consumes regularly. During illness, it quickly aids recovery. This much-needed vitamin C serves as an antiviral, antibacterial, immunity-boosting, cancer-killing antioxidant, among other benefits. Our health has significantly improved after a course of these vitamins. I recommend them to those who are often unwell.
Read More
7.5
Daily cancer support
This vitamin C was recommended by a nutritionist. We purchased it for a friend who is in remission from cancer, and she drinks it regularly as daily support.
Read More
7.5
Improves digestion
37 people found this helpful
Great product but I need to cut the tablets in half. After extensive research, I chose this product because Ester-C has a higher absorbency than standard vitamin C and is gentler on the stomach. It also includes beneficial citrus bioflavonoids. According to Livestrong.org, these bioflavonoids might assist with drug-resistant cancer cells by making them more responsive to chemotherapy, alongside potential heart disease protection through improved circulation. The only drawback is the large tablet size, which necessitates cutting them in half to avoid choking. However, this is a minor issue. Overall, I highly recommend this product.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
- All Researches
9
We delved into how vitamin C might influence cancer treatment, focusing on its effects on the immune system. Our findings revealed that vitamin C directly modifies certain proteins, leading to a new type of protein change called vitcylation. This process specifically affects a protein known as STAT1.
By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.
Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.
By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.
Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.
Read More
7
Novel nanoparticle system demonstrates enhanced cancer-fighting potential
We designed a specialized nanoparticle system combining copper-doped metal-organic frameworks with calcium ascorbate (a form of vitamin C) to fight cancer more effectively. The system is wrapped in hyaluronic acid, which acts like a homing beacon to target tumors.
Once inside tumor cells, the nanoparticles release calcium ascorbate, which generates hydrogen peroxide—a powerful cancer-fighting molecule. At the same time, the released copper works to strip away glutathione, a natural defense that cancer cells use to protect themselves. This one-two punch creates toxic hydroxyl radicals that damage cancer cells while reducing their ability to survive.
Our tests showed this approach significantly enhanced cancer cell death compared to traditional methods, suggesting a promising new strategy for more effective chemodynamic therapy.
Once inside tumor cells, the nanoparticles release calcium ascorbate, which generates hydrogen peroxide—a powerful cancer-fighting molecule. At the same time, the released copper works to strip away glutathione, a natural defense that cancer cells use to protect themselves. This one-two punch creates toxic hydroxyl radicals that damage cancer cells while reducing their ability to survive.
Our tests showed this approach significantly enhanced cancer cell death compared to traditional methods, suggesting a promising new strategy for more effective chemodynamic therapy.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Immunity-boosting effects
The most favourite vitamin C, as its effectiveness is clinically proven. It has a powerful dosage that the whole family consumes regularly. During illness, it quickly aids recovery. This much-needed vitamin C serves as an antiviral, antibacterial, immunity-boosting, cancer-killing antioxidant, among other benefits. Our health has significantly improved after a course of these vitamins. I recommend them to those who are often unwell.
Read More
7.5
Daily cancer support
This vitamin C was recommended by a nutritionist. We purchased it for a friend who is in remission from cancer, and she drinks it regularly as daily support.
Read More
7.5
Improves digestion
37 people found this helpful
Great product but I need to cut the tablets in half. After extensive research, I chose this product because Ester-C has a higher absorbency than standard vitamin C and is gentler on the stomach. It also includes beneficial citrus bioflavonoids. According to Livestrong.org, these bioflavonoids might assist with drug-resistant cancer cells by making them more responsive to chemotherapy, alongside potential heart disease protection through improved circulation. The only drawback is the large tablet size, which necessitates cutting them in half to avoid choking. However, this is a minor issue. Overall, I highly recommend this product.
Read More
Frequently Asked Questions
9
Immunity-boosting effects
The most favourite vitamin C, as its effectiveness is clinically proven. It has a powerful dosage that the whole family consumes regularly. During illness, it quickly aids recovery. This much-needed vitamin C serves as an antiviral, antibacterial, immunity-boosting, cancer-killing antioxidant, among other benefits. Our health has significantly improved after a course of these vitamins. I recommend them to those who are often unwell.
7.5
Daily cancer support
This vitamin C was recommended by a nutritionist. We purchased it for a friend who is in remission from cancer, and she drinks it regularly as daily support.
9
We delved into how vitamin C might influence cancer treatment, focusing on its effects on the immune system. Our findings revealed that vitamin C directly modifies certain proteins, leading to a new type of protein change called vitcylation. This process specifically affects a protein known as STAT1.
By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.
Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.
By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.
Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.
References
- Zhang M, Xue H, Yang J, Zhao X, Xue M, et al. Copper(II)-based metal-organic framework delivery of calcium ascorbate for enhanced chemodynamic therapy HO self-supply and glutathione depletion. Biomater Sci. 2024;12:1871. 10.1039/d3bm01922e
- He X, Wang Q, Cheng X, Wang W, Li Y, et al. Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response. Cell. 2025. 10.1016/j.cell.2025.01.043
