The safety and efficacy of 2% vitamin C solution spray for relief of mucosal irritation caused by Lugol chromoendoscopy: a multicenter, randomized, double-blind, parallel trial.
We investigated how vitamin C, specifically in the form of a 2% vitamin C solution spray, could help alleviate heartburn symptoms following Lugol chromoendoscopy, a procedure that involves staining the esophagus to better visualize abnormalities. In a well-structured study with 240 participants, we used a randomized, double-blind approach to compare the effectiveness of vitamin C to normal saline and sodium thiosulfate solutions.
Our results showed that vitamin C spray significantly reduced both acute heartburn symptoms and late discomfort when compared to the saline solution. Specifically, 33% of participants using vitamin C reported relief from acid regurgitation or heartburn, compared to just 15% with sodium thiosulfate. Additionally, patients noted an improvement in retrosternal pain, with 21% finding relief from the vitamin C treatment versus 9% from sodium thiosulfate.
Furthermore, vitamin C offered a quicker discoloration of the iodine-stained mucosa compared to saline, enhancing the overall experience of the procedure. These findings suggest that incorporating vitamin C spray into post-procedural care could be a helpful strategy for patients facing discomfort after undergoing Lugol chromoendoscopy.
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Most Useful Reviews
9
No gastrointestinal issues
1 people found this helpful
I experienced heartburn symptoms with other vitamin C products, but this one causes no gastrointestinal issues, which is why I like it.
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9
Prevents heartburn
1 people found this helpful
An excellent formula of Vitamin C, far better than ascorbic acid. It helps to relax and prevent colds, and notably does not cause heartburn.
Read More
9
No heartburn
1 people found this helpful
You can take it after or during meals, and at 1000mg, it’s easy to take once a day. After consistent use, I feel less susceptible to colds. Not having heartburn is a distinct advantage over other vitamin C options.
The safety and efficacy of 2% vitamin C solution spray for relief of mucosal irritation caused by Lugol chromoendoscopy: a multicenter, randomized, double-blind, parallel trial.
We investigated how vitamin C, specifically in the form of a 2% vitamin C solution spray, could help alleviate heartburn symptoms following Lugol chromoendoscopy, a procedure that involves staining the esophagus to better visualize abnormalities. In a well-structured study with 240 participants, we used a randomized, double-blind approach to compare the effectiveness of vitamin C to normal saline and sodium thiosulfate solutions.
Our results showed that vitamin C spray significantly reduced both acute heartburn symptoms and late discomfort when compared to the saline solution. Specifically, 33% of participants using vitamin C reported relief from acid regurgitation or heartburn, compared to just 15% with sodium thiosulfate. Additionally, patients noted an improvement in retrosternal pain, with 21% finding relief from the vitamin C treatment versus 9% from sodium thiosulfate.
Furthermore, vitamin C offered a quicker discoloration of the iodine-stained mucosa compared to saline, enhancing the overall experience of the procedure. These findings suggest that incorporating vitamin C spray into post-procedural care could be a helpful strategy for patients facing discomfort after undergoing Lugol chromoendoscopy.
Read More
User Reviews
USERS' SCORE
Good
Based on 19 Reviews
8.3
All Reviews
Positive Reviews
Negative Reviews
9
No gastrointestinal issues
1 people found this helpful
I experienced heartburn symptoms with other vitamin C products, but this one causes no gastrointestinal issues, which is why I like it.
Read More
9
Prevents heartburn
1 people found this helpful
An excellent formula of Vitamin C, far better than ascorbic acid. It helps to relax and prevent colds, and notably does not cause heartburn.
Read More
9
No heartburn
1 people found this helpful
You can take it after or during meals, and at 1000mg, it’s easy to take once a day. After consistent use, I feel less susceptible to colds. Not having heartburn is a distinct advantage over other vitamin C options.
Read More
9
No heartburn
It is vitamin C that you can trust and take for a long time. Although it is more expensive than other vitamin Cs, there is no heartburn and it is very good.
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9
No heartburn
For me, the best form of vitamin C does not cause heartburn or sour belching; I am very happy.
Heartburn is a common condition characterized by a burning sensation in the chest, often behind the breastbone. This discomfort is typically caused by acid reflux, where stomach acid flows back into the esophagus, the tube that connects the throat to the stomach. Symptoms may vary in intensity and duration, sometimes resulting in a bitter taste in the mouth, difficulty swallowing, or a sensation of food being stuck in the throat. While it can occur occasionally in healthy individuals after consuming certain foods or beverages, chronic heartburn, also known as gastroesophageal reflux disease (GERD), may require medical attention and lifestyle adjustments.
Diet plays a significant role in managing heartburn. Identifying and avoiding trigger foods—such as spicy dishes, citrus fruits, chocolate, and caffeinated drinks—can help alleviate symptoms. Over-the-counter antacids and medications can offer quick relief, while prescription options may be necessary for more severe cases. In addition to dietary changes, maintaining a healthy weight and avoiding large meals before bedtime can also promote better digestive health and reduce the frequency of heartburn. If symptoms persist or worsen, consulting a healthcare professional is advisable for a comprehensive evaluation and treatment plan.
Ester-C is a patented form of vitamin C (ascorbic acid) that is known for its unique formulation, which includes calcium ascorbate. This makes Ester-C less acidic than standard vitamin C, making it gentler on the stomach for those who may experience gastrointestinal discomfort from regular vitamin C supplementation. One of the key features touted by manufacturers of Ester-C is that it is better absorbed by the body and stays in the immune system longer, although scientific research on these claims can be mixed.
In addition to its purported benefits, Ester-C is often marketed as a supplement that supports immune health, collagen production, and serves as an antioxidant, helping to combat free radicals and oxidative stress. It's available in various forms, including capsules, tablets, and powders, making it easy to incorporate into your daily routine. While some users report positive effects and tolerance of Ester-C, it's essential to consult with a healthcare professional before adding any new supplement to your regimen, especially if you have existing conditions or are taking other medications.
Based on user reviews, results from taking this vitamin C supplement for heartburn can vary, but many users report immediate relief from their symptoms. For example, several reviewers noted that they did not experience heartburn at all when switching to this product, indicating that it may work quickly in providing relief from discomfort associated with traditional vitamin C options Read ReviewRead Review. Additionally, one long-term user mentioned they switched to this brand after previously struggling with heartburn and have since taken it for years without issues Read Review.
While some users highlighted the benefit of improved tolerance to vitamin C after consistent use, a clear timeframe for seeing results specifically regarding heartburn wasn’t universally defined. However, the general consensus among users suggests that if the formula suits your body, relief from heartburn could be both immediate and satisfactory Read Review.
Recent research provides promising evidence regarding the use of vitamin C spray for heartburn relief, particularly following specific medical procedures like Lugol chromoendoscopy. In a study involving 240 participants, those treated with a 2% vitamin C solution spray reported a significant reduction in acute heartburn symptoms and late discomfort compared to those given a saline solution. Approximately 33% of participants experienced relief from acid regurgitation or heartburn with vitamin C, as opposed to only 15% with alternative treatments. These findings point to vitamin C's potential as a supplementary treatment for alleviating discomfort related to heartburn after certain medical interventions [1].
Furthermore, the study highlighted that vitamin C not only alleviated heartburn symptoms but also improved the overall post-procedural experience by offering quicker visual clarity for the iodine-stained mucosa. This dual benefit underscores the possibility of integrating vitamin C spray into the care regimen of patients undergoing similar procedures, providing both symptom relief and a better procedural experience. While these results are promising, it's essential to consult with a healthcare professional before considering vitamin C or any supplement for heartburn relief [1].
Based on user reviews, many individuals have experienced significant improvements in their symptoms when switching to this vitamin C supplement. A common point mentioned is the lack of heartburn and gastrointestinal discomfort that often accompanies other vitamin C products. Users have reported that this supplement allows them to take vitamin C without adverse reactions such as heartburn or sour belching, marking it as a preferable option for those with sensitive stomachs Read ReviewRead ReviewRead Review. Furthermore, long-term users have expressed gratitude for not experiencing heartburn or stomach pain, even when taking higher doses, indicating that the product has been a reliable choice over time Read Review.
It's worth noting that individual results vary, as some users still find the pill size challenging. However, the overall sentiment suggests that for many, this vitamin C formula not only alleviates heartburn symptoms but might also enhance immune support and overall tolerance Read ReviewRead Review. Users report feeling less susceptible to colds and appreciate the quality and absorption levels of this supplement Read Review.
Based on user reviews, many people have found this vitamin C supplement to be effective when combined with other supplements for handling heartburn. Specifically, users appreciate that it does not cause any gastrointestinal issues, allowing them to take it alongside other vitamins without experiencing discomfort. For instance, one reviewer mentioned that they take this vitamin C in conjunction with vitamin D for immunity support during the pandemic, and they have avoided heartburn symptoms that were previously associated with other brands Read Review. Similarly, other users have noted that the supplement's formulation enables them to avoid heartburn in general, which suggests that it may be safely taken with other dietary supplements Read Review.
Users also emphasize the importance of the supplement's gentle formulation, stating that even those with sensitive stomachs can incorporate it into their routine without adverse reactions Read Review. Furthermore, the overall consensus is that this vitamin C product allows for higher doses without the uncomfortable side effects commonly associated with traditional vitamin C, making it a versatile option for individuals seeking comprehensive nutritional support without the worry of heartburn Read Review.
Based on user reviews, many users report that Ester C is a well-tolerated form of vitamin C that does not trigger heartburn or gastrointestinal issues. For instance, one user highlighted that they experienced heartburn symptoms with other vitamin C products, yet Ester C causes no such problems, making it a preferred choice Read Review. Another user echoed similar sentiments, stating that they have been using Ester C for years and have not encountered heartburn, which is a significant advantage over other options they’ve tried Read Review.
Regarding dosage, several reviews suggest that a daily intake of 1000 mg is common among users. One user mentioned taking 1000 mg once daily without any discomfort, feeling less susceptible to colds as an added benefit Read Review. Others noted that they take doses ranging from 500 mg to 3 grams daily, also reporting no heartburn reactions at those levels Read ReviewRead Review. It’s worth mentioning, however, that some users pointed out the larger size of the pills as a potential inconvenience when swallowing them Read Review.
9
No heartburn
1 people found this helpful
You can take it after or during meals, and at 1000mg, it’s easy to take once a day. After consistent use, I feel less susceptible to colds. Not having heartburn is a distinct advantage over other vitamin C options.
9
No stomach pain
The best! For several years, I’ve been buying Ester-C with bioflavonoids. I suffer from gastritis and have high stomach acidity, yet this Esther C does not cause heartburn or stomach pain. It's excellent for strengthening the immune system, collagen production, and is a great antioxidant. I also appreciate the large pack and 1000 mg in a single tablet.
7.5
Relief from heartburn
1 people found this helpful
A few years ago, I struggled with heartburn from vitamin C, but after switching to this product, I’ve been taking it for years without issue. I originally took 500mg one or twice a day, but now opt for 1000mg once daily. It’s a trustworthy product and I recommend the lower dosage for those who find large pills difficult.
7.5
No heartburn
The pill size is slightly large, requiring caution when swallowing. However, I haven’t experienced any stomach pain or heartburn with this vitamin C product, which I believe is of good quality due to its bioflavonoid content.
9
No gastrointestinal issues
1 people found this helpful
I experienced heartburn symptoms with other vitamin C products, but this one causes no gastrointestinal issues, which is why I like it.
9
Prevents heartburn
1 people found this helpful
An excellent formula of Vitamin C, far better than ascorbic acid. It helps to relax and prevent colds, and notably does not cause heartburn.
9
No discomfort
Excellent! I’ve been taking this vitamin for a long time. With my sensitive stomach, being Ester-C means I experience no discomfort or heartburn. I recommend it highly.
7.5
No heartburn
The ideal vitamin C! I’ve ordered this multiple times. My husband and I share it; a jar lasts us three months with one tablet each daily. Previous brands caused heartburn, but this one is fine. We also take vitamin D to support our immunity during the pandemic, and I recommend it!
9
No heartburn
I consume about 3g daily. I'm pleased that I don’t experience heartburn, although swallowing can be inconvenient due to the large pill size.
9
Good quality
This is vitamin C that doesn't trigger heartburn for me. I'm taking it carefully due to concerns about stones, but the quality is commendable.
9
No heartburn
I’ve used vitamin C without experiencing heartburn for an extended period. However, the size of the pills is quite large.
8
Vitamin C reduces heartburn symptoms
The safety and efficacy of 2% vitamin C solution spray for relief of mucosal irritation caused by Lugol chromoendoscopy: a multicenter, randomized, double-blind, parallel trial.
We investigated how vitamin C, specifically in the form of a 2% vitamin C solution spray, could help alleviate heartburn symptoms following Lugol chromoendoscopy, a procedure that involves staining the esophagus to better visualize abnormalities. In a well-structured study with 240 participants, we used a randomized, double-blind approach to compare the effectiveness of vitamin C to normal saline and sodium thiosulfate solutions.
Our results showed that vitamin C spray significantly reduced both acute heartburn symptoms and late discomfort when compared to the saline solution. Specifically, 33% of participants using vitamin C reported relief from acid regurgitation or heartburn, compared to just 15% with sodium thiosulfate. Additionally, patients noted an improvement in retrosternal pain, with 21% finding relief from the vitamin C treatment versus 9% from sodium thiosulfate.
Furthermore, vitamin C offered a quicker discoloration of the iodine-stained mucosa compared to saline, enhancing the overall experience of the procedure. These findings suggest that incorporating vitamin C spray into post-procedural care could be a helpful strategy for patients facing discomfort after undergoing Lugol chromoendoscopy.
References
Jin D, Wang J, Zhan Q, Huang K, Wang H, et al. The safety and efficacy of 2% vitamin C solution spray for relief of mucosal irritation caused by Lugol chromoendoscopy: a multicenter, randomized, double-blind, parallel trial. Gastrointest Endosc. 2020;92:554. 10.1016/j.gie.2019.11.028