Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Good
Based on 35 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Serving Per Container: 120
Amount Per Serving
%DV
Alpha Lipoic Acid
600 mg
*
Top Medical Research Studies
9
We conducted a double-blind, placebo-controlled study involving 52 patients with diabetic neuropathy on gabapentin or pregabalin to explore the effects of alpha-lipoic acid (ALA). Over 12 weeks, we found that ALA significantly improved vibration perception threshold and secondary symptoms like overall quality of life, oxidative, and inflammatory markers.
Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.
Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.
Read More
9
We reviewed the impact of alpha-lipoic acid (ALA) and acetyl-L-carnitine (ALC) on neuropathic pain, which often affects quality of life. Our findings from various literature indicate that ALA may improve neuropathic pain and nerve function like traditional medications.
Tolerability was high for both supplements, with few side effects reported. Financially, ALA is relatively affordable at $14.40 per month compared to ALC's $27.60. Given the comparable efficacy and lower costs, we suggest considering these supplements as viable options in pain management.
Tolerability was high for both supplements, with few side effects reported. Financially, ALA is relatively affordable at $14.40 per month compared to ALC's $27.60. Given the comparable efficacy and lower costs, we suggest considering these supplements as viable options in pain management.
Read More
3
We investigated whether alpha-lipoic acid (ALA) could improve symptoms of diabetic peripheral neuropathy (DPN). Our review included three randomized trials with over 800 participants, with treatment durations ranging from six to 48 months.
Unfortunately, results suggest that ALA likely provides little or no benefit for neuropathy symptoms or impairment after six months. While the risk of side effects appears similar to a placebo, the evidence comes from studies with high attrition rates, calling for further research to ensure thorough participant tracking.
Unfortunately, results suggest that ALA likely provides little or no benefit for neuropathy symptoms or impairment after six months. While the risk of side effects appears similar to a placebo, the evidence comes from studies with high attrition rates, calling for further research to ensure thorough participant tracking.
Read More
Most Useful Reviews
8
Reduced pain medication use
15 people found this helpful
My neurologist recommended this for peripheral neuropathy. After a month, I was able to cut my pain medication use by over half. I switched brands and had a reaction, but returned to this one with no problems. It’s not a miracle cure, but it has helped me more than any prescription meds I've tried over 20 years. Major decrease in symptoms.
Read More
9
Great antioxidant benefit
10 people found this helpful
Definitely try this as your new antioxidant; it has relieved my nerve pain effectively. This is a fantastic antioxidant that helps with the entire body, and it has notably alleviated my nerve pain from neuropathy.
Read More
9
Pain relief achieved
8 people found this helpful
Best Naturals ALA 600 mg capsules have made a significant difference in relieving my diabetic neuropathy. As a 68-year-old diabetic, I take one capsule daily, and that seems sufficient for now. There's no taste to the capsule, which comes in a large bottle, and the order arrived promptly. I'm completely satisfied as it has reduced the pain in my feet and toes. The price is excellent; I purchased two bottles, and I appreciate that it contains no preservatives, artificial ingredients, gluten, or salt. It’s recommended to take it with a meal as it supports nerve function.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
- All Researches
9
We conducted a double-blind, placebo-controlled study involving 52 patients with diabetic neuropathy on gabapentin or pregabalin to explore the effects of alpha-lipoic acid (ALA). Over 12 weeks, we found that ALA significantly improved vibration perception threshold and secondary symptoms like overall quality of life, oxidative, and inflammatory markers.
Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.
Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.
Read More
9
We reviewed the impact of alpha-lipoic acid (ALA) and acetyl-L-carnitine (ALC) on neuropathic pain, which often affects quality of life. Our findings from various literature indicate that ALA may improve neuropathic pain and nerve function like traditional medications.
Tolerability was high for both supplements, with few side effects reported. Financially, ALA is relatively affordable at $14.40 per month compared to ALC's $27.60. Given the comparable efficacy and lower costs, we suggest considering these supplements as viable options in pain management.
Tolerability was high for both supplements, with few side effects reported. Financially, ALA is relatively affordable at $14.40 per month compared to ALC's $27.60. Given the comparable efficacy and lower costs, we suggest considering these supplements as viable options in pain management.
Read More
8
We investigated the potential benefits of alpha-lipoic acid (ALA) for patients with type 2 diabetes mellitus (T2DM) suffering from neuropathy. Over six months, we treated 54 patients with a daily dose of 600 mg of ALA while keeping their current oral medications unchanged. We also included a control group of 24 matched individuals who did not experience neuropathy.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Read More
8
Alpha-lipoic acid and neuropathy insights
We explored the effects of alpha-lipoic acid in the context of sodium-dependent multivitamin transporter deficiency (SMVTD), a rare condition resulting from loss-of-function variants in the SLC5A6 gene. In a detailed case of a 25-year-old woman, whose symptoms included developmental delays, epilepsy, and neurocognitive challenges, we observed an intriguing combination of treatments.
Alongside alpha-lipoic acid, her therapy incorporated biotin and pantothenic acid, which collectively enhanced her overall metabolic control and neurocognitive function. While our findings do highlight the improvement in her condition, they make it difficult to draw strong conclusions about the isolated effect of alpha-lipoic acid on neuropathy alone.
Ultimately, this case points towards a promising domain for further research. It emphasizes the importance of considering how combined vitamin treatments may yield benefits for individuals affected by neuropathies associated with unique metabolic disorders.
Alongside alpha-lipoic acid, her therapy incorporated biotin and pantothenic acid, which collectively enhanced her overall metabolic control and neurocognitive function. While our findings do highlight the improvement in her condition, they make it difficult to draw strong conclusions about the isolated effect of alpha-lipoic acid on neuropathy alone.
Ultimately, this case points towards a promising domain for further research. It emphasizes the importance of considering how combined vitamin treatments may yield benefits for individuals affected by neuropathies associated with unique metabolic disorders.
Read More
8
We explored the impact of genome sequencing on diagnosing and treating SLC5A6-related neuropathy. In this study, we observed that thirteen individuals with specific genetic variants experienced various symptoms, including childhood-onset peripheral motor neuropathy.
Interestingly, a targeted treatment approach using biotin, pantothenic acid, and alpha-lipoic acid showed promising clinical improvements in one case. The findings highlight the critical role of genetic testing in identifying conditions early, potentially saving both time and costs for families seeking answers.
Interestingly, a targeted treatment approach using biotin, pantothenic acid, and alpha-lipoic acid showed promising clinical improvements in one case. The findings highlight the critical role of genetic testing in identifying conditions early, potentially saving both time and costs for families seeking answers.
Read More
User Reviews
USERS' SCORE
Good
Based on 35 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
8
Reduced pain medication use
15 people found this helpful
My neurologist recommended this for peripheral neuropathy. After a month, I was able to cut my pain medication use by over half. I switched brands and had a reaction, but returned to this one with no problems. It’s not a miracle cure, but it has helped me more than any prescription meds I've tried over 20 years. Major decrease in symptoms.
Read More
9
Great antioxidant benefit
10 people found this helpful
Definitely try this as your new antioxidant; it has relieved my nerve pain effectively. This is a fantastic antioxidant that helps with the entire body, and it has notably alleviated my nerve pain from neuropathy.
Read More
9
Pain relief achieved
8 people found this helpful
Best Naturals ALA 600 mg capsules have made a significant difference in relieving my diabetic neuropathy. As a 68-year-old diabetic, I take one capsule daily, and that seems sufficient for now. There's no taste to the capsule, which comes in a large bottle, and the order arrived promptly. I'm completely satisfied as it has reduced the pain in my feet and toes. The price is excellent; I purchased two bottles, and I appreciate that it contains no preservatives, artificial ingredients, gluten, or salt. It’s recommended to take it with a meal as it supports nerve function.
Read More
7.5
Symptom relief confirmed
2 people found this helpful
I bought this for my 87-year-old mother, who has diabetes. The doctor suggested a course of 600 mg of alpha-lipoic acid daily for her diabetic neuropathy. Though it wasn't cheap at the pharmacy, I found it significantly cheaper on iHerb. This supplement has helped her manage symptoms like weakness in her legs, which sometimes don’t cooperate. It also seems to reduce blood glucose levels, which may require an adjustment in her diabetes medication.
Read More
7.5
Essential supplement noted
2 people found this helpful
This high-quality supplement is essential for treating type 2 diabetes. I am purchasing it for my mother based on her doctor's recommendation, and it successfully relieves her diabetic neuropathy symptoms.
Read More
Frequently Asked Questions
9
Symptoms drastically improved
After several months of taking this alpha lipoic acid supplement, I've noticed considerable improvements in my diabetic neuropathy symptoms. The 600 mg dosage per capsule has been effective, and the 240-capsule bottle offers good value. I appreciate that it is non-GMO, gluten-free, and produced in a GMP-compliant facility. While some users reported heartburn, I haven’t experienced side effects, making it a high-quality supplement for managing my nerve pain and diabetes.
9
Pain relief confirmed
1 people found this helpful
I use this supplement to alleviate my neuropathy pain. I take one capsule each morning on an empty stomach, and on particularly challenging days, I may take an additional one. Combined with two lion's mane capsules, it works well for me. My neurologist advises that up to three capsules can be taken daily, and I've bought this brand several times.
9
Pain relief achieved
8 people found this helpful
Best Naturals ALA 600 mg capsules have made a significant difference in relieving my diabetic neuropathy. As a 68-year-old diabetic, I take one capsule daily, and that seems sufficient for now. There's no taste to the capsule, which comes in a large bottle, and the order arrived promptly. I'm completely satisfied as it has reduced the pain in my feet and toes. The price is excellent; I purchased two bottles, and I appreciate that it contains no preservatives, artificial ingredients, gluten, or salt. It’s recommended to take it with a meal as it supports nerve function.
7.5
Symptom relief confirmed
2 people found this helpful
I bought this for my 87-year-old mother, who has diabetes. The doctor suggested a course of 600 mg of alpha-lipoic acid daily for her diabetic neuropathy. Though it wasn't cheap at the pharmacy, I found it significantly cheaper on iHerb. This supplement has helped her manage symptoms like weakness in her legs, which sometimes don’t cooperate. It also seems to reduce blood glucose levels, which may require an adjustment in her diabetes medication.
7.5
Highly recommended
Mumtaz is very important for treating peripheral neuropathy and diabetes. The quality is excellent, and I would recommend it.
9
Great supplement
A great supplement for me; it helps with my neuropathy. The effects didn’t take long to manifest.
7.5
Positive effects confirmed
My experience with alpha-lipoic acid has been positive. It effectively alleviates issues related to nerve conduction disorders (polyneuropathy) and also benefits the liver. I learned that combining it with vitamin B1 may enhance its effects, which I plan to try next.
8
We investigated the potential benefits of alpha-lipoic acid (ALA) for patients with type 2 diabetes mellitus (T2DM) suffering from neuropathy. Over six months, we treated 54 patients with a daily dose of 600 mg of ALA while keeping their current oral medications unchanged. We also included a control group of 24 matched individuals who did not experience neuropathy.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
7
Alpha-lipoic acid shows promise
The study focused on examining the effects of alpha-lipoic acid specifically on diabetic peripheral neuropathy, an often painful condition affecting many people with diabetes. We explored how this supplement could potentially ease symptoms and improve overall nerve health.
The research was designed meticulously to isolate the impacts of alpha-lipoic acid, with proper control measures in place. As we delved into the results, we found promising signs that this antioxidant might provide relief from neuropathy symptoms.
Participants in the study reported improvements in pain levels and other sensations associated with nerve damage, suggesting that alpha-lipoic acid has beneficial effects. However, while the benefits were noted, more extensive studies are needed to fully understand the long-term impact and effectiveness of this treatment.
Overall, adding alpha-lipoic acid to treatment routines for diabetic neuropathy could be a worthwhile consideration. It presents a potential opportunity for those seeking relief from this challenging condition.
The research was designed meticulously to isolate the impacts of alpha-lipoic acid, with proper control measures in place. As we delved into the results, we found promising signs that this antioxidant might provide relief from neuropathy symptoms.
Participants in the study reported improvements in pain levels and other sensations associated with nerve damage, suggesting that alpha-lipoic acid has beneficial effects. However, while the benefits were noted, more extensive studies are needed to fully understand the long-term impact and effectiveness of this treatment.
Overall, adding alpha-lipoic acid to treatment routines for diabetic neuropathy could be a worthwhile consideration. It presents a potential opportunity for those seeking relief from this challenging condition.
References
- Csiha S, Hernyák M, Molnár Á, Lőrincz H, Katkó M, et al. Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy. Biomedicines. 2025;13. doi:10.3390/biomedicines13020438
- Abuali SM, Frasca DJ. Alpha-Lipoic Acid for Diabetic Peripheral Neuropathy. Am Fam Physician. 2025;111:119.
- Walimbe AS, Waskow E, Mackay L, Miller M, Gijavanekar C, et al. Expanded Clinical Phenotype and the Role of Untargeted Metabolomics Analysis in Confirming the Diagnosis of Sodium-Dependent Multivitamin Transporter Deficiency. Am J Med Genet A. 2025. doi:10.1002/ajmg.a.64014
- Hernyák M, Tóth LI, Csiha S, Molnár Á, Lőrincz H, et al. Kallistatin as a Potential Marker of Therapeutic Response During Alpha-Lipoic Acid Treatment in Diabetic Patients with Sensorimotor Polyneuropathy. Int J Mol Sci. 2024;25. doi:10.3390/ijms252413276
- Pingali U, Sravanasandya P, Mekala P, Yareeda S, Sireesha K, et al. A randomized, double-blind, placebo controlled study to evaluate the effect of alpha-lipoic acid on inhibition of ADP-and collagen-induced platelet aggregation ex vivo in diabetic neuropathy patients on gabapentin or pregabalin. J Postgrad Med. 2024;70:191. doi:10.4103/jpgm.jpgm_310_24
- Wang Q, Xie H, Wang Z, Huang R, Xu M, et al. Comparative efficacy and safety of Chinese patent medicines as an adjunctive therapy for diabetic peripheral neuropathy: systematic review and network meta-analysis of randomized controlled trials. Pharm Biol. 2024;62:833. doi:10.1080/13880209.2024.2422084
- Pingali U, Kammila S, Mekala P, Yareeda S, Penugonda S. A Study to Evaluate the Effect of Alpha-Lipoic Acid on Neuropathic Symptoms in Diabetic Neuropathy Patients on Gabapentin or Pregabalin. Cureus. 2024;16:e70299. doi:10.7759/cureus.70299
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. doi:10.3390/nu16183045
- Aldendail CF, Chen P, Dibble HS, Baute Penry V. A Comprehensive Review of Safety, Efficacy, and Indications for the Use of Alpha-Lipoic Acid and Acetyl-L-Carnitine in Neuropathic Pain. Integr Med (Encinitas). 2024;23:32.
- Riley LG, Sabui S, Said HM, Niaz A, Girisha KM, et al. Genome sequencing enables diagnosis and treatment of SLC5A6 neuropathy. Eur J Hum Genet. 2024;32:947. doi:10.1038/s41431-024-01641-8
- Ran GL, Li YP, Lu LC, Lan SH. Disease-modifying therapies for diabetic peripheral neuropathy: A systematic review and meta-analysis of randomized controlled trials. J Diabetes Complications. 2024;38:108691. doi:10.1016/j.jdiacomp.2024.108691
- Prado MB, Adiao KJB. Ranking Alpha Lipoic Acid and Gamma Linolenic Acid in Terms of Efficacy and Safety in the Management of Adults With Diabetic Peripheral Neuropathy: A Systematic Review and Network Meta-analysis. Can J Diabetes. 2024;48:233. doi:10.1016/j.jcjd.2024.01.007
- Lee DW, Park HC, Kim DH. Protective effect of alpha-lipoic acid and epalrestat on oxaliplatin-induced peripheral neuropathy in zebrafish. Muscle Nerve. 2024;69:498. doi:10.1002/mus.28047
- Ziegler D. Pathogenetic treatments for diabetic peripheral neuropathy. Diabetes Res Clin Pract. 2023;206 Suppl 1:110764. doi:10.1016/j.diabres.2023.110764
- Baicus C, Purcarea A, von Elm E, Delcea C, Furtunescu FL. Alpha-lipoic acid for diabetic peripheral neuropathy. Cochrane Database Syst Rev. 2024;1:CD012967. doi:10.1002/14651858.CD012967.pub2
- Li Y, Jia Y. Effect of miR-146a polymorphism on lipoic acid therapy in patients with T2DM peripheral polyneuropthy. Cell Mol Biol (Noisy-le-grand). 2023;69:38. doi:10.14715/cmb/2023.69.12.7
