Fiber
10
Burning feet relieved
Most Useful Review
THE ONLY PRODUCT FOR ME!!! LITERALLY SAVED MY LIFE. I cannot speak for others, only for myself. When you suffer from diabetic neuropathy and your feet burn, taking Jarrow Formula Methyl B-12 (5000 mcg) stops the burning! It works wonders. No buzzing or pins and needles, and I keep my stress down while controlling my sugar. I once bought a cheaper brand with folic acid and Vitamin C, but that was a BIG MISTAKE – my feet started burning again. I returned to the lovely Jarrow Methyl B-12 5000, and it was the best decision ever. Thanks, Jarrow!
10
Pain-free living
Most Useful Review
Methyl B-12 has been a lifesaver for my severe diabetic neuropathy. After 2 1/2 years of suffering, I’m now virtually pain-free. I can walk without a limp and have the energy to exercise, which will help me long-term. Feeling helpless for so long, I finally feel as if I have my life back. Though it may sound exaggerated, I assure you it’s the truth. People around me are amazed at the transformation.
Vitamin Bs
9.5
Improved foot pain
Most Useful Review
Now Foods, B-100mg, 100 tablets: For a week, I took the Now Foods 100mg B1 tablets, starting with 50 mg daily, now reduced to 25 mg per day for ankle edema and peripheral neuropathy due to thiamine deficiency. Correcting this deficiency orally takes time; however, my edema and foot pain are significantly better. I'll continue using them long-term to prevent recurrence. I've generally been pleased with Now Food products, and this one is no exception.
9.5
Effective nerve relief
Most Useful Review
The quality of this product is outstanding, featuring effective ingredients. It's potent for the nervous system, providing substantial relief from numbness in the hands and effectively addressing neuropathy associated with diabetes. The taste is excellent, and the quantity is adequate for long-term use.
Acetyl L Carnitine
9.5
Improved sensation
Most Useful Review
Great product! My acupuncturist suggested 1500 mg per day for neuropathy in my feet and legs. On the first day, I immediately felt sensation in my feet that I hadn’t experienced for a long time. I also have more energy and can walk further now. I will continue using this form of ALC alongside Alpha Lipoic Acid and other supplements.
8.8
Major support
Most Useful Review
Excellent! Five years ago, Acetyl-L-Carnitine was recommended for my Crohn's disease and it has tremendously helped in managing bowel symptoms. After initially trying it for 30 days, I noticed a difference when I ran out within four days. Now, I keep an extra bottle on hand. It also helps alleviate the neuropathy pain in my left foot.
B12
4
Vitamin B12's limited neuropathy effects
Association of co-existing vitamin B6 and B12 deficiency with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome: a case report.
Most Relevant Research
We explored the impact of vitamin B12 on neuropathy in the context of a unique case presenting with symptoms resembling POEMS syndrome. The patient, a man in his 40s, initially showed signs such as fatigue, imbalance, and painful numbness, which led to a diagnosis focused on vitamin B12 deficiency after initial evaluations.
After a month of treatment, his vitamin B12 levels improved, but unfortunately, there wasn't any significant relief in his neuropathic symptoms. Further investigation revealed he also had a deficiency in vitamin B6, as well as an IgA lambda monoclonal spike, which ultimately contributed to a diagnosis of POEMS syndrome.
This case highlights a vital consideration: while vitamin B12 treatment is essential, it may not always lead to expected improvements in neuropathy symptoms, especially in complex cases involving multiple deficiencies or syndromes like POEMS. Our findings emphasize the importance of a thorough evaluation and management for symptoms that mimic neuropathy, indicating that simply supplementing B12 might not suffice alone.
After a month of treatment, his vitamin B12 levels improved, but unfortunately, there wasn't any significant relief in his neuropathic symptoms. Further investigation revealed he also had a deficiency in vitamin B6, as well as an IgA lambda monoclonal spike, which ultimately contributed to a diagnosis of POEMS syndrome.
This case highlights a vital consideration: while vitamin B12 treatment is essential, it may not always lead to expected improvements in neuropathy symptoms, especially in complex cases involving multiple deficiencies or syndromes like POEMS. Our findings emphasize the importance of a thorough evaluation and management for symptoms that mimic neuropathy, indicating that simply supplementing B12 might not suffice alone.
10
Burning feet relieved
Most Useful Review
THE ONLY PRODUCT FOR ME!!! LITERALLY SAVED MY LIFE. I cannot speak for others, only for myself. When you suffer from diabetic neuropathy and your feet burn, taking Jarrow Formula Methyl B-12 (5000 mcg) stops the burning! It works wonders. No buzzing or pins and needles, and I keep my stress down while controlling my sugar. I once bought a cheaper brand with folic acid and Vitamin C, but that was a BIG MISTAKE – my feet started burning again. I returned to the lovely Jarrow Methyl B-12 5000, and it was the best decision ever. Thanks, Jarrow!
Multivitamins
9.5
Nerve support
Most Useful Review
I am very impressed with B-50. I've noticed significant support for my nervous system, especially an improvement in the neuropathy in my feet. The quality from NOW is exceptional, and I felt the effects of B-50 entering my system quickly.
9.5
Effective combination
Most Useful Review
This particular combination of B vitamins is excellent for neuropathy. European brands offer similar combos for triple the price, specifically aimed at nerve regeneration and pain relief. I will buy again.
Inositol
9.5
Neuropathy improved
Most Useful Review
I have managed to stop taking prescription Neurontin for foot neuropathy by taking this along with Vitamins B6 and B12. It has proven to be more effective without side effects.
9.5
Improved memory noted
Most Useful Review
I have been using Choline and Inositol for several years now and am very satisfied! During the initial days of taking it, I often experience headaches. However, I have noticed a real improvement in memory after starting this combination. Choline is essential for the neurotransmitter acetylcholine, facilitating signal transmission between neurons and muscles. It's also a primary component of the myelin sheath that protects nerves. I take this consistently with Menopause Support, which helps reduce anxiety during menopause. After about ten days, I clearly observe an improvement.
Alpha Lipoic Acid
8
Alpha-lipoic acid reduces AGEs
Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy.
Most Relevant Research
We investigated the potential benefits of alpha-lipoic acid (ALA) for patients with type 2 diabetes mellitus (T2DM) suffering from neuropathy. Over six months, we treated 54 patients with a daily dose of 600 mg of ALA while keeping their current oral medications unchanged. We also included a control group of 24 matched individuals who did not experience neuropathy.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
9.5
Good dosage
Most Useful Review
I bought this for my wife, and it helps her significantly with polyneuropathy. The dosage is commendable, and it works well.
Benfotiamine
7
Thiamine aids in CMT neuropathy
Pharmacological Doses of Thiamine Benefit Patients with the Charcot-Marie-Tooth Neuropathy by Changing Thiamine Diphosphate Levels and Affecting Regulation of Thiamine-Dependent Enzymes.
Most Relevant Research
We investigated the impact of daily thiamine (vitamin B1) supplementation on individuals with Charcot-Marie-Tooth (CMT) neuropathy. Our pilot study observed improvements in hand grip strength among patients taking 100 mg of thiamine. Additionally, we explored molecular changes related to thiamine coenzyme levels, noting differences in enzyme regulation between CMT patients and healthy controls.
While we found promising benefits for thiamine, including increased grip strength, we also noted unusual decreases in an enzyme related to thiamine, indicating that the effects can vary widely among patients.
While we found promising benefits for thiamine, including increased grip strength, we also noted unusual decreases in an enzyme related to thiamine, indicating that the effects can vary widely among patients.
9.5
Neuropathy relief
Most Useful Review
This is a miracle supplement! After years of battling with neuropathy, it became increasingly difficult to stand. I also suffered from restless leg syndrome that disrupted my sleep. After switching from Gabapentin to this supplement, my symptoms have decreased significantly to almost 98% gone; I only experience slight numbness now, which I can manage.