Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8
USERS' SCORE
Moderately Good
Based on 35 Reviews
7.2
Supplement Facts
Serving Size: 5 Drops
Amount Per Serving
%DV
Vitamin D (as cholecalciferol)
10 mcg (400 IU)
100%
L.reuteriDSM 17938(L. reuteriProtectis®)
100 million CFU
†
Top Medical Research Studies
9.5
We conducted a randomized, controlled trial in a pediatric emergency department to evaluate how effective Lactobacillus reuteri DSM 17938 is for treating acute gastroenteritis in young children. Our findings revealed that the probiotic significantly reduced the duration and frequency of diarrhea compared to a placebo.
Specifically, children given L. reuteri experienced less watery diarrhea and shorter episodes than those receiving no treatment. This safe and easy-to-administer supplement could be a valuable addition to standard care, especially in reducing complications from gastroenteritis.
Specifically, children given L. reuteri experienced less watery diarrhea and shorter episodes than those receiving no treatment. This safe and easy-to-administer supplement could be a valuable addition to standard care, especially in reducing complications from gastroenteritis.
Read More
8
We explored the effects of equine-derived Lactobacillus reuteri on diarrhea caused by E. coli. Our study highlighted that this probiotic could ease symptoms by improving gut microbiota balance and reinforcing the intestinal barrier.
We found that Lactobacillus reuteri supplementation not only curbed E. coli-induced diarrhea but also helped restore key tight junction proteins and adjusted levels of inflammatory markers. Additionally, it was effective in rebuilding beneficial gut bacteria that E. coli had diminished.
Overall, these findings point to the potential of Lactobacillus reuteri as a viable treatment option for diarrhea, with promising applications in probiotic product development.
We found that Lactobacillus reuteri supplementation not only curbed E. coli-induced diarrhea but also helped restore key tight junction proteins and adjusted levels of inflammatory markers. Additionally, it was effective in rebuilding beneficial gut bacteria that E. coli had diminished.
Overall, these findings point to the potential of Lactobacillus reuteri as a viable treatment option for diarrhea, with promising applications in probiotic product development.
Read More
8
We explored the impact of Lactobacillus reuteri on diarrhea caused by bile acid metabolism disorders. By comparing healthy and affected piglets, we found that the treatment reduces the harmful compound CDCA-3β-glucuronide. This is achieved through the activation of certain pathways, including FXR-SIRT1-LKB1, which alleviates diarrhea and protects gut cells from apoptosis.
Overall, these results suggest that Lactobacillus reuteri could play a significant role in managing diarrhea related to bile acid disorders.
Overall, these results suggest that Lactobacillus reuteri could play a significant role in managing diarrhea related to bile acid disorders.
Read More
Most Useful Reviews
9
Magic for tummy troubles
10 people found this helpful
I find this product incredibly useful for my children who suffer from stomach ache, diarrhoea, or constipation—it truly works like magic.
Read More
0
Disastrous experience
9 people found this helpful
Gave it to my twins: NIGHTMARE. I regret trying this product on my newborn twins. After just two drops, chaos ensued—both babies screamed in painful reactions followed by episodes of very severe dark green diarrhoea. I immediately discontinued use due to the overwhelming distress and horrific smell. Thankfully, they improved shortly after stopping the probiotics.
Read More
9
Life-changing experience
7 people found this helpful
Worth every penny! I rarely write reviews, but this changed my life! As a mother of five, finding the right formula has been challenging. My baby experienced severe gas and fussiness, especially during bouts of diarrhea. After using these specific probiotics, they have helped with fussy behaviour tremendously. Although it takes weeks to see results, it’s so worth it!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8
- All Researches
9.5
We conducted a randomized, controlled trial in a pediatric emergency department to evaluate how effective Lactobacillus reuteri DSM 17938 is for treating acute gastroenteritis in young children. Our findings revealed that the probiotic significantly reduced the duration and frequency of diarrhea compared to a placebo.
Specifically, children given L. reuteri experienced less watery diarrhea and shorter episodes than those receiving no treatment. This safe and easy-to-administer supplement could be a valuable addition to standard care, especially in reducing complications from gastroenteritis.
Specifically, children given L. reuteri experienced less watery diarrhea and shorter episodes than those receiving no treatment. This safe and easy-to-administer supplement could be a valuable addition to standard care, especially in reducing complications from gastroenteritis.
Read More
9
In our exploration of the effects of Qiwenghuangbo powder (QP) on weaned piglets, we found that a diet enriched with QP improved intestinal health and reduced diarrhea.
We noted that this improvement was linked to the enhanced growth and colonization of Limosilactobacillus reuteri, a beneficial bacteria.
Specifically, two strains of L. reuteri showed promise in alleviating inflammation and controlling harmful gut pathogens, confirming QP's potential for promoting gut health in young animals.
We noted that this improvement was linked to the enhanced growth and colonization of Limosilactobacillus reuteri, a beneficial bacteria.
Specifically, two strains of L. reuteri showed promise in alleviating inflammation and controlling harmful gut pathogens, confirming QP's potential for promoting gut health in young animals.
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9
Probiotics reduce VAP and diarrhea
We conducted a randomized, double-blind clinical trial to explore the role of probiotics in preventing ventilator-associated pneumonia (VAP) and diarrhea in children on mechanical ventilation. Our study included 72 children, divided into those receiving Limosilactobacillus reuteri probiotics and a placebo.
We found that probiotics significantly reduced the risk of VAP and diarrhea compared to the placebo. This indicates that probiotics could be an effective strategy for improving health outcomes in vulnerable pediatric patients.
We found that probiotics significantly reduced the risk of VAP and diarrhea compared to the placebo. This indicates that probiotics could be an effective strategy for improving health outcomes in vulnerable pediatric patients.
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8
We observed that rotavirus infection predominantly affects mature intestinal cells, leading to severe digestive issues, including diarrhea. This research delved into how 1α,25-hydroxyvitamin D (commonly known as vitamin D) might be influential in mitigating these detrimental effects. Various experiments were conducted with IPEC-J2 cells to analyze the impact of rotavirus on cell death and inflammation.
Our findings revealed that rotavirus not only led to cell death but also induced a specific form of cell death called ferroptosis. This situation was characterized by increased reactive oxygen species and decreased mitochondrial activity, factors that can worsen inflammation and damage gut cells. Interestingly, treatment with vitamin D significantly reduced these harmful effects. It appeared to operate through a specific pathway involving key proteins that protect cells from oxidative stress.
In summary, our study suggests that vitamin D has a protective role and inhibits rotavirus-induced cell damage and ferroptosis. By regulating certain cellular pathways, vitamin D may alleviate the intestinal distress caused by rotavirus, offering a potential therapeutic avenue against diarrhea linked to this virus. Overall, this research supports the consideration of vitamin D as a beneficial treatment in managing rotavirus infections and their associated symptoms.
Our findings revealed that rotavirus not only led to cell death but also induced a specific form of cell death called ferroptosis. This situation was characterized by increased reactive oxygen species and decreased mitochondrial activity, factors that can worsen inflammation and damage gut cells. Interestingly, treatment with vitamin D significantly reduced these harmful effects. It appeared to operate through a specific pathway involving key proteins that protect cells from oxidative stress.
In summary, our study suggests that vitamin D has a protective role and inhibits rotavirus-induced cell damage and ferroptosis. By regulating certain cellular pathways, vitamin D may alleviate the intestinal distress caused by rotavirus, offering a potential therapeutic avenue against diarrhea linked to this virus. Overall, this research supports the consideration of vitamin D as a beneficial treatment in managing rotavirus infections and their associated symptoms.
Read More
8
We explored the impact of Lactobacillus reuteri on diarrhea caused by bile acid metabolism disorders. By comparing healthy and affected piglets, we found that the treatment reduces the harmful compound CDCA-3β-glucuronide. This is achieved through the activation of certain pathways, including FXR-SIRT1-LKB1, which alleviates diarrhea and protects gut cells from apoptosis.
Overall, these results suggest that Lactobacillus reuteri could play a significant role in managing diarrhea related to bile acid disorders.
Overall, these results suggest that Lactobacillus reuteri could play a significant role in managing diarrhea related to bile acid disorders.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 35 Reviews
7.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Magic for tummy troubles
10 people found this helpful
I find this product incredibly useful for my children who suffer from stomach ache, diarrhoea, or constipation—it truly works like magic.
Read More
0
Disastrous experience
9 people found this helpful
Gave it to my twins: NIGHTMARE. I regret trying this product on my newborn twins. After just two drops, chaos ensued—both babies screamed in painful reactions followed by episodes of very severe dark green diarrhoea. I immediately discontinued use due to the overwhelming distress and horrific smell. Thankfully, they improved shortly after stopping the probiotics.
Read More
9
Life-changing experience
7 people found this helpful
Worth every penny! I rarely write reviews, but this changed my life! As a mother of five, finding the right formula has been challenging. My baby experienced severe gas and fussiness, especially during bouts of diarrhea. After using these specific probiotics, they have helped with fussy behaviour tremendously. Although it takes weeks to see results, it’s so worth it!
Read More
9
Lactose allergy solution
3 people found this helpful
The quality is excellent. I used it for my infant son, who has a lactose allergy and had diarrhoea and constant gas. This product has helped him significantly.
Read More
9
Improved digestion
3 people found this helpful
This great tool has corrected my child's digestion. Even with severe diarrhoea from teething, it has proved effective; I add it to his food without any taste or smell.
Read More
Frequently Asked Questions
7.5
Improved stool quality
15 people found this helpful
Very good! After just five days, my son's stool has improved significantly; he previously had constipation and occasional diarrhea. Thankfully, this product has made a positive difference.
7.5
Diarrhea relief
3 people found this helpful
This product has been a super tool for my child. Since giving her Biogay from the first month, we avoided colic. Additionally, it helped with diarrhoea caused by teething, showing improvement within a week.
0
Exacerbated condition
Alas, these drops not only did not help us, but also worsened the situation. My 2-month-old developed increased flatulence and diarrhoea.
9
Resolved diarrhoea
After using this, my daughter's diarrhoea issue was solved.
9
Stool improvement noticed
My child struggled with diarrhoea daily, likely due to being born via caesarean section, which may have led to lower probiotics. This liquid product made it easy to administer and after about a week, her stools started to form properly. I am hopeful the probiotics will establish in her gut.
9
Magic for tummy troubles
10 people found this helpful
I find this product incredibly useful for my children who suffer from stomach ache, diarrhoea, or constipation—it truly works like magic.
10
Colic and gas relief
Excellent for colic, diarrhoea, and gas relief. I keep reordering due to its effectiveness and reasonable price.
9
Lactose allergy solution
3 people found this helpful
The quality is excellent. I used it for my infant son, who has a lactose allergy and had diarrhoea and constant gas. This product has helped him significantly.
9
Improved digestion
3 people found this helpful
This great tool has corrected my child's digestion. Even with severe diarrhoea from teething, it has proved effective; I add it to his food without any taste or smell.
9
Effective booster
Excellent immune system booster, beneficial for diarrhoea and the digestive system, and helpful for gas. I recommend this.
0
Increased flatulence
1 people found this helpful
My 2-month-old daughter was crying due to gas in her abdomen. I tried reducing the dose from 5 drops to 3, but I think it made the flatulence worse. Additionally, my stool became somewhat loose and I experienced diarrhoea.
0
Ineffective treatment
I gave this to my baby, but it didn’t work; she had severe diarrhoea afterward.
9.5
We conducted a randomized, controlled trial in a pediatric emergency department to evaluate how effective Lactobacillus reuteri DSM 17938 is for treating acute gastroenteritis in young children. Our findings revealed that the probiotic significantly reduced the duration and frequency of diarrhea compared to a placebo.
Specifically, children given L. reuteri experienced less watery diarrhea and shorter episodes than those receiving no treatment. This safe and easy-to-administer supplement could be a valuable addition to standard care, especially in reducing complications from gastroenteritis.
Specifically, children given L. reuteri experienced less watery diarrhea and shorter episodes than those receiving no treatment. This safe and easy-to-administer supplement could be a valuable addition to standard care, especially in reducing complications from gastroenteritis.
8
We explored the impact of Lactobacillus reuteri on diarrhea caused by bile acid metabolism disorders. By comparing healthy and affected piglets, we found that the treatment reduces the harmful compound CDCA-3β-glucuronide. This is achieved through the activation of certain pathways, including FXR-SIRT1-LKB1, which alleviates diarrhea and protects gut cells from apoptosis.
Overall, these results suggest that Lactobacillus reuteri could play a significant role in managing diarrhea related to bile acid disorders.
Overall, these results suggest that Lactobacillus reuteri could play a significant role in managing diarrhea related to bile acid disorders.
8
We explored how adding Lactobacillus reuteri to treatment plans helps children suffering from diarrhea. After analyzing data from nine randomized controlled trials involving 963 participants, we found significant reductions in the number of diarrhea cases within the first few days of treatment.
While the probiotic improved symptoms and reduced the duration of diarrhea, it did not show effectiveness in preventing diarrheal diseases, such as those caused by rotavirus or following antibiotic use. The focus remains on enhancing probiotics for better outcomes.
While the probiotic improved symptoms and reduced the duration of diarrhea, it did not show effectiveness in preventing diarrheal diseases, such as those caused by rotavirus or following antibiotic use. The focus remains on enhancing probiotics for better outcomes.
8
Lactobacillus aids H. pylori treatment
We explored how Lactobacillus probiotics can assist in treating Helicobacter pylori infections. Our analysis involved 26 studies, which showed that adding Lactobacillus spp. to standard therapy significantly improved H. pylori eradication rates.
Notably, Lactobacillus also reduced gastrointestinal side effects like diarrhea and nausea. We found that L. reuteri was particularly effective, suggesting it could be a valuable addition to treatment regimens. This approach shows promise for enhancing recovery from H. pylori infections.
Notably, Lactobacillus also reduced gastrointestinal side effects like diarrhea and nausea. We found that L. reuteri was particularly effective, suggesting it could be a valuable addition to treatment regimens. This approach shows promise for enhancing recovery from H. pylori infections.
8
L. reuteri enhances piglet gut health
We explored the effects of Lactobacillus reuteri on piglets' fecal microbiota development. Through both maternal supplementation and direct oral administration, we found that L. reuteri positively influenced microbial diversity and maturation.
Notably, piglets that received this treatment showed enhanced resistance to diarrhea and improved growth. The changes in microbiota composition and metabolite profiles were evident from birth to weaning, indicating a significant role of L. reuteri in promoting gut health.
Overall, our findings suggest that incorporating L. reuteri in early piglet diets can support their overall health and development.
Notably, piglets that received this treatment showed enhanced resistance to diarrhea and improved growth. The changes in microbiota composition and metabolite profiles were evident from birth to weaning, indicating a significant role of L. reuteri in promoting gut health.
Overall, our findings suggest that incorporating L. reuteri in early piglet diets can support their overall health and development.
References
- Zhao Y, Zhu X, Lan Q, Wei Z, Shang P, et al. 1α,25-hydroxyvitamin D alleviated rotavirus infection induced ferroptosis in IPEC-J2 cells by regulating the ATF3-SLC7A11-GPX4 axis. Int J Biol Macromol. 2024;283:137484. doi:10.1016/j.ijbiomac.2024.137484
- Xu Q, Xue L, Wu Z, Kang S, Li J, et al. Dietary Qiwenghuangbo powder-enriched Limosilactobacillus reuteri protects the intestinal epithelium and alleviates inflammation via a strain-specific mechanism. Animal Model Exp Med. 2025. doi:10.1002/ame2.70016
- Iramain R, Jara A, Ortiz J, Cardozo L, Morinigo R. Lactobacillus reuteri protectis DSM 17938 at high doses versus placebo in children with acute gastroenteritis in a Pediatric Emergency Department. J Pediatr Gastroenterol Nutr. 2025. doi:10.1002/jpn3.70026
- Lin Z, Feng Y, Wang J, Men Z, Ma X. Microbiota governs host chenodeoxycholic acid glucuronidation to ameliorate bile acid disorder induced diarrhea. Microbiome. 2025;13:36. doi:10.1186/s40168-024-02011-8
- Xu X, Zhang H, Meng K, Cai H, Liu W, et al. ZY15 Alleviates Intestinal Inflammation and Barrier Dysfunction via AKT/mTOR/HIF-1α/RORγt/IL-17 Signaling and the Gut Microbiota in ETEC K88-Challenged . Antioxidants (Basel). 2025;14. doi:10.3390/antiox14010058
- Mishra V, Dash D, Panda AK, Pathak SK. Efficacy of Lactobacillus spp. Supplementation in Helicobacter pylori Eradication: A Systematic Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis. Helicobacter. 2024;29:e70006. doi:10.1111/hel.70006
- König J, Roca Rubio MF, Forsgård RA, Rode J, Axelsson J, et al. The effects of a 6-week intervention with Limosilactobacillus reuteri ATCC PTA 6475 alone and in combination with L. reuteri DSM 17938 on gut barrier function, immune markers, and symptoms in patients with IBS-D-An exploratory RCT. PLoS One. 2024;19:e0312464. doi:10.1371/journal.pone.0312464
- Tyrsin OY, Tyrsin DY, Nemenov DG, Ruzov AS, Odintsova VE, et al. Effect of Lactobacillus reuteri NCIMB 30351 drops on symptoms of infantile functional gastrointestinal disorders and gut microbiota in early infants: Results from a randomized, placebo-controlled clinical trial. Eur J Pediatr. 2024;183:2311. doi:10.1007/s00431-024-05473-y
- Wang D, Zeng J, Wujin C, Ullah Q, Su Z. Lactobacillus reuteri derived from horse alleviates Escherichia coli-induced diarrhea by modulating gut microbiota. Microb Pathog. 2024;188:106541. doi:10.1016/j.micpath.2024.106541
- Schwaiger K, Storch J, Bauer C, Bauer J. () : a probiotic candidate to reduce neonatal diarrhea in calves. Front Microbiol. 2023;14:1266905. doi:10.3389/fmicb.2023.1266905
- Lu X, Zhang M, Ma Y, Li G, Zhao X, et al. Protective effect of Limosilactobacillus reuteri-fermented yogurt on mouse intestinal barrier injury induced by enterotoxigenic Escherichia coli. J Sci Food Agric. 2023;103:7494. doi:10.1002/jsfa.12836
- Sun X, Kong J, Zhu S, Liu C. A systematic review and meta-analysis: the therapeutic and preventive effect of Lactobacillus reuteri DSM 17,938 addition in children with diarrhea. BMC Gastroenterol. 2023;23:141. doi:10.1186/s12876-023-02778-4
- Kambale RM, Ntagazibwa JN, Kasengi JB, Zigashane AB, Francisca IN, et al. Probiotics for children with uncomplicated severe acute malnutrition (PruSAM study): A randomized controlled trial in the Democratic Republic of Congo. Am J Clin Nutr. 2023;117:976. doi:10.1016/j.ajcnut.2023.01.019
- Wang G, Wang X, Ma Y, Cai S, Yang L, et al. Lactobacillus reuteri improves the development and maturation of fecal microbiota in piglets through mother-to-infant microbe and metabolite vertical transmission. Microbiome. 2022;10:211. doi:10.1186/s40168-022-01336-6
- Roshanzamiri S, Alemzadeh M, Ahmadizadeh SN, Behzad A, Hashemi SM, et al. Probiotic prophylaxis to prevent ventilator-associated pneumonia in children on mechanical ventilation: A randomized double-blind clinical trial. Front Pediatr. 2022;10:1045941. doi:10.3389/fped.2022.1045941
