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Top Medical Research Studies
Infants taking Lactobacillus reuteri showed significantly reduced episodes of regurgitation and faster gastric emptying. This probiotic appears to ease discomfort related to reflux, offering parents a potential solution to this common issue.
In our trial, involving 589 infants across nine neonatal units in Italy, we compared the effects of the probiotic to a placebo. Parents kept detailed logs of various health issues, including regurgitation and crying episodes.
The results showed that using Lactobacillus reuteri reduced these gastrointestinal problems and the associated socioeconomic burden. It’s promising news for parents facing these challenges!
Results showed fewer reflux episodes in the group taking probiotics, along with quicker feeding tolerance and improved growth markers. However, no significant differences were observed in infection rates. Overall, Lactobacillus reuteri appears beneficial for feeding tolerance and growth in preterm infants.
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Infants taking Lactobacillus reuteri showed significantly reduced episodes of regurgitation and faster gastric emptying. This probiotic appears to ease discomfort related to reflux, offering parents a potential solution to this common issue.
Results showed fewer reflux episodes in the group taking probiotics, along with quicker feeding tolerance and improved growth markers. However, no significant differences were observed in infection rates. Overall, Lactobacillus reuteri appears beneficial for feeding tolerance and growth in preterm infants.
In a well-structured randomized controlled trial, infants took a test formula for four weeks, allowing us to measure changes in their gastric emptying rate and regurgitation frequency.
The results were promising: infants on the test formula experienced a significant decrease in daily regurgitations compared to the control group, highlighting the potential benefits of this formulation for managing reflux in infants.
In our trial, involving 589 infants across nine neonatal units in Italy, we compared the effects of the probiotic to a placebo. Parents kept detailed logs of various health issues, including regurgitation and crying episodes.
The results showed that using Lactobacillus reuteri reduced these gastrointestinal problems and the associated socioeconomic burden. It’s promising news for parents facing these challenges!
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
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Frequently Asked Questions
Reflux, medically known as gastroesophageal reflux disease (GERD), occurs when stomach acid flows back into the esophagus, the tube that connects the throat to the stomach. This backflow can lead to symptoms such as heartburn, regurgitation, and difficulty swallowing. Reflux can affect people of all ages and may be triggered or worsened by factors such as diet, obesity, smoking, and certain medications. While occasional reflux is common and often manageable with lifestyle changes, chronic reflux can lead to more serious complications if not properly treated.
Managing reflux typically involves a combination of lifestyle modifications—such as avoiding trigger foods, eating smaller meals, and maintaining a healthy weight—and, in some cases, medication to reduce stomach acid production. In more severe cases, surgical options may be considered. If you suspect you have reflux or experience frequent symptoms, it’s advisable to consult a healthcare professional for an accurate diagnosis and personalized treatment plan.
Children's probiotics are dietary supplements specifically formulated to provide beneficial bacteria that support digestive health and the immune system in children. These probiotics contain various strains of live microorganisms, often including Lactobacillus and Bifidobacterium, which are known to help maintain a healthy balance of gut bacteria. The gut microbiome plays a crucial role in children's overall health, influencing their digestion, immune function, and even mood. Many parents turn to children's probiotics to help address issues like constipation, diarrhea, or colic, as well as to support their child’s immunity, especially during cold and flu season.
When selecting a children's probiotic, it’s essential to consider factors such as the specific strains included, the number of colony-forming units (CFUs), and whether it is tailored to your child's specific health needs. Probiotics can come in various forms, including powders, gummies, and liquids, making them easy to administer to little ones. However, it’s always advisable to consult a pediatrician before starting any new supplement regime for your child, as they can provide personalized recommendations based on the child's health history and current needs.
When it comes to relieving symptoms of reflux in children, probiotics may offer some benefits, although research is still ongoing. Probiotics are live bacteria and yeasts that are beneficial for digestive health and have been shown to help balance gut flora, which could potentially influence reflux symptoms. Some studies suggest that certain strains of probiotics may help reduce the severity of reflux or alleviate associated symptoms, such as discomfort and bloating. However, it’s crucial to consult with a pediatrician before introducing probiotics, especially in infants and young children, as their digestive systems are still developing.
It's important to note that while probiotics can play a supporting role in digestive health, they should not be seen as a standalone treatment for reflux. Lifestyle and dietary changes often have a more significant impact on managing this condition. Parents may also need to observe their child's eating habits and consider avoiding certain trigger foods that can exacerbate reflux symptoms. Overall, while there is promise in the use of probiotics for gastrointestinal issues in children, including reflux, further research is needed to fully understand their effectiveness and appropriate use.
Based on user reviews, it appears that results from using the supplement for reflux can vary, but many parents report noticeable improvements within a few days to a week. For instance, one parent mentioned seeing significant changes after just four days of use (Read Review). Other users have also described swift changes, with one stating that symptoms improved greatly after starting the drops (Read Review), while another indicated that reintroducing the product quickly alleviated their child's worsening symptoms (Read Review).
Overall, while individual experiences may vary, it's clear from the reviews that many parents find that within a week of administration, their child’s reflux symptoms significantly improve, making this product an appealing option for those looking for respite from reflux issues.
The evidence suggests that certain supplements, particularly probiotics like Lactobacillus reuteri, have significant support from scientific research for managing reflux, especially in infants. Studies have consistently demonstrated that L. reuteri can reduce the frequency of regurgitation and improve gastrointestinal function in infants suffering from reflux. For example, a controlled study involving 90 infants found that those treated with L. reuteri experienced fewer regurgitation episodes and improved overall gut health compared to a placebo group [2]. Additionally, another study confirmed similar benefits, indicating that L. reuteri could significantly alleviate symptoms associated with gastroesophageal reflux in infants [8].
On the other hand, the research surrounding other supplements, like Vitamin D3, shows mixed results. While it may help to reduce inflammation from reflux esophagitis to some extent, it does not effectively address the physical damage associated with chronic reflux conditions [1]. Therefore, while Lactobacillus reuteri is strongly supported for helping with reflux symptoms, Vitamin D3 appears to have limited effectiveness in treating the underlying issues related to reflux.
Based on user reviews, many parents report significant improvements in their children's reflux symptoms after using the recommended drops. For instance, one parent with a NICU baby mentioned that their child's condition improved drastically after using the drops, noting that they worked just as well as a pricier alternative (Read Review). Another reviewer echoed similar sentiments, highlighting how their baby's discomfort related to reflux was alleviated by these drops (Read Review). Additionally, the use of the product reportedly led to improvements in related issues such as gas and colic, with one parent expressing gratitude for the significant enhancements in their baby's overall comfort (Read Review).
Parents have also shared that improvements can be seen swiftly, with one user noticing positive changes in their baby's feeding experience within just four days of use (Read Review). While individual results can vary, overall, the feedback suggests a trend of reduced symptoms over time, making these drops a favorable option for many families dealing with reflux-related challenges.
Users have shared a variety of experiences regarding the combination of this supplement with other products for managing reflux. Many parents emphasize the effectiveness of these drops when used alongside other treatments, particularly in alleviating symptoms associated with reflux. One reviewer noted significant improvements in their NICU baby’s reflux condition when using this product, implying it worked just as well as more expensive alternatives they had tried (Read Review). Another user echoed this sentiment, observing a considerable reduction in reflux symptoms after using the drops (Read Review).
Additionally, some reviews suggest that the supplement, particularly when paired with probiotics, has led to multiple positive outcomes like reduced gas and colic, thereby enhancing overall comfort for babies suffering from reflux issues (Read Review). Parents also highlighted that their baby's health improved quickly after resuming the drops following a break in usage, suggesting a robust synergy between this supplement and other reflux management strategies (Read Review). Overall, these user experiences indicate that many find a successful combination approach when handling reflux, underscoring the supplement's versatility alongside other treatments.
When it comes to treating reflux in children, particularly infants, the optimal dose of Lactobacillus reuteri probiotic appears to be in line with various studies that highlight its effectiveness. Research indicates that administering Lactobacillus reuteri NCIMB 30351 can significantly reduce episodes of regurgitation, crying times, and improve bowel movements in infants experiencing gastroesophageal reflux. The studies suggest that using this probiotic can enhance gut health while managing reflux symptoms, with no adverse effects reported in the infants treated [2].
In randomized controlled trials, infants receiving Lactobacillus reuteri experienced notable decreases in regurgitation episodes and improvements in gastric emptying rates. These benefits have been observed over treatment durations ranging from four to 30 days [5], [8]. While specific dosages were not delineated across all studies, the general consensus indicates Lactobacillus reuteri to be a safe and practical option for managing reflux symptoms in infants, particularly during the early months of life [6]. Parents looking for natural solutions for their infants' reflux may find this probiotic to be an effective addition to their treatment regimen.
Additionally, the probiotic showed a positive impact on gut microbiota while inhibiting harmful bacteria. With no reported adverse effects, L. reuteri appears to be a safe and effective option for managing reflux and related symptoms in infants.
Infants taking Lactobacillus reuteri showed significantly reduced episodes of regurgitation and faster gastric emptying. This probiotic appears to ease discomfort related to reflux, offering parents a potential solution to this common issue.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
In a well-structured randomized controlled trial, infants took a test formula for four weeks, allowing us to measure changes in their gastric emptying rate and regurgitation frequency.
The results were promising: infants on the test formula experienced a significant decrease in daily regurgitations compared to the control group, highlighting the potential benefits of this formulation for managing reflux in infants.
By the end of the trial, those treated with the probiotic showed a significant decrease in daily regurgitation episodes, while only a few in the placebo group needed help for gastrointestinal issues.
Overall, our findings suggest that early administration of L. reuteri can be beneficial for preventing regurgitation in infants during their first month.
References
- Wei J, Zhang J, Jiang Y, Lian T, Zhang P, et al. Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3. In Vivo. 2023;37:79. doi:10.21873/invivo.13056
- Tyrsin OY, Tyrsin DY, Nemenov DG, Ruzov AS, Odintsova VE, et al. Effect of Lactobacillus reuteri NCIMB 30351 drops on symptoms of infantile functional gastrointestinal disorders and gut microbiota in early infants: Results from a randomized, placebo-controlled clinical trial. Eur J Pediatr. 2024;183:2311. doi:10.1007/s00431-024-05473-y
- Cui X, Shi Y, Gao S, Xue X, Fu J. Effects of Lactobacillus reuteri DSM 17938 in preterm infants: a double-blinded randomized controlled study. Ital J Pediatr. 2019;45:140. doi:10.1186/s13052-019-0716-9
- Belei O, Olariu L, Dobrescu A, Marcovici T, Marginean O. Is It Useful to Administer Probiotics Together With Proton Pump Inhibitors in Children With Gastroesophageal Reflux?. J Neurogastroenterol Motil. 2018;24:51. doi:10.5056/jnm17059
- Indrio F, Riezzo G, Giordano P, Ficarella M, Miolla MP, et al. Effect of a Partially Hydrolysed Whey Infant Formula Supplemented with Starch and Lactobacillus reuteri DSM 17938 on Regurgitation and Gastric Motility. Nutrients. 2017;9. doi:10.3390/nu9111181
- Garofoli F, Civardi E, Indrio F, Mazzucchelli I, Angelini M, et al. The early administration of Lactobacillus reuteri DSM 17938 controls regurgitation episodes in full-term breastfed infants. Int J Food Sci Nutr. 2014;65:646. doi:10.3109/09637486.2014.898251
- Indrio F, Di Mauro A, Riezzo G, Civardi E, Intini C, et al. Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trial. JAMA Pediatr. 2014;168:228. doi:10.1001/jamapediatrics.2013.4367
- Indrio F, Riezzo G, Raimondi F, Bisceglia M, Filannino A, et al. Lactobacillus reuteri accelerates gastric emptying and improves regurgitation in infants. Eur J Clin Invest. 2011;41:417. doi:10.1111/j.1365-2362.2010.02425.x
