We discovered that a diet enriched with omega-3 fatty acids can effectively reduce symptoms of allergic conjunctivitis (AC) in mice. This reduction occurred without influencing the typical immune responses usually associated with allergies. Instead, omega-3s worked by changing the lipid molecules linked to inflammation.
Notably, these fatty acids completely suppressed itching near the eyes and significantly decreased the presence of eosinophils, cells commonly involved in allergic reactions. However, total serum IgE levels and T2 cytokine expression remained unchanged, suggesting that omega-3s tackle AC symptoms in a unique way.
Read More
8
Omega-3s and skin allergies
ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α.
We uncovered intriguing insights into how eicosapentaenoic acid (EPA) and its metabolite, 12-hydroxyeicosapentaenoic acid (12-HEPE), play a role in managing allergic responses, particularly in the skin. Our study revealed that when mice consumed an omega-3 fatty acid-rich diet, 12-HEPE became a significant metabolite in their skin.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
Read More
9.5
Maternal omega-3 reduces allergy risks
Maternal Omega-3 Supplementation During Pregnancy, but Not Childhood Supplementation, Reduces the Risk of Food Allergy Diseases in Offspring.
We conducted a comprehensive meta-analysis to explore how omega-3 supplementation affects food allergy risks in children, focusing on whether maternal intake during pregnancy or childhood supplementation is more effective.
Our findings revealed that mothers who took omega-3 during pregnancy and lactation significantly lowered the chances of their infants developing allergies to eggs and peanuts.
However, omega-3 consumption later in childhood did not show similar benefits in allergy prevention. This emphasizes the critical timing of supplementation in allergy risk management.
Read More
Most Useful Reviews
9
No side effects
This is the best quality omega with a good dosage. It does not cause any side effects or allergies.
Read More
7.5
Improved skin hydration
1 people found this helpful
The dryness of my skin is due to my allergy to fish and seafood. I took an omega course which helped significantly. I experienced no allergies and felt less inclined to use cream. My skin became more hydrated, but once I stopped, everything reverted back. Now, I order a lot!
Read More
0
Caused allergies
Normal Omega; it’s profitable and effective. It worked for me but unfortunately, it caused allergies and side effects.
We conducted a comprehensive meta-analysis to explore how omega-3 supplementation affects food allergy risks in children, focusing on whether maternal intake during pregnancy or childhood supplementation is more effective.
Our findings revealed that mothers who took omega-3 during pregnancy and lactation significantly lowered the chances of their infants developing allergies to eggs and peanuts.
However, omega-3 consumption later in childhood did not show similar benefits in allergy prevention. This emphasizes the critical timing of supplementation in allergy risk management.
Read More
9.5
Docosahexaenoic acid helps asthma
Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase alleviate ovalbumin‑induced allergic asthma in mice by reducing airway inflammation and oxidative stress.
We explored the potential of lipid mediators derived from docosahexaenoic acid (DHA) for alleviating allergic asthma. Using a model where mice were challenged with ovalbumin (OVA) to induce asthma-like symptoms, we administered lipid mediators that included 17S-monohydroxy DHA, resolvin D5, and protectin DX. These treatments led to significant improvements in key aspects of asthma such as reduced inflammatory cell infiltration and lower levels of Th2 cytokines.
Following treatment with the lipid mediators, we observed decreased levels of interleukin-6, tumor necrosis factor-α, and IgE—important markers associated with allergic reactions. There was a notable reduction in inflammation and oxidative stress in lung tissues, which suggests a protective effect on the lungs. Additionally, histological examinations revealed fewer signs of inflammation and mucus secretion.
The results indicate that DHA-derived lipid mediators may effectively mitigate the symptoms of allergic asthma and offer a promising new approach for treatment. They seem to act by reducing inflammation and improving antioxidant defenses within the lungs.
Read More
9.5
New hypoallergenic formula shows promise
Hypoallergenicity assessment of an extensively hydrolyzed whey-protein formula in cow's milk allergic infants.
We set out to assess a new extensively hydrolyzed whey-protein formula, which includes docosahexaenoic acid (DHA), for infants with cow's milk allergy (CMA). This study involved 34 children, primarily with IgE-mediated reactions, participating in a double-blind, placebo-controlled food challenge. Remarkably, all the children tolerated the new formula during the trial. This is significant since the American Academy of Pediatrics states that successful tolerance in over 90% of CMA children is crucial for a product to be considered hypoallergenic.
Although our focus was on the overall efficacy and safety of this formula, it's important to note that while DHA was included, we stopped short of isolating its specific impact on allergy outcomes. Thus, while we noted that this new formula is well-tolerated and associated with healthy growth and gastrointestinal tolerability, we cannot definitively state the effect of DHA alone on allergies. We recognize that further research would be needed to explore DHA's specific role in allergy management.
Read More
9
Eicosapentaenoic acid benefits allergies
Evaluating the Effect of Eicosapentaenoic Acid in Children With Atopic Dermatitis: A Randomized Triple-Blind Clinical Trial.
We explored the impact of dietary eicosapentaenoic acid (EPA) in children suffering from atopic dermatitis, a common allergic skin condition. In a well-structured study, forty-eight children were divided into two groups: one received 250 mg of EPA twice daily, while the other was given a placebo for four weeks.
The study aimed to measure the effectiveness of EPA by examining improvements in the SCORing Atopic Dermatitis (SCORAD) index and the need for topical corticosteroids. What we found was quite promising—after just two weeks, the EPA group showed significant improvement in their SCORAD scores compared to the placebo group.
Additionally, by the end of four weeks, fewer children in the EPA group required corticosteroids, indicating a potential reduction in the severity of their condition. Overall, the results suggest that EPA supplementation is both effective and well-tolerated among young patients with atopic dermatitis, offering a supportive strategy for managing this allergy-related issue.
Read More
9
Eicosapentaenoic acid reduces inflammation
Effect of Omega-3 Polyunsaturated Fatty Acids Intake on Eosinophil Airway Inflammation in University Athletes.
We assessed how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, influences airway inflammation related to allergies in university athletes. In our study, we had 23 male participants divided into three groups based on their levels of airway inflammation, measured by fractional exhaled nitric oxide (FeNO).
These athletes took daily supplements containing 600 mg of EPA for three weeks. During this time, we tracked changes in their FeNO levels and other respiratory factors. Our findings revealed a significant drop in FeNO levels among athletes with eosinophilic airway inflammation, indicating a reduction in airway inflammation.
Notably, while the athletes with high FeNO levels benefited from the supplementation, those without eosinophilic characteristics saw no significant changes in their respiratory status. This suggests that EPA may be particularly effective for certain allergy-related conditions, rather than universally beneficial for all types of respiratory issues.
This is the best quality omega with a good dosage. It does not cause any side effects or allergies.
Read More
7.5
Improved skin hydration
1 people found this helpful
The dryness of my skin is due to my allergy to fish and seafood. I took an omega course which helped significantly. I experienced no allergies and felt less inclined to use cream. My skin became more hydrated, but once I stopped, everything reverted back. Now, I order a lot!
Read More
0
Caused allergies
Normal Omega; it’s profitable and effective. It worked for me but unfortunately, it caused allergies and side effects.
Read More
Frequently Asked Questions
Allergies are the body's immune system responses to substances known as allergens, which can be harmless in most individuals. When a person with allergies encounters these allergens, their immune system mistakenly identifies them as a threat and launches a response. This can lead to symptoms ranging from mild, such as sneezing, itching, and rashes, to severe reactions known as anaphylaxis, which can be life-threatening. Common allergens include pollen, pet dander, certain foods like nuts and shellfish, insect stings, and medications.
Managing allergies often involves avoiding known allergens and using medications such as antihistamines or corticosteroids to alleviate symptoms. In some cases, doctors might recommend allergy shots or immunotherapy to help patients build tolerance over time. If you suspect you have allergies, consulting with a healthcare professional for proper diagnosis and treatment options is crucial. Understanding your triggers and how to live with allergies can significantly improve your quality of life.
Omega-3 fish oil is a nutritional supplement derived from the fatty tissues of fish, particularly fatty fish like salmon, mackerel, and sardines. It is rich in omega-3 fatty acids, which are essential fats that the body cannot produce on its own. The most significant types of omega-3s found in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are known for their numerous health benefits. These include reducing inflammation, supporting heart health, and promoting brain function.
Incorporating omega-3 fish oil into your diet can be beneficial if you don’t consume enough fish regularly. Many health experts recommend oily fish as a part of a balanced diet due to their high omega-3 content. For those who find it difficult to include fish in their meals, fish oil supplements can offer a convenient alternative, providing the same essential fatty acids in concentrated form. However, it’s essential to choose high-quality supplements that are third-party tested for purity and potency to avoid contaminants such as heavy metals or other toxins that can impact health.
Omega-3 fish oil has been studied for its potential benefits in managing various health conditions, including allergies. Rich in EPA and DHA, two types of omega-3 fatty acids, fish oil is known for its anti-inflammatory properties, which may help alleviate symptoms associated with allergic reactions. Some research suggests that higher omega-3 intake can influence the immune system's response, potentially reducing the severity of allergy symptoms and promoting overall respiratory health.
However, it's essential to note that while some studies have shown promising results, the evidence remains mixed, and more research is needed to establish a firm link between omega-3 supplementation and allergy relief. Individuals with allergies should consult with a healthcare professional before starting any new supplement, as reactions can vary from person to person. Overall, while incorporating omega-3 fish oil into your diet could provide general health benefits and support anti-inflammatory processes, it should not be viewed as a standalone solution for allergy management.
When using Omega-3 fish oil as a supplement for allergies, users often report varying timelines for noticing improvements. Generally, it can take several weeks to a few months to observe significant results. This variation is due in part to individual differences, such as the severity of allergies and overall health, as well as the dosage of Omega-3 being consumed. Consistency is key; the benefits tend to accumulate over time with regular intake.
This supplement, particularly omega-3 fatty acids, has garnered attention in scientific research for its potential role in managing allergies. Studies have indicated that maternal intake of omega-3s during pregnancy can lower the risk of allergies in children. For instance, a meta-analysis found that mothers who supplemented with omega-3 fish oil significantly reduced their infants' chances of developing allergies to foods like eggs and peanuts [3]. Furthermore, another study showed that higher levels of polyunsaturated fatty acids in mothers were associated with a decreased risk of allergic conditions in their offspring [4].
Research also suggests promising effects of omega-3s on alleviating allergic symptoms. For example, specific metabolites of eicosapentaenoic acid (EPA) have demonstrated anti-allergic properties, such as reducing inflammation linked to skin contact allergies [22] and atopic dermatitis [19]. While evidence points towards omega-3 fatty acids being beneficial in allergy prevention and management, especially when consumed during pregnancy, additional studies are warranted to bolster these findings and further understand their efficacy [9].
Based on user reviews, many individuals have reported notable improvements in their symptoms after using omega supplements. For instance, one user indicated that they experienced significant hydration in their skin after starting an omega course, noting a reduction in their reliance on moisturizers, and reported no allergic reactions despite their existing allergy to fish and seafood Read Review. This highlights the potential for omega supplements to alleviate dryness and improve overall skin condition for those sensitive to traditional sources.
However, it's important to consider that individual results can vary greatly. Another user shared a different experience, stating that while the product was effective, it unfortunately caused allergic reactions and side effects for them Read Review. This variability underscores the necessity for potential users to consult with their healthcare provider to determine the best approach for their specific needs. Overall, while many users have seen positive effects on hydration and skin health, others may experience adverse reactions.
Based on user reviews, experiences with combining omega supplements with other supplements for handling allergies vary. Some users have reported that omega supplements can be effectively taken alongside other allergy remedies without experiencing adverse effects. One user emphasized the quality and dosage of their omega supplement, stating that it did not cause any side effects or allergies, which suggests compatibility with other allergy treatments Read Review.
Conversely, another user shared a negative experience, noting that while the omega supplement was beneficial, it unfortunately triggered allergies and side effects in their case Read Review. This highlights the importance of individual variability and underscores the necessity for potential users to consider this aspect when combining supplements. Ultimately, while many users report positive outcomes with omega supplements for allergies, others advise caution, particularly if they have a history of sensitivities.
Based on user reviews, there appears to be a spectrum of experiences regarding the optimal dosage of Omega 3 Fish Oil for treating allergies. One user highlighted the effectiveness of a specific omega product, stating it provided good dosage without causing any allergic reactions or side effects (Read Review). Meanwhile, another user who has a fish allergy noted that taking an omega course significantly improved their skin hydration, suggesting that a tailored dosage could be beneficial in managing allergy symptoms (Read Review).
However, it's important to heed caution as not all experiences were positive. One review shared that despite finding the omega product effective, it led to allergic reactions and side effects, indicating that dosage may need to be carefully monitored depending on individual sensitivity (Read Review). Users recommend a level of experimentation with dosages, starting low and adjusting as necessary, to find what works without adverse effects.
7.5
Improved skin hydration
1 people found this helpful
The dryness of my skin is due to my allergy to fish and seafood. I took an omega course which helped significantly. I experienced no allergies and felt less inclined to use cream. My skin became more hydrated, but once I stopped, everything reverted back. Now, I order a lot!
0
Caused allergies
Normal Omega; it’s profitable and effective. It worked for me but unfortunately, it caused allergies and side effects.
9
No side effects
This is the best quality omega with a good dosage. It does not cause any side effects or allergies.
9.5
Maternal omega-3 reduces allergy risks
Maternal Omega-3 Supplementation During Pregnancy, but Not Childhood Supplementation, Reduces the Risk of Food Allergy Diseases in Offspring.
We conducted a comprehensive meta-analysis to explore how omega-3 supplementation affects food allergy risks in children, focusing on whether maternal intake during pregnancy or childhood supplementation is more effective.
Our findings revealed that mothers who took omega-3 during pregnancy and lactation significantly lowered the chances of their infants developing allergies to eggs and peanuts.
However, omega-3 consumption later in childhood did not show similar benefits in allergy prevention. This emphasizes the critical timing of supplementation in allergy risk management.
8
Maternal PUFA may reduce offspring allergies
Association of Maternal Erythrocyte PUFA during Pregnancy with Offspring Allergy in the Chinese Population.
We explored the link between maternal fatty acids and allergies in children during their first 2 years of life, focusing on a group of 573 mother-infant pairs in China. By analyzing the fatty acid levels in mothers, we found that higher levels of total polyunsaturated fatty acids (PUFA), particularly arachidonic acid and omega-3, were linked to a lower risk of allergies in their children.
Interestingly, the relationship was even stronger in children whose mothers had allergies. Our findings suggest that maternal intake of specific omega-3 fatty acids might play a beneficial role in reducing allergy risks for their offspring.
8
Omega-3s and skin allergies
ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α.
We uncovered intriguing insights into how eicosapentaenoic acid (EPA) and its metabolite, 12-hydroxyeicosapentaenoic acid (12-HEPE), play a role in managing allergic responses, particularly in the skin. Our study revealed that when mice consumed an omega-3 fatty acid-rich diet, 12-HEPE became a significant metabolite in their skin.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
9
Eicosapentaenoic acid benefits allergies
Evaluating the Effect of Eicosapentaenoic Acid in Children With Atopic Dermatitis: A Randomized Triple-Blind Clinical Trial.
We explored the impact of dietary eicosapentaenoic acid (EPA) in children suffering from atopic dermatitis, a common allergic skin condition. In a well-structured study, forty-eight children were divided into two groups: one received 250 mg of EPA twice daily, while the other was given a placebo for four weeks.
The study aimed to measure the effectiveness of EPA by examining improvements in the SCORing Atopic Dermatitis (SCORAD) index and the need for topical corticosteroids. What we found was quite promising—after just two weeks, the EPA group showed significant improvement in their SCORAD scores compared to the placebo group.
Additionally, by the end of four weeks, fewer children in the EPA group required corticosteroids, indicating a potential reduction in the severity of their condition. Overall, the results suggest that EPA supplementation is both effective and well-tolerated among young patients with atopic dermatitis, offering a supportive strategy for managing this allergy-related issue.
7
Omega-3 supplementation's weak effectiveness
ω-3 LCPUFA supplementation during pregnancy and risk of allergic outcomes or sensitization in offspring: A systematic review and meta-analysis.
We conducted a systematic review and meta-analysis to explore whether omega-3 fatty acids taken during pregnancy affect allergic outcomes in children.
While our findings indicate that starting omega-3 supplementation during pregnancy may reduce the risk of sensitization to foods like egg and peanut, the overall evidence is somewhat limited.
This stems from the small number of studies available and concerns regarding their reliability, making it hard to draw definitive conclusions about omega-3's effects on allergies.
References
Saika A, Nagatake T, Kishino S, Kitamura N, Honda T, et al. The omega-3 postbiotic -10--15-octadecadienoic acid attenuates contact hypersensitivity in mice through downregulation of vascular endothelial growth factor A. Front Cell Infect Microbiol. 2024;14:1355679. doi:10.3389/fcimb.2024.1355679
Tsuji S, Adachi Y, Tsuchida A, Hamazaki K, Matsumura K, et al. Association of allergies in children younger than 3 years with levels of maternal intake of n-3 polyunsaturated fatty acids or fish during pregnancy: A nationwide birth cohort study, the Japan Environment and Children's Study. Allergol Int. 2024;73:282. doi:10.1016/j.alit.2023.12.004
Huynh LBP, Nguyen NN, Fan HY, Huang SY, Huang CH, et al. Maternal Omega-3 Supplementation During Pregnancy, but Not Childhood Supplementation, Reduces the Risk of Food Allergy Diseases in Offspring. J Allergy Clin Immunol Pract. 2023;11:2862. doi:10.1016/j.jaip.2023.06.005
Peng S, Du Z, He Y, Zhao F, Chen Y, et al. Association of Maternal Erythrocyte PUFA during Pregnancy with Offspring Allergy in the Chinese Population. Nutrients. 2022;14. doi:10.3390/nu14112312
Adjibade M, Davisse-Paturet C, Bernard JY, Adel-Patient K, Divaret-Chauveau A, et al. Enrichment of infant formula with long-chain polyunsaturated fatty acids and risk of infection and allergy in the nationwide ELFE birth cohort. Allergy. 2022;77:1522. doi:10.1111/all.15137
Miles EA, Childs CE, Calder PC. Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) and the Developing Immune System: A Narrative Review. Nutrients. 2021;13. doi:10.3390/nu13010247
Hirata SI, Nagatake T, Sawane K, Hosomi K, Honda T, et al. Maternal ω3 docosapentaenoic acid inhibits infant allergic dermatitis through TRAIL-expressing plasmacytoid dendritic cells in mice. Allergy. 2020;75:1939. doi:10.1111/all.14217
Huhmann R, Mueller RS. A cream containing omega-3-fatty acids, humectants and emollients as an aid in the treatment of equine Culicoides hypersensitivity. Vet Dermatol. 2019;30:155. doi:10.1111/vde.12728
Vahdaninia M, Mackenzie H, Dean T, Helps S. ω-3 LCPUFA supplementation during pregnancy and risk of allergic outcomes or sensitization in offspring: A systematic review and meta-analysis. Ann Allergy Asthma Immunol. 2019;122:302. doi:10.1016/j.anai.2018.12.008
Hirakata T, Lee HC, Ohba M, Saeki K, Okuno T, et al. Dietary ω-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating T2 immune responses. FASEB J. 2019;33:3392. doi:10.1096/fj.201801805R
Clausen M, Jonasson K, Keil T, Beyer K, Sigurdardottir ST. Fish oil in infancy protects against food allergy in Iceland-Results from a birth cohort study. Allergy. 2018;73:1305. doi:10.1111/all.13385
Hansen S, Strøm M, Maslova E, Dahl R, Hoffmann HJ, et al. Fish oil supplementation during pregnancy and allergic respiratory disease in the adult offspring. J Allergy Clin Immunol. 2017;139:104. doi:10.1016/j.jaci.2016.02.042
Best KP, Sullivan T, Palmer D, Gold M, Kennedy DJ, et al. Prenatal Fish Oil Supplementation and Allergy: 6-Year Follow-up of a Randomized Controlled Trial. Pediatrics. 2016;137. doi:10.1542/peds.2015-4443
Willemsen LEM. Dietary n-3 long chain polyunsaturated fatty acids in allergy prevention and asthma treatment. Eur J Pharmacol. 2016;785:174. doi:10.1016/j.ejphar.2016.03.062
Warstedt K, Furuhjelm C, Fälth-Magnusson K, Fagerås M, Duchén K. High levels of omega-3 fatty acids in milk from omega-3 fatty acid-supplemented mothers are related to less immunoglobulin E-associated disease in infancy. Acta Paediatr. 2016;105:1337. doi:10.1111/apa.13395
Ahmed N, Barrow CJ, Suphioglu C. Exploring the Effects of Omega-3 and Omega-6 Fatty Acids on Allergy Using a HEK-Blue Cell Line. Int J Mol Sci. 2016;17:220. doi:10.3390/ijms17020220
Li SY, Zheng PY, Zhai YY, Zhang YD, Gan H, et al. [Analysis of the effect of early subcutaneous specific immunotherapy on the levels of dust mite allergen-specific antibodies and polyunsaturated fatty acid metabolism]. Zhonghua Yu Fang Yi Xue Za Zhi. 2024;58:778. doi:10.3760/cma.j.cn112150-20240124-00083
Komulainen M, Saros L, Vahlberg T, Nermes M, Jartti T, et al. Maternal fish oil and/or probiotics intervention: Allergic diseases in children up to two years old. Pediatr Allergy Immunol. 2023;34:e14004. doi:10.1111/pai.14004
Mirrahimi B, Moazemi M, Eslami N, Jamshidi E, Mir M, et al. Evaluating the Effect of Eicosapentaenoic Acid in Children With Atopic Dermatitis: A Randomized Triple-Blind Clinical Trial. J Pediatr Pharmacol Ther. 2023;28:29. doi:10.5863/1551-6776-28.1.29
Imai T, Takada Y, Watanabe K. Effect of Omega-3 Polyunsaturated Fatty Acids Intake on Eosinophil Airway Inflammation in University Athletes. J Clin Med Res. 2022;14:466. doi:10.14740/jocmr4825
Decsi T, Marosvölgyi T, Muszil E, Bódy B, Szabó É. Long-Chain Polyunsaturated Fatty Acid Status at Birth and Development of Childhood Allergy: A Systematic Review. Life (Basel). 2022;12. doi:10.3390/life12040526
Saika A, Nagatake T, Hirata SI, Sawane K, Adachi J, et al. ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α. FASEB J. 2021;35:e21354. doi:10.1096/fj.202001687R
Kanda N, Hoashi T, Saeki H. Nutrition and Atopic Dermatitis. J Nippon Med Sch. 2021;88:171. doi:10.1272/jnms.JNMS.2021_88-317
Barman M, Rabe H, Hesselmar B, Johansen S, Sandberg AS, et al. Cord Blood Levels of EPA, a Marker of Fish Intake, Correlate with Infants' T- and B-Lymphocyte Phenotypes and Risk for Allergic Disease. Nutrients. 2020;12. doi:10.3390/nu12103000
Hoppenbrouwers T, Fogliano V, Garssen J, Pellegrini N, Willemsen LEM, et al. Specific Polyunsaturated Fatty Acids Can Modulate Human moDC2s and Subsequent Th2 Cytokine Release. Front Immunol. 2020;11:748. doi:10.3389/fimmu.2020.00748
Saika A, Nagatake T, Kishino S, Park SB, Honda T, et al. 17(),18()-epoxyeicosatetraenoic acid generated by cytochrome P450 BM-3 from inhibits the development of contact hypersensitivity via G-protein-coupled receptor 40-mediated neutrophil suppression. FASEB Bioadv. 2020;2:59. doi:10.1096/fba.2019-00061
Su Y, Choi HS, Kwon SK, Han Y, Cho SC, et al. Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase alleviate ovalbumin‑induced allergic asthma in mice by reducing airway inflammation and oxidative stress. Mol Med Rep. 2025;31. doi:10.3892/mmr.2025.13451
Sato A, Sato G, Yabuki A, Ogawa Y, Nemoto H, et al. Ameliorative effects of squid phospholipids from Todarodes pacificus on atopic dermatitis-like lesions in NC/Nga mice. Arch Dermatol Res. 2025;317:239. doi:10.1007/s00403-024-03773-9
Wang R, Patel D, Goruk S, Richard C, Field CJ. Feeding Docosahexaenoic Acid and Arachidonic Acid during Suckling and Weaning Contributes to Oral Tolerance Development by Beneficially Modulating the Intestinal Cytokine and Immunoglobulin Levels in an Allergy-Prone Brown Norway Rat Model. J Nutr. 2024;154:3790. doi:10.1016/j.tjnut.2024.10.021
Lee C, Dartt DA. Sex-dependent differential increase of specialized pro-resolving mediators in extracellular vesicles secreted by human primary conjunctival goblet cells during allergic inflammation. Life Sci. 2024;357:123058. doi:10.1016/j.lfs.2024.123058
Huang XW, Pang SW, Yang LZ, Han T, Chen JM, et al. TNFSF14 mediates the impact of docosahexaenoic acid on atopic dermatitis: a Mendelian randomization study. Eur Rev Med Pharmacol Sci. 2024;28:107. doi:10.26355/eurrev_202401_34896
Peh HY, Brüggemann TR, Duvall MG, Nshimiyimana R, Nijmeh J, et al. Resolvin D2 regulates type 2 inflammatory responses and promotes resolution of mouse allergic inflammation. Allergy. 2024;79:739. doi:10.1111/all.15920
Patel D, Munhoz J, Goruk S, Tsai S, Richard C, et al. Correction: Maternal diet supplementation with high-docosahexaenoic-acid canola oil, along with arachidonic acid, promotes immune system development in allergy-prone BALB/c mouse ofspring at 3 weeks of age. Eur J Nutr. 2024;63:341. doi:10.1007/s00394-023-03264-z
Patel D, Munhoz J, Goruk S, Richard C, Field CJ. The Programming Effect of Plant-Based DHA, Along with Equivalent AA, on Immune System and Oral Tolerance Development in Six-Week Allergy Prone BALB/c Pups. J Nutr. 2023;153:2482. doi:10.1016/j.tjnut.2023.06.002
Figueroa-Garduño I, Escamilla-Núñez C, Barraza-Villarreal A, Hernández-Cadena L, Onofre-Pardo EN, et al. Docosahexaenoic Acid Effect on Prenatal Exposure to Arsenic and Atopic Dermatitis in Mexican Preschoolers. Biol Trace Elem Res. 2023;201:3152. doi:10.1007/s12011-022-03411-3
Dahdah L, Roelofs M, Knipping K, de Vries E, Rijnierse A, et al. Hypoallergenicity assessment of an extensively hydrolyzed whey-protein formula in cow's milk allergic infants. Pediatr Allergy Immunol. 2022;33:e13814. doi:10.1111/pai.13814
Patel D, Goruk S, Richard C, Field CJ. Combined Supplementation with Arachidonic and Docosahexaenoic Acids in T Helper Type-2 Skewed Brown Norway Rat Offspring is Beneficial in the Induction of Oral Tolerance toward Ovalbumin and Immune System Development. J Nutr. 2022;152:2165. doi:10.1093/jn/nxac118