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SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.3
USERS' SCORE
Good
Based on 4 Reviews
8.6
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
30
Total Fat
2.5 g
3%**
Cholesterol
<5 mg
1%
Protein
<1 g
Vitamin E (as natural d-alpha tocopherol)
13.4 mg
89%
Norwegian Fish Oil
2.5 g
†
Total Omega-3 Fatty Acids*
1,600 mg
†
EPA (Eicosapentaenoic Acid)*
800 mg
†
DHA (Docosahexaenoic Acid)*
600 mg
†
Top Medical Research Studies
8
Eicosapentaenoic acid supports hypothyroidism
Effect of eicosapentaenoic acid ethyl ester on hypothyroid function.
High relevance to hypothyroidism research
We aimed to investigate how eicosapentaenoic acid ethyl ester, a form of omega-3 fatty acid derived from fish oil, influences thyroid function in patients with hypothyroidism. Interestingly, while it has generally been observed that plasma free fatty acid (FFA) levels remain normal in hypothyroid individuals, our findings indicated that some patients exhibited elevated FFA concentrations. This was compelling, as those with higher FFA levels showed milder symptoms of thyroid dysfunction compared to others with lower levels.
To delve deeper, we tested the effects of eicosapentaenoic acid in an animal model using hypothyroid rats. By administering eicosapentaenoic acid ethyl ester to these rats, we observed that it effectively inhibited the decline of thyroid hormone levels caused by a substance called MMI. Additionally, we noted that it positively influenced the structure of the thyroid follicles in these rats.
Our study suggests that eicosapentaenoic acid may not only support thyroid function but could also have potential benefits for managing conditions related to hypothyroidism. This opens up exciting possibilities for further research into natural treatments for thyroid health.
To delve deeper, we tested the effects of eicosapentaenoic acid in an animal model using hypothyroid rats. By administering eicosapentaenoic acid ethyl ester to these rats, we observed that it effectively inhibited the decline of thyroid hormone levels caused by a substance called MMI. Additionally, we noted that it positively influenced the structure of the thyroid follicles in these rats.
Our study suggests that eicosapentaenoic acid may not only support thyroid function but could also have potential benefits for managing conditions related to hypothyroidism. This opens up exciting possibilities for further research into natural treatments for thyroid health.
Read More
9
DHA promotes brain development in hypothyroidism
Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model.
Study highlights DHA's protective role
We explored the effects of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, in a study designed to understand its role in overcoming hypothyroidism-induced neuronal apoptosis, especially during crucial cerebellar development. Our research involved supplementing pregnant and lactating rats with a mixture of DHA and eicosapentaenoic acid (EPA) while inducing hypothyroidism using methimazole.
By examining the cerebellum of pups at postnatal day 16, we observed that DHA supplementation significantly curbed DNA fragmentation and reduced caspase-3 activation, both markers of cell death. This protective effect seemed linked to DHA's ability to lower levels of pro-apoptotic proteins like Bax, which typically rise when thyroid hormones are deficient.
Furthermore, we found that omega-3 fatty acids boosted levels of protective proteins like Bcl-2 and Bcl-x(L), which are usually suppressed in hypothyroid conditions. DHA also helped restore important signaling pathways impacted by hypothyroidism, such as phospho-AKT, phospho-ERK, and phospho-JNK, without affecting myelin basic protein levels, which are responsive to thyroid hormones.
Overall, our findings suggest that omega-3 fatty acids, particularly DHA, have a significant anti-apoptotic role in the developing brain during periods of thyroid hormone deficiency.
By examining the cerebellum of pups at postnatal day 16, we observed that DHA supplementation significantly curbed DNA fragmentation and reduced caspase-3 activation, both markers of cell death. This protective effect seemed linked to DHA's ability to lower levels of pro-apoptotic proteins like Bax, which typically rise when thyroid hormones are deficient.
Furthermore, we found that omega-3 fatty acids boosted levels of protective proteins like Bcl-2 and Bcl-x(L), which are usually suppressed in hypothyroid conditions. DHA also helped restore important signaling pathways impacted by hypothyroidism, such as phospho-AKT, phospho-ERK, and phospho-JNK, without affecting myelin basic protein levels, which are responsive to thyroid hormones.
Overall, our findings suggest that omega-3 fatty acids, particularly DHA, have a significant anti-apoptotic role in the developing brain during periods of thyroid hormone deficiency.
Read More
9
Eicosapentaenoic Acid supports brain development
Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model.
Effectiveness of EPA treatment analyzed
We investigated the role of eicosapentaenoic acid (EPA), an omega-3 fatty acid, in the context of hypothyroidism and its effects on brain development. Our study used a rat model where hypothyroidism was induced, allowing us to examine how EPA influences neuronal health during this critical phase of development.
Through our research, we found that supplementing EPA, along with docosahexaenoic acid (DHA), significantly reduced signs of neuronal apoptosis, which is a controlled process of cell death that can be detrimental when excessive. Specifically, we observed decreases in DNA fragmentation and activation of an important mediator of cell death—caspase-3—in the cerebella of hypothyroid pups.
One of the key findings highlighted that EPA helped counteract increases in a pro-apoptotic protein called Bax. At the same time, levels of protective proteins, such as Bcl-2 and Bcl-x(L), were restored, which are crucial in promoting cell survival. Additionally, EPA supplementation normalized several important signaling pathways affected by thyroid hormone deficiency, which play vital roles in neuronal health.
Overall, our findings contribute valuable insight into how eicosapentaenoic acid can offer protective benefits for brain development during periods of stress caused by hypothyroidism, illuminating potential therapeutic pathways for ongoing investigations.
Through our research, we found that supplementing EPA, along with docosahexaenoic acid (DHA), significantly reduced signs of neuronal apoptosis, which is a controlled process of cell death that can be detrimental when excessive. Specifically, we observed decreases in DNA fragmentation and activation of an important mediator of cell death—caspase-3—in the cerebella of hypothyroid pups.
One of the key findings highlighted that EPA helped counteract increases in a pro-apoptotic protein called Bax. At the same time, levels of protective proteins, such as Bcl-2 and Bcl-x(L), were restored, which are crucial in promoting cell survival. Additionally, EPA supplementation normalized several important signaling pathways affected by thyroid hormone deficiency, which play vital roles in neuronal health.
Overall, our findings contribute valuable insight into how eicosapentaenoic acid can offer protective benefits for brain development during periods of stress caused by hypothyroidism, illuminating potential therapeutic pathways for ongoing investigations.
Read More
Most Useful Reviews
9.5
Essential for treatment
My endocrinologist recommended this brand of Omega 3 for treating my hypothyroidism as fish oil is crucial for my condition.
Read More
9.5
Increased energy
I've had cold feet and low energy attributed to hypothyroidism. I tried Omega for the first time and was amazed by the results. My feet became warm, I stopped needing socks at home, my mind cleared, and my energy increased. Thank you for this formula!
Read More
8.8
Hair growth improvement
I used Omega 3 in my regimen against hair loss and for growth. This winter my hair fell out terribly. After researching and consulting my endocrinologist, I followed a regimen for three months. My hair stopped shedding, and my hairdresser noted a good undercoat. It involved taking collagen peptides, amino acids, Vitamin C, Omega 3, and other vitamins. Importantly, my iron and vitamin D levels were normal, and I have hypothyroidism without hormonal drugs. Hope this helps others.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.3
9
Eicosapentaenoic Acid supports brain development
Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model.
Effectiveness of EPA treatment analyzed
We investigated the role of eicosapentaenoic acid (EPA), an omega-3 fatty acid, in the context of hypothyroidism and its effects on brain development. Our study used a rat model where hypothyroidism was induced, allowing us to examine how EPA influences neuronal health during this critical phase of development.
Through our research, we found that supplementing EPA, along with docosahexaenoic acid (DHA), significantly reduced signs of neuronal apoptosis, which is a controlled process of cell death that can be detrimental when excessive. Specifically, we observed decreases in DNA fragmentation and activation of an important mediator of cell death—caspase-3—in the cerebella of hypothyroid pups.
One of the key findings highlighted that EPA helped counteract increases in a pro-apoptotic protein called Bax. At the same time, levels of protective proteins, such as Bcl-2 and Bcl-x(L), were restored, which are crucial in promoting cell survival. Additionally, EPA supplementation normalized several important signaling pathways affected by thyroid hormone deficiency, which play vital roles in neuronal health.
Overall, our findings contribute valuable insight into how eicosapentaenoic acid can offer protective benefits for brain development during periods of stress caused by hypothyroidism, illuminating potential therapeutic pathways for ongoing investigations.
Through our research, we found that supplementing EPA, along with docosahexaenoic acid (DHA), significantly reduced signs of neuronal apoptosis, which is a controlled process of cell death that can be detrimental when excessive. Specifically, we observed decreases in DNA fragmentation and activation of an important mediator of cell death—caspase-3—in the cerebella of hypothyroid pups.
One of the key findings highlighted that EPA helped counteract increases in a pro-apoptotic protein called Bax. At the same time, levels of protective proteins, such as Bcl-2 and Bcl-x(L), were restored, which are crucial in promoting cell survival. Additionally, EPA supplementation normalized several important signaling pathways affected by thyroid hormone deficiency, which play vital roles in neuronal health.
Overall, our findings contribute valuable insight into how eicosapentaenoic acid can offer protective benefits for brain development during periods of stress caused by hypothyroidism, illuminating potential therapeutic pathways for ongoing investigations.
Read More
9
DHA promotes brain development in hypothyroidism
Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model.
Study highlights DHA's protective role
We explored the effects of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, in a study designed to understand its role in overcoming hypothyroidism-induced neuronal apoptosis, especially during crucial cerebellar development. Our research involved supplementing pregnant and lactating rats with a mixture of DHA and eicosapentaenoic acid (EPA) while inducing hypothyroidism using methimazole.
By examining the cerebellum of pups at postnatal day 16, we observed that DHA supplementation significantly curbed DNA fragmentation and reduced caspase-3 activation, both markers of cell death. This protective effect seemed linked to DHA's ability to lower levels of pro-apoptotic proteins like Bax, which typically rise when thyroid hormones are deficient.
Furthermore, we found that omega-3 fatty acids boosted levels of protective proteins like Bcl-2 and Bcl-x(L), which are usually suppressed in hypothyroid conditions. DHA also helped restore important signaling pathways impacted by hypothyroidism, such as phospho-AKT, phospho-ERK, and phospho-JNK, without affecting myelin basic protein levels, which are responsive to thyroid hormones.
Overall, our findings suggest that omega-3 fatty acids, particularly DHA, have a significant anti-apoptotic role in the developing brain during periods of thyroid hormone deficiency.
By examining the cerebellum of pups at postnatal day 16, we observed that DHA supplementation significantly curbed DNA fragmentation and reduced caspase-3 activation, both markers of cell death. This protective effect seemed linked to DHA's ability to lower levels of pro-apoptotic proteins like Bax, which typically rise when thyroid hormones are deficient.
Furthermore, we found that omega-3 fatty acids boosted levels of protective proteins like Bcl-2 and Bcl-x(L), which are usually suppressed in hypothyroid conditions. DHA also helped restore important signaling pathways impacted by hypothyroidism, such as phospho-AKT, phospho-ERK, and phospho-JNK, without affecting myelin basic protein levels, which are responsive to thyroid hormones.
Overall, our findings suggest that omega-3 fatty acids, particularly DHA, have a significant anti-apoptotic role in the developing brain during periods of thyroid hormone deficiency.
Read More
8
Eicosapentaenoic acid supports hypothyroidism
Effect of eicosapentaenoic acid ethyl ester on hypothyroid function.
High relevance to hypothyroidism research
We aimed to investigate how eicosapentaenoic acid ethyl ester, a form of omega-3 fatty acid derived from fish oil, influences thyroid function in patients with hypothyroidism. Interestingly, while it has generally been observed that plasma free fatty acid (FFA) levels remain normal in hypothyroid individuals, our findings indicated that some patients exhibited elevated FFA concentrations. This was compelling, as those with higher FFA levels showed milder symptoms of thyroid dysfunction compared to others with lower levels.
To delve deeper, we tested the effects of eicosapentaenoic acid in an animal model using hypothyroid rats. By administering eicosapentaenoic acid ethyl ester to these rats, we observed that it effectively inhibited the decline of thyroid hormone levels caused by a substance called MMI. Additionally, we noted that it positively influenced the structure of the thyroid follicles in these rats.
Our study suggests that eicosapentaenoic acid may not only support thyroid function but could also have potential benefits for managing conditions related to hypothyroidism. This opens up exciting possibilities for further research into natural treatments for thyroid health.
To delve deeper, we tested the effects of eicosapentaenoic acid in an animal model using hypothyroid rats. By administering eicosapentaenoic acid ethyl ester to these rats, we observed that it effectively inhibited the decline of thyroid hormone levels caused by a substance called MMI. Additionally, we noted that it positively influenced the structure of the thyroid follicles in these rats.
Our study suggests that eicosapentaenoic acid may not only support thyroid function but could also have potential benefits for managing conditions related to hypothyroidism. This opens up exciting possibilities for further research into natural treatments for thyroid health.
Read More
7
Phospholipid changes in hypothyroidism
Effects of hypothyroidism on the distribution and fatty acyl composition of phospholipids in sarcoplasmic reticulum of fast skeletal muscle of the rat.
Limited impact of docosahexaenoic acid
We explored the effects of hypothyroidism on phospholipids in the sarcoplasmic reticulum of fast skeletal muscle in rats. Through comparing hypothyroid rats with control (euthyroid) rats, we observed notable changes in the levels of specific phospholipids, particularly phosphatidylethanolamine (PE) and phosphatidylcholine (PC). Hypothyroidism led to a 24% decrease in PE and an increase in PC, while levels of other phospholipids and cholesterol remained steady.
Our study examined the fatty acyl composition of these phospholipids as well. We found that both PE and PC compositions were quantitatively distinct, with hypothyroid conditions causing shifts in fatty acids. Specifically, we noted an increased presence of docosahexaenoic acid (22:6(n - 3)), as well as arachidonic acid (20:4(n - 6)), among others. Conversely, there were decreases in linoleic (18:2(n - 6)), palmitic (16:0), and oleic (18:1(n - 9)) acids.
Interestingly, a 14-day treatment with thyroid hormone significantly reversed the changes in phospholipid distribution and fatty acyl composition, bringing many values back to those seen in euthyroid rats. However, while some improvements were observed for docosahexaenoic acid, others such as linoleic and certain fatty acids in PC did not fully return to baseline levels. This indicates that, while there are changes associated with hypothyroidism that involve docosahexaenoic acid, the treatment does not completely restore the fatty acid profile.
Our study examined the fatty acyl composition of these phospholipids as well. We found that both PE and PC compositions were quantitatively distinct, with hypothyroid conditions causing shifts in fatty acids. Specifically, we noted an increased presence of docosahexaenoic acid (22:6(n - 3)), as well as arachidonic acid (20:4(n - 6)), among others. Conversely, there were decreases in linoleic (18:2(n - 6)), palmitic (16:0), and oleic (18:1(n - 9)) acids.
Interestingly, a 14-day treatment with thyroid hormone significantly reversed the changes in phospholipid distribution and fatty acyl composition, bringing many values back to those seen in euthyroid rats. However, while some improvements were observed for docosahexaenoic acid, others such as linoleic and certain fatty acids in PC did not fully return to baseline levels. This indicates that, while there are changes associated with hypothyroidism that involve docosahexaenoic acid, the treatment does not completely restore the fatty acid profile.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.6
9.5
Essential for treatment
My endocrinologist recommended this brand of Omega 3 for treating my hypothyroidism as fish oil is crucial for my condition.
9.5
Increased energy
I've had cold feet and low energy attributed to hypothyroidism. I tried Omega for the first time and was amazed by the results. My feet became warm, I stopped needing socks at home, my mind cleared, and my energy increased. Thank you for this formula!
8.8
Hair growth improvement
I used Omega 3 in my regimen against hair loss and for growth. This winter my hair fell out terribly. After researching and consulting my endocrinologist, I followed a regimen for three months. My hair stopped shedding, and my hairdresser noted a good undercoat. It involved taking collagen peptides, amino acids, Vitamin C, Omega 3, and other vitamins. Importantly, my iron and vitamin D levels were normal, and I have hypothyroidism without hormonal drugs. Hope this helps others.
Read More
8.8
Skin condition improvement
Super Omega 3 is the best for improving health. My endocrinologist advised consuming Omega 3 daily. I found it from Carlson Labs, which provided the needed dosage. Although pricey, it’s worthwhile. With my hypothyroidism, I noticed my dry skin improved within two weeks, and my hair began to shine. I will definitely order more.
Read More
