' 
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.4
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Soft Gel
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
1%**
Cholesterol
<5mg
<2%
Vitamin A (from cod live oil and retinyl palmitate)
27 mcg RAE
3%
Vitamin D (as cholecalciferol) (from cod liver oil and cholecalciferol concentrate)
100 mcg (4,000 IU)
500%
Vitamin E (as d-alpha tocopherol)
0.67 mg
4%
Norwegian Cod Liver Oil
500 mg
†
Total Omega-3 fatty Acids☆
115 mg
†
DHA (Docosahexaenoic Acid)☆
50 mg
†
EPA (Eicosapentaenoic Acid)☆
42 mg
†
Top Medical Research Studies
8
High-dose vitamin D reduces anxiety
Effects of an 8-week high-dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post-COVID syndrome: A randomized controlled trial.
Directly assesses vitamin D's impact
We conducted a study to understand how high-dose vitamin D supplementation might impact anxiety levels, particularly in patients experiencing post-COVID symptoms. In our double-blind, randomized controlled trial, we enrolled 80 individuals dealing with fatigue or neuropsychiatric issues after COVID-19.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Read More
8
Link between Vitamin D and anxiety
Association of serum vitamin D with anxiety in US adults: a cross-sectional study.
High relevance for vitamin D research
We examined if there is a connection between vitamin D levels and anxiety among US adults, utilizing data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2012. The study included over 12,000 participants and employed sophisticated statistical methods to determine the relationship between serum vitamin D and anxiety.
Our analyses revealed that higher levels of serum vitamin D were associated with a lower risk of experiencing anxiety. Specifically, we found a significant inverse relationship; as vitamin D levels increased, the likelihood of anxiety decreased. This connection remained strong even after adjusting for various factors that could influence the results.
Furthermore, smooth curve fitting techniques confirmed a negative association between vitamin D and anxiety risk. Nonetheless, while these findings are promising, we emphasize the need for further prospective studies to validate these results and fully understand the implications of vitamin D on mental health.
Our analyses revealed that higher levels of serum vitamin D were associated with a lower risk of experiencing anxiety. Specifically, we found a significant inverse relationship; as vitamin D levels increased, the likelihood of anxiety decreased. This connection remained strong even after adjusting for various factors that could influence the results.
Furthermore, smooth curve fitting techniques confirmed a negative association between vitamin D and anxiety risk. Nonetheless, while these findings are promising, we emphasize the need for further prospective studies to validate these results and fully understand the implications of vitamin D on mental health.
Read More
8
DHA improves milk and reduces anxiety
DHA Supplementation of Obese Rats throughout Pregnancy and Lactation Modifies Milk Composition and Anxiety Behavior of Offspring.
High relevance for anxiety research
We explored how supplementing obese mothers with docosahexaenoic acid (DHA) affects milk composition and the anxiety behavior of their offspring. In a study involving female Wistar rats, some were placed on a high-fat diet while others ate regular chow. We supplemented half of the mothers from one month before mating until they weaned their pups with DHA. The goal was to see if this supplementation could improve the quality of their milk and influence the anxiety levels of their babies.
Our findings indicated that the obese mother rats exhibited higher weight and fat levels and their milk contained less beneficial DHA but more corticosterone and leptin. Notably, their offspring showed a higher ratio of omega-6 to omega-3 fatty acids in the milk they consumed, which correlates to increased anxiety levels, especially in female pups. In contrast, those mothers who received DHA supplements had lower body weight and fat and produced milk with higher DHA content. Their offspring not only had a better balance of omega-6 to omega-3 fatty acids but also demonstrated reduced anxiety compared to those from mothers without supplementation.
Overall, this study highlights the significant positive impact of DHA supplementation during pregnancy and lactation in obese rats, as it not only improves the nutritional quality of their milk but also helps decrease anxiety levels in the offspring in a sex-dependent manner.
Our findings indicated that the obese mother rats exhibited higher weight and fat levels and their milk contained less beneficial DHA but more corticosterone and leptin. Notably, their offspring showed a higher ratio of omega-6 to omega-3 fatty acids in the milk they consumed, which correlates to increased anxiety levels, especially in female pups. In contrast, those mothers who received DHA supplements had lower body weight and fat and produced milk with higher DHA content. Their offspring not only had a better balance of omega-6 to omega-3 fatty acids but also demonstrated reduced anxiety compared to those from mothers without supplementation.
Overall, this study highlights the significant positive impact of DHA supplementation during pregnancy and lactation in obese rats, as it not only improves the nutritional quality of their milk but also helps decrease anxiety levels in the offspring in a sex-dependent manner.
Read More
Most Useful Reviews
8.8
Mood improvement
I initially took this for fertility due to low vitamin D levels. However, the improvement in my moods and clinical depression has been significant. I battle social anxiety and have noticed a difference socially. The capsules are tiny and easy to swallow. This will be a permanent part of my supplement regimen.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.4
- All Researches
9
DHA reduces anxiety risk
Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults.
Relevant but not conclusive
We explored the potential benefits of docosahexaenoic acid (DHA) in reducing anxiety among middle-aged and elderly adults. This was part of a larger study involving over 102,000 participants, where we assessed the impact of various polyunsaturated fatty acids (PUFAs) on mental health conditions, including anxiety and depression.
Our findings indicated that higher plasma levels of DHA, as well as omega-3 PUFAs in general, were linked to a lower risk of developing anxiety disorders. Specifically, we noted that participants in the highest quartile of PUFA levels, including DHA, showed a 14% reduction in the hazard of incident anxiety compared to those in the lowest quartile.
Further analysis of psychological symptoms revealed that those with elevated omega-3 PUFA levels, prominently DHA, experienced fewer adverse mental health issues. While we also considered white matter microstructures through neuroimaging with a subgroup of participants, the specific mechanisms behind DHA's positive effects on anxiety remain an area for future research.
Our findings indicated that higher plasma levels of DHA, as well as omega-3 PUFAs in general, were linked to a lower risk of developing anxiety disorders. Specifically, we noted that participants in the highest quartile of PUFA levels, including DHA, showed a 14% reduction in the hazard of incident anxiety compared to those in the lowest quartile.
Further analysis of psychological symptoms revealed that those with elevated omega-3 PUFA levels, prominently DHA, experienced fewer adverse mental health issues. While we also considered white matter microstructures through neuroimaging with a subgroup of participants, the specific mechanisms behind DHA's positive effects on anxiety remain an area for future research.
Read More
9
Omega-3s alleviate juvenile anxiety
Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression.
Moderate relevance; ingredient effects unclear
We investigated the effects of omega-3 fatty acids, particularly docosahexaenoic acid (DHA), on anxiety-like behaviors in juvenile mice subjected to a stress model. By exposing one-month-old C57/BL6 mice to alternating ultrasound frequencies designed to induce stress, we could observe the behavioral changes that occurred.
Mice were divided into two groups: one received a food supplement containing DHA and eicosapentaenoic acid (EPA), while the other group was given a placebo. After three weeks, we found that the stressed mice treated with the omega-3 supplement showed significant improvement. They displayed less anxiety-like behavior and did not show the typical signs of depression, such as decreased interest in sweet foods, which reflects anhedonia.
Interestingly, our analysis revealed that omega-3 supplementation seemed to counteract the negative effects induced by stress, likely due to its anti-inflammatory properties. In non-stressed mice, DHA also helped minimize anxiety symptoms, suggesting that these benefits could extend beyond just those experiencing stress. Overall, these findings suggest that omega-3 fatty acids like DHA may hold promise as a treatment approach for anxiety, particularly in vulnerable young individuals.
Mice were divided into two groups: one received a food supplement containing DHA and eicosapentaenoic acid (EPA), while the other group was given a placebo. After three weeks, we found that the stressed mice treated with the omega-3 supplement showed significant improvement. They displayed less anxiety-like behavior and did not show the typical signs of depression, such as decreased interest in sweet foods, which reflects anhedonia.
Interestingly, our analysis revealed that omega-3 supplementation seemed to counteract the negative effects induced by stress, likely due to its anti-inflammatory properties. In non-stressed mice, DHA also helped minimize anxiety symptoms, suggesting that these benefits could extend beyond just those experiencing stress. Overall, these findings suggest that omega-3 fatty acids like DHA may hold promise as a treatment approach for anxiety, particularly in vulnerable young individuals.
Read More
9
DHA improves anxiety in obesity
Fish oil supplementation alleviates metabolic and anxiodepressive effects of diet-induced obesity and associated changes in brain lipid composition in mice.
Moderate relevance with fish oil
We examined the effects of docosahexaenoic acid (DHA), found in fish oil, on anxiety and mood in mice fed a high-fat diet. In our study, male C57Bl/6J mice were divided into groups, with some receiving a standard diet and others consuming a saturated high-fat diet (HFD) for 20 weeks. Over the last five weeks, half of the mice received daily doses of fish oil, while the others received a control corn oil.
What we discovered was quite revealing. The supplementation of fish oil rich in DHA—and another fatty acid, eicosapentaenoic acid (EPA)—not only reduced food intake and corrected glucose intolerance but also significantly improved anxiety and depressive-like behaviors in the mice. This was assessed through various behavioral tests that highlight changes in activity and mood.
Beyond the behavioral improvements, we observed that these dietary changes influenced brain chemistry as well. Fish oil supplementation promoted healthier brain lipid profiles and reduced markers of inflammation and microglial activation, which are known to be linked with a state of anxiety and depression.
These compelling findings suggest that incorporating DHA, alongside EPA, into our diets could potentially provide a natural way to alleviate mood and metabolic disorders triggered by obesity.
What we discovered was quite revealing. The supplementation of fish oil rich in DHA—and another fatty acid, eicosapentaenoic acid (EPA)—not only reduced food intake and corrected glucose intolerance but also significantly improved anxiety and depressive-like behaviors in the mice. This was assessed through various behavioral tests that highlight changes in activity and mood.
Beyond the behavioral improvements, we observed that these dietary changes influenced brain chemistry as well. Fish oil supplementation promoted healthier brain lipid profiles and reduced markers of inflammation and microglial activation, which are known to be linked with a state of anxiety and depression.
These compelling findings suggest that incorporating DHA, alongside EPA, into our diets could potentially provide a natural way to alleviate mood and metabolic disorders triggered by obesity.
Read More
9
EPA supplementation reduces anxiety
Fish oil supplementation alleviates metabolic and anxiodepressive effects of diet-induced obesity and associated changes in brain lipid composition in mice.
Moderate relevance due to compound inclusion
We explored how eicosapentaenoic acid (EPA), found in fish oil, impacts anxiety and mood disorders related to obesity. In our study, male mice were fed a high-fat diet for 20 weeks, which led to weight gain and anxiety-like behaviors.
To see if EPA could help, we administered fish oil enriched with equal amounts of EPA and DHA for the last five weeks of the study. The results were quite promising. Mice that received the fish oil not only showed reduced anxiety behaviors but also demonstrated improved metabolic health.
Specifically, these mice had better glucose tolerance and reduced food intake, indicating that fish oil could potentially correct some of the metabolic issues that come with obesity. Overall, the addition of EPA-rich fish oil appears to lessen both anxiety and metabolic disturbances caused by a saturated high-fat diet, suggesting its potential benefits for mood and health in similar conditions.
To see if EPA could help, we administered fish oil enriched with equal amounts of EPA and DHA for the last five weeks of the study. The results were quite promising. Mice that received the fish oil not only showed reduced anxiety behaviors but also demonstrated improved metabolic health.
Specifically, these mice had better glucose tolerance and reduced food intake, indicating that fish oil could potentially correct some of the metabolic issues that come with obesity. Overall, the addition of EPA-rich fish oil appears to lessen both anxiety and metabolic disturbances caused by a saturated high-fat diet, suggesting its potential benefits for mood and health in similar conditions.
Read More
9
Dietary omega-3s combat stress
Preventing adolescent stress-induced cognitive and microbiome changes by diet.
Study assesses broader dietary impacts
We explored how a diet rich in specific nutrients, including eicosapentaenoic acid (an omega-3 fatty acid), can impact cognitive function and anxiety levels in adolescents. Using a mild stress model, we focused on the effects of social instability stress on young rats, which led to noticeable cognitive and behavioral changes.
Our findings revealed that when these stressed rats were given a prolonged diet enriched with eicosapentaenoic acid, docosahexaenoic acid, and vitamin A, their performance in memory tests improved significantly. In fact, their anxiety levels and cognitive function returned to levels comparable to those of non-stressed rats.
We also observed that the enriched diet helped normalize brain chemistry and the balance of gut microbiota, both of which were disrupted by stress. Importantly, these positive changes persisted into adulthood, indicating that proper nutrition during stressful periods could have long-lasting benefits.
By highlighting the protective effects of eicosapentaenoic acid within a nutritious diet, we suggest exciting possibilities for using diet to help manage stress and anxiety during key developmental years.
Our findings revealed that when these stressed rats were given a prolonged diet enriched with eicosapentaenoic acid, docosahexaenoic acid, and vitamin A, their performance in memory tests improved significantly. In fact, their anxiety levels and cognitive function returned to levels comparable to those of non-stressed rats.
We also observed that the enriched diet helped normalize brain chemistry and the balance of gut microbiota, both of which were disrupted by stress. Importantly, these positive changes persisted into adulthood, indicating that proper nutrition during stressful periods could have long-lasting benefits.
By highlighting the protective effects of eicosapentaenoic acid within a nutritious diet, we suggest exciting possibilities for using diet to help manage stress and anxiety during key developmental years.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Mood improvement
I initially took this for fertility due to low vitamin D levels. However, the improvement in my moods and clinical depression has been significant. I battle social anxiety and have noticed a difference socially. The capsules are tiny and easy to swallow. This will be a permanent part of my supplement regimen.
Read More
