' 
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.5
USERS' SCORE
Good
Based on 20 Reviews
8.8
Supplement Facts
Serving Size: 2 caplets
Amount Per Serving
%DV
Total Sugars
0 g
**
Includes 0g Added Sugars
0%*
Sugar Alcohol
0 g
**
Vitamin D
25 mcg (1000 IU)
125%
Calcium
1200 mg
92%
Magnesium
80 mg
19%
Sodium
5 mg
<1%
*Percent Daily Values are based on the a 2,000 calorie diet.**Daily Value not established
Top Medical Research Studies
9
Calcium and vitamin D reduce fractures
Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation.
Significant relevance for osteoporosis
We examined a collection of randomized controlled trials to determine the impact of calcium plus vitamin D supplementation on fracture prevention.
The results revealed a promising 15% reduction in total fractures and a remarkable 30% drop in hip fractures among those taking these supplements.
This convincing evidence supports the recommendation of calcium and vitamin D for reducing fracture risk, especially in older adults, whether living at home or in care facilities.
The results revealed a promising 15% reduction in total fractures and a remarkable 30% drop in hip fractures among those taking these supplements.
This convincing evidence supports the recommendation of calcium and vitamin D for reducing fracture risk, especially in older adults, whether living at home or in care facilities.
Read More
8
Vitamin D's impact on osteoporosis
The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis.
Highly relevant to osteoporosis treatment
We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
Read More
7
Vitamin D and osteoporosis insight
Daily or intermittent vitamin D supplementation in patients with or at risk of osteoporosis: Position statement from the GRIO.
High relevance for osteoporosis treatment
We explored the effects of vitamin D supplementation on osteoporosis, especially among individuals at risk for this condition. The Osteoporosis Research and Information Group (GRIO) highlighted the critical difference between daily and intermittent vitamin D dosing.
Current literature indicates that taking high doses of vitamin D intermittently, such as 60,000 IU a month, can actually elevate the chances of falls, fractures, and even premature death in some groups. Conversely, daily supplementation of 800-1000 IU, particularly alongside calcium, has been shown to reduce falls and non-vertebral fractures in the elderly who have a vitamin D deficiency.
Before anyone starts supplementing, it is crucial to measure their vitamin D levels to achieve a target concentration of 30 to 60 ng/mL. For those needing a quick boost in vitamin D levels—like patients showing symptoms of osteomalacia or those with critically low vitamin D—a starting loading dose followed by daily maintenance is the preferred approach. If daily options aren’t available, of course, a smaller intermittent dose can be a temporary solution until better options are accessible.
Current literature indicates that taking high doses of vitamin D intermittently, such as 60,000 IU a month, can actually elevate the chances of falls, fractures, and even premature death in some groups. Conversely, daily supplementation of 800-1000 IU, particularly alongside calcium, has been shown to reduce falls and non-vertebral fractures in the elderly who have a vitamin D deficiency.
Before anyone starts supplementing, it is crucial to measure their vitamin D levels to achieve a target concentration of 30 to 60 ng/mL. For those needing a quick boost in vitamin D levels—like patients showing symptoms of osteomalacia or those with critically low vitamin D—a starting loading dose followed by daily maintenance is the preferred approach. If daily options aren’t available, of course, a smaller intermittent dose can be a temporary solution until better options are accessible.
Read More
Most Useful Reviews
9.5
Lifesaver for bones
This product has been a lifesaver for my bones. At age 63 with osteoarthritis, osteoporosis, and degenerative disc disease, I faced multiple breaks. Since my doctor recommended this over two years ago, I’ve only had one break from a fall, and it strengthens my bones.
Read More
9.3
Improved bone density
Better with slow release—since I began this instead of regular Citracal, I believe it's better for me. It's absorbed more effectively as it releases throughout the day. I have osteoporosis, and after the removal of a parathyroid gland, I require a calcium supplement that works. My surgeon suggested Citracal post-operation, and I followed that advice, but switched to this one. As a registered nurse, I understand the importance of slow absorption. So far, my bone densities have improved with this and Reclast IV. Now, I am off Reclast and managing well without any broken bones.
Read More
9.5
Improved health metrics
Since starting these tablets after my osteoporosis diagnosis, they have been effective. My lab results and density tests indicate positive improvements.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.5
- All Researches
9
Calcium, Vitamin D, Zinc aids osteoporosis
Effects of a calcium/vitamin D/Zinc combination on anti-osteoporosis in ovariectomized rats.
Relevant and promising findings
We explored how the combination of calcium, vitamin D, and zinc impacts osteoporosis in ovariectomized rats. Using a well-structured study design, we divided 49 rats into various groups to compare results against a control.
Our findings suggest that this combined supplement helps enhance calcium absorption and reduces bone deterioration by lowering specific osteoporosis-related factors. This could point toward a potential alternative treatment for postmenopausal osteoporosis, though further research in humans is necessary.
Our findings suggest that this combined supplement helps enhance calcium absorption and reduces bone deterioration by lowering specific osteoporosis-related factors. This could point toward a potential alternative treatment for postmenopausal osteoporosis, though further research in humans is necessary.
Read More
9
Teriparatide enhances bone density
Teriparatide Treatment in Patients with Pregnancy- and Lactation-Associated Osteoporosis.
Significant relevance to osteoporosis treatment
We examined the effects of teriparatide combined with calcium and vitamin D versus standard calcium and vitamin D treatment on bone health in premenopausal women with pregnancy- and lactation-associated osteoporosis.
In our study, 19 women received teriparatide, while 8 only received calcium and vitamin D over 24 months. Results showed that those treated with teriparatide experienced significantly greater increases in bone mineral density at the lumbar spine after 12 and 24 months, indicating better bone health outcomes.
Overall, we found that teriparatide treatment substantially benefits women facing this rare condition.
In our study, 19 women received teriparatide, while 8 only received calcium and vitamin D over 24 months. Results showed that those treated with teriparatide experienced significantly greater increases in bone mineral density at the lumbar spine after 12 and 24 months, indicating better bone health outcomes.
Overall, we found that teriparatide treatment substantially benefits women facing this rare condition.
Read More
9
Nanoscale calcium salts improve osteoporosis
Nanoscale Calcium Salt-Based Formulations As Potential Therapeutics for Osteoporosis.
High relevance for osteoporosis treatment
We focused on the potential of nanoscale calcium salt formulations combined with vitamin D and natural minerals to treat osteoporosis. In our study, these innovative formulations showed promising results by enhancing bone density and reducing bone resorption in osteoporotic rats.
The tablets increased osteoblast activity and decreased osteoclast activity without causing toxicity. This dual action positions these calcium salt nanocomposites as a novel approach in osteoporosis management, offering a safer alternative to traditional treatments.
The tablets increased osteoblast activity and decreased osteoclast activity without causing toxicity. This dual action positions these calcium salt nanocomposites as a novel approach in osteoporosis management, offering a safer alternative to traditional treatments.
Read More
9
Calcium and vitamin D enhance treatment
Vitamin D and Calcium Addition during Denosumab Therapy over a Period of Four Years Significantly Improves Lumbar Bone Mineral Density in Japanese Osteoporosis Patients.
Highly relevant to osteoporosis care
We explored how adding vitamin D and calcium to denosumab therapy impacts bone health in patients with primary osteoporosis over four years.
The study involved two groups: one receiving just denosumab and another receiving denosumab with vitamin D and calcium.
Both groups saw improvements in bone health, but the combination group showed significant gains in hip bone density at 12 months and lumbar bone density from 24 to 48 months.
This suggests that ongoing vitamin D and calcium supplementation is beneficial alongside denosumab treatment.
The study involved two groups: one receiving just denosumab and another receiving denosumab with vitamin D and calcium.
Both groups saw improvements in bone health, but the combination group showed significant gains in hip bone density at 12 months and lumbar bone density from 24 to 48 months.
This suggests that ongoing vitamin D and calcium supplementation is beneficial alongside denosumab treatment.
Read More
9
Calcium and vitamin D reduce fractures
Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation.
Significant relevance for osteoporosis
We examined a collection of randomized controlled trials to determine the impact of calcium plus vitamin D supplementation on fracture prevention.
The results revealed a promising 15% reduction in total fractures and a remarkable 30% drop in hip fractures among those taking these supplements.
This convincing evidence supports the recommendation of calcium and vitamin D for reducing fracture risk, especially in older adults, whether living at home or in care facilities.
The results revealed a promising 15% reduction in total fractures and a remarkable 30% drop in hip fractures among those taking these supplements.
This convincing evidence supports the recommendation of calcium and vitamin D for reducing fracture risk, especially in older adults, whether living at home or in care facilities.
Read More
User Reviews
USERS' SCORE
Good
Based on 20 Reviews
8.8
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Lifesaver for bones
This product has been a lifesaver for my bones. At age 63 with osteoarthritis, osteoporosis, and degenerative disc disease, I faced multiple breaks. Since my doctor recommended this over two years ago, I’ve only had one break from a fall, and it strengthens my bones.
9.3
Improved bone density
Better with slow release—since I began this instead of regular Citracal, I believe it's better for me. It's absorbed more effectively as it releases throughout the day. I have osteoporosis, and after the removal of a parathyroid gland, I require a calcium supplement that works. My surgeon suggested Citracal post-operation, and I followed that advice, but switched to this one. As a registered nurse, I understand the importance of slow absorption. So far, my bone densities have improved with this and Reclast IV. Now, I am off Reclast and managing well without any broken bones.
Read More
9.5
Improved health metrics
Since starting these tablets after my osteoporosis diagnosis, they have been effective. My lab results and density tests indicate positive improvements.
9.5
Pain relief post-chemo
Mom helped after chemotherapy. I've bought this calcium for her before, as her osteoporosis worsened due to chemotherapy, leading to pain. The doctor advised calcium intake, and after starting it, her pain subsided. She said, “Calcium helped me immensely: my fingers ached post-chemo, but the calcium alleviated the pain.” My sister also benefited, as she could not raise her arms due to shoulder pain; after taking calcium, she can now lift them above her shoulders.
Read More
9.5
Works effectively
Brilliant! This product works well. My mother uses these pills for her osteoporosis.
