Last update
5/30/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 4 Reviews
8.9
Top Medical Research Studies
8
Sodium alginate's effect on neuropathy
We examined whether sodium alginate (SA), a natural substance from brown algae, can effectively treat diabetic neuropathy in rats induced by streptozotocin (STZ).
Over 28 days, we administered SA to rats and observed various health indicators, like insulin levels and the structure of nerve fibers.
While SA showed promise in balancing certain parameters and reducing inflammation, it did not have a significant effect on all aspects of diabetic neuropathy. This suggests that, while there are benefits, we still need more effective therapeutic options.
Over 28 days, we administered SA to rats and observed various health indicators, like insulin levels and the structure of nerve fibers.
While SA showed promise in balancing certain parameters and reducing inflammation, it did not have a significant effect on all aspects of diabetic neuropathy. This suggests that, while there are benefits, we still need more effective therapeutic options.
Read More
Most Useful Reviews
10
Burning feet relieved
70 people found this helpful
THE ONLY PRODUCT FOR ME!!! LITERALLY SAVED MY LIFE. I cannot speak for others, only for myself. When you suffer from diabetic neuropathy and your feet burn, taking Jarrow Formula Methyl B-12 (5000 mcg) stops the burning! It works wonders. No buzzing or pins and needles, and I keep my stress down while controlling my sugar. I once bought a cheaper brand with folic acid and Vitamin C, but that was a BIG MISTAKE – my feet started burning again. I returned to the lovely Jarrow Methyl B-12 5000, and it was the best decision ever. Thanks, Jarrow!
Read More
10
Pain-free living
26 people found this helpful
Methyl B-12 has been a lifesaver for my severe diabetic neuropathy. After 2 1/2 years of suffering, I’m now virtually pain-free. I can walk without a limp and have the energy to exercise, which will help me long-term. Feeling helpless for so long, I finally feel as if I have my life back. Though it may sound exaggerated, I assure you it’s the truth. People around me are amazed at the transformation.
Read More
9
Effective dosage
10 people found this helpful
This higher dosage worked wonders for my neuropathy! Taking one Jarrow 5000 mcg Methyl B-12 lozenge every third day has effectively combat my neuropathic pain in my feet. AND IT WORKS!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
Sodium alginate's effect on neuropathy
We examined whether sodium alginate (SA), a natural substance from brown algae, can effectively treat diabetic neuropathy in rats induced by streptozotocin (STZ).
Over 28 days, we administered SA to rats and observed various health indicators, like insulin levels and the structure of nerve fibers.
While SA showed promise in balancing certain parameters and reducing inflammation, it did not have a significant effect on all aspects of diabetic neuropathy. This suggests that, while there are benefits, we still need more effective therapeutic options.
Over 28 days, we administered SA to rats and observed various health indicators, like insulin levels and the structure of nerve fibers.
While SA showed promise in balancing certain parameters and reducing inflammation, it did not have a significant effect on all aspects of diabetic neuropathy. This suggests that, while there are benefits, we still need more effective therapeutic options.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.9
- All Reviews
- Positive Reviews
- Negative Reviews
10
Burning feet relieved
70 people found this helpful
THE ONLY PRODUCT FOR ME!!! LITERALLY SAVED MY LIFE. I cannot speak for others, only for myself. When you suffer from diabetic neuropathy and your feet burn, taking Jarrow Formula Methyl B-12 (5000 mcg) stops the burning! It works wonders. No buzzing or pins and needles, and I keep my stress down while controlling my sugar. I once bought a cheaper brand with folic acid and Vitamin C, but that was a BIG MISTAKE – my feet started burning again. I returned to the lovely Jarrow Methyl B-12 5000, and it was the best decision ever. Thanks, Jarrow!
Read More
10
Pain-free living
26 people found this helpful
Methyl B-12 has been a lifesaver for my severe diabetic neuropathy. After 2 1/2 years of suffering, I’m now virtually pain-free. I can walk without a limp and have the energy to exercise, which will help me long-term. Feeling helpless for so long, I finally feel as if I have my life back. Though it may sound exaggerated, I assure you it’s the truth. People around me are amazed at the transformation.
Read More
9
Effective dosage
10 people found this helpful
This higher dosage worked wonders for my neuropathy! Taking one Jarrow 5000 mcg Methyl B-12 lozenge every third day has effectively combat my neuropathic pain in my feet. AND IT WORKS!
Read More
9
No more discomfort
8 people found this helpful
I’m a type 2 diabetic experiencing burning sensations in my toes nightly. I tried this based on reviews, and for the first time in ages, I didn’t have any discomfort. I can confidently say that this works.
Read More
Frequently Asked Questions
10
Pain-free living
26 people found this helpful
Methyl B-12 has been a lifesaver for my severe diabetic neuropathy. After 2 1/2 years of suffering, I’m now virtually pain-free. I can walk without a limp and have the energy to exercise, which will help me long-term. Feeling helpless for so long, I finally feel as if I have my life back. Though it may sound exaggerated, I assure you it’s the truth. People around me are amazed at the transformation.
9
No more discomfort
8 people found this helpful
I’m a type 2 diabetic experiencing burning sensations in my toes nightly. I tried this based on reviews, and for the first time in ages, I didn’t have any discomfort. I can confidently say that this works.
10
Burning feet relieved
70 people found this helpful
THE ONLY PRODUCT FOR ME!!! LITERALLY SAVED MY LIFE. I cannot speak for others, only for myself. When you suffer from diabetic neuropathy and your feet burn, taking Jarrow Formula Methyl B-12 (5000 mcg) stops the burning! It works wonders. No buzzing or pins and needles, and I keep my stress down while controlling my sugar. I once bought a cheaper brand with folic acid and Vitamin C, but that was a BIG MISTAKE – my feet started burning again. I returned to the lovely Jarrow Methyl B-12 5000, and it was the best decision ever. Thanks, Jarrow!
9
Effective dosage
10 people found this helpful
This higher dosage worked wonders for my neuropathy! Taking one Jarrow 5000 mcg Methyl B-12 lozenge every third day has effectively combat my neuropathic pain in my feet. AND IT WORKS!
References
- Mohamed NA, Shouran NM, Essawy AE, Abdel-Moneim AM, Abdel Salam S. Mitigative effect of sodium alginate on streptozotocin (STZ)-induced diabetic neuropathy through regulation of redox status and miR-146a in the rat sciatic nerve. PeerJ. 2025;13:e19046. 10.7717/peerj.19046
