Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.6
USERS' SCORE
Good
Based on 9 Reviews
8.4
Supplement Facts
Serving Size: 1 tablet
Amount Per Serving
%DV
Selenium (as L-selenomethionine)
100 mcg
182%
Top Medical Research Studies
8
We explored the effects of selenium supplementation in patients suffering from Hashimoto thyroiditis (HT), a leading cause of hypothyroidism. By analyzing multiple randomized controlled trials, we aimed to see how selenium might impact thyroid function, particularly focusing on thyroid-stimulating hormone (TSH) levels and thyroid antibodies.
Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.
Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.
However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.
Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.
Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.
However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.
Read More
9
We conducted a double-blinded, randomized controlled trial to investigate how selenium affects individuals with autoimmune hypothyroidism. In our study, we divided 144 patients into two groups, one receiving a combination of levothyroxine (a common thyroid treatment) and selenium, while the other group was given a placebo along with the same thyroid medication. This design allowed us to effectively measure the results and make a fair comparison between the two groups.
After three months of treatment, we observed some interesting changes. The group that took selenium showed a significant reduction in anti-Tg antibodies—markers associated with thyroid autoimmunity—compared to the placebo group. We also found that their TSH levels decreased significantly, while their free T4 levels increased. This suggests that selenium not only helps lower immune system activity against the thyroid but also supports overall thyroid function.
Our findings suggest that incorporating selenium into the treatment plan for autoimmune hypothyroidism could be beneficial for patients. While this doesn't isolate selenium’s effects completely, as it was taken alongside levothyroxine, the results indicate its potential in managing thyroid health effectively.
After three months of treatment, we observed some interesting changes. The group that took selenium showed a significant reduction in anti-Tg antibodies—markers associated with thyroid autoimmunity—compared to the placebo group. We also found that their TSH levels decreased significantly, while their free T4 levels increased. This suggests that selenium not only helps lower immune system activity against the thyroid but also supports overall thyroid function.
Our findings suggest that incorporating selenium into the treatment plan for autoimmune hypothyroidism could be beneficial for patients. While this doesn't isolate selenium’s effects completely, as it was taken alongside levothyroxine, the results indicate its potential in managing thyroid health effectively.
Read More
8
We delved into the impact of nano-selenium on hypothyroidism, particularly how it might alleviate related oxidative stress in the liver and kidneys. In the study, rats were divided into different groups, including a control group and those treated with propylthiouracil (PTU) to induce hypothyroidism. Some of the hypothyroid rats also received varying doses of nano-selenium to assess its effects.
Over a six-week period, we measured indicators of liver and kidney function, such as specific enzyme levels and markers for oxidative damage. Results showed that hypothyroidism significantly increased levels of harmful substances while decreasing beneficial ones. However, when nano-selenium was administered, we observed a noticeable improvement in these key indicators.
Overall, the presence of nano-selenium appeared to protect against the damaging effects of hypothyroidism, helping to restore balance in oxidative stress levels. This suggests that selenium may hold promise as a supportive treatment for liver and kidney health in individuals with thyroid disorders. Future research will help us understand the specific mechanisms behind these positive effects.
Over a six-week period, we measured indicators of liver and kidney function, such as specific enzyme levels and markers for oxidative damage. Results showed that hypothyroidism significantly increased levels of harmful substances while decreasing beneficial ones. However, when nano-selenium was administered, we observed a noticeable improvement in these key indicators.
Overall, the presence of nano-selenium appeared to protect against the damaging effects of hypothyroidism, helping to restore balance in oxidative stress levels. This suggests that selenium may hold promise as a supportive treatment for liver and kidney health in individuals with thyroid disorders. Future research will help us understand the specific mechanisms behind these positive effects.
Read More
Most Useful Reviews
9
Enhanced thyroid function
36 people found this helpful
One of the best options available, this version of selenium has a good reputation. The round tablets, covered with a thin soluble film, are easy to break in half. When initially opened, they have a typical supplement smell that fades quickly. The 100 mg dosage is quite convenient: I take two, while my husband takes one. For my child with ARVI, it offers additional support. Selenium is crucial for thyroid function and is essential for managing hypothyroidism, particularly when combined with zinc, iodine, and vitamins D3. This combination enhances strength, energy, and mood. Selenium also aids in converting the hormone T4 to T3, which is vital for proper health.
Read More
7.5
Balances thyroid function
25 people found this helpful
This selenium effectively balances the thyroid gland's function. A deficiency can sometimes be the sole cause of hypothyroidism; thus, consulting an endocrinologist may be necessary for a selenium and iodine course. Dietary supplements are often required as the selenium content in food can vary based on soil quality. While selenium can cause dermatitis and hair loss if overdosed, I appreciate this one for its lower dosage of 100 mcg compared to others that offer 200 mcg.
Read More
7.5
Combination boosts effectiveness
18 people found this helpful
I found this product good—bioavailable and easy to consume; the dosage is ideal. A big plus is that it is yeast-free. Since I take it alongside vitamin E and iodine, the combined effect is substantial for my hypothyroid condition. Selenium assists in iodine absorption, which helps improve my menstrual cycle stability. I notice a marked difference when I take it versus when I do not, feeling less drowsy and more energetic when I do.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.6
- All Researches
9
We conducted a double-blinded, randomized controlled trial to investigate how selenium affects individuals with autoimmune hypothyroidism. In our study, we divided 144 patients into two groups, one receiving a combination of levothyroxine (a common thyroid treatment) and selenium, while the other group was given a placebo along with the same thyroid medication. This design allowed us to effectively measure the results and make a fair comparison between the two groups.
After three months of treatment, we observed some interesting changes. The group that took selenium showed a significant reduction in anti-Tg antibodies—markers associated with thyroid autoimmunity—compared to the placebo group. We also found that their TSH levels decreased significantly, while their free T4 levels increased. This suggests that selenium not only helps lower immune system activity against the thyroid but also supports overall thyroid function.
Our findings suggest that incorporating selenium into the treatment plan for autoimmune hypothyroidism could be beneficial for patients. While this doesn't isolate selenium’s effects completely, as it was taken alongside levothyroxine, the results indicate its potential in managing thyroid health effectively.
After three months of treatment, we observed some interesting changes. The group that took selenium showed a significant reduction in anti-Tg antibodies—markers associated with thyroid autoimmunity—compared to the placebo group. We also found that their TSH levels decreased significantly, while their free T4 levels increased. This suggests that selenium not only helps lower immune system activity against the thyroid but also supports overall thyroid function.
Our findings suggest that incorporating selenium into the treatment plan for autoimmune hypothyroidism could be beneficial for patients. While this doesn't isolate selenium’s effects completely, as it was taken alongside levothyroxine, the results indicate its potential in managing thyroid health effectively.
Read More
9
Selenium aids subclinical hypothyroidism
We approached the intriguing question of whether selenium, when combined with myo-inositol, could help those dealing with subclinical hypothyroidism. This study involved 148 women of reproductive age, who had their thyroid stimulating hormone (TSH) levels monitored over a six-month period while taking daily supplements.
Throughout the study, we observed substantial improvements in TSH levels, as well as reductions in autoantibody titers, which are markers of thyroid autoimmune activity. Participants also reported better management of symptoms typically associated with hypothyroidism, including more regular menstrual cycles and lower cholesterol levels. Remarkably, these benefits appeared alongside the treatment quite consistently.
Overall, the findings suggest that incorporating selenium and myo-inositol into the treatment plan for subclinical hypothyroidism could be quite beneficial. This combination may not only help stabilize thyroid function but could also improve the quality of life for women affected by this condition. The study holds promise for those seeking alternative options to manage their thyroid health effectively.
Throughout the study, we observed substantial improvements in TSH levels, as well as reductions in autoantibody titers, which are markers of thyroid autoimmune activity. Participants also reported better management of symptoms typically associated with hypothyroidism, including more regular menstrual cycles and lower cholesterol levels. Remarkably, these benefits appeared alongside the treatment quite consistently.
Overall, the findings suggest that incorporating selenium and myo-inositol into the treatment plan for subclinical hypothyroidism could be quite beneficial. This combination may not only help stabilize thyroid function but could also improve the quality of life for women affected by this condition. The study holds promise for those seeking alternative options to manage their thyroid health effectively.
Read More
8
Selenium and myo-inositol efficacy
We explored the impact of selenium supplementation on patients with autoimmune thyroiditis, particularly focusing on its effectiveness in restoring normal thyroid function. The study compared the effects of selenium alone against a combination therapy of selenium and myo-inositol (referred to as MI + Se).
Through a systematic review of three studies involving 288 participants, we observed that the combined treatment of selenium and myo-inositol resulted in a notable decrease in thyroid-stimulating hormone (TSH) levels. This suggests that combining these two supplements may enhance the restoring of thyroid function better than selenium alone.
However, while we noted significant reductions in TSH and thyroglobulin antibodies, other measures like TPO antibodies, T3, and T4 levels showed minimal or no significant changes. This indicates that while the MI + Se treatment could help in some areas, more extensive research is necessary to fully understand its effectiveness and to perhaps confirm these findings with larger, long-term studies.
Through a systematic review of three studies involving 288 participants, we observed that the combined treatment of selenium and myo-inositol resulted in a notable decrease in thyroid-stimulating hormone (TSH) levels. This suggests that combining these two supplements may enhance the restoring of thyroid function better than selenium alone.
However, while we noted significant reductions in TSH and thyroglobulin antibodies, other measures like TPO antibodies, T3, and T4 levels showed minimal or no significant changes. This indicates that while the MI + Se treatment could help in some areas, more extensive research is necessary to fully understand its effectiveness and to perhaps confirm these findings with larger, long-term studies.
Read More
8
We investigated how selenium affects thyroid function in older Chinese adults, focusing particularly on its potential impact on hypothyroidism. Our study included participants aged 65 and older, who provided samples of their fingernails and whole blood for analysis. We specifically looked at hormone levels, including thyroid stimulating hormone (TSH) and various forms of thyroxine, to assess thyroid health.
Our findings revealed a strong positive association between selenium levels in the blood and fingernails, suggesting that higher selenium status is linked with lower TSH levels. We observed that participants in higher selenium quartiles had lower TSH, which is typically associated with less risk of hypothyroidism. For instance, those with the highest selenium levels showed a reduced odds ratio for hypothyroidism.
However, our results also highlighted a complex relationship; while higher selenium levels seemed to lower the risk of hypothyroidism, they were simultaneously linked with an increased risk of hyperthyroidism. This dual effect suggests that selenium status also plays a role in thyroid dysfunctions, with both positive and negative implications for thyroid health.
In summary, higher selenium levels are associated with lower TSH levels and may reduce the risk of hypothyroidism, but they also pose a higher risk for hyperthyroidism in this older population. This study emphasizes the intricate balance of nutrients like selenium in managing thyroid health, particularly among aging adults.
Our findings revealed a strong positive association between selenium levels in the blood and fingernails, suggesting that higher selenium status is linked with lower TSH levels. We observed that participants in higher selenium quartiles had lower TSH, which is typically associated with less risk of hypothyroidism. For instance, those with the highest selenium levels showed a reduced odds ratio for hypothyroidism.
However, our results also highlighted a complex relationship; while higher selenium levels seemed to lower the risk of hypothyroidism, they were simultaneously linked with an increased risk of hyperthyroidism. This dual effect suggests that selenium status also plays a role in thyroid dysfunctions, with both positive and negative implications for thyroid health.
In summary, higher selenium levels are associated with lower TSH levels and may reduce the risk of hypothyroidism, but they also pose a higher risk for hyperthyroidism in this older population. This study emphasizes the intricate balance of nutrients like selenium in managing thyroid health, particularly among aging adults.
Read More
8
We observed the effects of selenium and zinc deficiencies on thyroid health in a particular case involving a 50-year-old man. This individual had undergone intestinal surgery, leaving him with a significant reduction in his small intestine. As a result, he was reliant on total parenteral nutrition (TPN) without trace element supplements for about six weeks.
During this period, lab tests indicated that his thyroid-stimulating hormone (TSH) levels were elevated, along with high free thyroxine (FT4) and low free triiodothyronine (FT3) levels—an unusual pattern that raised suspicion of selenium deficiency. After starting selenium supplementation, we were pleased to note an improvement: his FT3 levels increased, and FT4 levels returned to normal ranges, although TSH still showed some temporary elevation.
We considered that zinc deficiency could also play a role in this thyroid dysfunction. After introducing zinc into his treatment plan, we noticed a normalization of his overall thyroid function. This highlights the importance of evaluating both selenium and zinc levels when addressing thyroid health, particularly in patients on TPN.
Overall, while selenium supplementation showed significant improvement in the case, the role of zinc was also critical in fully resolving the thyroid dysfunction.
During this period, lab tests indicated that his thyroid-stimulating hormone (TSH) levels were elevated, along with high free thyroxine (FT4) and low free triiodothyronine (FT3) levels—an unusual pattern that raised suspicion of selenium deficiency. After starting selenium supplementation, we were pleased to note an improvement: his FT3 levels increased, and FT4 levels returned to normal ranges, although TSH still showed some temporary elevation.
We considered that zinc deficiency could also play a role in this thyroid dysfunction. After introducing zinc into his treatment plan, we noticed a normalization of his overall thyroid function. This highlights the importance of evaluating both selenium and zinc levels when addressing thyroid health, particularly in patients on TPN.
Overall, while selenium supplementation showed significant improvement in the case, the role of zinc was also critical in fully resolving the thyroid dysfunction.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Enhanced thyroid function
36 people found this helpful
One of the best options available, this version of selenium has a good reputation. The round tablets, covered with a thin soluble film, are easy to break in half. When initially opened, they have a typical supplement smell that fades quickly. The 100 mg dosage is quite convenient: I take two, while my husband takes one. For my child with ARVI, it offers additional support. Selenium is crucial for thyroid function and is essential for managing hypothyroidism, particularly when combined with zinc, iodine, and vitamins D3. This combination enhances strength, energy, and mood. Selenium also aids in converting the hormone T4 to T3, which is vital for proper health.
Read More
7.5
Balances thyroid function
25 people found this helpful
This selenium effectively balances the thyroid gland's function. A deficiency can sometimes be the sole cause of hypothyroidism; thus, consulting an endocrinologist may be necessary for a selenium and iodine course. Dietary supplements are often required as the selenium content in food can vary based on soil quality. While selenium can cause dermatitis and hair loss if overdosed, I appreciate this one for its lower dosage of 100 mcg compared to others that offer 200 mcg.
Read More
7.5
Combination boosts effectiveness
18 people found this helpful
I found this product good—bioavailable and easy to consume; the dosage is ideal. A big plus is that it is yeast-free. Since I take it alongside vitamin E and iodine, the combined effect is substantial for my hypothyroid condition. Selenium assists in iodine absorption, which helps improve my menstrual cycle stability. I notice a marked difference when I take it versus when I do not, feeling less drowsy and more energetic when I do.
Read More
9
Good for autoimmune thyroiditis
15 people found this helpful
This selenium offers excellent value. It's gluten and yeast-free, easily digestible, and comes at a good dosage. Selenium is essential for the thyroid's proper functioning. While iodine is necessary for hormone production, selenium is vital for converting inactive T4 into the active T3, crucial for those with autoimmune thyroiditis and hypothyroidism. The recommended intake for AIT is up to 200 micrograms daily, alongside adequate iodine, to prevent potential toxicity.
Read More
7.5
Improved health condition
3 people found this helpful
I take this selenium for my hypothyroidism and AIT at a 200 mcg dosage, as recommended by my doctor. My health has improved in combination with other medications. The selenium form here is organic, improving absorption and reducing the risk of side effects typically associated with inorganic selenium. The ability to adjust the dosage is also beneficial, and to date, I have experienced no adverse effects.
Read More
Frequently Asked Questions
7.5
Combination boosts effectiveness
18 people found this helpful
I found this product good—bioavailable and easy to consume; the dosage is ideal. A big plus is that it is yeast-free. Since I take it alongside vitamin E and iodine, the combined effect is substantial for my hypothyroid condition. Selenium assists in iodine absorption, which helps improve my menstrual cycle stability. I notice a marked difference when I take it versus when I do not, feeling less drowsy and more energetic when I do.
9
Slowed disease progression
2 people found this helpful
I use this for my Hashimoto's hypothyroidism. My doctor mentioned that studies link selenium to slowing the disease's progression. Although I need to take two pills since I couldn't find a 200 mcg version, the smaller size is manageable. I'm delighted with the result, as it has lowered my fasting blood glucose by 30 points.
9
Good for autoimmune thyroiditis
15 people found this helpful
This selenium offers excellent value. It's gluten and yeast-free, easily digestible, and comes at a good dosage. Selenium is essential for the thyroid's proper functioning. While iodine is necessary for hormone production, selenium is vital for converting inactive T4 into the active T3, crucial for those with autoimmune thyroiditis and hypothyroidism. The recommended intake for AIT is up to 200 micrograms daily, alongside adequate iodine, to prevent potential toxicity.
7.5
Improved health condition
3 people found this helpful
I take this selenium for my hypothyroidism and AIT at a 200 mcg dosage, as recommended by my doctor. My health has improved in combination with other medications. The selenium form here is organic, improving absorption and reducing the risk of side effects typically associated with inorganic selenium. The ability to adjust the dosage is also beneficial, and to date, I have experienced no adverse effects.
7.5
Better hormone assimilation
This vitamin is of excellent quality and worth the price. I take it to enhance the absorption of Eutirox for my hypothyroidism, following my endocrinologist's advice. The combination works much better.
7.5
Balances thyroid function
25 people found this helpful
This selenium effectively balances the thyroid gland's function. A deficiency can sometimes be the sole cause of hypothyroidism; thus, consulting an endocrinologist may be necessary for a selenium and iodine course. Dietary supplements are often required as the selenium content in food can vary based on soil quality. While selenium can cause dermatitis and hair loss if overdosed, I appreciate this one for its lower dosage of 100 mcg compared to others that offer 200 mcg.
8
We explored the effects of selenium supplementation in patients suffering from Hashimoto thyroiditis (HT), a leading cause of hypothyroidism. By analyzing multiple randomized controlled trials, we aimed to see how selenium might impact thyroid function, particularly focusing on thyroid-stimulating hormone (TSH) levels and thyroid antibodies.
Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.
Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.
However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.
Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.
Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.
However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.
9
We conducted a double-blinded, randomized controlled trial to investigate how selenium affects individuals with autoimmune hypothyroidism. In our study, we divided 144 patients into two groups, one receiving a combination of levothyroxine (a common thyroid treatment) and selenium, while the other group was given a placebo along with the same thyroid medication. This design allowed us to effectively measure the results and make a fair comparison between the two groups.
After three months of treatment, we observed some interesting changes. The group that took selenium showed a significant reduction in anti-Tg antibodies—markers associated with thyroid autoimmunity—compared to the placebo group. We also found that their TSH levels decreased significantly, while their free T4 levels increased. This suggests that selenium not only helps lower immune system activity against the thyroid but also supports overall thyroid function.
Our findings suggest that incorporating selenium into the treatment plan for autoimmune hypothyroidism could be beneficial for patients. While this doesn't isolate selenium’s effects completely, as it was taken alongside levothyroxine, the results indicate its potential in managing thyroid health effectively.
After three months of treatment, we observed some interesting changes. The group that took selenium showed a significant reduction in anti-Tg antibodies—markers associated with thyroid autoimmunity—compared to the placebo group. We also found that their TSH levels decreased significantly, while their free T4 levels increased. This suggests that selenium not only helps lower immune system activity against the thyroid but also supports overall thyroid function.
Our findings suggest that incorporating selenium into the treatment plan for autoimmune hypothyroidism could be beneficial for patients. While this doesn't isolate selenium’s effects completely, as it was taken alongside levothyroxine, the results indicate its potential in managing thyroid health effectively.
3
We conducted a study to determine if selenium supplementation could enhance the quality of life (QoL) for patients suffering from autoimmune thyroiditis. In a robust clinical trial involving 412 participants who were already receiving levothyroxine treatment, we set up a double-blind, randomized control design. This means that neither the participants nor the researchers knew who was receiving selenium and who was on a placebo, ensuring that our observations were as unbiased as possible.
Over 12 months, participants were given either 200 μg of selenium or a placebo daily. We assessed their quality of life multiple times using a questionnaire designed specifically for thyroid-related issues. While participants showed improvements in their QoL during the trial, we found no significant differences between the two groups after one year.
Interestingly, while selenium supplementation did lead to lower thyroid peroxidase antibody levels, it did not impact levothyroxine dosage or the balance of thyroid hormones in the body. Ultimately, both selenium and placebo groups experienced comparable improvements, indicating that selenium supplementation did not provide additional benefits beyond the placebo effect.
Over 12 months, participants were given either 200 μg of selenium or a placebo daily. We assessed their quality of life multiple times using a questionnaire designed specifically for thyroid-related issues. While participants showed improvements in their QoL during the trial, we found no significant differences between the two groups after one year.
Interestingly, while selenium supplementation did lead to lower thyroid peroxidase antibody levels, it did not impact levothyroxine dosage or the balance of thyroid hormones in the body. Ultimately, both selenium and placebo groups experienced comparable improvements, indicating that selenium supplementation did not provide additional benefits beyond the placebo effect.
7
Selenium's potential in hypothyroidism
We delved into the effects of selenium supplementation on adults with hypothyroidism, particularly focusing on inflammation and thyroid function. Our review included nineteen studies that rigorously evaluated how selenium might influence these health concerns.
We noticed that some evidence supports the idea that selenium can help reduce inflammation and improve certain thyroid parameters in individuals with hypothyroidism. However, it’s important to clarify that the amount of research on this is still quite limited. For example, while selenium showed promise in some areas, we found no studies directly linking it with oxidative stress or the body's antioxidant status.
Furthermore, we identified that vitamin D supplementation appeared not to impact inflammatory indicators among the reviewed trials. With regards to other dietary supplements, most were studied only once, which means we can’t draw firm conclusions about their effectiveness either. The bottom line is that we need more high-quality research to fully understand selenium’s role and how it might help those battling hypothyroidism.
We noticed that some evidence supports the idea that selenium can help reduce inflammation and improve certain thyroid parameters in individuals with hypothyroidism. However, it’s important to clarify that the amount of research on this is still quite limited. For example, while selenium showed promise in some areas, we found no studies directly linking it with oxidative stress or the body's antioxidant status.
Furthermore, we identified that vitamin D supplementation appeared not to impact inflammatory indicators among the reviewed trials. With regards to other dietary supplements, most were studied only once, which means we can’t draw firm conclusions about their effectiveness either. The bottom line is that we need more high-quality research to fully understand selenium’s role and how it might help those battling hypothyroidism.
References
- Nikkhah M, Vafa M, Abiri B, Golgiri F, Sarbakhsh P, et al. The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial. Med J Islam Repub Iran. 2024;38:133. doi:10.47176/mjiri.38.133
- Zuhair V, Sheikh AT, Shafi N, Babar A, Khan A, et al. Role of Supplementation with Selenium and Myo-Inositol Versus Selenium Alone in Patients of Autoimmune Thyroiditis: A Systematic Review and Meta-Analysis. Clin Med Insights Endocrinol Diabetes. 2024;17:11795514241300998. doi:10.1177/11795514241300998
- Li F, Su L, Shao R, Luo J, Chen Y, et al. Selenium Status Associates with Thyroid Hormone and Thyroid Dysfunction in Older Chinese Adults. Biol Trace Elem Res. 2025;203:1413. doi:10.1007/s12011-024-04286-2
- AkbariRad M, Mazloum Khorasani Z, Beizae B, Ayatollahi H, Emadzadeh M, et al. Effect of selenium on anti-Tg antibody in patients with autoimmune hypothyroidism: A randomized controlled trial. Caspian J Intern Med. 2024;15:340. doi:10.22088/cjim.15.2.340
- Nagano K, Motomura Y, Bando H, Yamamoto M, Kanie K, et al. Thyroid dysfunction due to trace element deficiency-not only selenium but also zinc. Hormones (Athens). 2024;23:675. doi:10.1007/s42000-024-00550-1
- Wang S, Chen P, He Y, Wei J, Tian L, et al. A follow-up study on factors affecting the recovery of patients with hypothyroidism in different selenium environments. BMC Endocr Disord. 2024;24:14. doi:10.1186/s12902-024-01536-1
- El-Shaer RAA, Ibrahim S, Hewady PM, Atef MM, El-Deeb OS, et al. Selenium protects against nesfatin-1 modulation of the hypothalamic-pituitary-testicular axis during hypothyroidism in male rats. Physiol Rep. 2024;12:e15923. doi:10.14814/phy2.15923
- Huwiler VV, Maissen-Abgottspon S, Stanga Z, Mühlebach S, Trepp R, et al. Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Thyroid. 2024;34:295. doi:10.1089/thy.2023.0556
- Larsen C, Winther KH, Cramon PK, Rasmussen ÅK, Feldt-Rasmusssen U, et al. Selenium supplementation and placebo are equally effective in improving quality of life in patients with hypothyroidism. Eur Thyroid J. 2024;13. doi:10.1530/ETJ-23-0175
- Kubiak K, Szmidt MK, Kaluza J, Zylka A, Sicinska E. Do Dietary Supplements Affect Inflammation, Oxidative Stress, and Antioxidant Status in Adults with Hypothyroidism or Hashimoto's Disease?-A Systematic Review of Controlled Trials. Antioxidants (Basel). 2023;12. doi:10.3390/antiox12101798
- Hosseini M, Behehsti F, Marefati N, Anaeigoudari A. Nano-selenium relieved hepatic and renal oxidative damage in hypothyroid rats. Physiol Rep. 2023;11:e15682. doi:10.14814/phy2.15682
- Wróblewski M, Wróblewska J, Nuszkiewicz J, Pawłowska M, Wesołowski R, et al. The Role of Selected Trace Elements in Oxidoreductive Homeostasis in Patients with Thyroid Diseases. Int J Mol Sci. 2023;24. doi:10.3390/ijms24054840
- Lu L, Huang Z, Wang X, Chen J. Interaction Between Dietary Selenium and Zinc Intakes on Hypothyroidism. Biol Trace Elem Res. 2023;201:4667. doi:10.1007/s12011-023-03563-w
- Payer J, Jackuliak P, Kužma M, Džupon M, Vaňuga P. Supplementation with myo-inositol and Selenium improves the clinical conditions and biochemical features of women with or at risk for subclinical hypothyroidism. Front Endocrinol (Lausanne). 2022;13:1067029. doi:10.3389/fendo.2022.1067029
- Hojjati Fard F, Sabzi F, Marefati N, Vafaee F, Beheshti F, et al. Nanoselenium improved learning, memory, and brain-derived neurotrophic factor and attenuated nitric oxide, and oxidative stress in the brain of juvenile hypothyroid rats. Metab Brain Dis. 2022;37:2719. doi:10.1007/s11011-022-01073-7
- Paparo SR, Ferrari SM, Patrizio A, Elia G, Ragusa F, et al. Myoinositol in Autoimmune Thyroiditis. Front Endocrinol (Lausanne). 2022;13:930756. doi:10.3389/fendo.2022.930756
- Berisha-Muharremi V, Tahirbegolli B, Phypers R, Hanna R. Efficacy of Combined Photobiomodulation Therapy with Supplements versus Supplements alone in Restoring Thyroid Gland Homeostasis in Hashimoto Thyroiditis: A Clinical Feasibility Parallel Trial with 6-Months Follow-Up. J Pers Med. 2023;13. doi:10.3390/jpm13081274
