Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.9
USERS' SCORE
Moderately Good
Based on 21 Reviews
7.8
Supplement Facts
Serving Size: 2 tablets
Serving Per Container: 90
Amount Per Serving
%DV
Calcium (as calcium hydroxyapatite, calcium citrate, calcium aspartate) †
1,000 mg
77%
Phosphorus (as calcium hydroxyapatite) †
500 mg
40%
Magnesium (as magnesium oxide, magnesium citrate, magnesium aspartate, magnesium taurinate) †
500 mg
119%
Top Medical Research Studies
9
We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Read More
9
In our exploration of osteoporosis treatment, we focused on the effects of magnesium, particularly when combined with phosphorylated collagen peptide-magnesium chelates. Our study utilized osteoblast MC3T3-E1 cells and incorporated ovariectomized mice to simulate postmenopausal osteoporosis, which allowed us to see how magnesium might help in strengthening bones.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
Read More
9
Nanopowder eggshells improve bone health
We examined how nanopowder eggshells (NPES) could influence bone health in both healthy and ovariectomy-induced osteoporosis rats.
In our research, we found that NPES treatment significantly enhanced indicators of bone formation, like calcium and osteocalcin, particularly in healthy rats.
Additionally, in the ovariectomized group, NPES treatment helped improve levels of vital nutrients and reduced bone resorption.
Overall, our findings suggest that NPES may play a beneficial role in bettering bone health in osteoporosis models.
In our research, we found that NPES treatment significantly enhanced indicators of bone formation, like calcium and osteocalcin, particularly in healthy rats.
Additionally, in the ovariectomized group, NPES treatment helped improve levels of vital nutrients and reduced bone resorption.
Overall, our findings suggest that NPES may play a beneficial role in bettering bone health in osteoporosis models.
Read More
Most Useful Reviews
0
Poor effectiveness noted
6 people found this helpful
I bought this for my mother, who has severe osteoporosis. She was on Calcemin Advance for five years without fractures, but in the last six months on this product, she suffered two broken vertebrae.
Read More
10
Better bone density
2 people found this helpful
I adore this product! Having taken it for years, my bone density is now better than normal. My mother had osteoporosis, which motivated me to seek preventive measures. How is that for a review?
Read More
9
Normal bone density
2 people found this helpful
After being diagnosed with osteoporosis years ago due to steroids, it was vital to manage this quickly. My doctor recommended calcium and magnesium along with daily walks. Since starting Country Life, my bone density has returned to normal, and I feel much more secure, especially after a recent fall.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.9
- All Researches
9
Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
Read More
9
We explored how salmon calcitonin (sCT) works in tandem with calcium antagonists—specifically verapamil, nifedipine, and diltiazem—to influence blood calcium and phosphorus levels in female rats with osteoporosis post-ovarian removal.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
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9
We examined how dietary intake of magnesium, along with potassium and sodium, influences bone health, specifically focusing on osteoporosis and bone mineral density (BMD) in adults across the U.S. Our analysis was based on data from the National Health and Nutrition Examination Surveys, which spanned from 2005 to 2018, involving over 10,000 participants.
The findings revealed a positive association between higher dietary intake of potassium, magnesium, and sodium and improved BMD of the femur. This means that those who consumed more of these nutrients tended to have stronger bones. Additionally, we observed that a higher intake of these minerals was linked to a lower occurrence of osteopenia and osteoporosis.
Our study highlights how magnesium, when part of a broader nutrient intake that includes potassium and sodium, could play a significant role in maintaining bone health. While our research points to a beneficial relationship, more targeted studies are needed to definitively isolate the effects of magnesium alone on osteoporosis. Overall, this reinforces the importance of a balanced diet for bone health.
The findings revealed a positive association between higher dietary intake of potassium, magnesium, and sodium and improved BMD of the femur. This means that those who consumed more of these nutrients tended to have stronger bones. Additionally, we observed that a higher intake of these minerals was linked to a lower occurrence of osteopenia and osteoporosis.
Our study highlights how magnesium, when part of a broader nutrient intake that includes potassium and sodium, could play a significant role in maintaining bone health. While our research points to a beneficial relationship, more targeted studies are needed to definitively isolate the effects of magnesium alone on osteoporosis. Overall, this reinforces the importance of a balanced diet for bone health.
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9
We delved into the use of a unique injectable hydrogel loaded with magnesium to address the challenges of repairing osteoporotic bone defects. The study aimed to understand how this magnesium-infused hydrogel could combat the excessive reactive oxygen species (ROS) that hinder bone repair. With impressive qualities such as excellent injectability and adaptability, the hydrogel can be introduced into irregular bone areas without the need for major surgery.
Once injected, the hydrogel not only transforms into a supportive scaffold but also begins to release hydrogen and magnesium ions. This release is key in reducing harmful intracellular ROS and guiding the immune response favorably by promoting macrophage polarization. We observed that this gel suppressed the formation of osteoclasts, the cells responsible for bone resorption, while simultaneously encouraging the growth of new bone cells.
Animal experiments further illuminated the effectiveness of the magnesium-loaded hydrogel, showing a remarkable ability to enhance the repair of bone defects by controlling inflammation and supporting bone formation. Overall, our findings shine a light on the potential of magnesium-based hydrogels as promising solutions for those dealing with osteoporosis-related bone damage.
Once injected, the hydrogel not only transforms into a supportive scaffold but also begins to release hydrogen and magnesium ions. This release is key in reducing harmful intracellular ROS and guiding the immune response favorably by promoting macrophage polarization. We observed that this gel suppressed the formation of osteoclasts, the cells responsible for bone resorption, while simultaneously encouraging the growth of new bone cells.
Animal experiments further illuminated the effectiveness of the magnesium-loaded hydrogel, showing a remarkable ability to enhance the repair of bone defects by controlling inflammation and supporting bone formation. Overall, our findings shine a light on the potential of magnesium-based hydrogels as promising solutions for those dealing with osteoporosis-related bone damage.
Read More
9
We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 21 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
0
Poor effectiveness noted
6 people found this helpful
I bought this for my mother, who has severe osteoporosis. She was on Calcemin Advance for five years without fractures, but in the last six months on this product, she suffered two broken vertebrae.
Read More
10
Better bone density
2 people found this helpful
I adore this product! Having taken it for years, my bone density is now better than normal. My mother had osteoporosis, which motivated me to seek preventive measures. How is that for a review?
Read More
9
Normal bone density
2 people found this helpful
After being diagnosed with osteoporosis years ago due to steroids, it was vital to manage this quickly. My doctor recommended calcium and magnesium along with daily walks. Since starting Country Life, my bone density has returned to normal, and I feel much more secure, especially after a recent fall.
Read More
9
Muscle cramps relief
2 people found this helpful
I have osteoporosis and take calcium with vitamin D3. After searching for an effective product, I can say this one works well. It not only helps with my bone health but has also alleviated my mother's muscle cramps.
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9
Diagnosis improved
2 people found this helpful
I've ordered this complex for a long time at my doctor’s recommendation. They prescribed calcium with a dosage of 1000 mg, which is hard to find. After several tests, my diagnosis was removed, indicating it works well for osteoporosis.
Read More
Frequently Asked Questions
10
Diagnosis reversed
1 people found this helpful
I ordered this complex for my mother, 65, who has early osteoporosis. The doctor prescribed calcium 1000 mg, hard to find locally. Surprisingly, after a few months of use, her diagnosis was praised and removed. It's definitely effective!
9
Normal bone density
2 people found this helpful
After being diagnosed with osteoporosis years ago due to steroids, it was vital to manage this quickly. My doctor recommended calcium and magnesium along with daily walks. Since starting Country Life, my bone density has returned to normal, and I feel much more secure, especially after a recent fall.
8
Better recovery noted
2 people found this helpful
I bought this calcium for my 85-year-old relative with osteoporosis who broke her leg twice. After starting this calcium, her recovery improved significantly, and she can walk faster with her walker now. We believe she should continue taking it for better absorption.
9
Muscle cramps relief
2 people found this helpful
I have osteoporosis and take calcium with vitamin D3. After searching for an effective product, I can say this one works well. It not only helps with my bone health but has also alleviated my mother's muscle cramps.
7.5
Increased bone density
Since I began taking vitamin D and collagen, I've noticed an improvement in my bone density, particularly as my mother had osteoporosis.
7.5
Effective calcium absorption
1 people found this helpful
Prior to buying this product, I lacked comprehensive calcium options. Target-Mins provide a specific calcium to magnesium ratio of 2:1 to maximise absorption. I take it to prevent osteoporosis and maintain a healthy diet and exercise.
7.5
Maintains calcium levels
This supplement ensures calcium availability in my body. Adequate calcium intake, combined with physical activity, can lower my risk of osteoporosis as I age.
9
Diagnosis improved
2 people found this helpful
I've ordered this complex for a long time at my doctor’s recommendation. They prescribed calcium with a dosage of 1000 mg, which is hard to find. After several tests, my diagnosis was removed, indicating it works well for osteoporosis.
9
Supports osteoporosis prevention
1 people found this helpful
This complex is very beneficial due to the high calcium content per tablet. I take one tablet a day for life to assist my mother, who is 93, in preventing osteoporosis. The calcium is easily absorbed, and the price is reasonable. The magnesium oxide helps calcium reach where it is needed, avoiding any deposits in blood vessels or kidneys. I also take vitamin D and K2 supplements for life. If my experience has been helpful, please click yes :)))
4
We conducted a thorough review of various treatments for osteoporosis in people living with HIV, particularly focusing on the role of calcium. Our analysis included randomized controlled trials that compared different treatment strategies, such as calcium combined with medications like zoledronate or alendronate.
While zoledronate showed promising results in improving bone mineral density, calcium was often used alongside these treatments. Unfortunately, this combination makes it difficult to isolate the specific effects of calcium on osteoporosis. We found that alendronate, although it helped reduce certain bone turnover markers, did not significantly improve bone density.
Overall, the study indicates that while calcium plays a role in treatment combinations, its isolated impact on osteoporosis remains unclear. We emphasized the need for more focused research to determine calcium's true effectiveness in enhancing bone health for those affected by HIV.
While zoledronate showed promising results in improving bone mineral density, calcium was often used alongside these treatments. Unfortunately, this combination makes it difficult to isolate the specific effects of calcium on osteoporosis. We found that alendronate, although it helped reduce certain bone turnover markers, did not significantly improve bone density.
Overall, the study indicates that while calcium plays a role in treatment combinations, its isolated impact on osteoporosis remains unclear. We emphasized the need for more focused research to determine calcium's true effectiveness in enhancing bone health for those affected by HIV.
9
Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
5
Calcium's risks for kidney stones
We explored the effects of calcium and vitamin D supplementation on osteoporosis, particularly focusing on the risk of kidney stones. In our study, 204 older adults in southwest China took daily doses of calcium and vitamin D for at least a year. We used various statistical analyses to understand the relationship between these supplements and kidney stone formation.
Our findings reveal that there is a potential link between the use of calcium supplements for osteoporosis and an increased risk of developing kidney stones. It seems that a history of kidney stones can elevate the likelihood of experiencing them again while undergoing such supplementation, likely due to higher urinary calcium levels.
While calcium is essential for bone health, our results suggest that patients need to be cautious. This research highlights the importance of monitoring kidney health while receiving calcium and vitamin D treatment to prevent complications like kidney stones.
Our findings reveal that there is a potential link between the use of calcium supplements for osteoporosis and an increased risk of developing kidney stones. It seems that a history of kidney stones can elevate the likelihood of experiencing them again while undergoing such supplementation, likely due to higher urinary calcium levels.
While calcium is essential for bone health, our results suggest that patients need to be cautious. This research highlights the importance of monitoring kidney health while receiving calcium and vitamin D treatment to prevent complications like kidney stones.
7
We explored the fascinating role of magnesium in osteoporosis, a condition that leads to weakened bones and increased fracture risk. Through our investigation, we observed that magnesium is vital for bone health and plays a significant part in bone formation and maintenance.
Magnesium deficiency can impact bone structure indirectly by interfering with calcium homeostasis. This interplay is orchestrated mainly through two key regulators: parathyroid hormone and vitamin D. Parathyroid hormone influences the production of essential proteins that regulate osteoclast formation, which is responsible for bone resorption.
We also learned that vitamin D works in tandem with magnesium to facilitate the balance between bone formation and resorption. When magnesium levels are low, this balance can tip in favor of bone loss, ultimately leading to osteoporosis. The RANK/RANKL/OPG signaling pathway is crucial in this context, as it governs the relationship between bone-building cells and those that break down bone.
Importantly, clinical studies indicate that magnesium supplementation may ease some symptoms of osteoporosis, although further research is needed to assess its effectiveness compared to other treatments. Overall, we understand that maintaining adequate magnesium levels is essential for bone health and may help prevent the progression of osteoporosis.
Magnesium deficiency can impact bone structure indirectly by interfering with calcium homeostasis. This interplay is orchestrated mainly through two key regulators: parathyroid hormone and vitamin D. Parathyroid hormone influences the production of essential proteins that regulate osteoclast formation, which is responsible for bone resorption.
We also learned that vitamin D works in tandem with magnesium to facilitate the balance between bone formation and resorption. When magnesium levels are low, this balance can tip in favor of bone loss, ultimately leading to osteoporosis. The RANK/RANKL/OPG signaling pathway is crucial in this context, as it governs the relationship between bone-building cells and those that break down bone.
Importantly, clinical studies indicate that magnesium supplementation may ease some symptoms of osteoporosis, although further research is needed to assess its effectiveness compared to other treatments. Overall, we understand that maintaining adequate magnesium levels is essential for bone health and may help prevent the progression of osteoporosis.
9
We explored a cutting-edge approach to tackle the challenges in repairing bones affected by osteoporosis. Drawing inspiration from the healing properties of hot springs, we created a unique calcium magnesium phosphate bone cement infused with manganese ions.
This innovative scaffold not only promotes the regeneration of neurovascular networks but also helps reduce harmful substances in the bone's environment. Our results indicate that this method significantly aids in bone healing, highlighting its potential for treating osteoporosis effectively.
This innovative scaffold not only promotes the regeneration of neurovascular networks but also helps reduce harmful substances in the bone's environment. Our results indicate that this method significantly aids in bone healing, highlighting its potential for treating osteoporosis effectively.
8
This study took a closer look at how magnesium could play a role in treating osteoporosis, particularly through a new type of bone cement made with magnesium-doped bioactive glass. We discovered that this special formulation of bone cement not only shows promise in improving mechanical strength but also helps encourage bone growth.
Interestingly, we found that when magnesium ions are released at a controlled pace, they can affect the size of hydroxyapatite crystals, which are significant in bone health. Our results showed that a specific version of the cement, called 2Mg-BG-800, had excellent setting times, compressive strength, and injectability, making it a practical option for use in medical settings.
Furthermore, we observed that this magnesium-infused cement could enhance the growth of bone marrow stem cells and even help shift the activity of immune cells towards a healing state. This suggests that it may be useful in regenerating bones, especially for those suffering from osteoporosis-related fractures.
Interestingly, we found that when magnesium ions are released at a controlled pace, they can affect the size of hydroxyapatite crystals, which are significant in bone health. Our results showed that a specific version of the cement, called 2Mg-BG-800, had excellent setting times, compressive strength, and injectability, making it a practical option for use in medical settings.
Furthermore, we observed that this magnesium-infused cement could enhance the growth of bone marrow stem cells and even help shift the activity of immune cells towards a healing state. This suggests that it may be useful in regenerating bones, especially for those suffering from osteoporosis-related fractures.
References
- Wang JC, Chung SM, Wu PT, Tu YK, Lai PC, et al. Optimizing bone health in people living with HIV: insights from a network meta-analysis of randomized controlled trials. EClinicalMedicine. 2025;81:103103. 10.1016/j.eclinm.2025.103103
- Chen L, Lin S, He X, Ye J, Huang Y, et al. A calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health. Int J Biol Macromol. 2025. 10.1016/j.ijbiomac.2025.141634
- Ma R, Romano E, Ashworth M, Vancampfort D, Solmi M, et al. Is there a disparity in osteoporosis referral and treatment among people with affective disorders? A ten-year data linkage study. Gen Hosp Psychiatry. 2025;94:56. 10.1016/j.genhosppsych.2025.02.009
- Chen J, Wang J, Jia W, Zhang Y, Li H, et al. Effect of salmon calcitonin combined with calcium antagonist on blood calcium and phosphorus ion concentration in osteoporosis rats. Eur J Med Res. 2025;30:115. 10.1186/s40001-025-02384-y
- Shi L, Bao Y, Deng X, Xu X, Hu J. Association between calcium and vitamin D supplementation and increased risk of kidney stone formation in patients with osteoporosis in Southwest China: a cross-sectional study. BMJ Open. 2025;15:e092901. 10.1136/bmjopen-2024-092901
- Joris V, Balmayor ER, van Griensven M. miR-125b differentially impacts mineralization in dexamethasone and calcium-treated human mesenchymal stem cells. Mol Ther Nucleic Acids. 2025;36:102446. 10.1016/j.omtn.2024.102446
- Hu W, Feng X, Wen C. Relationship between multi-nutrient intake and bone loss and osteoporosis in U.S. adults: Findings from NHANES. Medicine (Baltimore). 2024;103:e40768. 10.1097/MD.0000000000040768
- Li D, Dai D, Wang J, Zhang C. Honeycomb Bionic Graphene Oxide Quantum Dot/Layered Double Hydroxide Composite Nanocoating Promotes Osteoporotic Bone Regeneration via Activating Mitophagy. Small. 2024;20:e2403907. 10.1002/smll.202403907
- Zhou H, He Z, Cao Y, Chu L, Liang B, et al. An injectable magnesium-loaded hydrogel releases hydrogen to promote osteoporotic bone repair via ROS scavenging and immunomodulation. Theranostics. 2024;14:3739. 10.7150/thno.97412
- Liu L, Luo P, Wen P, Xu P. The role of magnesium in the pathogenesis of osteoporosis. Front Endocrinol (Lausanne). 2024;15:1406248. 10.3389/fendo.2024.1406248
- Huang L, Cai P, Bian M, Yu J, Xiao L, et al. Injectable and high-strength PLGA/CPC loaded ALN/MgO bone cement for bone regeneration by facilitating osteogenesis and inhibiting osteoclastogenesis in osteoporotic bone defects. Mater Today Bio. 2024;26:101092. 10.1016/j.mtbio.2024.101092
- Weng Z, Ye J, Cai C, Liu Z, Liu Y, et al. Inflammatory microenvironment regulation and osteogenesis promotion by bone-targeting calcium and magnesium repletion nanoplatform for osteoporosis therapy. J Nanobiotechnology. 2024;22:314. 10.1186/s12951-024-02581-7
- Dai Q, Wang Z, Liu C, Chen X, Cao X. High performance injectable Mg doped bioactive glass bone cement for the regulation of osteogenic immune microenvironment. Biomater Adv. 2024;160:213864. 10.1016/j.bioadv.2024.213864
- Li J, Chen Y, Zha D, Wu C, Li X, et al. Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. Lipids Health Dis. 2024;23:88. 10.1186/s12944-024-02083-3
- Qin L, Liu Q, Zhang T, Tang X, Mo X, et al. Association Between Combined Polymetallic Exposure and Osteoporosis. Biol Trace Elem Res. 2024;202:3945. 10.1007/s12011-023-04002-6
- Ma T, Guan Y, Feng J, Yang Y, Chen J, et al. Osteogenic effect of magnesium oxychloride cement modified with phytic acid and loaded with strontium ranelate. Biomater Res. 2023;27:128. 10.1186/s40824-023-00474-8
- Zhang C, Du B, Deng G, Zhang S, Yu T, et al. Anti-osteoporosis properties of phosphorylated collagen peptide-magnesium chelates in osteoblast MC3T3-E1 cells and ovariectomized mice. Chin Med J (Engl). 2024;137:1762. 10.1097/CM9.0000000000002877
- Zhao Y, Liu J, Hu L, Yao X, Tu R, et al. Novel "hot spring"-mimetic scaffolds for sequential neurovascular network reconstruction and osteoporosis reversion. Biomaterials. 2025;320:123191. 10.1016/j.biomaterials.2025.123191
- Al-Garawi ZS, Al-Qaisi AHI, Al-Shamari KA, Öztürkkan FE, Necefoğlu H. The utility of Hibiscus sabdariffa L. to prepare metal oxides NPs for clinical application on osteoporosis supported by theoretical study. Bioprocess Biosyst Eng. 2024;47:753. 10.1007/s00449-024-03012-5
- Düğer H, Uçan B, Çalışkan M, Bostan H, Demirci T, et al. Hypomagnesemia may be associated with symptomatic disease in patients with primary hyperparathyroidism. Endocrine. 2024;83:466. 10.1007/s12020-023-03577-3
- Han H, Chen S, Wang X, Jin J, Li X, et al. Association of the composite dietary antioxidant index with bone mineral density in the United States general population: data from NHANES 2005-2010. J Bone Miner Metab. 2023;41:631. 10.1007/s00774-023-01438-7
- Zhu Y, Jia G, Yang Y, Weng J, Liu S, et al. Biomimetic Porous Magnesium Alloy Scaffolds Promote the Repair of Osteoporotic Bone Defects in Rats through Activating the Wnt/β-Catenin Signaling Pathway. ACS Biomater Sci Eng. 2023;9:3435. 10.1021/acsbiomaterials.2c01097
- Fouhy LE, Mangano KM, Zhang X, Hughes BD, Tucker KL, et al. Association between a Calcium-to-Magnesium Ratio and Osteoporosis among Puerto Rican Adults. J Nutr. 2023;153:2642. 10.1016/j.tjnut.2023.05.009
- Xie Y, Bao Z, Wang Z, Du D, Chen G, et al. Magnesium Ascorbyl Phosphate Promotes Bone Formation Via CaMKII Signaling. J Bone Miner Res. 2023;38:1015. 10.1002/jbmr.4820
- Salama RHM, Ali SS, Salama THM, Almged MA, Alsanory TA, et al. Dietary Effects of Nanopowder Eggshells on Mineral Contents, Bone Turnover Biomarkers, and Regulators of Bone Resorption in Healthy Rats and Ovariectomy-Induced Osteoporosis Rat Model. Appl Biochem Biotechnol. 2023;195:5034. 10.1007/s12010-022-04038-9
