Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.6
USERS' SCORE
Good
Based on 7 Reviews
8.1
Supplement Facts
Serving Size:  One (1) Capsule
Amount Per Serving
%DV
Calories
0
 
Total Carbohydrate
0 g
0%+
Total Sugars
0 g
**
Incl. 0 g Added Sugars
 
0%+
Lactobacillus rhamnosus GG
83 mg (20 billion CFUs)
**
Inulin (Chicory root extract)
200 mg
**

Top Medical Research Studies

9.5
Inulin reduces neonatal diarrhea incidence
We explored the effect of inulin, a type of dietary fiber, on the health of piglets born to sows during pregnancy. In our study, multiparous sows were divided into two groups. One group received a diet without inulin, while the other group was fed a diet containing 1.6% inulin.

We observed that the inclusion of inulin in the diet significantly reduced the incidences of diarrhea in piglets. Specifically, the sows that consumed inulin had lower levels of urea nitrogen in their colostrum, which correlated with better health outcomes for their piglets. This led to increased survival rates and overall growth of the piglets, providing encouraging evidence that inulin can play an important role in enhancing neonatal health.

Overall, our findings suggest that maternal dietary fiber, particularly inulin, not only supports the health of the sows but also positively influences the wellbeing of their offspring, notably in reducing the risk of diarrhea in newborn piglets.
Read More
9
LRa05 effective for diarrhea in children
We examined the effectiveness of LRa05, a probiotic, in treating acute watery diarrhea in children. In a randomized controlled trial, 57 children received LRa05 while 54 received a placebo. Our findings showed that those who took LRa05 had shorter diarrhea durations and improved fecal consistency compared to the control group. Additionally, LRa05 improved gut microbiome composition and boosted levels of beneficial gut proteins. Overall, using LRa05 can be a helpful addition to managing diarrhea in young children.
Read More
9
Probiotics reduce antibiotic-related diarrhea
We conducted a multi-hospital study to tackle the common issue of antibiotic-associated diarrhea (AAD). By comparing probiotics, specifically Lactobacillus rhamnosus GG and Bifidobacterium longum BB536, with a placebo among 340 adult patients, we aimed to find out if these friendly bacteria could help.

Our findings revealed that probiotics significantly lowered both the incidence and duration of AAD compared to the placebo group. Patients reported positive outcomes, indicating high adherence to the treatment as well.
Read More

Most Useful Reviews

9
Effective for diarrhea.
2 people found this helpful
Doctor Recommended Culturelle for chronic diarrhoea. It appears to work remarkably well for me.
Read More
9
Effective for diarrhoea
1 people found this helpful
I purchased this for frequent diarrhoea rather than constipation. As it is Ultimate Strength, it definitely works. I also changed my diet and added digestive enzymes.
Read More
7.5
Quick improvement
One of the best probiotics 😲❤️ Summer brings vacations, street food and fruits, leading to frequent instances of poisoning and diarrhoea 🥲 I want to share this effective product that significantly restores microflora and halts diarrhoea. The capsules are conveniently sized, and you can open them to take with water. They serve well as a dietary supplement. The packaging is attractive, and I appreciate the quick improvement I noticed within 24 hours.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.6
  • All Researches
9.5
Inulin reduces neonatal diarrhea incidence
We explored the effect of inulin, a type of dietary fiber, on the health of piglets born to sows during pregnancy. In our study, multiparous sows were divided into two groups. One group received a diet without inulin, while the other group was fed a diet containing 1.6% inulin.

We observed that the inclusion of inulin in the diet significantly reduced the incidences of diarrhea in piglets. Specifically, the sows that consumed inulin had lower levels of urea nitrogen in their colostrum, which correlated with better health outcomes for their piglets. This led to increased survival rates and overall growth of the piglets, providing encouraging evidence that inulin can play an important role in enhancing neonatal health.

Overall, our findings suggest that maternal dietary fiber, particularly inulin, not only supports the health of the sows but also positively influences the wellbeing of their offspring, notably in reducing the risk of diarrhea in newborn piglets.
Read More
9.5
Exploring inulin's protective effects
We explored the impact of inulin on gut health, particularly its ability to combat diarrhea linked to iron fortification. In a study involving weaning mice, the introduction of iron through ferrous sulfate increased the diversity of gut bacteria but also led to a decline in beneficial bacteria, like Lactobacillus.

Notably, we observed that mice receiving a high dose of iron experienced heightened symptoms when infected with the pathogen Salmonella. These symptoms included significant weight and appetite loss, and decreased survival rates. However, when we supplemented the mice with inulin before exposure to the infection, these adverse effects were significantly reversed.

The research showed that inulin not only helped improve overall gut health but also alleviated the intestinal damage caused by iron fortification. This suggests that inulin could serve as a practical measure to mitigate the negative impacts of iron fortification on digestive health, particularly in populations vulnerable to diarrhea.
Read More
9
LRa05 effective for diarrhea in children
We examined the effectiveness of LRa05, a probiotic, in treating acute watery diarrhea in children. In a randomized controlled trial, 57 children received LRa05 while 54 received a placebo. Our findings showed that those who took LRa05 had shorter diarrhea durations and improved fecal consistency compared to the control group. Additionally, LRa05 improved gut microbiome composition and boosted levels of beneficial gut proteins. Overall, using LRa05 can be a helpful addition to managing diarrhea in young children.
Read More
9
Probiotics reduce antibiotic-related diarrhea
We conducted a multi-hospital study to tackle the common issue of antibiotic-associated diarrhea (AAD). By comparing probiotics, specifically Lactobacillus rhamnosus GG and Bifidobacterium longum BB536, with a placebo among 340 adult patients, we aimed to find out if these friendly bacteria could help.

Our findings revealed that probiotics significantly lowered both the incidence and duration of AAD compared to the placebo group. Patients reported positive outcomes, indicating high adherence to the treatment as well.
Read More
9
Lactobacillus rhamnosus aids diarrhea
We investigated how Lactobacillus rhamnosus, specifically a postbiotic preparation known as mLGG, affects diarrhea linked to the Spike protein of SARS-CoV-2. In our tests using human intestinal cells, we found that the Spike protein triggers diarrhea by increasing oxidative stress and chloride secretion.

Our findings showed that pretreating the cells with mLGG significantly reduced these harmful effects. This suggests that Lactobacillus rhamnosus can help ease diarrhea by blocking the enterotoxic impact of the Spike protein, confirming its role as an effective therapy for acute gastroenteritis.
Read More

User Reviews

USERS' SCORE
Good
Based on 7 Reviews
8.1
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Effective for diarrhea.
2 people found this helpful
Doctor Recommended Culturelle for chronic diarrhoea. It appears to work remarkably well for me.
Read More
9
Effective for diarrhoea
1 people found this helpful
I purchased this for frequent diarrhoea rather than constipation. As it is Ultimate Strength, it definitely works. I also changed my diet and added digestive enzymes.
Read More
7.5
Quick improvement
One of the best probiotics 😲❤️ Summer brings vacations, street food and fruits, leading to frequent instances of poisoning and diarrhoea 🥲 I want to share this effective product that significantly restores microflora and halts diarrhoea. The capsules are conveniently sized, and you can open them to take with water. They serve well as a dietary supplement. The packaging is attractive, and I appreciate the quick improvement I noticed within 24 hours.
Read More
7.5
Significant improvement.
51 people found this helpful
Colitis, Crohn's, antibiotics...no more fear! When a product deserves a review, I gladly take 15 minutes out of my day to write one; this one is worth 50 reviews. Back in June, I was prescribed Flagyl and Cipro, strong antibiotics known to cause Clostridium difficile, leading to severe diarrhoea. This resulted from too many antibiotics combined with my chronic Crohn's disease, which involves ongoing diarrhoea linked to my limited intestine health. After switching to Flagyl alone in August, I struggled with escalating pain and bowel movements. However, I discovered Culturelle probiotics, which surprisingly helped ease my symptoms within a few days. Recently, I began another course of antibiotics; luckily, my Crohn's symptoms remain mild, and I’m hopeful the probiotics will aid recovery. I'm looking forward to providing further updates soon.
Read More
6
Improved bowel firmness.
6 people found this helpful
Fixed my loose bowel issues that had persisted for months. I work out extensively and often questioned whether it was due to my diet or a previous antibiotic treatment affecting my stomach. After trying probiotics with scepticism, I noticed significant improvement as my stool began firming up after consuming about two-thirds of the pack. I've also enjoyed better sleep, free from the disruptions caused by my stomach. I'm purchasing another kit to maintain these results and combining it with Kefir for added benefits. So far, I'm extremely pleased with the outcomes!
Read More

Frequently Asked Questions

7.5
Quick improvement
One of the best probiotics 😲❤️ Summer brings vacations, street food and fruits, leading to frequent instances of poisoning and diarrhoea 🥲 I want to share this effective product that significantly restores microflora and halts diarrhoea. The capsules are conveniently sized, and you can open them to take with water. They serve well as a dietary supplement. The packaging is attractive, and I appreciate the quick improvement I noticed within 24 hours.
9
Effective for diarrhoea
1 people found this helpful
I purchased this for frequent diarrhoea rather than constipation. As it is Ultimate Strength, it definitely works. I also changed my diet and added digestive enzymes.
7.5
Useful for travel
Excellent! These probiotics are high quality, containing a massive 20 billion. This is the best type I've tried. I find it beneficial to take when travelling, as variations in food can lead to constipation or diarrhoea. It’s especially useful during antibiotic use, which kills good bacteria in the digestive system. If I ever experience food poisoning, I’ll be sure to use it.
9
LRa05 effective for diarrhea in children
We examined the effectiveness of LRa05, a probiotic, in treating acute watery diarrhea in children. In a randomized controlled trial, 57 children received LRa05 while 54 received a placebo. Our findings showed that those who took LRa05 had shorter diarrhea durations and improved fecal consistency compared to the control group. Additionally, LRa05 improved gut microbiome composition and boosted levels of beneficial gut proteins. Overall, using LRa05 can be a helpful addition to managing diarrhea in young children.
9
Probiotics reduce antibiotic-related diarrhea
We conducted a multi-hospital study to tackle the common issue of antibiotic-associated diarrhea (AAD). By comparing probiotics, specifically Lactobacillus rhamnosus GG and Bifidobacterium longum BB536, with a placebo among 340 adult patients, we aimed to find out if these friendly bacteria could help.

Our findings revealed that probiotics significantly lowered both the incidence and duration of AAD compared to the placebo group. Patients reported positive outcomes, indicating high adherence to the treatment as well.
8
Probiotics may prevent antibiotic diarrhea
We explored the impact of probiotics, especially Lactobacillus rhamnosus GG, on antibiotic-associated diarrhea. The research indicates that this specific strain can indeed play a role in alleviating diarrhea caused by disruptions in gut microbiota after antibiotic use. Systematic reviews and clinical trials support its effectiveness, showing that taking the probiotic shortly after starting antibiotics can help manage symptoms and restore gut health. However, it’s important to note that not all probiotics may yield the same results, and careful dosing is crucial for effectiveness.
8
Inulin reduces antibiotic-associated diarrhea
We explored the impact of adding a combined prebiotic and probiotics to an optimized treatment plan for Helicobacter pylori infection, with a focus on how this approach affects diarrhea. Our research involved 120 patients suffering from chronic gastroduodenal diseases alongside H. pylori infection, looking closely at whether inulin, part of the combined prebiotic Zakofalk, could improve diarrhea symptoms associated with antibiotic treatment.

During the study, we carefully tracked the effectiveness of this treatment regimen in alleviating antibiotic-associated diarrhea (AAD), a common issue that can lead to poor patient compliance. We found that incorporating Zakofalk not only significantly enhanced the chances of successful eradication of H. pylori but also effectively restored the gut microbiota's health, reducing instances of AAD.

Overall, our results suggest that by addressing the microbiome with inulin and probiotics, we can improve the tolerability of treatments and help patients feel better during their course of therapy. This indicates that inulin has valuable effects in the battle against AAD.
We examined the role of inulin, a type of prebiotic, alongside probiotics like Lactobacillus and Bifidobacterium, in managing severe gastroenteritis caused by rotavirus, particularly in children. One of the significant factors in rotavirus infection is a protein called NSP4, which contributes to diarrhea by affecting gut cells. Our observations suggest that inulin may enhance the benefits of probiotics in reducing rotavirus severity by blocking this harmful protein's effects.

By combining inulin with these beneficial bacteria, we observed an improvement in the body's antiviral response, which includes lower levels of rotavirus infectivity and viral shedding. Furthermore, our analysis indicated that this combination could lead to shorter illness duration and reduced severity of diarrhea, making it a valuable option for prevention and managing infections.

Overall, we recognize that inulin, when used with probiotics, could be an important ally in combating severe diarrhea caused by rotavirus, providing hope for better health outcomes in vulnerable populations like young children.
8
Probiotics may reduce pediatric diarrhea
We explored how probiotics, particularly Lactobacillus rhamnosus, might help prevent and treat antibiotic-associated diarrhea (AAD) in children. Our analysis included 20 systematic reviews and utilized various assessment tools to evaluate their quality.

While high doses of probiotics showed significant effects, we noticed concerns about the quality of reporting and evidence in many reviews. This means that, while the potential is there, cautious interpretation of results is necessary as further improvements in study methodology are needed.

References

  1. Shin I, Kang Y, Ahn J, Kim Y, Nam J, et al. The potential probiotic role of Lacticaseibacillus rhamnosus on growth performance, gut health, and immune responses of weaned pigs. J Anim Sci. 2025. 10.1093/jas/skaf089
  2. Chen K, Zeng K, Jin S, Ma Y, Cai L, et al. LRa05 in the treatment of acute diarrhea in children: a randomized controlled trial. Front Nutr. 2024;11:1479186. 10.3389/fnut.2024.1479186
  3. Gwee KA, Lee WRW, Chua Q, Chiou FK, Aw MM, et al. The evidence for probiotics in the treatment of digestive disorders in the pediatric population. J Gastroenterol Hepatol. 2025;40:41. 10.1111/jgh.16809
  4. Shah J, Adnan SH, Yousaf MS, Din SJU, Haq MU, et al. A Multi-Hospital Comparative Study on the Efficacy of Probiotics Versus Placebo in Preventing Antibiotic-Associated Diarrhea in Adult Patients. Cureus. 2024;16:e70881. 10.7759/cureus.70881
  5. Shawky LM, Abo El Wafa SM, Behery M, Bahr MH, Abu Alnasr MT, et al. Lactobacillus rhamnosus GG and Tannic Acid Synergistically Promote the Gut Barrier Integrity in a Rat Model of Experimental Diarrhea via Selective Immunomodulatory Cytokine Targeting. Mol Nutr Food Res. 2024;68:e2400295. 10.1002/mnfr.202400295
  6. Anvarifard P, Anbari M, Ghalichi F, Ghoreishi Z, Zarezadeh M. The effectiveness of probiotics as an adjunct therapy in patients under mechanical ventilation: an umbrella systematic review and meta-analysis. Food Funct. 2024;15:5737. 10.1039/d3fo04653b
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  13. Mego M, Danis R, Chovanec J, Jurisova S, Bystricky B, et al. Randomized double-blind, placebo-controlled multicenter phase III study of prevention of irinotecan-induced diarrhea by a probiotic mixture containing Bifidobacterium BB-12 LGG in colorectal cancer patients. Front Oncol. 2023;13:1168654. 10.3389/fonc.2023.1168654
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  24. Butorova LI, Ardatskaya MD, Osadchuk MA, Kadnikova NG, Lukianova EI, et al. [Comparison of clinical-metabolic efficacy of pre- and probiotics in the conducted optimized protocols of eradication therapy of Helicobacter pylori infection]. Ter Arkh. 2020;92:64. 10.26442/00403660.2020.04.000647
  25. Ayala-Monter MA, Hernández-Sánchez D, González-Muñoz S, Pinto-Ruiz R, Martínez-Aispuro JA, et al. Growth performance and health of nursing lambs supplemented with inulin and Lactobacillus casei. Asian-Australas J Anim Sci. 2019;32:1137. 10.5713/ajas.18.0630
  26. Lépine AFP, de Wit N, Oosterink E, Wichers H, Mes J, et al. Attenuates -Induced Stress of Epithelial Cells by Modulating Tight-Junction Genes and Cytokine Responses. Front Microbiol. 2018;9:1439. 10.3389/fmicb.2018.01439
  27. Lohner S, Jakobik V, Mihályi K, Soldi S, Vasileiadis S, et al. Inulin-Type Fructan Supplementation of 3- to 6-Year-Old Children Is Associated with Higher Fecal Bifidobacterium Concentrations and Fewer Febrile Episodes Requiring Medical Attention. J Nutr. 2018;148:1300. 10.1093/jn/nxy120
  28. Lin F, Wu H, Zeng M, Yu G, Dong S, et al. Probiotic/prebiotic correction for adverse effects of iron fortification on intestinal resistance to Salmonella infection in weaning mice. Food Funct. 2018;9:1070. 10.1039/c7fo00990a
  29. Shukla G, Sharma A, Bhatia R, Sharma M. Prophylactic Potential of Synbiotic (Lactobacillus casei and Inulin) in Malnourished Murine Giardiasis: an Immunological and Ultrastructural Study. Probiotics Antimicrob Proteins. 2019;11:165. 10.1007/s12602-017-9368-5
  30. Nowak P, Kasprowicz-Potocka M, Zaworska A, Nowak W, Stefańska B, et al. The effect of eubiotic feed additives on the performance of growing pigs and the activity of intestinal microflora. Arch Anim Nutr. 2017;71:455. 10.1080/1745039X.2017.1390181
  31. Gonzalez-Ochoa G, Flores-Mendoza LK, Icedo-Garcia R, Gomez-Flores R, Tamez-Guerra P. Modulation of rotavirus severe gastroenteritis by the combination of probiotics and prebiotics. Arch Microbiol. 2017;199:953. 10.1007/s00203-017-1400-3
  32. Borde A, Ekman A, Larsson A, Carlin N, Holmgren J, et al. Preparation and preclinical evaluation of a freeze-dried formulation of a novel combined multivalent whole-cell/B-subunit oral vaccine against enterotoxigenic Escherichia coli diarrhea. Eur J Pharm Biopharm. 2016;108:18. 10.1016/j.ejpb.2016.07.011
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