Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.8
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.8
Supplement Facts
Serving Size: Five (5) Drops
Amount Per Serving
%DV
Calories
0
Total Carbohydrate
0 g
0%
Total Sugars
0 g
**
Incl. 0 g Added Sugars
**
Vitamin D (as cholecalciferol)
10 mcg (400 IU)
100%
Probiotic Blend
29 mg (2.5 billion CFUs)
Lactobacillus rhamnosus GG
**
Bifidobacterium animalis subsp. lactis (BB-12®)
**
Top Medical Research Studies
9.5
Bifidobacterium lactis reduced diarrhea duration
We explored the impact of Bifidobacterium animalis subsp. lactis BLa80 on diarrhea in young children through a well-structured, randomized, double-blinded, placebo-controlled study.
Our findings show that children receiving the probiotic experienced a significantly shorter duration of diarrhea and a higher recovery rate compared to those given a placebo.
Notably, we also observed beneficial changes in gut microbiome composition and gene functions that promote immune response.
This evidence suggests that Bifidobacterium lactis can effectively support recovery from acute diarrhea in children.
Our findings show that children receiving the probiotic experienced a significantly shorter duration of diarrhea and a higher recovery rate compared to those given a placebo.
Notably, we also observed beneficial changes in gut microbiome composition and gene functions that promote immune response.
This evidence suggests that Bifidobacterium lactis can effectively support recovery from acute diarrhea in children.
Read More
9
We evaluated the effectiveness of Bifidobacterium lactis XLTG11 in treating acute watery diarrhea in children through a rigorous randomized, double-blind, placebo-controlled trial.
Children who received the probiotic alongside their conventional treatment had significantly shorter diarrhea durations and hospital stays compared to those who only got standard care. Additionally, those taking Bifidobacterium showed better improvement rates and healthier gut microbiomes after treatment.
Overall, this study suggests that Bifidobacterium lactis can be a beneficial adjunct therapy for children suffering from diarrhea.
Children who received the probiotic alongside their conventional treatment had significantly shorter diarrhea durations and hospital stays compared to those who only got standard care. Additionally, those taking Bifidobacterium showed better improvement rates and healthier gut microbiomes after treatment.
Overall, this study suggests that Bifidobacterium lactis can be a beneficial adjunct therapy for children suffering from diarrhea.
Read More
9
We examined the effectiveness of LRa05, a probiotic, in treating acute watery diarrhea in children. In a randomized controlled trial, 57 children received LRa05 while 54 received a placebo. Our findings showed that those who took LRa05 had shorter diarrhea durations and improved fecal consistency compared to the control group. Additionally, LRa05 improved gut microbiome composition and boosted levels of beneficial gut proteins. Overall, using LRa05 can be a helpful addition to managing diarrhea in young children.
Read More
Most Useful Reviews
1
Caused runny stools
4 people found this helpful
Sadly, this probiotic caused severe diarrhoea in our 8-month-old daughter. We switched from another brand, so we're unsure if it was the change or not. After stopping, the diarrhoea ceased, indicating that this may have been the cause. The drops tasted gritty and unpleasant. Definitely not purchasing again.
Read More
10
Diarrhoea resolved quickly
1 people found this helpful
As someone knowledgeable about dietary supplements, I started giving this to my 6-month-old son, who was experiencing diarrhoea. Remarkably, the diarrhoea resolved the following day, and I appreciate that it contains Vitamin D as well. We provide this daily, and it seems to be beneficial as he tries new solid foods.
Read More
8
Prevented diarrhoea
1 people found this helpful
This probiotic is a lifesaver for sick babies. Our baby developed his first ear infection and needed antibiotics. To avoid adverse side effects like diarrhoea, our paediatrician advised using a probiotic proactively. Luckily, it worked wonders because he recovered quickly with no tummy issues.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.8
- All Researches
9.5
Bifidobacterium lactis reduced diarrhea duration
We explored the impact of Bifidobacterium animalis subsp. lactis BLa80 on diarrhea in young children through a well-structured, randomized, double-blinded, placebo-controlled study.
Our findings show that children receiving the probiotic experienced a significantly shorter duration of diarrhea and a higher recovery rate compared to those given a placebo.
Notably, we also observed beneficial changes in gut microbiome composition and gene functions that promote immune response.
This evidence suggests that Bifidobacterium lactis can effectively support recovery from acute diarrhea in children.
Our findings show that children receiving the probiotic experienced a significantly shorter duration of diarrhea and a higher recovery rate compared to those given a placebo.
Notably, we also observed beneficial changes in gut microbiome composition and gene functions that promote immune response.
This evidence suggests that Bifidobacterium lactis can effectively support recovery from acute diarrhea in children.
Read More
9
We examined the effectiveness of LRa05, a probiotic, in treating acute watery diarrhea in children. In a randomized controlled trial, 57 children received LRa05 while 54 received a placebo. Our findings showed that those who took LRa05 had shorter diarrhea durations and improved fecal consistency compared to the control group. Additionally, LRa05 improved gut microbiome composition and boosted levels of beneficial gut proteins. Overall, using LRa05 can be a helpful addition to managing diarrhea in young children.
Read More
9
We conducted a multi-hospital study to tackle the common issue of antibiotic-associated diarrhea (AAD). By comparing probiotics, specifically Lactobacillus rhamnosus GG and Bifidobacterium longum BB536, with a placebo among 340 adult patients, we aimed to find out if these friendly bacteria could help.
Our findings revealed that probiotics significantly lowered both the incidence and duration of AAD compared to the placebo group. Patients reported positive outcomes, indicating high adherence to the treatment as well.
Our findings revealed that probiotics significantly lowered both the incidence and duration of AAD compared to the placebo group. Patients reported positive outcomes, indicating high adherence to the treatment as well.
Read More
9
We investigated how Lactobacillus rhamnosus, specifically a postbiotic preparation known as mLGG, affects diarrhea linked to the Spike protein of SARS-CoV-2. In our tests using human intestinal cells, we found that the Spike protein triggers diarrhea by increasing oxidative stress and chloride secretion.
Our findings showed that pretreating the cells with mLGG significantly reduced these harmful effects. This suggests that Lactobacillus rhamnosus can help ease diarrhea by blocking the enterotoxic impact of the Spike protein, confirming its role as an effective therapy for acute gastroenteritis.
Our findings showed that pretreating the cells with mLGG significantly reduced these harmful effects. This suggests that Lactobacillus rhamnosus can help ease diarrhea by blocking the enterotoxic impact of the Spike protein, confirming its role as an effective therapy for acute gastroenteritis.
Read More
9
Probiotic improves diarrhea symptoms
We evaluated how well the probiotic Neobiotic Lactobalance®, containing Lactobacillus rhamnosus, helps relieve diarrhea linked to irritable bowel syndrome (IBS) and antibiotic-associated diarrhea (AAD).
In our study of 54 patients, we noted significant reductions in diarrhea severity and abdominal pain after 21 days of daily probiotic intake. For those with IBS, symptoms decreased nearly threefold, while AAD patients saw even greater improvements.
Additionally, microbiological analysis confirmed that the probiotic improved gut health by increasing beneficial bacteria. Overall, we found Neobiotic Lactobalance® effective in normalizing gut flora and alleviating diarrhea symptoms.
In our study of 54 patients, we noted significant reductions in diarrhea severity and abdominal pain after 21 days of daily probiotic intake. For those with IBS, symptoms decreased nearly threefold, while AAD patients saw even greater improvements.
Additionally, microbiological analysis confirmed that the probiotic improved gut health by increasing beneficial bacteria. Overall, we found Neobiotic Lactobalance® effective in normalizing gut flora and alleviating diarrhea symptoms.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
1
Caused runny stools
4 people found this helpful
Sadly, this probiotic caused severe diarrhoea in our 8-month-old daughter. We switched from another brand, so we're unsure if it was the change or not. After stopping, the diarrhoea ceased, indicating that this may have been the cause. The drops tasted gritty and unpleasant. Definitely not purchasing again.
Read More
10
Diarrhoea resolved quickly
1 people found this helpful
As someone knowledgeable about dietary supplements, I started giving this to my 6-month-old son, who was experiencing diarrhoea. Remarkably, the diarrhoea resolved the following day, and I appreciate that it contains Vitamin D as well. We provide this daily, and it seems to be beneficial as he tries new solid foods.
Read More
8
Prevented diarrhoea
1 people found this helpful
This probiotic is a lifesaver for sick babies. Our baby developed his first ear infection and needed antibiotics. To avoid adverse side effects like diarrhoea, our paediatrician advised using a probiotic proactively. Luckily, it worked wonders because he recovered quickly with no tummy issues.
Read More
Frequently Asked Questions
9
We examined the effectiveness of LRa05, a probiotic, in treating acute watery diarrhea in children. In a randomized controlled trial, 57 children received LRa05 while 54 received a placebo. Our findings showed that those who took LRa05 had shorter diarrhea durations and improved fecal consistency compared to the control group. Additionally, LRa05 improved gut microbiome composition and boosted levels of beneficial gut proteins. Overall, using LRa05 can be a helpful addition to managing diarrhea in young children.
9
We conducted a multi-hospital study to tackle the common issue of antibiotic-associated diarrhea (AAD). By comparing probiotics, specifically Lactobacillus rhamnosus GG and Bifidobacterium longum BB536, with a placebo among 340 adult patients, we aimed to find out if these friendly bacteria could help.
Our findings revealed that probiotics significantly lowered both the incidence and duration of AAD compared to the placebo group. Patients reported positive outcomes, indicating high adherence to the treatment as well.
Our findings revealed that probiotics significantly lowered both the incidence and duration of AAD compared to the placebo group. Patients reported positive outcomes, indicating high adherence to the treatment as well.
8
Probiotics may prevent antibiotic diarrhea
We explored the impact of probiotics, especially Lactobacillus rhamnosus GG, on antibiotic-associated diarrhea. The research indicates that this specific strain can indeed play a role in alleviating diarrhea caused by disruptions in gut microbiota after antibiotic use. Systematic reviews and clinical trials support its effectiveness, showing that taking the probiotic shortly after starting antibiotics can help manage symptoms and restore gut health. However, it’s important to note that not all probiotics may yield the same results, and careful dosing is crucial for effectiveness.
9
Probiotic improves diarrhea symptoms
We evaluated how well the probiotic Neobiotic Lactobalance®, containing Lactobacillus rhamnosus, helps relieve diarrhea linked to irritable bowel syndrome (IBS) and antibiotic-associated diarrhea (AAD).
In our study of 54 patients, we noted significant reductions in diarrhea severity and abdominal pain after 21 days of daily probiotic intake. For those with IBS, symptoms decreased nearly threefold, while AAD patients saw even greater improvements.
Additionally, microbiological analysis confirmed that the probiotic improved gut health by increasing beneficial bacteria. Overall, we found Neobiotic Lactobalance® effective in normalizing gut flora and alleviating diarrhea symptoms.
In our study of 54 patients, we noted significant reductions in diarrhea severity and abdominal pain after 21 days of daily probiotic intake. For those with IBS, symptoms decreased nearly threefold, while AAD patients saw even greater improvements.
Additionally, microbiological analysis confirmed that the probiotic improved gut health by increasing beneficial bacteria. Overall, we found Neobiotic Lactobalance® effective in normalizing gut flora and alleviating diarrhea symptoms.
9
We evaluated the effectiveness of Bifidobacterium lactis XLTG11 in treating acute watery diarrhea in children through a rigorous randomized, double-blind, placebo-controlled trial.
Children who received the probiotic alongside their conventional treatment had significantly shorter diarrhea durations and hospital stays compared to those who only got standard care. Additionally, those taking Bifidobacterium showed better improvement rates and healthier gut microbiomes after treatment.
Overall, this study suggests that Bifidobacterium lactis can be a beneficial adjunct therapy for children suffering from diarrhea.
Children who received the probiotic alongside their conventional treatment had significantly shorter diarrhea durations and hospital stays compared to those who only got standard care. Additionally, those taking Bifidobacterium showed better improvement rates and healthier gut microbiomes after treatment.
Overall, this study suggests that Bifidobacterium lactis can be a beneficial adjunct therapy for children suffering from diarrhea.
8
We explored how probiotics, particularly Lactobacillus rhamnosus, might help prevent and treat antibiotic-associated diarrhea (AAD) in children. Our analysis included 20 systematic reviews and utilized various assessment tools to evaluate their quality.
While high doses of probiotics showed significant effects, we noticed concerns about the quality of reporting and evidence in many reviews. This means that, while the potential is there, cautious interpretation of results is necessary as further improvements in study methodology are needed.
While high doses of probiotics showed significant effects, we noticed concerns about the quality of reporting and evidence in many reviews. This means that, while the potential is there, cautious interpretation of results is necessary as further improvements in study methodology are needed.
References
- Zhao Y, Zhu X, Lan Q, Wei Z, Shang P, et al. 1α,25-hydroxyvitamin D alleviated rotavirus infection induced ferroptosis in IPEC-J2 cells by regulating the ATF3-SLC7A11-GPX4 axis. Int J Biol Macromol. 2024;283:137484. 10.1016/j.ijbiomac.2024.137484
- Shin I, Kang Y, Ahn J, Kim Y, Nam J, et al. The potential probiotic role of Lacticaseibacillus rhamnosus on growth performance, gut health, and immune responses of weaned pigs. J Anim Sci. 2025. 10.1093/jas/skaf089
- Chen K, Zeng K, Jin S, Ma Y, Cai L, et al. LRa05 in the treatment of acute diarrhea in children: a randomized controlled trial. Front Nutr. 2024;11:1479186. 10.3389/fnut.2024.1479186
- Gwee KA, Lee WRW, Chua Q, Chiou FK, Aw MM, et al. The evidence for probiotics in the treatment of digestive disorders in the pediatric population. J Gastroenterol Hepatol. 2025;40:41. 10.1111/jgh.16809
- Shah J, Adnan SH, Yousaf MS, Din SJU, Haq MU, et al. A Multi-Hospital Comparative Study on the Efficacy of Probiotics Versus Placebo in Preventing Antibiotic-Associated Diarrhea in Adult Patients. Cureus. 2024;16:e70881. 10.7759/cureus.70881
- Shawky LM, Abo El Wafa SM, Behery M, Bahr MH, Abu Alnasr MT, et al. Lactobacillus rhamnosus GG and Tannic Acid Synergistically Promote the Gut Barrier Integrity in a Rat Model of Experimental Diarrhea via Selective Immunomodulatory Cytokine Targeting. Mol Nutr Food Res. 2024;68:e2400295. 10.1002/mnfr.202400295
- Anvarifard P, Anbari M, Ghalichi F, Ghoreishi Z, Zarezadeh M. The effectiveness of probiotics as an adjunct therapy in patients under mechanical ventilation: an umbrella systematic review and meta-analysis. Food Funct. 2024;15:5737. 10.1039/d3fo04653b
- Alharbi BF, Alateek AA. Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic review. Travel Med Infect Dis. 2024;59:102703. 10.1016/j.tmaid.2024.102703
- Abdulah DM, Sulaiman SJ, Ahmed ZW. Effect of probiotics plus zinc supplementation on clinical outcomes of infants and children with acute infectious diarrhea: a randomized controlled trial. Clin Exp Pediatr. 2024;67:203. 10.3345/cep.2023.01340
- Waitzberg D, Guarner F, Hojsak I, Ianiro G, Polk DB, et al. Can the Evidence-Based Use of Probiotics (Notably Saccharomyces boulardii CNCM I-745 and Lactobacillus rhamnosus GG) Mitigate the Clinical Effects of Antibiotic-Associated Dysbiosis?. Adv Ther. 2024;41:901. 10.1007/s12325-024-02783-3
- Saviano A, Petruzziello C, Cancro C, Macerola N, Petti A, et al. The Efficacy of a Mix of Probiotics ( LMG P-27481 and GG ATCC 53103) in Preventing Antibiotic-Associated Diarrhea and Infection in Hospitalized Patients: Single-Center, Open-Label, Randomized Trial. Microorganisms. 2024;12. 10.3390/microorganisms12010198
- Poeta M, Cioffi V, Tarallo A, Damiano C, Lo Vecchio A, et al. Postbiotic Preparation of against Diarrhea and Oxidative Stress Induced by Spike Protein of SARS-CoV-2 in Human Enterocytes. Antioxidants (Basel). 2023;12. 10.3390/antiox12101878
- Drozdov VN, Shikh EV, Astapovskii AA, Khalaidzheva KN, Solovieva SA, et al. [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea]. Vopr Pitan. 2023;92:92. 10.33029/0042-8833-2023-92-4-92-103
- Mego M, Danis R, Chovanec J, Jurisova S, Bystricky B, et al. Randomized double-blind, placebo-controlled multicenter phase III study of prevention of irinotecan-induced diarrhea by a probiotic mixture containing Bifidobacterium BB-12 LGG in colorectal cancer patients. Front Oncol. 2023;13:1168654. 10.3389/fonc.2023.1168654
- Yang Q, Hu Z, Lei Y, Li X, Xu C, et al. Overview of systematic reviews of probiotics in the prevention and treatment of antibiotic-associated diarrhea in children. Front Pharmacol. 2023;14:1153070. 10.3389/fphar.2023.1153070
- Niu H, Zhou X, Liu P, Wu Y, Lyu L, et al. Lactobacillus rhamnosus MN-431 Metabolic Tryptophan Alleviates Complementary Food-Induced Diarrhea through PXR-NF-κB Pathway and AHR-Th17 Cell Response Pathways. Mol Nutr Food Res. 2023;67:e2200530. 10.1002/mnfr.202200530
- Li J, Li Q, Wu Q, Gao N, Wang Z, et al. Exopolysaccharides of Lactobacillus rhamnosus GG ameliorate Salmonella typhimurium-induced intestinal inflammation via the TLR4/NF-κB/MAPK pathway. J Anim Sci Biotechnol. 2023;14:23. 10.1186/s40104-023-00830-7
- Uttarwar RG, Mekonnen SA, Van Beeck W, Wang A, Finnegan P, et al. Effects of Bifidobacterium animalis subsp. lactis BB-12 and yogurt on mice during oral antibiotic administration. Microbiol Res. 2024;286:127794. 10.1016/j.micres.2024.127794
- Jeong JJ, Jin YJ, Ganesan R, Park HJ, Min BH, et al. Multistrain Probiotics Alleviate Diarrhea by Modulating Microbiome-Derived Metabolites and Serotonin Pathway. Probiotics Antimicrob Proteins. 2024. 10.1007/s12602-024-10232-4
- Chen K, Jin S, Ma Y, Cai L, Xu P, et al. Adjudicative efficacy of Bifidobacterium animalis subsp. lactis BLa80 in treating acute diarrhea in children: a randomized, double-blinded, placebo-controlled study. Eur J Clin Nutr. 2024;78:501. 10.1038/s41430-024-01428-6
- Chen K, Jin S, Ma Y, Cai L, Xu P, et al. Adjunctive efficacy of Lactis XLTG11 for Acute diarrhea in children: A randomized, blinded, placebo-controlled study. Nutrition. 2023;111:112052. 10.1016/j.nut.2023.112052
- Pang J, Liu Y, Kang L, Ye H, Zang J, et al. Bifidobacterium animalis Promotes the Growth of Weaning Piglets by Improving Intestinal Development, Enhancing Antioxidant Capacity, and Modulating Gut Microbiota. Appl Environ Microbiol. 2022;88:e0129622. 10.1128/aem.01296-22
- Şahin K, Şahintürk Y, Köker G, Özçelik Köker G, Bostan F, et al. Metformin with Versus without Concomitant Probiotic Therapy in Newly Diagnosed Patients with Type 2 Diabetes or Prediabetes: A Comparative Analysis in Relation to Glycemic Control, Gastrointestinal Side Effects, and Treatment Compliance. Turk J Gastroenterol. 2022;33:925. 10.5152/tjg.2022.211063
- Lukasik J, Dierikx T, Besseling-van der Vaart I, de Meij T, Szajewska H. Multispecies Probiotic for the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Clinical Trial. JAMA Pediatr. 2022;176:860. 10.1001/jamapediatrics.2022.1973
- Xu B, Liang S, Zhao J, Li X, Guo J, et al. subsp. XLTG11 improves antibiotic-related diarrhea by alleviating inflammation, enhancing intestinal barrier function and regulating intestinal flora. Food Funct. 2022;13:6404. 10.1039/d1fo04305f
- Liu B, Wang C, Huasai S, Han A, Zhang J, et al. Compound Probiotics Improve the Diarrhea Rate and Intestinal Microbiota of Newborn Calves. Animals (Basel). 2022;12. 10.3390/ani12030322
- Michels M, Córneo E, Cucker L, Simon CS, de Jesus GFA, et al. Bifidobacterium lactis CCT 7858 Improves Gastrointestinal Symptoms by Antibiotics Treatment: a Double-Blind, Randomized, Placebo-Controlled Trial. Probiotics Antimicrob Proteins. 2023;15:738. 10.1007/s12602-021-09900-6
- Cheng J, Laitila A, Ouwehand AC. subsp. HN019 Effects on Gut Health: A Review. Front Nutr. 2021;8:790561. 10.3389/fnut.2021.790561
- Li Z, Zhu G, Li C, Lai H, Liu X, et al. Which Probiotic Is the Most Effective for Treating Acute Diarrhea in Children? A Bayesian Network Meta-Analysis of Randomized Controlled Trials. Nutrients. 2021;13. 10.3390/nu13124319
- Guo Y, Li Z, Deng M, Li Y, Liu G, et al. Effects of a multi-strain probiotic on growth, health, and fecal bacterial flora of neonatal dairy calves. Anim Biosci. 2022;35:204. 10.5713/ab.21.0084
- Merenstein D, Fraser CM, Roberts RF, Liu T, Grant-Beurmann S, et al. subsp. BB-12 Protects against Antibiotic-Induced Functional and Compositional Changes in Human Fecal Microbiome. Nutrients. 2021;13. 10.3390/nu13082814
- Kluijfhout S, Trieu TV, Vandenplas Y. Efficacy of the Probiotic Probiotical Confirmed in Acute Gastroenteritis. Pediatr Gastroenterol Hepatol Nutr. 2020;23:464. 10.5223/pghn.2020.23.5.464
