Last update
5/21/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: Five (5) Drops
Amount Per Serving
%DV
Calories
0
Total Carbohydrate
0 g
0%
Total Sugars
0 g
**
Incl. 0 g Added Sugars
**
Vitamin D (as cholecalciferol)
10 mcg (400 IU)
100%
Probiotic Blend
29 mg (2.5 billion CFUs)
Lactobacillus rhamnosus GG
**
Bifidobacterium animalis subsp. lactis (BB-12®)
**
Top Medical Research Studies
8
We explored the potential benefits of vitamin D supplementation for reducing the risk of influenza infections. Through a comprehensive analysis of multiple Randomized Controlled Trials (RCTs), we aimed to clarify whether taking vitamin D can help prevent the flu.
Our investigation identified 10 relevant trials that included a total of 4,859 participants. These studies varied in their dosages and duration of vitamin D use, allowing us to assess overall effectiveness across different populations.
The findings were encouraging: our analysis demonstrated that vitamin D supplementation appears to significantly reduce the risk of getting influenza, suggesting that those who increase their vitamin D intake might be better protected during flu season.
Importantly, we did not find significant differences between the studies that could affect our result, and there was no hint of publication bias. Consequently, we can confidently suggest that including vitamin D in our health strategies could enhance our defenses against the flu.
Our investigation identified 10 relevant trials that included a total of 4,859 participants. These studies varied in their dosages and duration of vitamin D use, allowing us to assess overall effectiveness across different populations.
The findings were encouraging: our analysis demonstrated that vitamin D supplementation appears to significantly reduce the risk of getting influenza, suggesting that those who increase their vitamin D intake might be better protected during flu season.
Importantly, we did not find significant differences between the studies that could affect our result, and there was no hint of publication bias. Consequently, we can confidently suggest that including vitamin D in our health strategies could enhance our defenses against the flu.
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0
We investigated whether high-dose vitamin D supplementation could lessen cold and flu symptoms in preschool children. Conducted in Toronto, this study involved over 700 children aged 1 to 5, who received either a high dose of 2000 IU or a standard dose of 400 IU for one winter season.
Despite hopes that higher doses would help, our findings showed no significant reduction in the severity of upper respiratory tract infections, outpatient visits, emergency room visits, or the need for antibiotics compared to the standard dose.
Ultimately, taking more vitamin D than recommended doesn’t seem beneficial for alleviating flu symptoms in kids.
Despite hopes that higher doses would help, our findings showed no significant reduction in the severity of upper respiratory tract infections, outpatient visits, emergency room visits, or the need for antibiotics compared to the standard dose.
Ultimately, taking more vitamin D than recommended doesn’t seem beneficial for alleviating flu symptoms in kids.
Read More
9
We evaluated the impact of EpiCor, a yeast-derived postbiotic, on flu and cold symptoms in children aged 4-12. Over the course of 84 days, 256 children either received EpiCor or a placebo during the flu season.
Our findings showed that those taking EpiCor experienced significantly less severity in cold and flu symptoms compared to the placebo group. This included fewer sore throats and muscle aches, along with reduced reliance on cold and flu medications.
Overall, EpiCor appears to be a safe option to help boost immune function in children during cold and flu season.
Our findings showed that those taking EpiCor experienced significantly less severity in cold and flu symptoms compared to the placebo group. This included fewer sore throats and muscle aches, along with reduced reliance on cold and flu medications.
Overall, EpiCor appears to be a safe option to help boost immune function in children during cold and flu season.
Read More
Most Useful Reviews
9
Remarkable results
1 people found this helpful
Great for acid reflux and spitting up. I was hopeful (but skeptical) that this would help my baby's acid reflux. I'm amazed at the result! Within a week, he went from soaking two burp rags with spit-up every feeding to hardly any! He no longer fusses or refuses milk during feedings. I'm incredibly thankful.
Read More
7.5
Effective product
1 people found this helpful
Great Probiotic, annoying bottle. This product has really helped with my baby's colic, gas and reflux. I love that the vitamin D is included, so it's one less thing to remember. The only downside is the packaging and dropper—it’s impossible not to get the product all over the bottle, and it tends to crust up around the lid.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
- All Researches
9
We evaluated the impact of EpiCor, a yeast-derived postbiotic, on flu and cold symptoms in children aged 4-12. Over the course of 84 days, 256 children either received EpiCor or a placebo during the flu season.
Our findings showed that those taking EpiCor experienced significantly less severity in cold and flu symptoms compared to the placebo group. This included fewer sore throats and muscle aches, along with reduced reliance on cold and flu medications.
Overall, EpiCor appears to be a safe option to help boost immune function in children during cold and flu season.
Our findings showed that those taking EpiCor experienced significantly less severity in cold and flu symptoms compared to the placebo group. This included fewer sore throats and muscle aches, along with reduced reliance on cold and flu medications.
Overall, EpiCor appears to be a safe option to help boost immune function in children during cold and flu season.
Read More
9
We recently examined how vitamin D impacts our body's response to influenza H1N1, an important viral infection. Utilizing 142 clinical cases from the Department of Otolaryngology at Sun Yat-sen University, we dug into the effects of vitamin D deficiency on chronic rhinosinusitis (CRS), a condition that frequently involves damage to the airway's lining. By studying airway organoids treated with vitamin D, we were able to simulate how this treatment might bolster our defenses against flu viruses and bacteria like Staphylococcus aureus.
Our observations showed that many patients with CRS suffered from vitamin D deficiency. Notably, those who received vitamin D treatment exhibited faster cell growth in the nasal epithelium. When exposed to the H1N1 virus, these treated organoids demonstrated a remarkable ability to fend off the infection better than those without vitamin D. This protection stemmed from enhancements in host defenses, including improved production of antimicrobial proteins, reduced inflammation, and better epithelial integrity—crucial factors in fighting off infections.
We also uncovered some fascinating insights about the biological mechanisms at work. Vitamin D seemed to actively influence how epithelial cells develop and repair themselves while managing immune responses against infections. These findings underscore the significance of addressing vitamin D deficiency, especially for those vulnerable to respiratory illnesses.
Our observations showed that many patients with CRS suffered from vitamin D deficiency. Notably, those who received vitamin D treatment exhibited faster cell growth in the nasal epithelium. When exposed to the H1N1 virus, these treated organoids demonstrated a remarkable ability to fend off the infection better than those without vitamin D. This protection stemmed from enhancements in host defenses, including improved production of antimicrobial proteins, reduced inflammation, and better epithelial integrity—crucial factors in fighting off infections.
We also uncovered some fascinating insights about the biological mechanisms at work. Vitamin D seemed to actively influence how epithelial cells develop and repair themselves while managing immune responses against infections. These findings underscore the significance of addressing vitamin D deficiency, especially for those vulnerable to respiratory illnesses.
Read More
8
Probiotic shows potential, inconclusive for flu
We examined how the probiotic Bifidobacterium lactis Probio-M8 impacts acute respiratory tract infections in young hospitalized children. This double-blind, placebo-controlled study involved 120 children divided into two groups: one receiving probiotics and the other a placebo.
Our findings suggest that the probiotic could help manage respiratory infections safely, potentially reducing antibiotic use and shortening hospital stays. However, the overall effectiveness in preventing flu is still inconclusive, and more research is necessary to solidify these benefits.
Our findings suggest that the probiotic could help manage respiratory infections safely, potentially reducing antibiotic use and shortening hospital stays. However, the overall effectiveness in preventing flu is still inconclusive, and more research is necessary to solidify these benefits.
Read More
8
We explored how the probiotic Lactobacillus paracasei can enhance the immune response to influenza in a mouse model. The study showed that feeding mice this probiotic led to a stronger defense against the flu, with quicker viral clearance and fewer inflammatory cells in the lungs.
While this research highlights promising benefits of probiotics like L. paracasei, it was done in mice, meaning we need more studies to understand their effects in children. Overall, these findings suggest that certain probiotics may help improve immune control of respiratory infections.
While this research highlights promising benefits of probiotics like L. paracasei, it was done in mice, meaning we need more studies to understand their effects in children. Overall, these findings suggest that certain probiotics may help improve immune control of respiratory infections.
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8
We explored how vitamin D supplementation might help reduce the risk of respiratory infections, particularly the flu, in care homes. Our systematic review of several randomized controlled trials focused on interventions to reduce the transmission of acute respiratory infections, looking beyond just vaccines.
Our findings highlighted that high-dose vitamin D supplementation led to a significant decrease in the incidence of acute respiratory infections, reducing the likelihood of getting sick. Specifically, one trial indicated a 40% reduction in these infections among participants receiving vitamin D compared to those who did not.
However, not all studies we reviewed showed compelling results for related supplements like vitamins, minerals, probiotics, and herbal aids, which did not significantly impact infection rates. This means that while vitamin D supplementation shows promise, more research is needed to fully understand its effects and confirm its benefits in combating flu and other respiratory illnesses.
Our findings highlighted that high-dose vitamin D supplementation led to a significant decrease in the incidence of acute respiratory infections, reducing the likelihood of getting sick. Specifically, one trial indicated a 40% reduction in these infections among participants receiving vitamin D compared to those who did not.
However, not all studies we reviewed showed compelling results for related supplements like vitamins, minerals, probiotics, and herbal aids, which did not significantly impact infection rates. This means that while vitamin D supplementation shows promise, more research is needed to fully understand its effects and confirm its benefits in combating flu and other respiratory illnesses.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Remarkable results
1 people found this helpful
Great for acid reflux and spitting up. I was hopeful (but skeptical) that this would help my baby's acid reflux. I'm amazed at the result! Within a week, he went from soaking two burp rags with spit-up every feeding to hardly any! He no longer fusses or refuses milk during feedings. I'm incredibly thankful.
Read More
7.5
Effective product
1 people found this helpful
Great Probiotic, annoying bottle. This product has really helped with my baby's colic, gas and reflux. I love that the vitamin D is included, so it's one less thing to remember. The only downside is the packaging and dropper—it’s impossible not to get the product all over the bottle, and it tends to crust up around the lid.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Al-Akel FC, Chiperi LE, Eszter VK, Bacârea A. Role as a Probiotic in Children's Health and Disease Prophylaxis-A Systematic Review. Life (Basel). 2024;14. 10.3390/life14121613
- Singh RG, Garcia-Campayo V, Green JB, Paton N, Saunders JD, et al. Efficacy of a yeast postbiotic on cold/flu symptoms in healthy children: A randomized-controlled trial. Pediatr Res. 2024;96:1739. 10.1038/s41390-024-03331-z
- Zhao Y, Dong BR, Hao Q. Probiotics for preventing acute upper respiratory tract infections. Cochrane Database Syst Rev. 2022;8:CD006895. 10.1002/14651858.CD006895.pub4
- Mageswary MU, Ang XY, Lee BK, Chung YF, Azhar SNA, et al. Probiotic Bifidobacterium lactis Probio-M8 treated and prevented acute RTI, reduced antibiotic use and hospital stay in hospitalized young children: a randomized, double-blind, placebo-controlled study. Eur J Nutr. 2022;61:1679. 10.1007/s00394-021-02689-8
- Belkacem N, Serafini N, Wheeler R, Derrien M, Boucinha L, et al. Lactobacillus paracasei feeding improves immune control of influenza infection in mice. PLoS One. 2017;12:e0184976. 10.1371/journal.pone.0184976
- Di Pierro F, Colombo M, Zanvit A, Rottoli AS. Positive clinical outcomes derived from using K12 to prevent streptococcal pharyngotonsillitis in children: a pilot investigation. Drug Healthc Patient Saf. 2016;8:77. PubMed
- Willcox ML, Lavu D, Yousaf U, Dalton S, Roberts N, et al. The effectiveness of interventions to reduce the transmission of acute respiratory infections in care homes: a systematic review. J Public Health (Oxf). 2024;46:551. 10.1093/pubmed/fdae178
- Liao S, Huang Y, Zhang J, Xiong Q, Chi M, et al. Vitamin D promotes epithelial tissue repair and host defense responses against influenza H1N1 virus and Staphylococcus aureus infections. Respir Res. 2023;24:175. 10.1186/s12931-023-02477-4
- van Helmond N, Brobyn TL, LaRiccia PJ, Cafaro T, Hunter K, et al. Vitamin D3 Supplementation at 5000 IU Daily for the Prevention of Influenza-like Illness in Healthcare Workers: A Pragmatic Randomized Clinical Trial. Nutrients. 2022;15. 10.3390/nu15010180
- Arora J, Patel DR, Nicol MJ, Field CJ, Restori KH, et al. Vitamin D and the Ability to Produce 1,25(OH)D Are Critical for Protection from Viral Infection of the Lungs. Nutrients. 2022;14. 10.3390/nu14153061
- Huang YN, Chi H, Chiu NC, Huang CY, Li ST, et al. A randomized trial of vitamin D supplementation to prevent seasonal influenza and enterovirus infection in children. J Microbiol Immunol Infect. 2022;55:803. 10.1016/j.jmii.2022.01.003
- Zhu Z, Zhu X, Gu L, Zhan Y, Chen L, et al. Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials. Front Nutr. 2021;8:799709. 10.3389/fnut.2021.799709
- Godan Hauptman A, Lukić-Grlić A, Vraneš J, Milošević M, Gagro A. The effect of standard-dose wintertime vitamin D supplementation on influenza infection in immunized nursing home elderly residents. Croat Med J. 2021;62:495. PubMed
- Abioye AI, Bromage S, Fawzi W. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis. BMJ Glob Health. 2021;6. 10.1136/bmjgh-2020-003176
- Slusky DJG, Zeckhauser RJ. Sunlight and Protection Against Influenza. Econ Hum Biol. 2021;40:100942. 10.1016/j.ehb.2020.100942
- Hueniken K, Aglipay M, Birken CS, Parkin PC, Loeb MB, et al. Effect of High-Dose Vitamin D Supplementation on Upper Respiratory Tract Infection Symptom Severity in Healthy Children. Pediatr Infect Dis J. 2019;38:564. 10.1097/INF.0000000000002225
