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Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Our findings showed that the probiotic group experienced quicker symptom relief and a longer time before symptoms returned, compared to the placebo. We also noted improvements in gut microbiota diversity following the treatment. Thus, Bifidobacterium lactis appears to provide significant benefits as an adjunct therapy for managing reflux symptoms.
We found that both treatment groups experienced significant reductions in gut transit times and a decrease in various GI symptoms. The placebo group did not show any notable improvements.
Overall, B. lactis HN019 seems effective in easing reflux-related symptoms and improving gut health.
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Importantly, we noted that the probiotic mixture also seemed to decrease reflux episodes from 60% to 20%. This suggests that not only does Ecologic®Relief help with constipation, but it may also provide relief from reflux symptoms during pregnancy. We believe more extensive studies will be beneficial to confirm these findings.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Our findings showed that the probiotic group experienced quicker symptom relief and a longer time before symptoms returned, compared to the placebo. We also noted improvements in gut microbiota diversity following the treatment. Thus, Bifidobacterium lactis appears to provide significant benefits as an adjunct therapy for managing reflux symptoms.
We found that both treatment groups experienced significant reductions in gut transit times and a decrease in various GI symptoms. The placebo group did not show any notable improvements.
Overall, B. lactis HN019 seems effective in easing reflux-related symptoms and improving gut health.
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Frequently Asked Questions
Reflux, medically known as gastroesophageal reflux disease (GERD), occurs when stomach acid flows back into the esophagus, the tube that connects the throat to the stomach. This backflow can lead to symptoms such as heartburn, regurgitation, and difficulty swallowing. Reflux can affect people of all ages and may be triggered or worsened by factors such as diet, obesity, smoking, and certain medications. While occasional reflux is common and often manageable with lifestyle changes, chronic reflux can lead to more serious complications if not properly treated.
Managing reflux typically involves a combination of lifestyle modifications—such as avoiding trigger foods, eating smaller meals, and maintaining a healthy weight—and, in some cases, medication to reduce stomach acid production. In more severe cases, surgical options may be considered. If you suspect you have reflux or experience frequent symptoms, it’s advisable to consult a healthcare professional for an accurate diagnosis and personalized treatment plan.
Children's probiotics are dietary supplements specifically formulated to provide beneficial bacteria that support digestive health and the immune system in children. These probiotics contain various strains of live microorganisms, often including Lactobacillus and Bifidobacterium, which are known to help maintain a healthy balance of gut bacteria. The gut microbiome plays a crucial role in children's overall health, influencing their digestion, immune function, and even mood. Many parents turn to children's probiotics to help address issues like constipation, diarrhea, or colic, as well as to support their child’s immunity, especially during cold and flu season.
When selecting a children's probiotic, it’s essential to consider factors such as the specific strains included, the number of colony-forming units (CFUs), and whether it is tailored to your child's specific health needs. Probiotics can come in various forms, including powders, gummies, and liquids, making them easy to administer to little ones. However, it’s always advisable to consult a pediatrician before starting any new supplement regime for your child, as they can provide personalized recommendations based on the child's health history and current needs.
When it comes to relieving symptoms of reflux in children, probiotics may offer some benefits, although research is still ongoing. Probiotics are live bacteria and yeasts that are beneficial for digestive health and have been shown to help balance gut flora, which could potentially influence reflux symptoms. Some studies suggest that certain strains of probiotics may help reduce the severity of reflux or alleviate associated symptoms, such as discomfort and bloating. However, it’s crucial to consult with a pediatrician before introducing probiotics, especially in infants and young children, as their digestive systems are still developing.
It's important to note that while probiotics can play a supporting role in digestive health, they should not be seen as a standalone treatment for reflux. Lifestyle and dietary changes often have a more significant impact on managing this condition. Parents may also need to observe their child's eating habits and consider avoiding certain trigger foods that can exacerbate reflux symptoms. Overall, while there is promise in the use of probiotics for gastrointestinal issues in children, including reflux, further research is needed to fully understand their effectiveness and appropriate use.
When it comes to children's probiotics for reflux, the timeline for seeing results can vary significantly from one child to another. Generally, many parents report noticing improvements within a few days to two weeks of consistent use. This can depend on several factors, including the child's individual digestive health, the specific strains of probiotics being used, and adherence to the recommended dosage. Some children may experience faster relief, while others might require more time to see changes in symptoms.
It's essential to monitor your child's response to the probiotics closely and consult with a healthcare professional for tailored advice. If symptoms persist beyond a few weeks, or if you notice any new or worsening symptoms, it's crucial to seek guidance from a pediatrician. Remember, probiotics are best used as a complementary approach alongside other dietary and lifestyle modifications for managing reflux.
When evaluating the scientific support for specific supplements related to reflux, Bifidobacterium lactis stands out. A recent randomized controlled trial involving 110 patients with reflux esophagitis demonstrated that those who received Bifidobacterium along with their usual medication experienced quicker symptom relief and longer intervals before symptoms returned compared to the placebo group. This suggests that Bifidobacterium lactis could serve as an effective adjunct therapy for managing reflux symptoms [2]. Additionally, other studies have shown that this probiotic can positively influence gut health, making it a promising candidate for those seeking relief from reflux-related discomfort [4].
On the other hand, while Vitamin D3 shows potential in reducing inflammation associated with reflux esophagitis, its impact is more limited. Research indicates that while Vitamin D3 can lower levels of pro-inflammatory cytokines in acute cases, it doesn’t significantly repair the esophageal damage in chronic cases. This implies that while it might be beneficial for early-stage reflux, it does not provide a comprehensive solution [1]. Therefore, Bifidobacterium lactis appears to be more robustly supported by scientific evidence when it comes to relieving reflux symptoms compared to Vitamin D3.
Our findings showed that the probiotic group experienced quicker symptom relief and a longer time before symptoms returned, compared to the placebo. We also noted improvements in gut microbiota diversity following the treatment. Thus, Bifidobacterium lactis appears to provide significant benefits as an adjunct therapy for managing reflux symptoms.
We found that both treatment groups experienced significant reductions in gut transit times and a decrease in various GI symptoms. The placebo group did not show any notable improvements.
Overall, B. lactis HN019 seems effective in easing reflux-related symptoms and improving gut health.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
References
- Wei J, Zhang J, Jiang Y, Lian T, Zhang P, et al. Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3. In Vivo. 2023;37:79. doi:10.21873/invivo.13056
- Gan L, Wang Y, Huang S, Zheng L, Feng Q, et al. Therapeutic Evaluation of subsp. MH-02 as an Adjunctive Treatment in Patients with Reflux Esophagitis: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16030342
- de Milliano I, Tabbers MM, van der Post JA, Benninga MA. Is a multispecies probiotic mixture effective in constipation during pregnancy? 'A pilot study'. Nutr J. 2012;11:80. doi:10.1186/1475-2891-11-80
- Waller PA, Gopal PK, Leyer GJ, Ouwehand AC, Reifer C, et al. Dose-response effect of Bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults. Scand J Gastroenterol. 2011;46:1057. doi:10.3109/00365521.2011.584895
