Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.3
USERS' SCORE
Medium or Average
Based on 3 Reviews
6.9
Supplement Facts
Serving Size: Five (5) Drops
Amount Per Serving
%DV
Calories
0
Total Carbohydrate
0 g
0%
Total Sugars
0 g
**
Incl. 0 g Added Sugars
**
Vitamin D (as cholecalciferol)
10 mcg (400 IU)
100%
Probiotic Blend
29 mg (2.5 billion CFUs)
Lactobacillus rhamnosus GG
**
Bifidobacterium animalis subsp. lactis (BB-12®)
**
Top Medical Research Studies
8
We investigated how Vitamin D3 affects inflammation caused by reflux esophagitis—a condition where stomach acid irritates the esophagus. In our study, we used 70 male rats, dividing them into groups to examine the impact of Vitamin D3 at different doses on inflammation levels.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Read More
8
We examined the effects of Bifidobacterium lactis as a complementary treatment for reflux esophagitis (RE) in a randomized, double-blind, placebo-controlled study. A total of 110 RE patients received rabeprazole while being supplemented with either Bifidobacterium or a placebo over 8 weeks.
Our findings showed that the probiotic group experienced quicker symptom relief and a longer time before symptoms returned, compared to the placebo. We also noted improvements in gut microbiota diversity following the treatment. Thus, Bifidobacterium lactis appears to provide significant benefits as an adjunct therapy for managing reflux symptoms.
Our findings showed that the probiotic group experienced quicker symptom relief and a longer time before symptoms returned, compared to the placebo. We also noted improvements in gut microbiota diversity following the treatment. Thus, Bifidobacterium lactis appears to provide significant benefits as an adjunct therapy for managing reflux symptoms.
Read More
8
In our exploration, we examined how Bifidobacterium lactis HN019 could influence gut transit time and gastrointestinal symptoms. We enrolled 100 adults with functional GI issues, splitting them into groups to receive either high-dose, low-dose, or placebo for two weeks.
We found that both treatment groups experienced significant reductions in gut transit times and a decrease in various GI symptoms. The placebo group did not show any notable improvements.
Overall, B. lactis HN019 seems effective in easing reflux-related symptoms and improving gut health.
We found that both treatment groups experienced significant reductions in gut transit times and a decrease in various GI symptoms. The placebo group did not show any notable improvements.
Overall, B. lactis HN019 seems effective in easing reflux-related symptoms and improving gut health.
Read More
Most Useful Reviews
0
Probiotic discomfort
57 people found this helpful
My daughter is six weeks old and I suspected she was spitting up excessively due to mild reflux. The doctor suggested a probiotic and vitamin D combo. I researched brands and chose these drops because they were affordable and from a reputable brand. As soon as I administered them, she spent half the night awake, screaming in pain. I questioned whether the drops could have been too heavy on her stomach, as I didn't mix them with breast milk or formula. This is not worth the risk after witnessing her pain; probiotics may not suit her.
Read More
10
Reflux improvement
1 people found this helpful
I was initially sceptical about this product's efficacy for my baby's acid reflux, but I am genuinely amazed by the results! Within a week, he went from soaking two burp rags to hardly any spit-up at all! He no longer fusses or refuses milk during feedings. I am extremely grateful.
Read More
7.5
Colic support
1 people found this helpful
This product has truly assisted with my baby's colic, gas, and reflux issues. I also appreciate the inclusion of vitamin D, simplifying things for me. However, the packaging and dropper can be frustrating; it tends to make messes around the bottle.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.3
- All Researches
9
We aimed to explore the effectiveness of a specific probiotic mixture called Ecologic®Relief in treating constipation among pregnant women. Over four weeks, participants reported significant improvements in their bowel habits, including increased defecation frequency and reduced sensations of obstruction and incomplete evacuation.
Importantly, we noted that the probiotic mixture also seemed to decrease reflux episodes from 60% to 20%. This suggests that not only does Ecologic®Relief help with constipation, but it may also provide relief from reflux symptoms during pregnancy. We believe more extensive studies will be beneficial to confirm these findings.
Importantly, we noted that the probiotic mixture also seemed to decrease reflux episodes from 60% to 20%. This suggests that not only does Ecologic®Relief help with constipation, but it may also provide relief from reflux symptoms during pregnancy. We believe more extensive studies will be beneficial to confirm these findings.
Read More
8
We investigated how Vitamin D3 affects inflammation caused by reflux esophagitis—a condition where stomach acid irritates the esophagus. In our study, we used 70 male rats, dividing them into groups to examine the impact of Vitamin D3 at different doses on inflammation levels.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Read More
8
We examined the effects of Bifidobacterium lactis as a complementary treatment for reflux esophagitis (RE) in a randomized, double-blind, placebo-controlled study. A total of 110 RE patients received rabeprazole while being supplemented with either Bifidobacterium or a placebo over 8 weeks.
Our findings showed that the probiotic group experienced quicker symptom relief and a longer time before symptoms returned, compared to the placebo. We also noted improvements in gut microbiota diversity following the treatment. Thus, Bifidobacterium lactis appears to provide significant benefits as an adjunct therapy for managing reflux symptoms.
Our findings showed that the probiotic group experienced quicker symptom relief and a longer time before symptoms returned, compared to the placebo. We also noted improvements in gut microbiota diversity following the treatment. Thus, Bifidobacterium lactis appears to provide significant benefits as an adjunct therapy for managing reflux symptoms.
Read More
8
In our exploration, we examined how Bifidobacterium lactis HN019 could influence gut transit time and gastrointestinal symptoms. We enrolled 100 adults with functional GI issues, splitting them into groups to receive either high-dose, low-dose, or placebo for two weeks.
We found that both treatment groups experienced significant reductions in gut transit times and a decrease in various GI symptoms. The placebo group did not show any notable improvements.
Overall, B. lactis HN019 seems effective in easing reflux-related symptoms and improving gut health.
We found that both treatment groups experienced significant reductions in gut transit times and a decrease in various GI symptoms. The placebo group did not show any notable improvements.
Overall, B. lactis HN019 seems effective in easing reflux-related symptoms and improving gut health.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 3 Reviews
6.9
- All Reviews
- Positive Reviews
- Negative Reviews
0
Probiotic discomfort
57 people found this helpful
My daughter is six weeks old and I suspected she was spitting up excessively due to mild reflux. The doctor suggested a probiotic and vitamin D combo. I researched brands and chose these drops because they were affordable and from a reputable brand. As soon as I administered them, she spent half the night awake, screaming in pain. I questioned whether the drops could have been too heavy on her stomach, as I didn't mix them with breast milk or formula. This is not worth the risk after witnessing her pain; probiotics may not suit her.
Read More
10
Reflux improvement
1 people found this helpful
I was initially sceptical about this product's efficacy for my baby's acid reflux, but I am genuinely amazed by the results! Within a week, he went from soaking two burp rags to hardly any spit-up at all! He no longer fusses or refuses milk during feedings. I am extremely grateful.
Read More
7.5
Colic support
1 people found this helpful
This product has truly assisted with my baby's colic, gas, and reflux issues. I also appreciate the inclusion of vitamin D, simplifying things for me. However, the packaging and dropper can be frustrating; it tends to make messes around the bottle.
Read More
Frequently Asked Questions
8
We examined the effects of Bifidobacterium lactis as a complementary treatment for reflux esophagitis (RE) in a randomized, double-blind, placebo-controlled study. A total of 110 RE patients received rabeprazole while being supplemented with either Bifidobacterium or a placebo over 8 weeks.
Our findings showed that the probiotic group experienced quicker symptom relief and a longer time before symptoms returned, compared to the placebo. We also noted improvements in gut microbiota diversity following the treatment. Thus, Bifidobacterium lactis appears to provide significant benefits as an adjunct therapy for managing reflux symptoms.
Our findings showed that the probiotic group experienced quicker symptom relief and a longer time before symptoms returned, compared to the placebo. We also noted improvements in gut microbiota diversity following the treatment. Thus, Bifidobacterium lactis appears to provide significant benefits as an adjunct therapy for managing reflux symptoms.
8
In our exploration, we examined how Bifidobacterium lactis HN019 could influence gut transit time and gastrointestinal symptoms. We enrolled 100 adults with functional GI issues, splitting them into groups to receive either high-dose, low-dose, or placebo for two weeks.
We found that both treatment groups experienced significant reductions in gut transit times and a decrease in various GI symptoms. The placebo group did not show any notable improvements.
Overall, B. lactis HN019 seems effective in easing reflux-related symptoms and improving gut health.
We found that both treatment groups experienced significant reductions in gut transit times and a decrease in various GI symptoms. The placebo group did not show any notable improvements.
Overall, B. lactis HN019 seems effective in easing reflux-related symptoms and improving gut health.
8
We investigated how Vitamin D3 affects inflammation caused by reflux esophagitis—a condition where stomach acid irritates the esophagus. In our study, we used 70 male rats, dividing them into groups to examine the impact of Vitamin D3 at different doses on inflammation levels.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
References
- Wei J, Zhang J, Jiang Y, Lian T, Zhang P, et al. Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3. In Vivo. 2023;37:79. 10.21873/invivo.13056
- Gan L, Wang Y, Huang S, Zheng L, Feng Q, et al. Therapeutic Evaluation of subsp. MH-02 as an Adjunctive Treatment in Patients with Reflux Esophagitis: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2024;16. 10.3390/nu16030342
- de Milliano I, Tabbers MM, van der Post JA, Benninga MA. Is a multispecies probiotic mixture effective in constipation during pregnancy? 'A pilot study'. Nutr J. 2012;11:80. 10.1186/1475-2891-11-80
- Waller PA, Gopal PK, Leyer GJ, Ouwehand AC, Reifer C, et al. Dose-response effect of Bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults. Scand J Gastroenterol. 2011;46:1057. 10.3109/00365521.2011.584895
