5/14/2025
Last update
5/14/2025
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.4
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: One (1) Capsule
Amount Per Serving
%DV
Calories
0
Total Carbohydrate
0 g
0%+
Total Sugars
0 g
**
Incl. 0 g Added Sugars
0%+
Lactobacillus rhamnosus GG
40 mg (10 billion CFUs)
**
Inulin (Chicory Root Extract)
200 mg
**
Top Medical Research Studies
9
Probiotic may stabilize estrogen levels
We examined whether a probiotic containing the strain KABP052 could help stabilize estrogen levels in peri- and postmenopausal women. In a thorough randomized, double-blind study, we compared women taking the probiotic to those given a placebo.
Over 12 weeks, those who received KABP052 showed notably higher estradiol and estrone levels, suggesting that this probiotic can effectively modulate estrogen during menopause. This promising finding opens new avenues for using probiotics to support menopausal health.
Over 12 weeks, those who received KABP052 showed notably higher estradiol and estrone levels, suggesting that this probiotic can effectively modulate estrogen during menopause. This promising finding opens new avenues for using probiotics to support menopausal health.
Read More
9
We investigated how orally administered probiotics, particularly Lactobacillus rhamnosus, can impact the vaginal flora of postmenopausal women. In a randomized, double-blind study, participants received either probiotic capsules or a placebo for 14 days.
Our findings revealed that 60% of the women taking the probiotics experienced a significant improvement in their vaginal flora, compared to just 16% in the placebo group. This suggests that Lactobacillus rhamnosus may effectively support vaginal health during menopause.
Our findings revealed that 60% of the women taking the probiotics experienced a significant improvement in their vaginal flora, compared to just 16% in the placebo group. This suggests that Lactobacillus rhamnosus may effectively support vaginal health during menopause.
Read More
8
We explored the role of Lactobacillus in postmenopausal women through a detailed analysis of vaginal microbiota and inflammation markers.
This study involved a subset of women from a larger trial, assessing various treatment options for vulvovaginal discomfort.
We found that even after menopause, Lactobacillus dominance correlates with reduced inflammatory markers in the vagina. This indicates that keeping a healthy balance of Lactobacillus can still positively influence vaginal health post-menopause.
This study involved a subset of women from a larger trial, assessing various treatment options for vulvovaginal discomfort.
We found that even after menopause, Lactobacillus dominance correlates with reduced inflammatory markers in the vagina. This indicates that keeping a healthy balance of Lactobacillus can still positively influence vaginal health post-menopause.
Read More
Most Useful Reviews
9
IBS relief
53 people found this helpful
This stuff gave me my life back! Since menopause three years ago, my IBS symptoms greatly increased. I maintain a plant-based diet, exercise, and sometimes track my food intake. After a food poisoning bout, my doctor recommended Culturelle. Previously, I'd been drinking a probiotic tea that helped somewhat, but it contained only one type of probiotic. Since taking Culturelle daily, my stomach issues no longer hinder me, and I feel much better. It's remarkable how we tolerate IBS symptoms. I’ve had only positive effects from Culturelle and definitely recommend it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.4
- All Researches
9
Probiotics improve post-menopausal vaginal health
We explored the potential of probiotics to enhance vaginal health in post-menopausal women. Through a clinical trial involving 50 participants aged 45 to 65, we administered a daily probiotic supplement for 28 days.
The results were promising, showing a noteworthy reduction in menopause-related symptoms, including a 50% improvement in vaginal well-being. Remarkably, we also noted significant decreases in inflammatory markers alongside a positive shift in vaginal microbiota, with increased lactobacilli.
Our findings suggest that these specific probiotic strains can effectively support post-menopausal women’s health.
The results were promising, showing a noteworthy reduction in menopause-related symptoms, including a 50% improvement in vaginal well-being. Remarkably, we also noted significant decreases in inflammatory markers alongside a positive shift in vaginal microbiota, with increased lactobacilli.
Our findings suggest that these specific probiotic strains can effectively support post-menopausal women’s health.
Read More
9
Lactobacillus effective for vaginal health
We evaluated the effects of VagiBIOM, a Lactobacillus-based vaginal suppository, on vaginal health among peri- and premenopausal women facing bacterial vaginosis (BV). In a randomized, double-blind, placebo-controlled trial with 66 participants, we measured changes in vaginal pH and health after 4 weeks of treatment.
Results showed significant improvements in vaginal health index scores and reductions in vaginal pH and itching symptoms. Notably, two Lactobacillus species identified in the treatment group indicated enhanced vaginal microbiome diversity. VagiBIOM appears effective in relieving BV-related symptoms in women experiencing menopause.
Results showed significant improvements in vaginal health index scores and reductions in vaginal pH and itching symptoms. Notably, two Lactobacillus species identified in the treatment group indicated enhanced vaginal microbiome diversity. VagiBIOM appears effective in relieving BV-related symptoms in women experiencing menopause.
Read More
9
Probiotic may stabilize estrogen levels
We examined whether a probiotic containing the strain KABP052 could help stabilize estrogen levels in peri- and postmenopausal women. In a thorough randomized, double-blind study, we compared women taking the probiotic to those given a placebo.
Over 12 weeks, those who received KABP052 showed notably higher estradiol and estrone levels, suggesting that this probiotic can effectively modulate estrogen during menopause. This promising finding opens new avenues for using probiotics to support menopausal health.
Over 12 weeks, those who received KABP052 showed notably higher estradiol and estrone levels, suggesting that this probiotic can effectively modulate estrogen during menopause. This promising finding opens new avenues for using probiotics to support menopausal health.
Read More
9
We investigated how orally administered probiotics, particularly Lactobacillus rhamnosus, can impact the vaginal flora of postmenopausal women. In a randomized, double-blind study, participants received either probiotic capsules or a placebo for 14 days.
Our findings revealed that 60% of the women taking the probiotics experienced a significant improvement in their vaginal flora, compared to just 16% in the placebo group. This suggests that Lactobacillus rhamnosus may effectively support vaginal health during menopause.
Our findings revealed that 60% of the women taking the probiotics experienced a significant improvement in their vaginal flora, compared to just 16% in the placebo group. This suggests that Lactobacillus rhamnosus may effectively support vaginal health during menopause.
Read More
9
We conducted a study to understand how a nutraceutical compound, which includes inulin, affects menopausal women experiencing recurrent urinary tract infections (UTIs). Our approach involved recruiting women who had a history of these infections and wished to explore treatments that avoided antibiotics.
Participants were divided into two groups: one used the nutraceutical compound daily for ten days each month, while the other did not. Over a span of 12 months, we tracked the number of UTI occurrences and checked for any improvement in symptoms using a Visual Analog Scale.
Our results indicated that those in the treatment group experienced a significant reduction in UTI episodes and better relief from symptoms after a year. This suggested that the combined effects of D-mannose, cranberry, bearberry, and inulin may offer a natural remedy for managing UTIs in menopausal women.
Overall, we found that inulin, as part of this nutraceutical mix, seems beneficial in reducing UTI occurrences, although the isolated impact of inulin specifically was not directly assessed in this study.
Participants were divided into two groups: one used the nutraceutical compound daily for ten days each month, while the other did not. Over a span of 12 months, we tracked the number of UTI occurrences and checked for any improvement in symptoms using a Visual Analog Scale.
Our results indicated that those in the treatment group experienced a significant reduction in UTI episodes and better relief from symptoms after a year. This suggested that the combined effects of D-mannose, cranberry, bearberry, and inulin may offer a natural remedy for managing UTIs in menopausal women.
Overall, we found that inulin, as part of this nutraceutical mix, seems beneficial in reducing UTI occurrences, although the isolated impact of inulin specifically was not directly assessed in this study.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
IBS relief
53 people found this helpful
This stuff gave me my life back! Since menopause three years ago, my IBS symptoms greatly increased. I maintain a plant-based diet, exercise, and sometimes track my food intake. After a food poisoning bout, my doctor recommended Culturelle. Previously, I'd been drinking a probiotic tea that helped somewhat, but it contained only one type of probiotic. Since taking Culturelle daily, my stomach issues no longer hinder me, and I feel much better. It's remarkable how we tolerate IBS symptoms. I’ve had only positive effects from Culturelle and definitely recommend it.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Byrne EH, Song H, Srinivasan S, Fredricks DN, Reed SD, et al. Association between vaginal microbiota and vaginal inflammatory immune markers in postmenopausal women. Menopause. 2024;31:575. 10.1097/GME.0000000000002362
- Resciniti SM, Biesiekierski JR, Ghasem-Zadeh A, Moschonis G. The Effectiveness of a Lactobacilli-Based Probiotic Food Supplement on Bone Mineral Density and Bone Metabolism in Australian Early Postmenopausal Women: Protocol for a Double-Blind Randomized Placebo-Controlled Trial. Nutrients. 2024;16. 10.3390/nu16081150
- Vicariotto F, Malfa P, Viciani E, Dell'Atti F, Squarzanti DF, et al. Efficacy of PBS067, subsp. BL050, and LRH020 in the Amelioration of Vaginal Microbiota in Post-Menopausal Women: A Prospective Observational Clinical Trial. Nutrients. 2024;16. 10.3390/nu16030402
- Vivekanandan V, Khan ZH, Venugopal G, Musunuru B, Mishra P, et al. VagiBIOM Lactobacillus suppository improves vaginal health index in perimenopausal women with bacterial vaginosis: a randomized control trial. Sci Rep. 2024;14:3317. 10.1038/s41598-024-53770-1
- Bayat Z, Damirchi A, Hasannejad-Bibalan M, Babaei P. Metabotropic Effect of Probiotic Supplementation and High-Intensity Interval Training in Menopause-Induced Metabolic Syndrome in Rats. J Menopausal Med. 2023;29:29. 10.6118/jmm.22037
- Sawada D, Sugawara T, Hirota T, Nakamura Y. Effects of CP2305 on Mild Menopausal Symptoms in Middle-Aged Women. Nutrients. 2022;14. 10.3390/nu14091695
- Bhardwaj A, Sapra L, Madan D, Ahuja V, Sharma HP, et al. Gut-resident Tregs (GTregs) play a pivotal role in maintaining bone health under post-menopausal osteoporotic conditions. J Leukoc Biol. 2025. 10.1093/jleuko/qiaf008
- Honda S, Tominaga Y, Espadaler-Mazo J, Huedo P, Aguiló M, et al. Supplementation with a Probiotic Formula Having β-Glucuronidase Activity Modulates Serum Estrogen Levels in Healthy Peri- and Postmenopausal Women. J Med Food. 2024;27:720. 10.1089/jmf.2023.k.0320
- Kwak YK, Daroczy K, Colque P, Kühn I, Möllby R, et al. Persistence of Lactobacilli in Postmenopausal Women - A Double-Blind, Randomized, Pilot Study. Gynecol Obstet Invest. 2017;82:144. 10.1159/000446946
- Bisanz JE, Seney S, McMillan A, Vongsa R, Koenig D, et al. A systems biology approach investigating the effect of probiotics on the vaginal microbiome and host responses in a double blind, placebo-controlled clinical trial of post-menopausal women. PLoS One. 2014;9:e104511. 10.1371/journal.pone.0104511
- Parma M, Dindelli M, Caputo L, Redaelli A, Quaranta L, et al. The role of vaginal Lactobacillus Rhamnosus (Normogin®) in preventing Bacterial Vaginosis in women with history of recurrences, undergoing surgical menopause: a prospective pilot study. Eur Rev Med Pharmacol Sci. 2013;17:1399.
- Petricevic L, Unger FM, Viernstein H, Kiss H. Randomized, double-blind, placebo-controlled study of oral lactobacilli to improve the vaginal flora of postmenopausal women. Eur J Obstet Gynecol Reprod Biol. 2008;141:54. 10.1016/j.ejogrb.2008.06.003
- Reid G, Burton J, Hammond JA, Bruce AW. Nucleic acid-based diagnosis of bacterial vaginosis and improved management using probiotic lactobacilli. J Med Food. 2004;7:223.
- de Fátima Laureano Martins J, Souza-Silva TG, Paula HAA, Rafael VDC, Sartori SSR, et al. Yacon-based product improves intestinal hypertrophy and modulates the production of glucagon-like peptide-1 in postmenopausal experimental model. Life Sci. 2022;291:120245. 10.1016/j.lfs.2021.120245
- Mainini G, Passaro M, Schiattarella A, Franciscis P, Donna MCD, et al. Prevention and treatment of cystitis during menopause: efficacy of a nutraceutical containing D-mannose, inulin, cranberry, bearberry, and . Prz Menopauzalny. 2020;19:130. 10.5114/pm.2020.99567
- Topolska K, Radzki RP, Filipiak-Florkiewicz A, Bieńko M, Florkiewicz A, et al. Could fructan sources in strawberry matrix be more effective as a tool for improvement of bone structure than these compounds added to diet alone? - Study on osteopenic rat model. Ann Agric Environ Med. 2020;27:19. 10.26444/aaem/108656
- Vitale SG, Caruso S, Rapisarda AMC, Cianci S, Cianci A. Isoflavones, calcium, vitamin D and inulin improve quality of life, sexual function, body composition and metabolic parameters in menopausal women: result from a prospective, randomized, placebo-controlled, parallel-group study. Prz Menopauzalny. 2018;17:32. 10.5114/pm.2018.73791
- Kruger MC, Chan YM, Lau LT, Lau CC, Chin YS, et al. Calcium and vitamin D fortified milk reduces bone turnover and improves bone density in postmenopausal women over 1 year. Eur J Nutr. 2018;57:2785. 10.1007/s00394-017-1544-6
- Cianci A, Colacurci N, Paoletti AM, Perino A, Cicinelli E, et al. Soy isoflavones, inulin, calcium, and vitamin D3 in post-menopausal hot flushes: an observational study. Clin Exp Obstet Gynecol. 2015;42:743.
- Timan P, Rojanasthien N, Manorot M, Sangdee C, Teekachunhatean S. Effect of synbiotic fermented milk on oral bioavailability of isoflavones in postmenopausal women. Int J Food Sci Nutr. 2014;65:761. 10.3109/09637486.2014.908169
- Bevilacqua M, Righini V, Certan D, Gandolini G, Alemanni M. Effect of a mixture of calcium, vitamin D, inulin and soy isoflavones on bone metabolism in post-menopausal women: a retrospective analysis. Aging Clin Exp Res. 2013;25:611. 10.1007/s40520-013-0093-y
- Adolphi B, Scholz-Ahrens KE, de Vrese M, Açil Y, Laue C, et al. Short-term effect of bedtime consumption of fermented milk supplemented with calcium, inulin-type fructans and caseinphosphopeptides on bone metabolism in healthy, postmenopausal women. Eur J Nutr. 2009;48:45. 10.1007/s00394-008-0759-y
- Piazza C, Privitera MG, Melilli B, Incognito T, Marano MR, et al. Influence of inulin on plasma isoflavone concentrations in healthy postmenopausal women. Am J Clin Nutr. 2007;86:775.
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