Since Menopause, 3 years ago, I have experienced a dramatic uptick in my IBS related symptoms. I eat plant based and try to exercise, relax, even keep a food journal at times when symptoms get bad to track any foods that are hard for me to tolerate. Well, after a recent bought of food poisoning, I saw my doctor, and she recommended Culturelle. I had previously been drinking a probiotic tea twice a week, which helped some, but it only contained one type of probiotic. Since taking Culturelle daily, I no longer have to worry about my stomach issues being a factor everywhere I go. It's amazing how much we tolerate in terms of brain fog, irritability, chronic pain, etc. when we have IBS. Now that I feel much better, I realize that it was not always the food I was eating, but my body's ability to effectively digest food and have a healthy gut to begin with. I would say give it a try, and see if it helps. Today's food manufacturing and farming methods seem to prevent us from coming in contact with good bacteria, so it perhaps we need a little help to repopulate the good bacteria, especially as we get older. I have had only positive effects from Culturelle and nothing negative. I would definitely recommend it. Wish I had tried it years ago