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SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.9
USERS' SCORE
Good
Based on 8 Reviews
8.6
Supplement Facts
Serving Size: 1 vegan softgel
Amount Per Serving
%DV
Calories
5
_
Total Fat
0.5 g
<1%‡
Microalgae Oil (40% DHA)which typically provides:
500 mg
*
DHA (Docosahexaenoic Acid) [Ω-3]
200 mg
*
Top Medical Research Studies
9
Docosahexaenoic acid's anti-inflammatory effects
Resolvin D2 regulates type 2 inflammatory responses and promotes resolution of mouse allergic inflammation.
High relevance to allergy treatment
We examined how docosahexaenoic acid, particularly its metabolite resolvin D2, influences allergic reactions and inflammation. Our focus was on type 2 inflammatory responses, often seen in allergic conditions. Through rigorous methodologies, including control groups, the study assessed how resolvin D2 can help in regulating these responses and promote the resolution of allergy-related inflammation in mice.
Our findings revealed that resolvin D2 plays a significant role in effectively managing allergic inflammation. It helps to mitigate the intense reactions typically associated with allergies, providing a clearer path toward alleviating symptoms.
This research demonstrates the potential of docosahexaenoic acid in offering therapeutic benefits for those suffering from type 2 inflammation due to allergies, and suggests that targeted treatments could improve overall allergen management.
Our findings revealed that resolvin D2 plays a significant role in effectively managing allergic inflammation. It helps to mitigate the intense reactions typically associated with allergies, providing a clearer path toward alleviating symptoms.
This research demonstrates the potential of docosahexaenoic acid in offering therapeutic benefits for those suffering from type 2 inflammation due to allergies, and suggests that targeted treatments could improve overall allergen management.
Read More
9.5
Docosahexaenoic acid helps asthma
Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase alleviate ovalbumin‑induced allergic asthma in mice by reducing airway inflammation and oxidative stress.
Study examines DHA's anti-asthmatic effects
We explored the potential of lipid mediators derived from docosahexaenoic acid (DHA) for alleviating allergic asthma. Using a model where mice were challenged with ovalbumin (OVA) to induce asthma-like symptoms, we administered lipid mediators that included 17S-monohydroxy DHA, resolvin D5, and protectin DX. These treatments led to significant improvements in key aspects of asthma such as reduced inflammatory cell infiltration and lower levels of Th2 cytokines.
Following treatment with the lipid mediators, we observed decreased levels of interleukin-6, tumor necrosis factor-α, and IgE—important markers associated with allergic reactions. There was a notable reduction in inflammation and oxidative stress in lung tissues, which suggests a protective effect on the lungs. Additionally, histological examinations revealed fewer signs of inflammation and mucus secretion.
The results indicate that DHA-derived lipid mediators may effectively mitigate the symptoms of allergic asthma and offer a promising new approach for treatment. They seem to act by reducing inflammation and improving antioxidant defenses within the lungs.
Following treatment with the lipid mediators, we observed decreased levels of interleukin-6, tumor necrosis factor-α, and IgE—important markers associated with allergic reactions. There was a notable reduction in inflammation and oxidative stress in lung tissues, which suggests a protective effect on the lungs. Additionally, histological examinations revealed fewer signs of inflammation and mucus secretion.
The results indicate that DHA-derived lipid mediators may effectively mitigate the symptoms of allergic asthma and offer a promising new approach for treatment. They seem to act by reducing inflammation and improving antioxidant defenses within the lungs.
Read More
9
DHA enhances allergy response mediators
Sex-dependent differential increase of specialized pro-resolving mediators in extracellular vesicles secreted by human primary conjunctival goblet cells during allergic inflammation.
Direct effect on allergic inflammation
We investigated how docosahexaenoic acid (DHA) influences allergic responses in conjunctival goblet cells, the cells that help maintain eye surface health. By stimulating human primary conjunctival goblet cells with histamine, we measured various lipid mediators in the extracellular vesicles they secreted.
Our findings revealed that in the presence of DHA during allergic inflammation, we observed a significant increase in two specialized pro-resolving mediators, LXA4 and RvD1. This increase was especially pronounced in female cells, showing respective fold increases of 5.3 and 6.9, while male responses remained markedly lower with only 0.5 and 0.8.
These results suggest that DHA not only enhances the production of beneficial mediators but also highlights a notable difference between male and female responses to allergic reactions. This novel insight could improve our understanding of allergy treatment, especially regarding why males may experience more severe allergic conjunctivitis.
Our findings revealed that in the presence of DHA during allergic inflammation, we observed a significant increase in two specialized pro-resolving mediators, LXA4 and RvD1. This increase was especially pronounced in female cells, showing respective fold increases of 5.3 and 6.9, while male responses remained markedly lower with only 0.5 and 0.8.
These results suggest that DHA not only enhances the production of beneficial mediators but also highlights a notable difference between male and female responses to allergic reactions. This novel insight could improve our understanding of allergy treatment, especially regarding why males may experience more severe allergic conjunctivitis.
Read More
Most Useful Reviews
9.5
Immediate moisturising effect
The ingredients are excellent and suitable for my fish allergies. The quality is fantastic as I noticed an immediate moisturising effect on my skin from the second day. I also appreciate that there is no aftertaste; it is sweet and easy to swallow.
Read More
9.5
Helpful for allergies
We use this for our dog, who has various protein allergies. This vegan product has been very beneficial for him, and so far, we haven't encountered any issues.
Read More
9.5
Good for allergies
This product is good for allergy sufferers.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.9
9.5
Docosahexaenoic acid helps asthma
Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase alleviate ovalbumin‑induced allergic asthma in mice by reducing airway inflammation and oxidative stress.
Study examines DHA's anti-asthmatic effects
We explored the potential of lipid mediators derived from docosahexaenoic acid (DHA) for alleviating allergic asthma. Using a model where mice were challenged with ovalbumin (OVA) to induce asthma-like symptoms, we administered lipid mediators that included 17S-monohydroxy DHA, resolvin D5, and protectin DX. These treatments led to significant improvements in key aspects of asthma such as reduced inflammatory cell infiltration and lower levels of Th2 cytokines.
Following treatment with the lipid mediators, we observed decreased levels of interleukin-6, tumor necrosis factor-α, and IgE—important markers associated with allergic reactions. There was a notable reduction in inflammation and oxidative stress in lung tissues, which suggests a protective effect on the lungs. Additionally, histological examinations revealed fewer signs of inflammation and mucus secretion.
The results indicate that DHA-derived lipid mediators may effectively mitigate the symptoms of allergic asthma and offer a promising new approach for treatment. They seem to act by reducing inflammation and improving antioxidant defenses within the lungs.
Following treatment with the lipid mediators, we observed decreased levels of interleukin-6, tumor necrosis factor-α, and IgE—important markers associated with allergic reactions. There was a notable reduction in inflammation and oxidative stress in lung tissues, which suggests a protective effect on the lungs. Additionally, histological examinations revealed fewer signs of inflammation and mucus secretion.
The results indicate that DHA-derived lipid mediators may effectively mitigate the symptoms of allergic asthma and offer a promising new approach for treatment. They seem to act by reducing inflammation and improving antioxidant defenses within the lungs.
Read More
9.5
New hypoallergenic formula shows promise
Hypoallergenicity assessment of an extensively hydrolyzed whey-protein formula in cow's milk allergic infants.
Impact of DHA on allergies unclear
We set out to assess a new extensively hydrolyzed whey-protein formula, which includes docosahexaenoic acid (DHA), for infants with cow's milk allergy (CMA). This study involved 34 children, primarily with IgE-mediated reactions, participating in a double-blind, placebo-controlled food challenge. Remarkably, all the children tolerated the new formula during the trial. This is significant since the American Academy of Pediatrics states that successful tolerance in over 90% of CMA children is crucial for a product to be considered hypoallergenic.
Although our focus was on the overall efficacy and safety of this formula, it's important to note that while DHA was included, we stopped short of isolating its specific impact on allergy outcomes. Thus, while we noted that this new formula is well-tolerated and associated with healthy growth and gastrointestinal tolerability, we cannot definitively state the effect of DHA alone on allergies. We recognize that further research would be needed to explore DHA's specific role in allergy management.
Although our focus was on the overall efficacy and safety of this formula, it's important to note that while DHA was included, we stopped short of isolating its specific impact on allergy outcomes. Thus, while we noted that this new formula is well-tolerated and associated with healthy growth and gastrointestinal tolerability, we cannot definitively state the effect of DHA alone on allergies. We recognize that further research would be needed to explore DHA's specific role in allergy management.
Read More
9
DHA and ARA enhance immune tolerance
Feeding Docosahexaenoic Acid and Arachidonic Acid during Suckling and Weaning Contributes to Oral Tolerance Development by Beneficially Modulating the Intestinal Cytokine and Immunoglobulin Levels in an Allergy-Prone Brown Norway Rat Model.
Significant findings on allergy prevention
We explored how adding docosahexaenoic acid (DHA) and arachidonic acid (ARA) in the diets of allergy-prone Brown Norway rats affects allergy responses. Our study involved feeding these essential fatty acids to both mother rats and their pups during the crucial suckling and weaning periods.
By comparing groups that received these supplements to those that did not, we aimed to understand how these dietary changes might influence immune development and oral tolerance—the body’s ability to accept food without triggering an allergy.
At the end of our study, we found that the ARA + DHA supplementation during early life boosted DHA levels in the intestinal fats and increased important immunological markers such as secretory IgA and specific cytokines. This suggests that DHA and ARA may help create an environment in the gut that supports healthy immune responses and reduces allergy risk.
Overall, our findings highlight the potential benefits of these fatty acids for nurturing a more tolerant immune system in the early stages of life.
By comparing groups that received these supplements to those that did not, we aimed to understand how these dietary changes might influence immune development and oral tolerance—the body’s ability to accept food without triggering an allergy.
At the end of our study, we found that the ARA + DHA supplementation during early life boosted DHA levels in the intestinal fats and increased important immunological markers such as secretory IgA and specific cytokines. This suggests that DHA and ARA may help create an environment in the gut that supports healthy immune responses and reduces allergy risk.
Overall, our findings highlight the potential benefits of these fatty acids for nurturing a more tolerant immune system in the early stages of life.
Read More
9
DHA enhances allergy response mediators
Sex-dependent differential increase of specialized pro-resolving mediators in extracellular vesicles secreted by human primary conjunctival goblet cells during allergic inflammation.
Direct effect on allergic inflammation
We investigated how docosahexaenoic acid (DHA) influences allergic responses in conjunctival goblet cells, the cells that help maintain eye surface health. By stimulating human primary conjunctival goblet cells with histamine, we measured various lipid mediators in the extracellular vesicles they secreted.
Our findings revealed that in the presence of DHA during allergic inflammation, we observed a significant increase in two specialized pro-resolving mediators, LXA4 and RvD1. This increase was especially pronounced in female cells, showing respective fold increases of 5.3 and 6.9, while male responses remained markedly lower with only 0.5 and 0.8.
These results suggest that DHA not only enhances the production of beneficial mediators but also highlights a notable difference between male and female responses to allergic reactions. This novel insight could improve our understanding of allergy treatment, especially regarding why males may experience more severe allergic conjunctivitis.
Our findings revealed that in the presence of DHA during allergic inflammation, we observed a significant increase in two specialized pro-resolving mediators, LXA4 and RvD1. This increase was especially pronounced in female cells, showing respective fold increases of 5.3 and 6.9, while male responses remained markedly lower with only 0.5 and 0.8.
These results suggest that DHA not only enhances the production of beneficial mediators but also highlights a notable difference between male and female responses to allergic reactions. This novel insight could improve our understanding of allergy treatment, especially regarding why males may experience more severe allergic conjunctivitis.
Read More
9
Docosahexaenoic acid's anti-inflammatory effects
Resolvin D2 regulates type 2 inflammatory responses and promotes resolution of mouse allergic inflammation.
High relevance to allergy treatment
We examined how docosahexaenoic acid, particularly its metabolite resolvin D2, influences allergic reactions and inflammation. Our focus was on type 2 inflammatory responses, often seen in allergic conditions. Through rigorous methodologies, including control groups, the study assessed how resolvin D2 can help in regulating these responses and promote the resolution of allergy-related inflammation in mice.
Our findings revealed that resolvin D2 plays a significant role in effectively managing allergic inflammation. It helps to mitigate the intense reactions typically associated with allergies, providing a clearer path toward alleviating symptoms.
This research demonstrates the potential of docosahexaenoic acid in offering therapeutic benefits for those suffering from type 2 inflammation due to allergies, and suggests that targeted treatments could improve overall allergen management.
Our findings revealed that resolvin D2 plays a significant role in effectively managing allergic inflammation. It helps to mitigate the intense reactions typically associated with allergies, providing a clearer path toward alleviating symptoms.
This research demonstrates the potential of docosahexaenoic acid in offering therapeutic benefits for those suffering from type 2 inflammation due to allergies, and suggests that targeted treatments could improve overall allergen management.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.6
9.5
Immediate moisturising effect
The ingredients are excellent and suitable for my fish allergies. The quality is fantastic as I noticed an immediate moisturising effect on my skin from the second day. I also appreciate that there is no aftertaste; it is sweet and easy to swallow.
9.5
Helpful for allergies
We use this for our dog, who has various protein allergies. This vegan product has been very beneficial for him, and so far, we haven't encountered any issues.
9.5
Good for allergies
This product is good for allergy sufferers.
9.5
Effective dosage
It is very good for allergies and overall health, with a suitable dosage and no taste.
9.5
Vegan option prevents allergies
This vegan option is often out of stock, so you need to keep an eye on it. It helps avoid fish allergies, making it a good choice for those supplementing DHA.
