Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.6
USERS' SCORE
Good
Based on 8 Reviews
8.6
Supplement Facts
Serving Size:  1 vegan softgel
Amount Per Serving
%DV
Calories
5
_
Total Fat
0.5 g
<1%‡
Microalgae Oil (40% DHA)which typically provides:
500 mg
*
DHA (Docosahexaenoic Acid) [Ω-3]
200 mg
*

Top Medical Research Studies

8
Omega-3s reduce allergic symptoms
We discovered that a diet enriched with omega-3 fatty acids can effectively reduce symptoms of allergic conjunctivitis (AC) in mice. This reduction occurred without influencing the typical immune responses usually associated with allergies. Instead, omega-3s worked by changing the lipid molecules linked to inflammation.

Notably, these fatty acids completely suppressed itching near the eyes and significantly decreased the presence of eosinophils, cells commonly involved in allergic reactions. However, total serum IgE levels and T2 cytokine expression remained unchanged, suggesting that omega-3s tackle AC symptoms in a unique way.
Read More
9.5
We conducted a comprehensive meta-analysis to explore how omega-3 supplementation affects food allergy risks in children, focusing on whether maternal intake during pregnancy or childhood supplementation is more effective.

Our findings revealed that mothers who took omega-3 during pregnancy and lactation significantly lowered the chances of their infants developing allergies to eggs and peanuts.

However, omega-3 consumption later in childhood did not show similar benefits in allergy prevention. This emphasizes the critical timing of supplementation in allergy risk management.
Read More
9
Docosahexaenoic acid's anti-inflammatory effects
We examined how docosahexaenoic acid, particularly its metabolite resolvin D2, influences allergic reactions and inflammation. Our focus was on type 2 inflammatory responses, often seen in allergic conditions. Through rigorous methodologies, including control groups, the study assessed how resolvin D2 can help in regulating these responses and promote the resolution of allergy-related inflammation in mice.

Our findings revealed that resolvin D2 plays a significant role in effectively managing allergic inflammation. It helps to mitigate the intense reactions typically associated with allergies, providing a clearer path toward alleviating symptoms.

This research demonstrates the potential of docosahexaenoic acid in offering therapeutic benefits for those suffering from type 2 inflammation due to allergies, and suggests that targeted treatments could improve overall allergen management.
Read More

Most Useful Reviews

9
Immediate moisturising effect
2 people found this helpful
The ingredients are excellent and suitable for my fish allergies. The quality is fantastic as I noticed an immediate moisturising effect on my skin from the second day. I also appreciate that there is no aftertaste; it is sweet and easy to swallow.
Read More
9
Helpful for allergies
We use this for our dog, who has various protein allergies. This vegan product has been very beneficial for him, and so far, we haven't encountered any issues.
Read More
9
Good for allergies
This product is good for allergy sufferers.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.6
  • All Researches
9.5
We conducted a comprehensive meta-analysis to explore how omega-3 supplementation affects food allergy risks in children, focusing on whether maternal intake during pregnancy or childhood supplementation is more effective.

Our findings revealed that mothers who took omega-3 during pregnancy and lactation significantly lowered the chances of their infants developing allergies to eggs and peanuts.

However, omega-3 consumption later in childhood did not show similar benefits in allergy prevention. This emphasizes the critical timing of supplementation in allergy risk management.
Read More
9.5
Docosahexaenoic acid helps asthma
We explored the potential of lipid mediators derived from docosahexaenoic acid (DHA) for alleviating allergic asthma. Using a model where mice were challenged with ovalbumin (OVA) to induce asthma-like symptoms, we administered lipid mediators that included 17S-monohydroxy DHA, resolvin D5, and protectin DX. These treatments led to significant improvements in key aspects of asthma such as reduced inflammatory cell infiltration and lower levels of Th2 cytokines.

Following treatment with the lipid mediators, we observed decreased levels of interleukin-6, tumor necrosis factor-α, and IgE—important markers associated with allergic reactions. There was a notable reduction in inflammation and oxidative stress in lung tissues, which suggests a protective effect on the lungs. Additionally, histological examinations revealed fewer signs of inflammation and mucus secretion.

The results indicate that DHA-derived lipid mediators may effectively mitigate the symptoms of allergic asthma and offer a promising new approach for treatment. They seem to act by reducing inflammation and improving antioxidant defenses within the lungs.
Read More
We set out to assess a new extensively hydrolyzed whey-protein formula, which includes docosahexaenoic acid (DHA), for infants with cow's milk allergy (CMA). This study involved 34 children, primarily with IgE-mediated reactions, participating in a double-blind, placebo-controlled food challenge. Remarkably, all the children tolerated the new formula during the trial. This is significant since the American Academy of Pediatrics states that successful tolerance in over 90% of CMA children is crucial for a product to be considered hypoallergenic.

Although our focus was on the overall efficacy and safety of this formula, it's important to note that while DHA was included, we stopped short of isolating its specific impact on allergy outcomes. Thus, while we noted that this new formula is well-tolerated and associated with healthy growth and gastrointestinal tolerability, we cannot definitively state the effect of DHA alone on allergies. We recognize that further research would be needed to explore DHA's specific role in allergy management.
Read More
9
DHA and ARA enhance immune tolerance
We explored how adding docosahexaenoic acid (DHA) and arachidonic acid (ARA) in the diets of allergy-prone Brown Norway rats affects allergy responses. Our study involved feeding these essential fatty acids to both mother rats and their pups during the crucial suckling and weaning periods.

By comparing groups that received these supplements to those that did not, we aimed to understand how these dietary changes might influence immune development and oral tolerance—the body’s ability to accept food without triggering an allergy.

At the end of our study, we found that the ARA + DHA supplementation during early life boosted DHA levels in the intestinal fats and increased important immunological markers such as secretory IgA and specific cytokines. This suggests that DHA and ARA may help create an environment in the gut that supports healthy immune responses and reduces allergy risk.

Overall, our findings highlight the potential benefits of these fatty acids for nurturing a more tolerant immune system in the early stages of life.
Read More
9
DHA enhances allergy response mediators
We investigated how docosahexaenoic acid (DHA) influences allergic responses in conjunctival goblet cells, the cells that help maintain eye surface health. By stimulating human primary conjunctival goblet cells with histamine, we measured various lipid mediators in the extracellular vesicles they secreted.

Our findings revealed that in the presence of DHA during allergic inflammation, we observed a significant increase in two specialized pro-resolving mediators, LXA4 and RvD1. This increase was especially pronounced in female cells, showing respective fold increases of 5.3 and 6.9, while male responses remained markedly lower with only 0.5 and 0.8.

These results suggest that DHA not only enhances the production of beneficial mediators but also highlights a notable difference between male and female responses to allergic reactions. This novel insight could improve our understanding of allergy treatment, especially regarding why males may experience more severe allergic conjunctivitis.
Read More

User Reviews

USERS' SCORE
Good
Based on 8 Reviews
8.6
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Immediate moisturising effect
2 people found this helpful
The ingredients are excellent and suitable for my fish allergies. The quality is fantastic as I noticed an immediate moisturising effect on my skin from the second day. I also appreciate that there is no aftertaste; it is sweet and easy to swallow.
Read More
9
Helpful for allergies
We use this for our dog, who has various protein allergies. This vegan product has been very beneficial for him, and so far, we haven't encountered any issues.
Read More
9
Good for allergies
This product is good for allergy sufferers.
Read More
9
Effective dosage
It is very good for allergies and overall health, with a suitable dosage and no taste.
Read More
9
Vegan option prevents allergies
This vegan option is often out of stock, so you need to keep an eye on it. It helps avoid fish allergies, making it a good choice for those supplementing DHA.
Read More

Frequently Asked Questions

9
Immediate moisturising effect
2 people found this helpful
The ingredients are excellent and suitable for my fish allergies. The quality is fantastic as I noticed an immediate moisturising effect on my skin from the second day. I also appreciate that there is no aftertaste; it is sweet and easy to swallow.
9
Allergy risk eliminated
Probably the best omega I've tried. Being vegan eliminates the allergy risks associated with fish.
9
Vegan option prevents allergies
This vegan option is often out of stock, so you need to keep an eye on it. It helps avoid fish allergies, making it a good choice for those supplementing DHA.
9
Effective dosage
It is very good for allergies and overall health, with a suitable dosage and no taste.
9
Good for allergies
This product is good for allergy sufferers.
9
Helpful for allergies
We use this for our dog, who has various protein allergies. This vegan product has been very beneficial for him, and so far, we haven't encountered any issues.
9.5
We conducted a comprehensive meta-analysis to explore how omega-3 supplementation affects food allergy risks in children, focusing on whether maternal intake during pregnancy or childhood supplementation is more effective.

Our findings revealed that mothers who took omega-3 during pregnancy and lactation significantly lowered the chances of their infants developing allergies to eggs and peanuts.

However, omega-3 consumption later in childhood did not show similar benefits in allergy prevention. This emphasizes the critical timing of supplementation in allergy risk management.
We investigated how docosahexaenoic acid (DHA), an omega-3 fatty acid commonly found in fish and algae, could impact allergies, specifically atopic dermatitis (AD). This condition affects many people by causing itchy and inflamed skin. Our analysis utilized Mendelian randomization methods, which help us infer causal relationships based on genetic data while ensuring the findings are reliable and robust.

Our findings revealed a notable link between DHA levels and a reduced risk of developing atopic dermatitis. We observed a decrease in AD risk associated with higher DHA levels, with significant statistical evidence supporting this connection. Furthermore, we dug deeper into mechanisms that might explain how DHA works. We explored the role of tumor necrosis factor ligand superfamily member 14 (TNFSF14), finding that it might mediate the relationship between DHA and AD.

Overall, our research provides genetic evidence that DHA could play a role in minimizing AD risks. It opens the door for future investigations to better understand the underlying processes. This adds to the growing interest in dietary solutions for managing allergies and skin conditions like atopic dermatitis.
8
Omega-3s reduce allergic symptoms
We discovered that a diet enriched with omega-3 fatty acids can effectively reduce symptoms of allergic conjunctivitis (AC) in mice. This reduction occurred without influencing the typical immune responses usually associated with allergies. Instead, omega-3s worked by changing the lipid molecules linked to inflammation.

Notably, these fatty acids completely suppressed itching near the eyes and significantly decreased the presence of eosinophils, cells commonly involved in allergic reactions. However, total serum IgE levels and T2 cytokine expression remained unchanged, suggesting that omega-3s tackle AC symptoms in a unique way.
7
Omega-3 supplementation's weak effectiveness
We conducted a systematic review and meta-analysis to explore whether omega-3 fatty acids taken during pregnancy affect allergic outcomes in children.

While our findings indicate that starting omega-3 supplementation during pregnancy may reduce the risk of sensitization to foods like egg and peanut, the overall evidence is somewhat limited.

This stems from the small number of studies available and concerns regarding their reliability, making it hard to draw definitive conclusions about omega-3's effects on allergies.
4
Omega-3 fish oil shows limited allergy benefits
We assessed whether prenatal supplementation with omega-3 fish oil could lower the risk of allergies in children at age six.

In a study with over 700 kids with family histories of allergies, mothers were given either fish oil or vegetable oil during pregnancy.

The results indicated no significant difference in IgE-related allergic conditions between the two groups. However, there was a hint that fish oil might reduce sensitization to house dust mites, suggesting some potential benefits.
7
Omega-3 fish oil's mixed allergy effects
We examined the potential of omega-3 long chain polyunsaturated fatty acids (LCPUFA) from fish oil in allergy prevention. While animal studies suggest promising protective effects, especially in food allergies and asthma, human data remains mixed. Observational studies hint that a higher intake of omega-3s may guard against allergies in early life, particularly when combined with lower omega-6 intake.

However, clinical trials have not consistently shown positive outcomes for asthma patients in terms of lung function, despite some evidence pointing to reduced airway inflammation. More research with larger groups is needed to determine its true effectiveness.

References

  1. Saika A, Nagatake T, Kishino S, Kitamura N, Honda T, et al. The omega-3 postbiotic -10--15-octadecadienoic acid attenuates contact hypersensitivity in mice through downregulation of vascular endothelial growth factor A. Front Cell Infect Microbiol. 2024;14:1355679. doi:10.3389/fcimb.2024.1355679
  2. Tsuji S, Adachi Y, Tsuchida A, Hamazaki K, Matsumura K, et al. Association of allergies in children younger than 3 years with levels of maternal intake of n-3 polyunsaturated fatty acids or fish during pregnancy: A nationwide birth cohort study, the Japan Environment and Children's Study. Allergol Int. 2024;73:282. doi:10.1016/j.alit.2023.12.004
  3. Huynh LBP, Nguyen NN, Fan HY, Huang SY, Huang CH, et al. Maternal Omega-3 Supplementation During Pregnancy, but Not Childhood Supplementation, Reduces the Risk of Food Allergy Diseases in Offspring. J Allergy Clin Immunol Pract. 2023;11:2862. doi:10.1016/j.jaip.2023.06.005
  4. Peng S, Du Z, He Y, Zhao F, Chen Y, et al. Association of Maternal Erythrocyte PUFA during Pregnancy with Offspring Allergy in the Chinese Population. Nutrients. 2022;14. doi:10.3390/nu14112312
  5. Adjibade M, Davisse-Paturet C, Bernard JY, Adel-Patient K, Divaret-Chauveau A, et al. Enrichment of infant formula with long-chain polyunsaturated fatty acids and risk of infection and allergy in the nationwide ELFE birth cohort. Allergy. 2022;77:1522. doi:10.1111/all.15137
  6. Miles EA, Childs CE, Calder PC. Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) and the Developing Immune System: A Narrative Review. Nutrients. 2021;13. doi:10.3390/nu13010247
  7. Hirata SI, Nagatake T, Sawane K, Hosomi K, Honda T, et al. Maternal ω3 docosapentaenoic acid inhibits infant allergic dermatitis through TRAIL-expressing plasmacytoid dendritic cells in mice. Allergy. 2020;75:1939. doi:10.1111/all.14217
  8. Huhmann R, Mueller RS. A cream containing omega-3-fatty acids, humectants and emollients as an aid in the treatment of equine Culicoides hypersensitivity. Vet Dermatol. 2019;30:155. doi:10.1111/vde.12728
  9. Vahdaninia M, Mackenzie H, Dean T, Helps S. ω-3 LCPUFA supplementation during pregnancy and risk of allergic outcomes or sensitization in offspring: A systematic review and meta-analysis. Ann Allergy Asthma Immunol. 2019;122:302. doi:10.1016/j.anai.2018.12.008
  10. Hirakata T, Lee HC, Ohba M, Saeki K, Okuno T, et al. Dietary ω-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating T2 immune responses. FASEB J. 2019;33:3392. doi:10.1096/fj.201801805R
  11. Clausen M, Jonasson K, Keil T, Beyer K, Sigurdardottir ST. Fish oil in infancy protects against food allergy in Iceland-Results from a birth cohort study. Allergy. 2018;73:1305. doi:10.1111/all.13385
  12. Hansen S, Strøm M, Maslova E, Dahl R, Hoffmann HJ, et al. Fish oil supplementation during pregnancy and allergic respiratory disease in the adult offspring. J Allergy Clin Immunol. 2017;139:104. doi:10.1016/j.jaci.2016.02.042
  13. Best KP, Sullivan T, Palmer D, Gold M, Kennedy DJ, et al. Prenatal Fish Oil Supplementation and Allergy: 6-Year Follow-up of a Randomized Controlled Trial. Pediatrics. 2016;137. doi:10.1542/peds.2015-4443
  14. Willemsen LEM. Dietary n-3 long chain polyunsaturated fatty acids in allergy prevention and asthma treatment. Eur J Pharmacol. 2016;785:174. doi:10.1016/j.ejphar.2016.03.062
  15. Warstedt K, Furuhjelm C, Fälth-Magnusson K, Fagerås M, Duchén K. High levels of omega-3 fatty acids in milk from omega-3 fatty acid-supplemented mothers are related to less immunoglobulin E-associated disease in infancy. Acta Paediatr. 2016;105:1337. doi:10.1111/apa.13395
  16. Ahmed N, Barrow CJ, Suphioglu C. Exploring the Effects of Omega-3 and Omega-6 Fatty Acids on Allergy Using a HEK-Blue Cell Line. Int J Mol Sci. 2016;17:220. doi:10.3390/ijms17020220
  17. Su Y, Choi HS, Kwon SK, Han Y, Cho SC, et al. Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase alleviate ovalbumin‑induced allergic asthma in mice by reducing airway inflammation and oxidative stress. Mol Med Rep. 2025;31. doi:10.3892/mmr.2025.13451
  18. Sato A, Sato G, Yabuki A, Ogawa Y, Nemoto H, et al. Ameliorative effects of squid phospholipids from Todarodes pacificus on atopic dermatitis-like lesions in NC/Nga mice. Arch Dermatol Res. 2025;317:239. doi:10.1007/s00403-024-03773-9
  19. Wang R, Patel D, Goruk S, Richard C, Field CJ. Feeding Docosahexaenoic Acid and Arachidonic Acid during Suckling and Weaning Contributes to Oral Tolerance Development by Beneficially Modulating the Intestinal Cytokine and Immunoglobulin Levels in an Allergy-Prone Brown Norway Rat Model. J Nutr. 2024;154:3790. doi:10.1016/j.tjnut.2024.10.021
  20. Lee C, Dartt DA. Sex-dependent differential increase of specialized pro-resolving mediators in extracellular vesicles secreted by human primary conjunctival goblet cells during allergic inflammation. Life Sci. 2024;357:123058. doi:10.1016/j.lfs.2024.123058
  21. Huang XW, Pang SW, Yang LZ, Han T, Chen JM, et al. TNFSF14 mediates the impact of docosahexaenoic acid on atopic dermatitis: a Mendelian randomization study. Eur Rev Med Pharmacol Sci. 2024;28:107. doi:10.26355/eurrev_202401_34896
  22. Peh HY, Brüggemann TR, Duvall MG, Nshimiyimana R, Nijmeh J, et al. Resolvin D2 regulates type 2 inflammatory responses and promotes resolution of mouse allergic inflammation. Allergy. 2024;79:739. doi:10.1111/all.15920
  23. Patel D, Munhoz J, Goruk S, Tsai S, Richard C, et al. Correction: Maternal diet supplementation with high-docosahexaenoic-acid canola oil, along with arachidonic acid, promotes immune system development in allergy-prone BALB/c mouse ofspring at 3 weeks of age. Eur J Nutr. 2024;63:341. doi:10.1007/s00394-023-03264-z
  24. Komulainen M, Saros L, Vahlberg T, Nermes M, Jartti T, et al. Maternal fish oil and/or probiotics intervention: Allergic diseases in children up to two years old. Pediatr Allergy Immunol. 2023;34:e14004. doi:10.1111/pai.14004
  25. Patel D, Munhoz J, Goruk S, Richard C, Field CJ. The Programming Effect of Plant-Based DHA, Along with Equivalent AA, on Immune System and Oral Tolerance Development in Six-Week Allergy Prone BALB/c Pups. J Nutr. 2023;153:2482. doi:10.1016/j.tjnut.2023.06.002
  26. Figueroa-Garduño I, Escamilla-Núñez C, Barraza-Villarreal A, Hernández-Cadena L, Onofre-Pardo EN, et al. Docosahexaenoic Acid Effect on Prenatal Exposure to Arsenic and Atopic Dermatitis in Mexican Preschoolers. Biol Trace Elem Res. 2023;201:3152. doi:10.1007/s12011-022-03411-3
  27. Dahdah L, Roelofs M, Knipping K, de Vries E, Rijnierse A, et al. Hypoallergenicity assessment of an extensively hydrolyzed whey-protein formula in cow's milk allergic infants. Pediatr Allergy Immunol. 2022;33:e13814. doi:10.1111/pai.13814
  28. Patel D, Goruk S, Richard C, Field CJ. Combined Supplementation with Arachidonic and Docosahexaenoic Acids in T Helper Type-2 Skewed Brown Norway Rat Offspring is Beneficial in the Induction of Oral Tolerance toward Ovalbumin and Immune System Development. J Nutr. 2022;152:2165. doi:10.1093/jn/nxac118
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