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SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 1 Reviews
8.5
Supplement Facts
Serving Size: 1 vegan softgel
Amount Per Serving
%DV
Calories
5
_
Total Fat
0.5 g
<1%‡
Microalgae Oil (40% DHA)which typically provides:
500 mg
*
DHA (Docosahexaenoic Acid) [Ω-3]
200 mg
*
Top Medical Research Studies
9
DHA's potential in gout inflammation
DHA protects against monosodium urate-induced inflammation through modulation of oxidative stress.
Direct relevance to gout treatment
We explored how docosahexaenoic acid (DHA) might help manage inflammation related to gout, specifically by examining its effects on monosodium urate (MSU) phagocytized by immune cells. Our study revealed that DHA significantly reduced the production and release of key inflammatory markers like interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in cell experiments.
We also observed that DHA helps lessen the production of harmful reactive oxygen species (ROS) that can contribute to inflammation. Notably, DHA aided the movement of a critical protein, nuclear factor E2-related factor 2 (Nrf2), into the cell nucleus, which then promoted the expression of several protective antioxidant enzymes. This is important because these enzymes play a vital role in maintaining cellular balance and mitigating oxidative stress.
Additionally, DHA improved mitochondrial function that was impaired by MSU, highlighting its protective effects. In real-world settings, when we administered DHA-rich microalgal oil to laboratory mice, we noted a decrease in the number of neutrophils, or inflammation-prone white blood cells, alongside lowered inflammatory responses.
Overall, our findings suggest that DHA or its rich sources like microalgal oil could be a valuable natural option for preventing inflammation linked to gout by tackling oxidative stress effectively.
We also observed that DHA helps lessen the production of harmful reactive oxygen species (ROS) that can contribute to inflammation. Notably, DHA aided the movement of a critical protein, nuclear factor E2-related factor 2 (Nrf2), into the cell nucleus, which then promoted the expression of several protective antioxidant enzymes. This is important because these enzymes play a vital role in maintaining cellular balance and mitigating oxidative stress.
Additionally, DHA improved mitochondrial function that was impaired by MSU, highlighting its protective effects. In real-world settings, when we administered DHA-rich microalgal oil to laboratory mice, we noted a decrease in the number of neutrophils, or inflammation-prone white blood cells, alongside lowered inflammatory responses.
Overall, our findings suggest that DHA or its rich sources like microalgal oil could be a valuable natural option for preventing inflammation linked to gout by tackling oxidative stress effectively.
Read More
8
Exploration of DHA and gout
Dissecting the causal effect between gut microbiota, DHA, and urate metabolism: A large-scale bidirectional Mendelian randomization.
Study supports DHA's potential effects
We investigated the connection between gut microbiota, docosahexaenoic acid (DHA), and urate metabolism to see how they interact and affect conditions like gout. The study utilized extensive data from a large number of participants, pulling information from various databases focusing on microbiota taxa, gout prevalence, and urate levels.
Our findings highlight that the gut microbiota plays a significant role in hosting urate metabolism; specifically, we observed that certain microbiota taxa had a common causal effect on both gout and urate levels. Notably, two specific bacterial groups showed protective effects on urate levels, linked to the increased presence of DHA.
This indicates that changes in our gut bacteria could not only improve urate metabolism but might also signal changes in gout risk. However, while DHA appears to be involved in this process, the link is complex and warrants further exploration to better understand its influence on gout treatment and prevention.
Our findings highlight that the gut microbiota plays a significant role in hosting urate metabolism; specifically, we observed that certain microbiota taxa had a common causal effect on both gout and urate levels. Notably, two specific bacterial groups showed protective effects on urate levels, linked to the increased presence of DHA.
This indicates that changes in our gut bacteria could not only improve urate metabolism but might also signal changes in gout risk. However, while DHA appears to be involved in this process, the link is complex and warrants further exploration to better understand its influence on gout treatment and prevention.
Read More
8
Omega-3 fatty acids reduce gout inflammation
Omega-3-carboxylic acids provide efficacious anti-inflammatory activity in models of crystal-mediated inflammation.
Relevant effects on gout inflammation
We assessed the effectiveness of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, in reducing inflammation related to gout and other crystal-mediated conditions. In the study, human macrophages and blood cells were exposed to inflammatory crystals to measure the anti-inflammatory response of DHA.
Notably, we found that DHA was able to lower the production of interleukin-1β (IL-1β), a key player in inflammation, both in laboratory settings and in live animal models. When tested in rat models of gout, DHA showed a dose-dependent reduction in cell migration and fluid buildup typically associated with crystal-induced inflammation.
Interestingly, DHA treatment resulted in significant reductions in pain and swelling comparable to the well-known medication indomethacin. However, it's worth noting that higher levels of palmitic acid in complex omega-3 formulations may lessen the overall anti-inflammatory effect of DHA on IL-1β.
Overall, our findings suggest that omega-3 carboxylic acids, particularly docosahexaenoic acid, can effectively combat inflammation related to gout and may offer new avenues for treatment of related conditions.
Notably, we found that DHA was able to lower the production of interleukin-1β (IL-1β), a key player in inflammation, both in laboratory settings and in live animal models. When tested in rat models of gout, DHA showed a dose-dependent reduction in cell migration and fluid buildup typically associated with crystal-induced inflammation.
Interestingly, DHA treatment resulted in significant reductions in pain and swelling comparable to the well-known medication indomethacin. However, it's worth noting that higher levels of palmitic acid in complex omega-3 formulations may lessen the overall anti-inflammatory effect of DHA on IL-1β.
Overall, our findings suggest that omega-3 carboxylic acids, particularly docosahexaenoic acid, can effectively combat inflammation related to gout and may offer new avenues for treatment of related conditions.
Read More
Most Useful Reviews
8.8
Gout relief noted
Vegan Omega 3 is new to me, but I have experienced no adverse effects. The inflammation from gout has decreased, and I hope this product will resolve the issue.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
9
DHA's potential in gout inflammation
DHA protects against monosodium urate-induced inflammation through modulation of oxidative stress.
Direct relevance to gout treatment
We explored how docosahexaenoic acid (DHA) might help manage inflammation related to gout, specifically by examining its effects on monosodium urate (MSU) phagocytized by immune cells. Our study revealed that DHA significantly reduced the production and release of key inflammatory markers like interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in cell experiments.
We also observed that DHA helps lessen the production of harmful reactive oxygen species (ROS) that can contribute to inflammation. Notably, DHA aided the movement of a critical protein, nuclear factor E2-related factor 2 (Nrf2), into the cell nucleus, which then promoted the expression of several protective antioxidant enzymes. This is important because these enzymes play a vital role in maintaining cellular balance and mitigating oxidative stress.
Additionally, DHA improved mitochondrial function that was impaired by MSU, highlighting its protective effects. In real-world settings, when we administered DHA-rich microalgal oil to laboratory mice, we noted a decrease in the number of neutrophils, or inflammation-prone white blood cells, alongside lowered inflammatory responses.
Overall, our findings suggest that DHA or its rich sources like microalgal oil could be a valuable natural option for preventing inflammation linked to gout by tackling oxidative stress effectively.
We also observed that DHA helps lessen the production of harmful reactive oxygen species (ROS) that can contribute to inflammation. Notably, DHA aided the movement of a critical protein, nuclear factor E2-related factor 2 (Nrf2), into the cell nucleus, which then promoted the expression of several protective antioxidant enzymes. This is important because these enzymes play a vital role in maintaining cellular balance and mitigating oxidative stress.
Additionally, DHA improved mitochondrial function that was impaired by MSU, highlighting its protective effects. In real-world settings, when we administered DHA-rich microalgal oil to laboratory mice, we noted a decrease in the number of neutrophils, or inflammation-prone white blood cells, alongside lowered inflammatory responses.
Overall, our findings suggest that DHA or its rich sources like microalgal oil could be a valuable natural option for preventing inflammation linked to gout by tackling oxidative stress effectively.
Read More
8
Exploration of DHA and gout
Dissecting the causal effect between gut microbiota, DHA, and urate metabolism: A large-scale bidirectional Mendelian randomization.
Study supports DHA's potential effects
We investigated the connection between gut microbiota, docosahexaenoic acid (DHA), and urate metabolism to see how they interact and affect conditions like gout. The study utilized extensive data from a large number of participants, pulling information from various databases focusing on microbiota taxa, gout prevalence, and urate levels.
Our findings highlight that the gut microbiota plays a significant role in hosting urate metabolism; specifically, we observed that certain microbiota taxa had a common causal effect on both gout and urate levels. Notably, two specific bacterial groups showed protective effects on urate levels, linked to the increased presence of DHA.
This indicates that changes in our gut bacteria could not only improve urate metabolism but might also signal changes in gout risk. However, while DHA appears to be involved in this process, the link is complex and warrants further exploration to better understand its influence on gout treatment and prevention.
Our findings highlight that the gut microbiota plays a significant role in hosting urate metabolism; specifically, we observed that certain microbiota taxa had a common causal effect on both gout and urate levels. Notably, two specific bacterial groups showed protective effects on urate levels, linked to the increased presence of DHA.
This indicates that changes in our gut bacteria could not only improve urate metabolism but might also signal changes in gout risk. However, while DHA appears to be involved in this process, the link is complex and warrants further exploration to better understand its influence on gout treatment and prevention.
Read More
8
Omega-3 fatty acids reduce gout inflammation
Omega-3-carboxylic acids provide efficacious anti-inflammatory activity in models of crystal-mediated inflammation.
Relevant effects on gout inflammation
We assessed the effectiveness of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, in reducing inflammation related to gout and other crystal-mediated conditions. In the study, human macrophages and blood cells were exposed to inflammatory crystals to measure the anti-inflammatory response of DHA.
Notably, we found that DHA was able to lower the production of interleukin-1β (IL-1β), a key player in inflammation, both in laboratory settings and in live animal models. When tested in rat models of gout, DHA showed a dose-dependent reduction in cell migration and fluid buildup typically associated with crystal-induced inflammation.
Interestingly, DHA treatment resulted in significant reductions in pain and swelling comparable to the well-known medication indomethacin. However, it's worth noting that higher levels of palmitic acid in complex omega-3 formulations may lessen the overall anti-inflammatory effect of DHA on IL-1β.
Overall, our findings suggest that omega-3 carboxylic acids, particularly docosahexaenoic acid, can effectively combat inflammation related to gout and may offer new avenues for treatment of related conditions.
Notably, we found that DHA was able to lower the production of interleukin-1β (IL-1β), a key player in inflammation, both in laboratory settings and in live animal models. When tested in rat models of gout, DHA showed a dose-dependent reduction in cell migration and fluid buildup typically associated with crystal-induced inflammation.
Interestingly, DHA treatment resulted in significant reductions in pain and swelling comparable to the well-known medication indomethacin. However, it's worth noting that higher levels of palmitic acid in complex omega-3 formulations may lessen the overall anti-inflammatory effect of DHA on IL-1β.
Overall, our findings suggest that omega-3 carboxylic acids, particularly docosahexaenoic acid, can effectively combat inflammation related to gout and may offer new avenues for treatment of related conditions.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Reviews
8.5
8.8
Gout relief noted
Vegan Omega 3 is new to me, but I have experienced no adverse effects. The inflammation from gout has decreased, and I hope this product will resolve the issue.
