5/9/2025
Last update
5/9/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 18 Researches
6.8
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
Supplement Facts
Serving Size: 1 tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
2 mg
118%
Folate (as folic acid)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41667%
Top Medical Research Studies
8
We set out to explore how dietary folate intake might influence severe headaches and migraines. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004, we included a substantial sample of 4,107 participants in our analysis.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
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8
We investigated the connection between serum folate levels and the occurrence of severe headaches or migraines using a large dataset from the National Health and Nutrition Examination Survey. In total, we analyzed information from 13,351 participants, with 2,742 of them reporting severe headaches or migraines within the last three months.
Our findings indicated that lower serum folate levels were associated with a higher likelihood of experiencing severe headaches or migraines. Specifically, we found that for every increase in serum folate, there was a significant decrease in the odds of having these painful episodes, with an odds ratio of 0.5. This means that individuals with higher folate levels were less likely to suffer from migraines.
The analysis further revealed that this relationship was particularly strong among women, those aged between 20 to 50 years, and non-Hispanic White participants. For instance, women with higher serum folate had an even lower likelihood of experiencing migraines, with an odds ratio of 0.38.
While we established a clear association, it’s important to note that our study didn’t specifically investigate folate treatment effectiveness. Further research is essential to confirm our findings and explore how folate could potentially be incorporated into treatment strategies for migraine sufferers.
Our findings indicated that lower serum folate levels were associated with a higher likelihood of experiencing severe headaches or migraines. Specifically, we found that for every increase in serum folate, there was a significant decrease in the odds of having these painful episodes, with an odds ratio of 0.5. This means that individuals with higher folate levels were less likely to suffer from migraines.
The analysis further revealed that this relationship was particularly strong among women, those aged between 20 to 50 years, and non-Hispanic White participants. For instance, women with higher serum folate had an even lower likelihood of experiencing migraines, with an odds ratio of 0.38.
While we established a clear association, it’s important to note that our study didn’t specifically investigate folate treatment effectiveness. Further research is essential to confirm our findings and explore how folate could potentially be incorporated into treatment strategies for migraine sufferers.
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7
We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
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Most Useful Reviews
0
Migraine trigger
11 people found this helpful
After using these for a few weeks, I experienced severe migraine headaches right upon waking. Upon stopping them, I found no headaches occurred on subsequent days. Further research indicated that mannitol can trigger migraines for some. I’ll be giving what's left to my husband, as I am disappointed.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 18 Researches
6.8
- All Researches
9.5
In examining the role of vitamin B6 in migraine treatment, we delved into a unique regimen combining vitamin B complex with zinc sulfate. The study highlighted a group of 30 individuals suffering from migraines who were administered 75 mg of zinc sulfate daily for six weeks, alongside vitamin B-complex and vitamin A or E during the first ten days. This approach led to promising outcomes, with a significant number of participants showing relief from their migraine symptoms.
While vitamin B6 was part of the treatment protocol, it wasn't evaluated independently within the analysis. This lack of isolation makes it challenging to gauge the specific impact of vitamin B6 on migraine effectiveness.
Overall, the study suggests that there is potential for dietary interventions, particularly involving zinc and B vitamins, in alleviating migraine symptoms. However, more structured studies would be needed to determine the precise effectiveness of vitamin B6 on its own. Monitoring mineral levels may also enhance recovery strategies for individuals affected by migraines.
While vitamin B6 was part of the treatment protocol, it wasn't evaluated independently within the analysis. This lack of isolation makes it challenging to gauge the specific impact of vitamin B6 on migraine effectiveness.
Overall, the study suggests that there is potential for dietary interventions, particularly involving zinc and B vitamins, in alleviating migraine symptoms. However, more structured studies would be needed to determine the precise effectiveness of vitamin B6 on its own. Monitoring mineral levels may also enhance recovery strategies for individuals affected by migraines.
Read More
8
We looked into how vitamin B supplementation affects migraines among women and the role of specific gene variants. In a 6-month study involving 206 female migraineurs, we found that daily vitamins B6, B9, and B12 significantly decreased homocysteine levels, headache severity, and migraine-related disabilities. Interestingly, women with specific genetic markers showed an even greater improvement. The benefits of supplements were significant, suggesting they can effectively reduce migraine symptoms by addressing underlying conditions tied to genetics.
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8
We examined how vitamin supplementation could affect migraine symptoms in patients. In a randomized, double-blind trial with 52 participants, daily vitamins, including B12, led to a significant 39% reduction in homocysteine levels.
More importantly, we saw a striking decrease in migraine disability—from 60% to 30%—and a drop in headache frequency and severity. Interestingly, those with the C allele of the MTHFR C677T genotype experienced even greater benefits.
While the results are promising, we need more extensive studies to confirm vitamin therapy's effectiveness in managing migraines.
More importantly, we saw a striking decrease in migraine disability—from 60% to 30%—and a drop in headache frequency and severity. Interestingly, those with the C allele of the MTHFR C677T genotype experienced even greater benefits.
While the results are promising, we need more extensive studies to confirm vitamin therapy's effectiveness in managing migraines.
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8
We conducted a compelling study to find out how vitamin B6, along with other B vitamins, affects those who suffer from migraine headaches. Our research involved a structured, randomized, double-blind, placebo-controlled trial with 120 women experiencing episodic migraines. Participants were divided into groups that received either individual B vitamins like B1, B6, B12, and B9, a vitamin B complex, or a placebo for a duration of 12 weeks.
Throughout the study, we carefully monitored the frequency of headache attacks, the amount of abortive medication used, and the overall impact of migraines on daily life through questionnaires. The findings were quite promising—women taking vitamin B6, along with the other B vitamins, experienced a significant reduction in headache attacks compared to those on the placebo.
Furthermore, those receiving vitamins also reported improvements in migraine-related disability and a decrease in their reliance on abortive drugs. While our results highlight the potential benefit of B vitamins, including B6, in managing migraines, further research is essential to solidify these findings and determine the best treatment strategies.
Throughout the study, we carefully monitored the frequency of headache attacks, the amount of abortive medication used, and the overall impact of migraines on daily life through questionnaires. The findings were quite promising—women taking vitamin B6, along with the other B vitamins, experienced a significant reduction in headache attacks compared to those on the placebo.
Furthermore, those receiving vitamins also reported improvements in migraine-related disability and a decrease in their reliance on abortive drugs. While our results highlight the potential benefit of B vitamins, including B6, in managing migraines, further research is essential to solidify these findings and determine the best treatment strategies.
Read More
8
Vitamin B6 shows promise in migraine
We conducted a double-blind, randomized placebo-controlled trial to assess how vitamin B6, when combined with folic acid, influences migraine characteristics, specifically in those experiencing migraine with aura. In our study, 95 participants between 18 and 65 years old were evaluated in Isfahan, Iran, to observe the effects of these supplements on headache severity, frequency, and duration over three months.
Our findings showed that combining folic acid with vitamin B6 resulted in notable improvements for participants. There was a significant decrease in headache severity, attack frequency, and the overall impact on their lives as recorded in headache diaries. However, it's worth mentioning that while these enhancements were clear for headache severity and frequency, the effect on attack duration was less pronounced when we controlled for other factors.
Interestingly, when folic acid was taken without vitamin B6, there were no significant benefits observed compared to the placebo group. This suggests that while vitamin B6 plays a beneficial role when combined with folic acid, its isolated effect on migraines remains unclear and requires further exploration.
Our findings showed that combining folic acid with vitamin B6 resulted in notable improvements for participants. There was a significant decrease in headache severity, attack frequency, and the overall impact on their lives as recorded in headache diaries. However, it's worth mentioning that while these enhancements were clear for headache severity and frequency, the effect on attack duration was less pronounced when we controlled for other factors.
Interestingly, when folic acid was taken without vitamin B6, there were no significant benefits observed compared to the placebo group. This suggests that while vitamin B6 plays a beneficial role when combined with folic acid, its isolated effect on migraines remains unclear and requires further exploration.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
0
Migraine trigger
11 people found this helpful
After using these for a few weeks, I experienced severe migraine headaches right upon waking. Upon stopping them, I found no headaches occurred on subsequent days. Further research indicated that mannitol can trigger migraines for some. I’ll be giving what's left to my husband, as I am disappointed.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Matin H, Taghian F, Chitsaz A. Artificial intelligence analysis to explore synchronize exercise, cobalamin, and magnesium as new actors to therapeutic of migraine symptoms: a randomized, placebo-controlled trial. Neurol Sci. 2022;43:4413. 10.1007/s10072-021-05843-6
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. 10.1111/ane.13251
- Togha M, Razeghi Jahromi S, Ghorbani Z, Martami F, Seifishahpar M. Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study. Headache. 2019;59:1492. 10.1111/head.13618
- Menon S, Lea RA, Roy B, Hanna M, Wee S, et al. Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation. Pharmacogenet Genomics. 2012;22:741. 10.1097/FPC.0b013e3283576b6b
- Lea R, Colson N, Quinlan S, Macmillan J, Griffiths L. The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability. Pharmacogenet Genomics. 2009;19:422. 10.1097/FPC.0b013e32832af5a3
- Nematgorgani S, Razeghi-Jahromi S, Jafari E, Togha M, Rafiee P, et al. B vitamins and their combination could reduce migraine headaches: A randomized double-blind controlled trial. Curr J Neurol. 2022;21:105. 10.18502/cjn.v21i2.10494
- Askari G, Nasiri M, Mozaffari-Khosravi H, Rezaie M, Bagheri-Bidakhavidi M, et al. The effects of folic acid and pyridoxine supplementation on characteristics of migraine attacks in migraine patients with aura: A double-blind, randomized placebo-controlled, clinical trial. Nutrition. 2017;38:74. 10.1016/j.nut.2017.01.007
- Woods E, Dawson C, Senthil L, Geberhiwot T. Cerebral venous thrombosis as the first presentation of classical homocystinuria in an adult patient. BMJ Case Rep. 2017;2017. 10.1136/bcr-2016-217477
- Menon S, Nasir B, Avgan N, Ghassabian S, Oliver C, et al. The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients. J Headache Pain. 2016;17:60. 10.1186/s10194-016-0652-7
- Dhillon KS, Singh J, Lyall JS. A new horizon into the pathobiology, etiology and treatment of migraine. Med Hypotheses. 2011;77:147. 10.1016/j.mehy.2011.03.050
- Strozenko LA, Ponomaryov VS, Sanina OO, Lobanov YF. [The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children]. Zh Nevrol Psikhiatr Im S S Korsakova. 2025;125:47. 10.17116/jnevro202512501147
- Zhao D, Long X, Wang J. Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey. Front Nutr. 2024;11:1456502. 10.3389/fnut.2024.1456502
- Luwen H, Ping C, Qing-Rong O, Lei X, Linlin L, et al. Association between serum folate levels and migraine or severe headaches: A nationwide cross-sectional study. Medicine (Baltimore). 2024;103:e40458. 10.1097/MD.0000000000040458
- Abdelsadek SE, Tahoun SA, Mansour FM, Abdulsalam MF, Ahmed AM. The correlation between vitamin B12 serum levels and migraine: a case-control study. Neurol Res. 2025;47:195. 10.1080/01616412.2025.2462735
- Zheng H, Shi YZ, Liang JT, Lu LL, Chen M. Modifiable factors for migraine prophylaxis: A mendelian randomization analysis. Front Pharmacol. 2023;14:1010996. 10.3389/fphar.2023.1010996
- Üstün Özek S. A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine. Arq Neuropsiquiatr. 2022;80:586. 10.1590/0004-282X-ANP-2021-0192
- Aydin H, Bucak IH, Geyik M. Vitamin B12 and folic acid levels in pediatric migraine patients. Acta Neurol Belg. 2021;121:1741. 10.1007/s13760-020-01491-3
- van der Kuy PH, Merkus FW, Lohman JJ, ter Berg JW, Hooymans PM. Hydroxocobalamin, a nitric oxide scavenger, in the prophylaxis of migraine: an open, pilot study. Cephalalgia. 2002;22:513.
