Last update
3/31/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
2 mg
118%
Folate (as folic acid)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41667%
Top Medical Research Studies
7
We explored the links between dietary micronutrients, including folate, and two forms of reflux disease—non-erosive reflux disease (NERD) and erosive esophagitis. In a study involving nearly 12,000 participants who reported their dietary intake and reflux symptoms from 2004 to 2008, we aimed to uncover how these nutrients might influence the occurrence of reflux conditions.
Our analysis revealed that many micronutrients, such as vitamin A, calcium, and importantly, folate, were associated with a lower risk of developing NERD. Specifically, higher intake of folate was linked to a decrease in the likelihood of experiencing this type of reflux, particularly among women. On the other hand, we found that these micronutrients did not significantly impact erosive esophagitis, except for vitamin C.
The findings suggest that while folate can play a role in managing NERD, its effects may be more pronounced in women compared to men. This insight could be valuable for dietary recommendations aimed at reducing reflux symptoms in the future.
Our analysis revealed that many micronutrients, such as vitamin A, calcium, and importantly, folate, were associated with a lower risk of developing NERD. Specifically, higher intake of folate was linked to a decrease in the likelihood of experiencing this type of reflux, particularly among women. On the other hand, we found that these micronutrients did not significantly impact erosive esophagitis, except for vitamin C.
The findings suggest that while folate can play a role in managing NERD, its effects may be more pronounced in women compared to men. This insight could be valuable for dietary recommendations aimed at reducing reflux symptoms in the future.
Read More
Most Useful Reviews
9
Helps with reflux
1 people found this helpful
I've been using this B12 supplement since 2015. It has helped with my acid reflux, and a vegan probiotic resolved it completely. Although I’m not a vegan, I find that vegan supplements typically contain minimal fillers, which makes them more trustworthy for me.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
- All Researches
7
We explored the links between dietary micronutrients, including folate, and two forms of reflux disease—non-erosive reflux disease (NERD) and erosive esophagitis. In a study involving nearly 12,000 participants who reported their dietary intake and reflux symptoms from 2004 to 2008, we aimed to uncover how these nutrients might influence the occurrence of reflux conditions.
Our analysis revealed that many micronutrients, such as vitamin A, calcium, and importantly, folate, were associated with a lower risk of developing NERD. Specifically, higher intake of folate was linked to a decrease in the likelihood of experiencing this type of reflux, particularly among women. On the other hand, we found that these micronutrients did not significantly impact erosive esophagitis, except for vitamin C.
The findings suggest that while folate can play a role in managing NERD, its effects may be more pronounced in women compared to men. This insight could be valuable for dietary recommendations aimed at reducing reflux symptoms in the future.
Our analysis revealed that many micronutrients, such as vitamin A, calcium, and importantly, folate, were associated with a lower risk of developing NERD. Specifically, higher intake of folate was linked to a decrease in the likelihood of experiencing this type of reflux, particularly among women. On the other hand, we found that these micronutrients did not significantly impact erosive esophagitis, except for vitamin C.
The findings suggest that while folate can play a role in managing NERD, its effects may be more pronounced in women compared to men. This insight could be valuable for dietary recommendations aimed at reducing reflux symptoms in the future.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Helps with reflux
1 people found this helpful
I've been using this B12 supplement since 2015. It has helped with my acid reflux, and a vegan probiotic resolved it completely. Although I’m not a vegan, I find that vegan supplements typically contain minimal fillers, which makes them more trustworthy for me.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Nam SY, Park BJ, Cho YA, Ryu KH. Gender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis. J Neurogastroenterol Motil. 2019;25:82. 10.5056/jnm18114
Data last updated:
