Folate may reduce NERD riskGender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis.
We explored the links between dietary micronutrients, including folate, and two forms of reflux disease—non-erosive reflux disease (NERD) and erosive esophagitis. In a study involving nearly 12,000 participants who reported their dietary intake and reflux symptoms from 2004 to 2008, we aimed to uncover how these nutrients might influence the occurrence of reflux conditions.
Our analysis revealed that many micronutrients, such as vitamin A, calcium, and importantly, folate, were associated with a lower risk of developing NERD. Specifically, higher intake of folate was linked to a decrease in the likelihood of experiencing this type of reflux, particularly among women. On the other hand, we found that these micronutrients did not significantly impact erosive esophagitis, except for vitamin C.
The findings suggest that while folate can play a role in managing NERD, its effects may be more pronounced in women compared to men. This insight could be valuable for dietary recommendations aimed at reducing reflux symptoms in the future.
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