Last update
4/1/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.2
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.9
Supplement Facts
Serving Size: 1 Veggie Capsule
Serving Per Container: 60
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
200 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
8
We systematically reviewed randomized controlled trials comparing coenzyme Q10 with placebo for migraine prevention in adults. Our meta-analysis examined study data from major medical databases through December 2019, assessing how CoQ10 affects migraine severity, attack frequency, and headache duration.
The evidence suggests CoQ10 has beneficial effects in reducing both how often migraines occur and how long they last. These findings indicate CoQ10 may be a useful preventive option for migraine sufferers, though further research could help clarify optimal dosing and its effects when combined with other supplements.
The evidence suggests CoQ10 has beneficial effects in reducing both how often migraines occur and how long they last. These findings indicate CoQ10 may be a useful preventive option for migraine sufferers, though further research could help clarify optimal dosing and its effects when combined with other supplements.
Read More
4
Moderate evidence for coenzyme Q10 migraine prevention
Researchers examined the evidence for various nutraceutical approaches to migraine prevention, including coenzyme Q10. The analysis revealed that coenzyme Q10 carries Level C evidence—meaning modest research support—for helping prevent migraines, with the advantage of causing few adverse effects.
This moderate level of evidence suggests coenzyme Q10 may offer some benefit, though stronger research is still needed to confirm its effectiveness compared to other prevention strategies. The low rate of side effects makes it a relatively safe option worth considering for migraine sufferers.
This moderate level of evidence suggests coenzyme Q10 may offer some benefit, though stronger research is still needed to confirm its effectiveness compared to other prevention strategies. The low rate of side effects makes it a relatively safe option worth considering for migraine sufferers.
Read More
0
CoQ10 ineffective; melatonin resolved pediatric stabbing headache
A 7-year-old boy experienced primary stabbing headache—brief, sharp jabs lasting just a few seconds that struck without warning. After a trial of Coenzyme Q10 produced no improvement, we switched to melatonin treatment, which resulted in complete symptom relief without any adverse effects during follow-up.
This case highlights melatonin as a potentially innovative and safe therapeutic option for this rare pediatric headache condition, offering hope where traditional medications like indomethacin often fall short or cause unwanted side effects.
This case highlights melatonin as a potentially innovative and safe therapeutic option for this rare pediatric headache condition, offering hope where traditional medications like indomethacin often fall short or cause unwanted side effects.
Read More
Most Useful Reviews
9
No more headaches
7 people found this helpful
Did wonders for me! For months, I awoke each morning with a mild headache and a terrible lack of energy. I regularly took several aspirin to ease the headaches. After starting CoQ10, I noticed a difference in just 4 days. Now, after 6 days, I haven’t had a headache in the morning. My energy levels have also improved; I wake up ready to go. I’m not entirely certain how this supplement works, but I’m extremely happy with my results.
Read More
2
No headache relief
6 people found this helpful
Not for me. I purchased this brand of CoQ10 to combine it with the magnesium I already take in hopes of addressing my migraines. The capsule is a bit large but easy to take, with a neutral flavour and reasonable price. Unfortunately, I experienced dreadful nausea and headache the next afternoon and only felt better after stopping it two nights later, realising it was the cause of my discomfort. I'm truly disappointed that it didn't work out for me.
Read More
9
Increased energy
2 people found this helpful
My husband and I both use this product. I’ve noticed a significant increase in my energy levels and improved focus. Along with fresh omega and Dr. Best betaine HCI pepsin, I feel so much healthier. Thank you, Dr. Best!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.2
- All Researches
9
Double-blind trial shows migraine improvement
We tested whether combining Coenzyme Q10 (30 mg/day) and L-carnitine (500 mg/day) could help migraine sufferers in a rigorous double-blind, placebo-controlled study involving 56 adults aged 20–40. Over 8 weeks, the supplement combination significantly reduced migraine severity, duration, and frequency compared to placebo. The treatment also lowered serum lactate levels, a marker of mitochondrial energy problems linked to migraines. These results suggest that addressing mitochondrial dysfunction through this supplement combination may offer real benefits for migraine management.
Read More
9
We delved into the role of Coenzyme Q10 (CoQ10) in managing headache symptoms, particularly migraines. This exploration stemmed from the understanding that migraines are complex and may be influenced by various factors, including energy deficits in the brain.
CoQ10 is recognized for its function in boosting mitochondrial energy metabolism, which is seen as a potential avenue for alleviating headaches. We learned that certain nutrients, including CoQ10, have shown promise in reducing the frequency and severity of migraine attacks. In fact, studies reported significant reductions in headache occurrences when individuals incorporated CoQ10 into their regimen.
While we found evidence supporting CoQ10's effectiveness, it's important to note that it’s often studied alongside other supplements. This means that while CoQ10 may play a beneficial role, it's challenging to pinpoint its isolated effects definitively. Nevertheless, the insights from the research suggest that adding CoQ10 to our preventive strategies for migraines could be a worthy consideration.
CoQ10 is recognized for its function in boosting mitochondrial energy metabolism, which is seen as a potential avenue for alleviating headaches. We learned that certain nutrients, including CoQ10, have shown promise in reducing the frequency and severity of migraine attacks. In fact, studies reported significant reductions in headache occurrences when individuals incorporated CoQ10 into their regimen.
While we found evidence supporting CoQ10's effectiveness, it's important to note that it’s often studied alongside other supplements. This means that while CoQ10 may play a beneficial role, it's challenging to pinpoint its isolated effects definitively. Nevertheless, the insights from the research suggest that adding CoQ10 to our preventive strategies for migraines could be a worthy consideration.
Read More
8
Combination supplement shows preliminary migraine symptom relief
We evaluated how a combination supplement—containing CoQ10, riboflavin, magnesium, and feverfew—affected vestibular migraine symptoms in 82 patients over three months. Participants received lifestyle advice on sleep, hydration, exercise, and nutrition alongside the supplement.
The results were encouraging: symptom severity and frequency both improved by roughly 44%, with about half of patients reporting meaningful improvement. No serious side effects were noted. While these findings suggest nonprescription therapies may help reduce vertigo and dizziness associated with vestibular migraine, the study design has limitations that prevent us from definitively attributing benefits to CoQ10 alone—the supplement contained multiple active ingredients, and there was no control group for comparison.
The results were encouraging: symptom severity and frequency both improved by roughly 44%, with about half of patients reporting meaningful improvement. No serious side effects were noted. While these findings suggest nonprescription therapies may help reduce vertigo and dizziness associated with vestibular migraine, the study design has limitations that prevent us from definitively attributing benefits to CoQ10 alone—the supplement contained multiple active ingredients, and there was no control group for comparison.
Read More
8
We systematically reviewed randomized controlled trials comparing coenzyme Q10 with placebo for migraine prevention in adults. Our meta-analysis examined study data from major medical databases through December 2019, assessing how CoQ10 affects migraine severity, attack frequency, and headache duration.
The evidence suggests CoQ10 has beneficial effects in reducing both how often migraines occur and how long they last. These findings indicate CoQ10 may be a useful preventive option for migraine sufferers, though further research could help clarify optimal dosing and its effects when combined with other supplements.
The evidence suggests CoQ10 has beneficial effects in reducing both how often migraines occur and how long they last. These findings indicate CoQ10 may be a useful preventive option for migraine sufferers, though further research could help clarify optimal dosing and its effects when combined with other supplements.
Read More
8
Multi-compound supplement trial shows promise in pediatric headaches
We examined 92 children and teens (ages 6-17) with primary headaches who received one of three supplement compounds over 12 months. Compound 3, which included magnesium oxide, feverfew, andrographis, coenzyme Q10, and vitamin B2, proved particularly effective.
All three supplement regimens significantly reduced headache frequency and decreased the need for pain medications (p=0.000001). Compound 3 showed mixed results depending on headache type—it outperformed the others for migraines with aura, but was less effective for other headache types compared to compound 2.
Overall, parents and children found the supplements well-tolerated and effective for headache prevention, making them a promising complementary approach to traditional medications.
All three supplement regimens significantly reduced headache frequency and decreased the need for pain medications (p=0.000001). Compound 3 showed mixed results depending on headache type—it outperformed the others for migraines with aura, but was less effective for other headache types compared to compound 2.
Overall, parents and children found the supplements well-tolerated and effective for headache prevention, making them a promising complementary approach to traditional medications.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
No more headaches
7 people found this helpful
Did wonders for me! For months, I awoke each morning with a mild headache and a terrible lack of energy. I regularly took several aspirin to ease the headaches. After starting CoQ10, I noticed a difference in just 4 days. Now, after 6 days, I haven’t had a headache in the morning. My energy levels have also improved; I wake up ready to go. I’m not entirely certain how this supplement works, but I’m extremely happy with my results.
Read More
2
No headache relief
6 people found this helpful
Not for me. I purchased this brand of CoQ10 to combine it with the magnesium I already take in hopes of addressing my migraines. The capsule is a bit large but easy to take, with a neutral flavour and reasonable price. Unfortunately, I experienced dreadful nausea and headache the next afternoon and only felt better after stopping it two nights later, realising it was the cause of my discomfort. I'm truly disappointed that it didn't work out for me.
Read More
9
Increased energy
2 people found this helpful
My husband and I both use this product. I’ve noticed a significant increase in my energy levels and improved focus. Along with fresh omega and Dr. Best betaine HCI pepsin, I feel so much healthier. Thank you, Dr. Best!
Read More
8
Fewer migraines
2 people found this helpful
My wife includes CoQ10 in her daily regimen to manage her migraines. A small study indicated that in 80 patients diagnosed with migraine, there was over a 50% reduction in migraine frequency monthly. This suggests that CoQ10 may effectively reduce both the frequency and severity of headaches.
Read More
10
Migraine relief
An excellent and original product! The ingredients are very effective. Since I started using it, my chronic migraines have disappeared. I highly recommend it and will always buy it again. Thank you, iHerb!
Read More
Frequently Asked Questions
9
No more headaches
7 people found this helpful
Did wonders for me! For months, I awoke each morning with a mild headache and a terrible lack of energy. I regularly took several aspirin to ease the headaches. After starting CoQ10, I noticed a difference in just 4 days. Now, after 6 days, I haven’t had a headache in the morning. My energy levels have also improved; I wake up ready to go. I’m not entirely certain how this supplement works, but I’m extremely happy with my results.
8
Headache prevention
I take this daily as a dietary supplement. My elderly parents take two capsules each morning to prevent headaches. After a break, I noticed feeling less cheerful with headaches occurring more often. Once I returned to the regimen, everything improved within two weeks.
8
Fewer migraines
2 people found this helpful
My wife includes CoQ10 in her daily regimen to manage her migraines. A small study indicated that in 80 patients diagnosed with migraine, there was over a 50% reduction in migraine frequency monthly. This suggests that CoQ10 may effectively reduce both the frequency and severity of headaches.
9
No headaches noted
I read that coenzyme is very necessary for people with migraines. I drank it for half a year and really did not have a headache.
9
Increased energy
2 people found this helpful
My husband and I both use this product. I’ve noticed a significant increase in my energy levels and improved focus. Along with fresh omega and Dr. Best betaine HCI pepsin, I feel so much healthier. Thank you, Dr. Best!
8
Pressure and headaches
I ordered this for my mother to stabilise her blood pressure and support her heart after losing her father. Her blood pressure normalised, and she stopped complaining of headaches, and her overall condition improved. She continues to take her doctor's prescribed medications alongside this product.
7
Natural supplements reduce migraine frequency with safety
We reviewed scientific literature on herbal supplements and nutraceuticals for migraine management, focusing on coenzyme Q10, vitamin B2, feverfew, and magnesium. Our systematic review of studies from the past decade involving adults showed that these natural supplements helped reduce how often migraines occurred.
Results were less clear regarding migraine severity and duration, with studies showing mixed findings. The good news: these supplements had no serious side effects, making them a gentler alternative for people who struggle with pharmaceutical migraine medications or prefer natural approaches to prevention.
Results were less clear regarding migraine severity and duration, with studies showing mixed findings. The good news: these supplements had no serious side effects, making them a gentler alternative for people who struggle with pharmaceutical migraine medications or prefer natural approaches to prevention.
8
We systematically reviewed randomized controlled trials comparing coenzyme Q10 with placebo for migraine prevention in adults. Our meta-analysis examined study data from major medical databases through December 2019, assessing how CoQ10 affects migraine severity, attack frequency, and headache duration.
The evidence suggests CoQ10 has beneficial effects in reducing both how often migraines occur and how long they last. These findings indicate CoQ10 may be a useful preventive option for migraine sufferers, though further research could help clarify optimal dosing and its effects when combined with other supplements.
The evidence suggests CoQ10 has beneficial effects in reducing both how often migraines occur and how long they last. These findings indicate CoQ10 may be a useful preventive option for migraine sufferers, though further research could help clarify optimal dosing and its effects when combined with other supplements.
4
Moderate evidence for coenzyme Q10 migraine prevention
Researchers examined the evidence for various nutraceutical approaches to migraine prevention, including coenzyme Q10. The analysis revealed that coenzyme Q10 carries Level C evidence—meaning modest research support—for helping prevent migraines, with the advantage of causing few adverse effects.
This moderate level of evidence suggests coenzyme Q10 may offer some benefit, though stronger research is still needed to confirm its effectiveness compared to other prevention strategies. The low rate of side effects makes it a relatively safe option worth considering for migraine sufferers.
This moderate level of evidence suggests coenzyme Q10 may offer some benefit, though stronger research is still needed to confirm its effectiveness compared to other prevention strategies. The low rate of side effects makes it a relatively safe option worth considering for migraine sufferers.
9
We delved into the role of Coenzyme Q10 (CoQ10) in managing headache symptoms, particularly migraines. This exploration stemmed from the understanding that migraines are complex and may be influenced by various factors, including energy deficits in the brain.
CoQ10 is recognized for its function in boosting mitochondrial energy metabolism, which is seen as a potential avenue for alleviating headaches. We learned that certain nutrients, including CoQ10, have shown promise in reducing the frequency and severity of migraine attacks. In fact, studies reported significant reductions in headache occurrences when individuals incorporated CoQ10 into their regimen.
While we found evidence supporting CoQ10's effectiveness, it's important to note that it’s often studied alongside other supplements. This means that while CoQ10 may play a beneficial role, it's challenging to pinpoint its isolated effects definitively. Nevertheless, the insights from the research suggest that adding CoQ10 to our preventive strategies for migraines could be a worthy consideration.
CoQ10 is recognized for its function in boosting mitochondrial energy metabolism, which is seen as a potential avenue for alleviating headaches. We learned that certain nutrients, including CoQ10, have shown promise in reducing the frequency and severity of migraine attacks. In fact, studies reported significant reductions in headache occurrences when individuals incorporated CoQ10 into their regimen.
While we found evidence supporting CoQ10's effectiveness, it's important to note that it’s often studied alongside other supplements. This means that while CoQ10 may play a beneficial role, it's challenging to pinpoint its isolated effects definitively. Nevertheless, the insights from the research suggest that adding CoQ10 to our preventive strategies for migraines could be a worthy consideration.
7
We explored the impact of coenzyme Q10 in treating headaches, particularly in children and adolescents. The review highlighted various complementary therapies for primary headaches and indicated that coenzyme Q10, along with other dietary supplements like riboflavin, magnesium, and vitamin D, may offer some benefits.
While evidence suggests that coenzyme Q10 could aid in reducing headaches, it’s important to understand that it was evaluated alongside other treatments. This means the exact contribution of coenzyme Q10 on its own might be less clear. We noted that patients experiencing headaches often turn to complementary therapies due to a perceived lack of adequate medical care.
Overall, our findings suggest that coenzyme Q10 could be a part of a broader strategy to manage headaches. Its potential effectiveness highlights the need for more in-depth studies to isolate its benefits and understand how it fits into headache treatment plans.
While evidence suggests that coenzyme Q10 could aid in reducing headaches, it’s important to understand that it was evaluated alongside other treatments. This means the exact contribution of coenzyme Q10 on its own might be less clear. We noted that patients experiencing headaches often turn to complementary therapies due to a perceived lack of adequate medical care.
Overall, our findings suggest that coenzyme Q10 could be a part of a broader strategy to manage headaches. Its potential effectiveness highlights the need for more in-depth studies to isolate its benefits and understand how it fits into headache treatment plans.
9
Double-blind trial shows migraine improvement
We tested whether combining Coenzyme Q10 (30 mg/day) and L-carnitine (500 mg/day) could help migraine sufferers in a rigorous double-blind, placebo-controlled study involving 56 adults aged 20–40. Over 8 weeks, the supplement combination significantly reduced migraine severity, duration, and frequency compared to placebo. The treatment also lowered serum lactate levels, a marker of mitochondrial energy problems linked to migraines. These results suggest that addressing mitochondrial dysfunction through this supplement combination may offer real benefits for migraine management.
8
We've looked into how coenzyme Q10 impacts headaches, particularly in those who suffer from migraines. Research suggests that this vitamin-like substance can help prevent headaches with minimal side effects, making it an appealing option for those seeking relief.
In fact, studies indicate that coenzyme Q10’s effectiveness in preventing migraines is comparable to some commonly prescribed medications, such as topiramate and propranolol. This is encouraging news for patients, especially since these traditional medications can come with a host of side effects.
Overall, it seems that coenzyme Q10 is a well-tolerated and potentially effective approach for migraine prevention. This makes it a viable first-line option for many sufferers, including children and adolescents, who may benefit from its natural profile without the burden of harsh side effects.
In fact, studies indicate that coenzyme Q10’s effectiveness in preventing migraines is comparable to some commonly prescribed medications, such as topiramate and propranolol. This is encouraging news for patients, especially since these traditional medications can come with a host of side effects.
Overall, it seems that coenzyme Q10 is a well-tolerated and potentially effective approach for migraine prevention. This makes it a viable first-line option for many sufferers, including children and adolescents, who may benefit from its natural profile without the burden of harsh side effects.
References
- Takle M, Strelzik J, Langdon R, Turner A, McClintock W, et al. Coenzyme Q10 Supplementation May Be Correlated With Resolution of New Daily Persistent Headache. J Child Neurol. 2025. 10.1177/08830738251366866
- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. 10.1007/s11916-025-01358-3
- Hannigan IP, Rosengren SM, Di Tanna GL, Watson SRD, Welgampola MS. Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study. Intern Med J. 2024;54:916. 10.1111/imj.16314
- Dahri M, Sarafan Sadeghi A, Pahlavani N, Nattagh-Eshtivani E, Hashemilar M, et al. The Effects of Coenzyme Q10 Supplementation on Oxidative Status and Lipid Profile in Migraine Patients: A Randomized Double-Blinded Controlled Clinical Trial. Clin Nutr Res. 2023;12:257. 10.7762/cnr.2023.12.4.257
- Yaghini O, Hoseini N, Ghazavi MR, Mansouri V, Nasiri J, et al. A Comparative Study on the Efficacy of Coenzyme Q10 and Amitriptyline in the Prophylactic Treatment of Migraine Headaches in Children: A Randomized Controlled Trial. Adv Biomed Res. 2022;11:43. 10.4103/abr.abr_235_20
- Kaur K, Hernandez V, Al Hajaj SW, Ebrahim AM, Razack M, et al. The Efficacy of Herbal Supplements and Nutraceuticals for Prevention of Migraine: Can They Help?. Cureus. 2021;13:e14868. 10.7759/cureus.14868
- Sazali S, Badrin S, Norhayati MN, Idris NS. Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis. BMJ Open. 2021;11:e039358. 10.1136/bmjopen-2020-039358
- Vikelis M, Dermitzakis EV, Vlachos GS, Soldatos P, Spingos KC, et al. Open Label Prospective Experience of Supplementation with a Fixed Combination of Magnesium, Vitamin B2, Feverfew, Andrographis Paniculata and Coenzyme Q10 for Episodic Migraine Prophylaxis. J Clin Med. 2020;10. 10.3390/jcm10010067
- Onofri A, Necozione S, Tozzi E. Complementary and alternative medicine (CAM) in headache of children and adolescents: open-label Italian study. Clin Ter. 2020;171:e393. 10.7417/CT.2020.2246
- Parohan M, Sarraf P, Javanbakht MH, Foroushani AR, Ranji-Burachaloo S, et al. The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial. Nutr Neurosci. 2021;24:317. 10.1080/1028415X.2019.1627770
- Moscano F, Guiducci M, Maltoni L, Striano P, Ledda MG, et al. An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache. Ital J Pediatr. 2019;45:36. 10.1186/s13052-019-0624-z
- Hajihashemi P, Askari G, Khorvash F, Reza Maracy M, Nourian M. The effects of concurrent Coenzyme Q10, L-carnitine supplementation in migraine prophylaxis: A randomized, placebo-controlled, double-blind trial. Cephalalgia. 2019;39:648. 10.1177/0333102418821661
- Zeng Z, Li Y, Lu S, Huang W, Di W. Efficacy of CoQ10 as supplementation for migraine: A meta-analysis. Acta Neurol Scand. 2019;139:284. 10.1111/ane.13051
- Bermúdez Salazar M, Rojas Cerón CA, Arana Muñoz RS. Prophylaxis with melatonin for primary stabbing headache in pediatrics: a case report. Colomb Med (Cali). 2018;49:244. 10.25100/cm.v49i2.3857
- Dahri M, Tarighat-Esfanjani A, Asghari-Jafarabadi M, Hashemilar M. Oral coenzyme Q10 supplementation in patients with migraine: Effects on clinical features and inflammatory markers. Nutr Neurosci. 2019;22:607. 10.1080/1028415X.2017.1421039
- Guilbot A, Bangratz M, Ait Abdellah S, Lucas C. A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study. BMC Complement Altern Med. 2017;17:433. 10.1186/s12906-017-1933-7
- Tavasoli A, Rezazadeh M, Kachuei M. Eyebrow bleeding as a rare migraine symptom: a case report. Ann Med Surg (Lond). 2024;86:7377. 10.1097/MS9.0000000000002655
- Hajhashemy Z, Golpour-Hamedani S, Eshaghian N, Sadeghi O, Khorvash F, et al. Practical supplements for prevention and management of migraine attacks: a narrative review. Front Nutr. 2024;11:1433390. 10.3389/fnut.2024.1433390
- Gaul C, Zaranek L, Goßrau G. [Complementary and supplementary procedures in the treatment of headache]. Schmerz. 2023;37:448. 10.1007/s00482-023-00738-1
- Quintana S, Russo M, Torelli P. Nutraceuticals and migraine: further strategy for the treatment of specific conditions. Neurol Sci. 2022;43:6565. 10.1007/s10072-022-06250-1
- Ariyanfar S, Razeghi Jahromi S, Togha M, Ghorbani Z. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep. 2022;26:193. 10.1007/s11916-022-01019-9
- Lisicki M, Schoenen J. Metabolic treatments of migraine. Expert Rev Neurother. 2020;20:295. 10.1080/14737175.2020.1729130
