Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.5
USERS' SCORE
Good
Based on 22 Reviews
8.1
Supplement Facts
Serving Size:  1 Veggie Capsule
Serving Per Container:  60
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
200 mg
 †
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
 †

Top Medical Research Studies

We conducted a study to see how coenzyme Q10 (CoQ10) supplementation impacts migraine symptoms and inflammation. This randomized double-blind trial involved 45 non-menopausal women with episodic migraines.

Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.

Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
Read More
We investigated whether coenzyme Q10 (CoQ10) could help reduce migraines. By examining five studies with 346 participants, we learned that CoQ10 may not significantly cut down on the number of attacks or their severity.

However, it appears to decrease the number of migraine days and duration each month. This suggests that while CoQ10 may not be a cure-all, it could help those suffering from migraines find some relief. Further research will be necessary to confirm these findings.
Read More
8
Co-Q10 potentially benefits migraine patients
We investigated how Coenzyme Q10 (Co-Q10) affects migraine symptoms in a well-structured clinical trial. Over the course of 12 weeks, 84 women aged 18 to 50 diagnosed with episodic migraines participated in a randomized, double-blind study, where they received either Co-Q10 (400 mg/day) or a placebo.

Upon analyzing the results, we observed some promising outcomes. Participants who took Co-Q10 experienced a significant reduction in malondialdehyde (MDA) levels, an indicator of oxidative stress. Additionally, there was a noteworthy increase in high-density lipoprotein cholesterol (HDL-C) levels, which is beneficial for overall heart health. We also noted a decrease in body fat percentage among those receiving Co-Q10.

However, while some improvements were documented, Co-Q10 did not show a significant effect on total antioxidant capacity or other lipid profile measures like low-density lipoprotein cholesterol and triglycerides. Therefore, while Co-Q10 may hold potential for enhancing certain health aspects in migraine sufferers, its overall impact on migraine management and other related parameters remains mixed.
Read More

Most Useful Reviews

9
Significant pain relief
9 people found this helpful
I suffer from migraine and chronic neck and shoulder pain. My doctors suggested 200mg of CoQ10 three times daily, which has made a remarkable difference! After running out once, I noticed the pain returned. It's been a staple supplement since, and I advocate its use to anyone enduring migraine pain.
Read More
7.5
Migraine relief
8 people found this helpful
Great product! I use this for migraine prevention and benefit from its other advantages. I combine it with CoQ10, Magnesium, B2 and butterbur—a powerful mix.
Read More
10
Must buy for migraines
1 people found this helpful
Awesome. I've been purchasing these for five years. They help immensely with my migraines; this is a must buy.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.5
  • All Researches
9
We explored how the combination of nano-curcumin and coenzyme Q10 (CoQ10) affects migraine symptoms and patients' quality of life. In a double-blind, placebo-controlled study involving 100 participants, we assessed the impacts on headache frequency, severity, and duration over eight weeks.

Our findings were promising: the group taking both nano-curcumin and CoQ10 showed significant improvements compared to those receiving the placebo or single supplements alone. Remarkably, this combination enhanced migraine-specific scores without any reported side effects. Overall, it highlights the potential benefits of these supplements in managing migraine.
Read More
9
CoQ10 and L-carnitine aid migraines
We explored the impact of Coenzyme Q10 in combination with L-carnitine on migraine symptoms in a well-structured trial involving 56 participants aged 20-40. Over eight weeks, subjects received these supplements or a placebo.

Our findings show a substantial improvement in migraine-related aspects, including a decrease in headache severity, duration, and frequency, alongside lower serum lactate levels. This suggests that these supplements could be beneficial for those suffering from migraines.
Read More
We conducted a study to see how coenzyme Q10 (CoQ10) supplementation impacts migraine symptoms and inflammation. This randomized double-blind trial involved 45 non-menopausal women with episodic migraines.

Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.

Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
Read More
9
Favorable outcomes in migraine prevention
We explored the effects of a daily supplement containing coenzyme Q10, feverfew, and magnesium on migraine prevention. In our observational study, which included adult migraine sufferers, participants took the supplement for three months after a one-month baseline phase.

Results revealed a significant reduction in migraine days, dropping from an average of 4.9 days to 1.3 days by the third month. Additionally, 75% of participants experienced at least a 50% reduction in migraine frequency.

The treatment was well tolerated and also appeared to improve anxiety and depressive symptoms, enhancing overall quality of life.
Read More
9
CoQ10 helps children’s migraines
We aimed to explore how a nutraceutical combination of Ginkgolide B, Coenzyme Q10, Riboflavin, and Magnesium could help children with neurofibromatosis type 1 manage migraine without aura. Over six months, 18 school-aged children took this supplement twice a day and kept journals tracking their migraine symptoms.

Remarkably, we observed significant reductions in frequency, intensity, duration, and overall migraine-related disability. Our findings reveal that this nutraceutical blend may effectively alleviate migraine symptoms for these children, marking a promising step forward in managing headaches associated with NF1.
Read More

User Reviews

USERS' SCORE
Good
Based on 22 Reviews
8.1
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Significant pain relief
9 people found this helpful
I suffer from migraine and chronic neck and shoulder pain. My doctors suggested 200mg of CoQ10 three times daily, which has made a remarkable difference! After running out once, I noticed the pain returned. It's been a staple supplement since, and I advocate its use to anyone enduring migraine pain.
Read More
7.5
Migraine relief
8 people found this helpful
Great product! I use this for migraine prevention and benefit from its other advantages. I combine it with CoQ10, Magnesium, B2 and butterbur—a powerful mix.
Read More
10
Must buy for migraines
1 people found this helpful
Awesome. I've been purchasing these for five years. They help immensely with my migraines; this is a must buy.
Read More
9
Migraine improvement
1 people found this helpful
I’ve benefited from this repeatedly. Fatigue and muscle pain vanished, and my migraines improved significantly after using this product.
Read More
10
No headaches experienced
I read that coenzyme Q10 is vital for people with migraines. After taking it for six months, I really haven't had a headache.
Read More

Frequently Asked Questions

10
No headaches experienced
I read that coenzyme Q10 is vital for people with migraines. After taking it for six months, I really haven't had a headache.
7.5
Lowered migraine frequency
I’ve noticed that coenzyme Q10 is effective in preventing my migraines. My frequency has dropped from two to three a week to less than once a week, significantly boosting my energy as well.
7.5
Migraine frequency reduction
2 people found this helpful
My wife takes these daily for her migraines. A small study showed over 50% reduction in monthly migraine frequency, suggesting CoQ10 may reduce both the duration and severity of attacks.
9
Migraine improvement
1 people found this helpful
I’ve benefited from this repeatedly. Fatigue and muscle pain vanished, and my migraines improved significantly after using this product.
7.5
Migraine alleviation
I drink this as prescribed by my doctor. It has effectively reduced my migraines, but consistency in taking it is essential.
2
No effect on migraines
Unfortunately, coenzyme Q10 did not help my migraine, and I won’t purchase it again. Although Dr Best is a reputable brand, I didn’t feel any effect.
7.5
Migraine relief
8 people found this helpful
Great product! I use this for migraine prevention and benefit from its other advantages. I combine it with CoQ10, Magnesium, B2 and butterbur—a powerful mix.
9
Migraine symptom relief
Excellent! I began taking coenzyme Q10 after reading about its effectiveness alongside alpha-lipoic acid for reducing migraine symptoms, and I feel much better now.
7
CoQ10 shows limited migraine effectiveness
We explored the effectiveness of Coenzyme Q10 (CoQ10) in preventing migraines. The findings suggest that CoQ10 has limited evidence supporting its use, classified as Level C. This means that while some patients may benefit, the overall results are not strong enough to warrant a confident recommendation. Importantly, adverse side effects appear low, making it a relatively safe option. However, we must approach it with care, looking at other proven alternatives for migraine prevention.
We aimed to understand how coenzyme Q10 affects migraine symptoms. This review highlighted that low levels of essential nutrients, including coenzyme Q10, may influence the severity and frequency of migraine attacks.

Our investigation revealed that oxidative stress and inflammation contribute to migraines. Coenzyme Q10 is noted for its role in mitochondrial function, which is vital for energy production in our cells. By supporting these processes, coenzyme Q10 could potentially alleviate migraine episodes.

Evidence from various studies indicated that coenzyme Q10 supplementation could lead to a reduction in migraine frequency and intensity. While we saw promising results, it’s clear that further prospective studies are necessary to establish a more definitive understanding of its effects.
We explored the potential benefits of Coenzyme Q10 (CoQ10) as a treatment for migraines, diving into several studies that highlighted its role in managing this challenging condition. Research indicated that oxidative stress could play a part in migraines, and CoQ10, known for its antioxidant properties, seemed an interesting candidate to investigate.

Although the effectiveness of CoQ10 for migraine relief is not yet firmly established, some preliminary short-term studies suggest that it might offer some benefits. Among various studies, we noticed that combining CoQ10 with other treatments made it difficult to isolate its specific effects, highlighting a need for further research.

Our findings suggest that while there’s promise in CoQ10 as a migraine remedy, more comprehensive and controlled studies are essential to truly understand its potential and effectiveness. As of now, the scientific community continues to call for prospective research with larger sample sizes and longer follow-ups to clarify these initial observations.
We explored the potential role of coenzyme Q10 as a treatment option for migraines, particularly against the backdrop of mitochondrial dysfunction. This condition suggests that individuals with migraines may experience an imbalance between energy supply and demand in their brains. Through our examination of existing trials, we noted that some studies have found promising results for coenzyme Q10, especially among those who had lower levels of this nutrient before treatment.

However, it's important to be candid about the study’s limitations. Many of these trials lacked proper control groups or sufficient sample sizes to draw more conclusive results. Although the initial findings are intriguing, more rigorous research is needed to verify whether coenzyme Q10 can genuinely make a difference for migraine sufferers.

Overall, we recognize the potential that coenzyme Q10 holds as an adjunctive therapy for migraines, particularly as part of a personalized approach that considers individual nutrient deficiencies. By focusing on tailored treatments, we may pave the way for more effective management of migraines in the future.
We explored the effects of coenzyme Q10 on migraine headaches through a comprehensive review of existing studies. Our goal was to determine if this supplement can effectively reduce the frequency of migraine attacks, as well as their severity and duration.

Upon reviewing various studies that included adult participants between the ages of 18 and 65, we found promising results regarding the frequency of migraines. Coenzyme Q10 appeared to help decrease how often these painful episodes occurred.

However, when it came to the severity and duration of the migraines, the results were mixed. Some studies showed slight improvements, while others did not demonstrate significant benefits. Importantly, we noted that participants reported no concerning side effects from taking coenzyme Q10, which is great news for those looking for natural alternatives to traditional medications.

Overall, we believe that coenzyme Q10 could be a valuable option for individuals who experience adverse reactions to conventional migraine treatments and prefer a more holistic approach.
We examined the potential benefits of coenzyme Q10 for migraine treatment. The study highlights that while there is growing interest in using this supplement to help manage migraines, the exact effects remain somewhat unclear due to limited specific studies.

Coenzyme Q10 is considered a nutraceutical, which means it's a natural substance that may support health. In this context, it's being looked at as a preventative option for migraines, with the hope that it could minimize the need for more traditional medications after surgeries.

While the review suggests the intriguing possibility of using coenzyme Q10, we should also recognize that no significant evidence currently points to its effectiveness in directly treating migraines, leaving us with a need for further research to understand its true role.
We explored how coenzyme Q10 (CoQ10) can influence migraines by reviewing randomized controlled trials that compared this supplement to placebos.

The systematic analysis revealed that CoQ10 has a beneficial impact on reducing both the frequency and duration of migraine attacks.

This is promising for those suffering from migraines, as it suggests that CoQ10 may aid in managing their symptoms effectively.
We examined the potential of coenzyme Q10 (CoQ10) as a preventive treatment for migraines. Evidence indicates that CoQ10 can effectively help reduce the frequency of migraines with minimal side effects.

Our findings suggest that its efficacy is comparable to conventional treatments like topiramate and propranolol, making it an appealing option for those seeking an alternative.

With its promising profile, CoQ10 could be a first-line treatment for migraine prevention, especially in children and adolescents.
8
Co-Q10 potentially benefits migraine patients
We investigated how Coenzyme Q10 (Co-Q10) affects migraine symptoms in a well-structured clinical trial. Over the course of 12 weeks, 84 women aged 18 to 50 diagnosed with episodic migraines participated in a randomized, double-blind study, where they received either Co-Q10 (400 mg/day) or a placebo.

Upon analyzing the results, we observed some promising outcomes. Participants who took Co-Q10 experienced a significant reduction in malondialdehyde (MDA) levels, an indicator of oxidative stress. Additionally, there was a noteworthy increase in high-density lipoprotein cholesterol (HDL-C) levels, which is beneficial for overall heart health. We also noted a decrease in body fat percentage among those receiving Co-Q10.

However, while some improvements were documented, Co-Q10 did not show a significant effect on total antioxidant capacity or other lipid profile measures like low-density lipoprotein cholesterol and triglycerides. Therefore, while Co-Q10 may hold potential for enhancing certain health aspects in migraine sufferers, its overall impact on migraine management and other related parameters remains mixed.

References

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  2. Sazali S, Badrin S, Norhayati MN, Idris NS. Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis. BMJ Open. 2021;11:e039358. doi:10.1136/bmjopen-2020-039358
  3. Lisicki M, Schoenen J. Metabolic treatments of migraine. Expert Rev Neurother. 2020;20:295. doi:10.1080/14737175.2020.1729130
  4. Parohan M, Sarraf P, Javanbakht MH, Foroushani AR, Ranji-Burachaloo S, et al. The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial. Nutr Neurosci. 2021;24:317. doi:10.1080/1028415X.2019.1627770
  5. Moscano F, Guiducci M, Maltoni L, Striano P, Ledda MG, et al. An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache. Ital J Pediatr. 2019;45:36. doi:10.1186/s13052-019-0624-z
  6. Parohan M, Sarraf P, Javanbakht MH, Ranji-Burachaloo S, Djalali M. Effect of coenzyme Q10 supplementation on clinical features of migraine: a systematic review and dose-response meta-analysis of randomized controlled trials. Nutr Neurosci. 2020;23:868. doi:10.1080/1028415X.2019.1572940
  7. Hajihashemi P, Askari G, Khorvash F, Reza Maracy M, Nourian M. The effects of concurrent Coenzyme Q10, L-carnitine supplementation in migraine prophylaxis: A randomized, placebo-controlled, double-blind trial. Cephalalgia. 2019;39:648. doi:10.1177/0333102418821661
  8. Zeng Z, Li Y, Lu S, Huang W, Di W. Efficacy of CoQ10 as supplementation for migraine: A meta-analysis. Acta Neurol Scand. 2019;139:284. doi:10.1111/ane.13051
  9. Dahri M, Tarighat-Esfanjani A, Asghari-Jafarabadi M, Hashemilar M. Oral coenzyme Q10 supplementation in patients with migraine: Effects on clinical features and inflammatory markers. Nutr Neurosci. 2019;22:607. doi:10.1080/1028415X.2017.1421039
  10. Guilbot A, Bangratz M, Ait Abdellah S, Lucas C. A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study. BMC Complement Altern Med. 2017;17:433. doi:10.1186/s12906-017-1933-7
  11. Shoeibi A, Olfati N, Soltani Sabi M, Salehi M, Mali S, et al. Effectiveness of coenzyme Q10 in prophylactic treatment of migraine headache: an open-label, add-on, controlled trial. Acta Neurol Belg. 2017;117:103. doi:10.1007/s13760-016-0697-z
  12. Gaul C, Diener HC, Danesch U. Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial. J Headache Pain. 2015;16:516. doi:10.1186/s10194-015-0516-6
  13. Carotenuto M, Esposito M. Nutraceuticals safety and efficacy in migraine without aura in a population of children affected by neurofibromatosis type I. Neurol Sci. 2013;34:1905. doi:10.1007/s10072-013-1403-z
  14. Pringsheim T, Davenport W, Mackie G, Worthington I, Aubé M, et al. Canadian Headache Society guideline for migraine prophylaxis. Can J Neurol Sci. 2012;39:S1.
  15. Slater SK, Nelson TD, Kabbouche MA, LeCates SL, Horn P, et al. A randomized, double-blinded, placebo-controlled, crossover, add-on study of CoEnzyme Q10 in the prevention of pediatric and adolescent migraine. Cephalalgia. 2011;31:897. doi:10.1177/0333102411406755
  16. Schiapparelli P, Allais G, Castagnoli Gabellari I, Rolando S, Terzi MG, et al. Non-pharmacological approach to migraine prophylaxis: part II. Neurol Sci. 2010;31 Suppl 1:S137. doi:10.1007/s10072-010-0307-4
  17. Tavasoli A, Rezazadeh M, Kachuei M. Eyebrow bleeding as a rare migraine symptom: a case report. Ann Med Surg (Lond). 2024;86:7377. doi:10.1097/MS9.0000000000002655
  18. Hajhashemy Z, Golpour-Hamedani S, Eshaghian N, Sadeghi O, Khorvash F, et al. Practical supplements for prevention and management of migraine attacks: a narrative review. Front Nutr. 2024;11:1433390. doi:10.3389/fnut.2024.1433390
  19. Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Espada-Rubio S, Agúndez JAG. Oxidative Stress and Migraine. Mol Neurobiol. 2024;61:8344. doi:10.1007/s12035-024-04114-7
  20. Hannigan IP, Rosengren SM, Di Tanna GL, Watson SRD, Welgampola MS. Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study. Intern Med J. 2024;54:916. doi:10.1111/imj.16314
  21. Dahri M, Sarafan Sadeghi A, Pahlavani N, Nattagh-Eshtivani E, Hashemilar M, et al. The Effects of Coenzyme Q10 Supplementation on Oxidative Status and Lipid Profile in Migraine Patients: A Randomized Double-Blinded Controlled Clinical Trial. Clin Nutr Res. 2023;12:257. doi:10.7762/cnr.2023.12.4.257
  22. Ebrahimi A, Kamyab A, Hosseini S, Ebrahimi S, Ashkani-Esfahani S. Involvement of Coenzyme Q10 in Various Neurodegenerative and Psychiatric Diseases. Biochem Res Int. 2023;2023:5510874. doi:10.1155/2023/5510874
  23. Stearns SA, Xun H, Haddad A, Rinkinen J, Bustos VP, et al. Therapeutic Options for Migraines in the Microsurgical Patient: A Scoping Review. Plast Reconstr Surg. 2024;153:988e. doi:10.1097/PRS.0000000000010861
  24. Yaghini O, Hoseini N, Ghazavi MR, Mansouri V, Nasiri J, et al. A Comparative Study on the Efficacy of Coenzyme Q10 and Amitriptyline in the Prophylactic Treatment of Migraine Headaches in Children: A Randomized Controlled Trial. Adv Biomed Res. 2022;11:43. doi:10.4103/abr.abr_235_20
  25. Ariyanfar S, Razeghi Jahromi S, Togha M, Ghorbani Z. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep. 2022;26:193. doi:10.1007/s11916-022-01019-9
  26. Grech O, Mollan SP, Wakerley BR, Fulton D, Lavery GG, et al. The Role of Metabolism in Migraine Pathophysiology and Susceptibility. Life (Basel). 2021;11. doi:10.3390/life11050415
  27. Kaur K, Hernandez V, Al Hajaj SW, Ebrahim AM, Razack M, et al. The Efficacy of Herbal Supplements and Nutraceuticals for Prevention of Migraine: Can They Help?. Cureus. 2021;13:e14868. doi:10.7759/cureus.14868
  28. Vikelis M, Dermitzakis EV, Vlachos GS, Soldatos P, Spingos KC, et al. Open Label Prospective Experience of Supplementation with a Fixed Combination of Magnesium, Vitamin B2, Feverfew, Andrographis Paniculata and Coenzyme Q10 for Episodic Migraine Prophylaxis. J Clin Med. 2020;10. doi:10.3390/jcm10010067
  29. Onofri A, Necozione S, Tozzi E. Complementary and alternative medicine (CAM) in headache of children and adolescents: open-label Italian study. Clin Ter. 2020;171:e393. doi:10.7417/CT.2020.2246
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