Last update
5/16/2026
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.3
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
9
Potential therapeutic for fibromyalgia
We explored the potential benefits of Coenzyme Q10 (CoQ10) for improving symptoms of fibromyalgia (FM) in a patient. Fibromyalgia is a challenging chronic pain condition with no clear cause, and recent research indicates that issues with mitochondrial function and oxidative stress might contribute to its symptoms.
In our observations, this patient exhibited low levels of CoQ10, which aligns with findings from other studies. After administering oral CoQ10 supplementation, the patient reported a noticeable improvement in her symptoms.
At the cellular level, we saw evidence that CoQ10 treatment helped restore mitochondrial function, increased the number of mitochondrial DNA copies, reduced oxidative stress, and boosted mitochondrial biogenesis. These changes suggest that CoQ10 may play a significant role in managing fibromyalgia symptoms and could be considered as an alternative therapeutic option for those suffering from this condition.
In our observations, this patient exhibited low levels of CoQ10, which aligns with findings from other studies. After administering oral CoQ10 supplementation, the patient reported a noticeable improvement in her symptoms.
At the cellular level, we saw evidence that CoQ10 treatment helped restore mitochondrial function, increased the number of mitochondrial DNA copies, reduced oxidative stress, and boosted mitochondrial biogenesis. These changes suggest that CoQ10 may play a significant role in managing fibromyalgia symptoms and could be considered as an alternative therapeutic option for those suffering from this condition.
Read More
9
We conducted a thorough investigation to understand if Coenzyme Q10 (CoQ10) could provide relief for those suffering from fibromyalgia (FM). In our randomized, double-blind, placebo-controlled trial, we involved 20 FM patients and offered them either 300 mg of CoQ10 daily or a placebo over a span of forty days.
Our findings revealed a significant improvement for participants who took CoQ10. Notably, we observed marked reductions in their fibromyalgia impact questionnaire (FIQ) scores, particularly in areas related to pain, fatigue, and morning tiredness. The reduction in pain was especially striking, with improvements evident on the visual pain scale and in the number of tender points reported.
Furthermore, we also noted beneficial changes at the molecular level, including recovery of inflammation and antioxidant levels. These changes corresponded with enhanced gene expressions linked to mitochondrial function and AMPK activity, suggesting that CoQ10 might have a broader therapeutic potential.
Overall, our research opens new avenues for viewing how CoQ10 can play a role in managing fibromyalgia, and highlights AMPK as a possible target for future treatments.
Our findings revealed a significant improvement for participants who took CoQ10. Notably, we observed marked reductions in their fibromyalgia impact questionnaire (FIQ) scores, particularly in areas related to pain, fatigue, and morning tiredness. The reduction in pain was especially striking, with improvements evident on the visual pain scale and in the number of tender points reported.
Furthermore, we also noted beneficial changes at the molecular level, including recovery of inflammation and antioxidant levels. These changes corresponded with enhanced gene expressions linked to mitochondrial function and AMPK activity, suggesting that CoQ10 might have a broader therapeutic potential.
Overall, our research opens new avenues for viewing how CoQ10 can play a role in managing fibromyalgia, and highlights AMPK as a possible target for future treatments.
Read More
9
We explored the connection between mitochondrial dysfunction, inflammation, and fibromyalgia (FM) by studying 30 women diagnosed with FM alongside 20 healthy women. Our focus was on coenzyme Q₁₀ (CoQ₁₀), a crucial antioxidant in our cells that supports mitochondrial health and energy production.
We noticed that women with FM had lower levels of CoQ₁₀ and mitochondrial DNA, accompanied by higher levels of reactive oxygen species (ROS) and an inflammatory marker called TNF-alpha in their blood. Interestingly, we found a strong negative correlation between CoQ₁₀ and TNF-alpha levels, suggesting that as CoQ₁₀ decreased, inflammation increased.
To investigate further, we examined the effects of CoQ₁₀ deficiency in both an in vitro (using blood cells) and an in vivo (mice) model. When we supplemented with oral CoQ₁₀, there was a remarkable restoration of biochemical balance and a significant improvement in clinical symptoms of FM. This leads us to consider that inflammation might stem from mitochondrial dysfunction in FM, highlighting mitochondria as a potential new target for treatment.
Overall, our findings suggest that supplementing with CoQ₁₀ could hold promise for alleviating symptoms of fibromyalgia and managing inflammation effectively.
We noticed that women with FM had lower levels of CoQ₁₀ and mitochondrial DNA, accompanied by higher levels of reactive oxygen species (ROS) and an inflammatory marker called TNF-alpha in their blood. Interestingly, we found a strong negative correlation between CoQ₁₀ and TNF-alpha levels, suggesting that as CoQ₁₀ decreased, inflammation increased.
To investigate further, we examined the effects of CoQ₁₀ deficiency in both an in vitro (using blood cells) and an in vivo (mice) model. When we supplemented with oral CoQ₁₀, there was a remarkable restoration of biochemical balance and a significant improvement in clinical symptoms of FM. This leads us to consider that inflammation might stem from mitochondrial dysfunction in FM, highlighting mitochondria as a potential new target for treatment.
Overall, our findings suggest that supplementing with CoQ₁₀ could hold promise for alleviating symptoms of fibromyalgia and managing inflammation effectively.
Read More
Most Useful Reviews
7
Positive effects noted
5 people found this helpful
This supplement has been invaluable for my fibromyalgia symptoms. I've tried various types on Iherb, and all have been excellent. It has helped regulate my heartbeat, and I find the packaging to be excellent value for its price and quality.
Read More
6
Helps absorption
1 people found this helpful
I used CoQ10 in my anti-ageing regimen and for heart health and fibromyalgia symptoms. The inclusion of Bioperine greatly aids absorption. This veggie cap is good quality and tasteless. Although this is my first experience with the powder form, I prefer the oil-based softgels. Delivery took nearly a week. I take it once daily after lunch, depending on my routine.
Read More
9
Reduces fatigue
Coenzyme Q10 is vital for ATP production in cells, which supports body function and efficient exercise. It also reduces oxidative stress, impacting muscle function, enhances performance, and lessens fatigue. Having Fibromyalgia, I find it has helped me immensely. I highly recommend it!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.3
- All Researches
9
We conducted a thorough investigation to understand if Coenzyme Q10 (CoQ10) could provide relief for those suffering from fibromyalgia (FM). In our randomized, double-blind, placebo-controlled trial, we involved 20 FM patients and offered them either 300 mg of CoQ10 daily or a placebo over a span of forty days.
Our findings revealed a significant improvement for participants who took CoQ10. Notably, we observed marked reductions in their fibromyalgia impact questionnaire (FIQ) scores, particularly in areas related to pain, fatigue, and morning tiredness. The reduction in pain was especially striking, with improvements evident on the visual pain scale and in the number of tender points reported.
Furthermore, we also noted beneficial changes at the molecular level, including recovery of inflammation and antioxidant levels. These changes corresponded with enhanced gene expressions linked to mitochondrial function and AMPK activity, suggesting that CoQ10 might have a broader therapeutic potential.
Overall, our research opens new avenues for viewing how CoQ10 can play a role in managing fibromyalgia, and highlights AMPK as a possible target for future treatments.
Our findings revealed a significant improvement for participants who took CoQ10. Notably, we observed marked reductions in their fibromyalgia impact questionnaire (FIQ) scores, particularly in areas related to pain, fatigue, and morning tiredness. The reduction in pain was especially striking, with improvements evident on the visual pain scale and in the number of tender points reported.
Furthermore, we also noted beneficial changes at the molecular level, including recovery of inflammation and antioxidant levels. These changes corresponded with enhanced gene expressions linked to mitochondrial function and AMPK activity, suggesting that CoQ10 might have a broader therapeutic potential.
Overall, our research opens new avenues for viewing how CoQ10 can play a role in managing fibromyalgia, and highlights AMPK as a possible target for future treatments.
Read More
9
We explored the connection between mitochondrial dysfunction, inflammation, and fibromyalgia (FM) by studying 30 women diagnosed with FM alongside 20 healthy women. Our focus was on coenzyme Q₁₀ (CoQ₁₀), a crucial antioxidant in our cells that supports mitochondrial health and energy production.
We noticed that women with FM had lower levels of CoQ₁₀ and mitochondrial DNA, accompanied by higher levels of reactive oxygen species (ROS) and an inflammatory marker called TNF-alpha in their blood. Interestingly, we found a strong negative correlation between CoQ₁₀ and TNF-alpha levels, suggesting that as CoQ₁₀ decreased, inflammation increased.
To investigate further, we examined the effects of CoQ₁₀ deficiency in both an in vitro (using blood cells) and an in vivo (mice) model. When we supplemented with oral CoQ₁₀, there was a remarkable restoration of biochemical balance and a significant improvement in clinical symptoms of FM. This leads us to consider that inflammation might stem from mitochondrial dysfunction in FM, highlighting mitochondria as a potential new target for treatment.
Overall, our findings suggest that supplementing with CoQ₁₀ could hold promise for alleviating symptoms of fibromyalgia and managing inflammation effectively.
We noticed that women with FM had lower levels of CoQ₁₀ and mitochondrial DNA, accompanied by higher levels of reactive oxygen species (ROS) and an inflammatory marker called TNF-alpha in their blood. Interestingly, we found a strong negative correlation between CoQ₁₀ and TNF-alpha levels, suggesting that as CoQ₁₀ decreased, inflammation increased.
To investigate further, we examined the effects of CoQ₁₀ deficiency in both an in vitro (using blood cells) and an in vivo (mice) model. When we supplemented with oral CoQ₁₀, there was a remarkable restoration of biochemical balance and a significant improvement in clinical symptoms of FM. This leads us to consider that inflammation might stem from mitochondrial dysfunction in FM, highlighting mitochondria as a potential new target for treatment.
Overall, our findings suggest that supplementing with CoQ₁₀ could hold promise for alleviating symptoms of fibromyalgia and managing inflammation effectively.
Read More
9
Potential therapeutic for fibromyalgia
We explored the potential benefits of Coenzyme Q10 (CoQ10) for improving symptoms of fibromyalgia (FM) in a patient. Fibromyalgia is a challenging chronic pain condition with no clear cause, and recent research indicates that issues with mitochondrial function and oxidative stress might contribute to its symptoms.
In our observations, this patient exhibited low levels of CoQ10, which aligns with findings from other studies. After administering oral CoQ10 supplementation, the patient reported a noticeable improvement in her symptoms.
At the cellular level, we saw evidence that CoQ10 treatment helped restore mitochondrial function, increased the number of mitochondrial DNA copies, reduced oxidative stress, and boosted mitochondrial biogenesis. These changes suggest that CoQ10 may play a significant role in managing fibromyalgia symptoms and could be considered as an alternative therapeutic option for those suffering from this condition.
In our observations, this patient exhibited low levels of CoQ10, which aligns with findings from other studies. After administering oral CoQ10 supplementation, the patient reported a noticeable improvement in her symptoms.
At the cellular level, we saw evidence that CoQ10 treatment helped restore mitochondrial function, increased the number of mitochondrial DNA copies, reduced oxidative stress, and boosted mitochondrial biogenesis. These changes suggest that CoQ10 may play a significant role in managing fibromyalgia symptoms and could be considered as an alternative therapeutic option for those suffering from this condition.
Read More
9
We set out to explore the role of coenzyme Q10 (CoQ10) in treating the symptoms of fibromyalgia (FM), particularly focusing on headaches associated with this condition. Our study included 20 FM patients and 15 healthy individuals as a comparison group to examine oxidative stress and bioenergetic status in blood mononuclear cells (BMCs).
We discovered that patients with FM had lower levels of CoQ10, catalase, and ATP in their BMCs compared to the healthy controls. Additionally, levels of lipid peroxidation (LPO) were significantly higher in the FM group. Notably, our findings indicated that lower CoQ10 and catalase levels correlated with worsening headache symptoms, suggesting a link between mitochondrial dysfunction and pain.
After supplementing FM patients with oral CoQ10, we observed a restoration of biochemical markers alongside significant clinical improvements, including reduced headache symptoms. This points to CoQ10's potential as a valuable treatment for FM, although we recommend further research involving larger, placebo-controlled trials to confirm these findings.
We discovered that patients with FM had lower levels of CoQ10, catalase, and ATP in their BMCs compared to the healthy controls. Additionally, levels of lipid peroxidation (LPO) were significantly higher in the FM group. Notably, our findings indicated that lower CoQ10 and catalase levels correlated with worsening headache symptoms, suggesting a link between mitochondrial dysfunction and pain.
After supplementing FM patients with oral CoQ10, we observed a restoration of biochemical markers alongside significant clinical improvements, including reduced headache symptoms. This points to CoQ10's potential as a valuable treatment for FM, although we recommend further research involving larger, placebo-controlled trials to confirm these findings.
Read More
8
CoQ10 reduces fibromyalgia pain through mitochondrial restoration
Researchers tested whether CoQ10 could help fibromyalgia-like muscle pain in rats by examining both fast and slow muscle types. When rats were given CoQ10, their pain sensitivity decreased and their muscles showed dramatic improvements.
CoQ10 restored depleted energy-producing nutrients, reduced harmful oxidative damage, and strengthened the muscles' natural antioxidant defenses. Most importantly, CoQ10 activated genes that rebuild mitochondria—the powerhouses inside muscle cells—and triggered the production of irisin, a beneficial muscle-signaling molecule that promotes cellular health and recovery.
These results suggest CoQ10 works through multiple pathways to ease fibromyalgia symptoms, making it a promising natural approach to managing the condition's underlying muscle dysfunction.
CoQ10 restored depleted energy-producing nutrients, reduced harmful oxidative damage, and strengthened the muscles' natural antioxidant defenses. Most importantly, CoQ10 activated genes that rebuild mitochondria—the powerhouses inside muscle cells—and triggered the production of irisin, a beneficial muscle-signaling molecule that promotes cellular health and recovery.
These results suggest CoQ10 works through multiple pathways to ease fibromyalgia symptoms, making it a promising natural approach to managing the condition's underlying muscle dysfunction.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
7
Positive effects noted
5 people found this helpful
This supplement has been invaluable for my fibromyalgia symptoms. I've tried various types on Iherb, and all have been excellent. It has helped regulate my heartbeat, and I find the packaging to be excellent value for its price and quality.
Read More
6
Helps absorption
1 people found this helpful
I used CoQ10 in my anti-ageing regimen and for heart health and fibromyalgia symptoms. The inclusion of Bioperine greatly aids absorption. This veggie cap is good quality and tasteless. Although this is my first experience with the powder form, I prefer the oil-based softgels. Delivery took nearly a week. I take it once daily after lunch, depending on my routine.
Read More
9
Reduces fatigue
Coenzyme Q10 is vital for ATP production in cells, which supports body function and efficient exercise. It also reduces oxidative stress, impacting muscle function, enhances performance, and lessens fatigue. Having Fibromyalgia, I find it has helped me immensely. I highly recommend it!
Read More
8
Combats fatigue
I've used CoQ10 for years to combat the fatigue linked to fibromyalgia. It helps my body produce energy. I've paid much more for CoQ10 from other brands, but this one offers similar results at a better price.
Read More
8
Increases energy levels
Excellent! I have Fibromyalgia, and this vitamin has significantly helped with my lack of energy and pain.
Read More
Frequently Asked Questions
7
Seems effective
I've only been using it for a week, but it appears effective for my fibromyalgia. I will continue using it.
6
Improves symptoms
Good price-performance ratio. I take two daily, in the morning and at lunch, to alleviate fatigue and fibromyalgia symptoms. While I feel improvement, it’s hard to determine how much is due to this supplement as I'm also taking others.
7
Positive effects noted
5 people found this helpful
This supplement has been invaluable for my fibromyalgia symptoms. I've tried various types on Iherb, and all have been excellent. It has helped regulate my heartbeat, and I find the packaging to be excellent value for its price and quality.
8
Systematic review supports CoQ10 for fibromyalgia symptom relief
A systematic review examined CoQ10's effectiveness across rheumatic diseases by analyzing 20 published studies involving 483 patients. Most of the 15 fibromyalgia studies showed that CoQ10 supplementation improved pain, fatigue, sleep quality, and overall symptom scores on the Fibromyalgia Impact Questionnaire.
Patients also experienced better mood and reduced tender point sensitivity. CoQ10 appeared well-tolerated with minimal side effects, suggesting it could serve as a helpful complementary treatment alongside standard fibromyalgia care. The evidence supports further investigation with larger patient groups.
Patients also experienced better mood and reduced tender point sensitivity. CoQ10 appeared well-tolerated with minimal side effects, suggesting it could serve as a helpful complementary treatment alongside standard fibromyalgia care. The evidence supports further investigation with larger patient groups.
8
Systematic review: CoQ10 and vitamins reduce fibromyalgia pain
We reviewed 17 scientific studies examining how antioxidant supplements affect pain in fibromyalgia patients. Our analysis revealed that antioxidants successfully reduced pain in about half the studies examined. Notably, when patients took supplements for at least 6 weeks, 80% experienced meaningful pain relief.
Coenzyme Q10 and vitamins showed particularly promising results. These findings suggest that antioxidant supplementation may help manage fibromyalgia's debilitating pain by combating oxidative stress. However, researchers emphasized the need for larger, more standardized studies to fully understand which antioxidants work best and at what doses.
Coenzyme Q10 and vitamins showed particularly promising results. These findings suggest that antioxidant supplementation may help manage fibromyalgia's debilitating pain by combating oxidative stress. However, researchers emphasized the need for larger, more standardized studies to fully understand which antioxidants work best and at what doses.
2
CoQ10 shows limited direct benefit; mitochondrial imbalance detected
We compared mitochondrial markers in 33 fibromyalgia patients and 30 healthy controls using blood tests and advanced lab techniques. CoQ10 levels alone didn't distinguish patient groups, but the ratio between mitochondrial mass and cellular cleanup processes showed promise in linking to symptom severity.
CoQ10 treatment produced mixed results—some patients benefited while others didn't, possibly depending on their initial mitochondrial health. While these findings suggest mitochondrial imbalance plays a role in fibromyalgia, we cannot yet determine whether it causes the disease or results from it. These markers may eventually help diagnose fibromyalgia and monitor how well antioxidant therapies work.
CoQ10 treatment produced mixed results—some patients benefited while others didn't, possibly depending on their initial mitochondrial health. While these findings suggest mitochondrial imbalance plays a role in fibromyalgia, we cannot yet determine whether it causes the disease or results from it. These markers may eventually help diagnose fibromyalgia and monitor how well antioxidant therapies work.
5
Dietary interventions show mixed promise; evidence remains insufficient
We examined 22 studies investigating 17 different dietary and nutritional interventions for fibromyalgia, a condition marked by widespread chronic pain, fatigue, and sleep problems. Several approaches showed promise: people following vegan diets and low-FODMAP diets reported significant pain improvements, while supplements like coenzyme Q10, green algae, acetyl-l-carnitine, and vitamins C and E also demonstrated measurable benefits.
However, the evidence remains limited. Most studies had design flaws, small sample sizes, and significant differences in methodology that made drawing firm conclusions difficult. While these findings suggest certain dietary changes and supplements may help, we cannot yet confidently recommend any single nutritional approach as a standard fibromyalgia treatment without stronger, more consistent research.
However, the evidence remains limited. Most studies had design flaws, small sample sizes, and significant differences in methodology that made drawing firm conclusions difficult. While these findings suggest certain dietary changes and supplements may help, we cannot yet confidently recommend any single nutritional approach as a standard fibromyalgia treatment without stronger, more consistent research.
8
CoQ10 reduces fibromyalgia pain, fatigue, sleep issues
Fibromyalgia patients often have low CoQ10 levels and high oxidative stress. We tested a water-soluble CoQ10 supplement (200 mg twice daily) in 22 women with fibromyalgia using a randomized, controlled cross-over design.
The results were encouraging: CoQ10 supplementation significantly reduced pain-related symptoms by 24–37%, cut fatigue by about 22%, and improved sleep disturbance by roughly 33% compared to the control group. These findings suggest CoQ10 plays a meaningful role in alleviating key fibromyalgia symptoms.
The results were encouraging: CoQ10 supplementation significantly reduced pain-related symptoms by 24–37%, cut fatigue by about 22%, and improved sleep disturbance by roughly 33% compared to the control group. These findings suggest CoQ10 plays a meaningful role in alleviating key fibromyalgia symptoms.
9
We conducted a thorough investigation to understand if Coenzyme Q10 (CoQ10) could provide relief for those suffering from fibromyalgia (FM). In our randomized, double-blind, placebo-controlled trial, we involved 20 FM patients and offered them either 300 mg of CoQ10 daily or a placebo over a span of forty days.
Our findings revealed a significant improvement for participants who took CoQ10. Notably, we observed marked reductions in their fibromyalgia impact questionnaire (FIQ) scores, particularly in areas related to pain, fatigue, and morning tiredness. The reduction in pain was especially striking, with improvements evident on the visual pain scale and in the number of tender points reported.
Furthermore, we also noted beneficial changes at the molecular level, including recovery of inflammation and antioxidant levels. These changes corresponded with enhanced gene expressions linked to mitochondrial function and AMPK activity, suggesting that CoQ10 might have a broader therapeutic potential.
Overall, our research opens new avenues for viewing how CoQ10 can play a role in managing fibromyalgia, and highlights AMPK as a possible target for future treatments.
Our findings revealed a significant improvement for participants who took CoQ10. Notably, we observed marked reductions in their fibromyalgia impact questionnaire (FIQ) scores, particularly in areas related to pain, fatigue, and morning tiredness. The reduction in pain was especially striking, with improvements evident on the visual pain scale and in the number of tender points reported.
Furthermore, we also noted beneficial changes at the molecular level, including recovery of inflammation and antioxidant levels. These changes corresponded with enhanced gene expressions linked to mitochondrial function and AMPK activity, suggesting that CoQ10 might have a broader therapeutic potential.
Overall, our research opens new avenues for viewing how CoQ10 can play a role in managing fibromyalgia, and highlights AMPK as a possible target for future treatments.
References
- Belviranlı M, Okudan N, Sezer T. Coenzyme Q10 improves redox homeostasis, mitochondrial biogenesis, and irisin signaling in fast- and slow-twitch muscle fibers in a reserpine-induced fibromyalgia-like myalgia model. Life Sci. 2026;394:124366. 10.1016/j.lfs.2026.124366
- Kahraman T, Ayaz A. Dietary Phytonutrients in Fibromyalgia: Integrating Mechanisms, Biomarkers, and Clinical Evidence-A Narrative Review. Medicina (Kaunas). 2025;61. 10.3390/medicina61122211
- Belviranlı M, Okudan N, Sezer T. Coenzyme Q10 Ameliorates Fibromyalgia-like Symptoms and Cognitive Deficits by Enhancing Hippocampal PGC-1α/FNDC5/BDNF Pathway in Reserpine-Treated Rats. Mol Neurobiol. 2025;63:248. 10.1007/s12035-025-05585-y
- Moghazy HM, Seham AA, Mahmoud M, Gebril SM, Monir DM. Involvement of the PINK1/PARKIN pathway in enhancing mitochondrial function and mitophagy in reserpine-induced fibromyalgia mice through strength exercise and coenzyme Q10. Eur J Appl Physiol. 2025. 10.1007/s00421-025-05990-0
- Rosselló Aubach L, Fornós Roca X, Fernández Álvarez ME. Effects of Coenzyme Q10, Tryptophan, and Magnesium Supplementation on Fatigue in Patients with Fibromyalgia - A Randomized Trial. J Diet Suppl. 2025. 10.1080/19390211.2025.2483269
- Freire de Carvalho J, Skare T. Coenzyme Q10 supplementation in rheumatic diseases: A systematic review. Clin Nutr ESPEN. 2024;59:63. 10.1016/j.clnesp.2023.11.016
- Barletta MA, Marino G, Spagnolo B, Bianchi FP, Falappone PCF, et al. Coenzyme Q10 + alpha lipoic acid for chronic COVID syndrome. Clin Exp Med. 2023;23:667. 10.1007/s10238-022-00871-8
- Fernández-Araque A, Verde Z, Torres-Ortega C, Sainz-Gil M, Velasco-Gonzalez V, et al. Effects of Antioxidants on Pain Perception in Patients with Fibromyalgia-A Systematic Review. J Clin Med. 2022;11. 10.3390/jcm11092462
- Martínez-Lara A, Moreno-Fernández AM, Jiménez-Guerrero M, Díaz-López C, De-Miguel M, et al. Mitochondrial Imbalance as a New Approach to the Study of Fibromyalgia. Open Access Rheumatol. 2020;12:175. 10.2147/OARRR.S257470
- Lowry E, Marley J, McVeigh JG, McSorley E, Allsopp P, et al. Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis. Nutrients. 2020;12. 10.3390/nu12092664
- Brum EDS, Fialho MFP, Fischer SPM, Hartmann DD, Gonçalves DF, et al. Relevance of Mitochondrial Dysfunction in the Reserpine-Induced Experimental Fibromyalgia Model. Mol Neurobiol. 2020;57:4202. 10.1007/s12035-020-01996-1
- Schweiger V, Secchettin E, Castellani C, Martini A, Mazzocchi E, et al. Comparison between Acupuncture and Nutraceutical Treatment with Migratens in Patients with Fibromyalgia Syndrome: A Prospective Randomized Clinical Trial. Nutrients. 2020;12. 10.3390/nu12030821
- Sawaddiruk P, Apaijai N, Paiboonworachat S, Kaewchur T, Kasitanon N, et al. Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients reducing brain activity and mitochondrial dysfunction. Free Radic Res. 2019;53:901. 10.1080/10715762.2019.1645955
- Mehrabani S, Askari G, Miraghajani M, Tavakoly R, Arab A. Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies. Complement Ther Med. 2019;43:181. 10.1016/j.ctim.2019.01.022
- Di Pierro F, Rossi A, Consensi A, Giacomelli C, Bazzichi L. Role for a water-soluble form of CoQ10 in female subjects affected by fibromyalgia. A preliminary study. Clin Exp Rheumatol. 2017;35 Suppl 105:20. PubMed
- Alcocer-Gómez E, Cano-García FJ, Cordero MD. Effect of coenzyme Q10 evaluated by 1990 and 2010 ACR Diagnostic Criteria for Fibromyalgia and SCL-90-R: four case reports and literature review. Nutrition. 2013;29:1422. 10.1016/j.nut.2013.05.005
- Cordero MD, Alcocer-Gómez E, Culic O, Carrión AM, de Miguel M, et al. NLRP3 inflammasome is activated in fibromyalgia: the effect of coenzyme Q10. Antioxid Redox Signal. 2014;20:1169. 10.1089/ars.2013.5198
- Morris G, Anderson G, Berk M, Maes M. Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications. Mol Neurobiol. 2013;48:883. 10.1007/s12035-013-8477-8
- Cordero MD, Alcocer-Gómez E, de Miguel M, Culic O, Carrión AM, et al. Can coenzyme q10 improve clinical and molecular parameters in fibromyalgia?. Antioxid Redox Signal. 2013;19:1356. 10.1089/ars.2013.5260
- Miyamae T, Seki M, Naga T, Uchino S, Asazuma H, et al. Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation. Redox Rep. 2013;18:12. 10.1179/1351000212Y.0000000036
- Cordero MD, Díaz-Parrado E, Carrión AM, Alfonsi S, Sánchez-Alcazar JA, et al. Is inflammation a mitochondrial dysfunction-dependent event in fibromyalgia?. Antioxid Redox Signal. 2013;18:800. 10.1089/ars.2012.4892
- Cordero MD, Cotán D, del-Pozo-Martín Y, Carrión AM, de Miguel M, et al. Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient. Nutrition. 2012;28:1200. 10.1016/j.nut.2012.03.018
- Cordero MD, Cano-García FJ, Alcocer-Gómez E, De Miguel M, Sánchez-Alcázar JA. Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q₁₀ effect on clinical improvement. PLoS One. 2012;7:e35677. 10.1371/journal.pone.0035677
