Last update
4/9/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.2
USERS' SCORE
Medium or Average
Based on 17 Reviews
6.3
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
8
We systematically reviewed randomized controlled trials comparing coenzyme Q10 with placebo for migraine prevention in adults. Our meta-analysis examined study data from major medical databases through December 2019, assessing how CoQ10 affects migraine severity, attack frequency, and headache duration.
The evidence suggests CoQ10 has beneficial effects in reducing both how often migraines occur and how long they last. These findings indicate CoQ10 may be a useful preventive option for migraine sufferers, though further research could help clarify optimal dosing and its effects when combined with other supplements.
The evidence suggests CoQ10 has beneficial effects in reducing both how often migraines occur and how long they last. These findings indicate CoQ10 may be a useful preventive option for migraine sufferers, though further research could help clarify optimal dosing and its effects when combined with other supplements.
Read More
4
Moderate evidence for coenzyme Q10 migraine prevention
Researchers examined the evidence for various nutraceutical approaches to migraine prevention, including coenzyme Q10. The analysis revealed that coenzyme Q10 carries Level C evidence—meaning modest research support—for helping prevent migraines, with the advantage of causing few adverse effects.
This moderate level of evidence suggests coenzyme Q10 may offer some benefit, though stronger research is still needed to confirm its effectiveness compared to other prevention strategies. The low rate of side effects makes it a relatively safe option worth considering for migraine sufferers.
This moderate level of evidence suggests coenzyme Q10 may offer some benefit, though stronger research is still needed to confirm its effectiveness compared to other prevention strategies. The low rate of side effects makes it a relatively safe option worth considering for migraine sufferers.
Read More
0
CoQ10 ineffective; melatonin resolved pediatric stabbing headache
A 7-year-old boy experienced primary stabbing headache—brief, sharp jabs lasting just a few seconds that struck without warning. After a trial of Coenzyme Q10 produced no improvement, we switched to melatonin treatment, which resulted in complete symptom relief without any adverse effects during follow-up.
This case highlights melatonin as a potentially innovative and safe therapeutic option for this rare pediatric headache condition, offering hope where traditional medications like indomethacin often fall short or cause unwanted side effects.
This case highlights melatonin as a potentially innovative and safe therapeutic option for this rare pediatric headache condition, offering hope where traditional medications like indomethacin often fall short or cause unwanted side effects.
Read More
Most Useful Reviews
9
Eliminated headaches
15 people found this helpful
I’ve been taking CoQ10 for several years and it has completely resolved my constant headaches. I recommended it to my wife and two others, all of whom have also experienced relief. This product truly works!
Read More
9
Headaches forgotten
1 people found this helpful
I’m pleased with Doctor's Best Coenzyme Q10; it has helped me forget about my headaches.
Read More
9
Significant headache reduction
These capsules are fantastic. They have notably reduced my headaches.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.2
- All Researches
9
Double-blind trial shows migraine improvement
We tested whether combining Coenzyme Q10 (30 mg/day) and L-carnitine (500 mg/day) could help migraine sufferers in a rigorous double-blind, placebo-controlled study involving 56 adults aged 20–40. Over 8 weeks, the supplement combination significantly reduced migraine severity, duration, and frequency compared to placebo. The treatment also lowered serum lactate levels, a marker of mitochondrial energy problems linked to migraines. These results suggest that addressing mitochondrial dysfunction through this supplement combination may offer real benefits for migraine management.
Read More
9
We delved into the role of Coenzyme Q10 (CoQ10) in managing headache symptoms, particularly migraines. This exploration stemmed from the understanding that migraines are complex and may be influenced by various factors, including energy deficits in the brain.
CoQ10 is recognized for its function in boosting mitochondrial energy metabolism, which is seen as a potential avenue for alleviating headaches. We learned that certain nutrients, including CoQ10, have shown promise in reducing the frequency and severity of migraine attacks. In fact, studies reported significant reductions in headache occurrences when individuals incorporated CoQ10 into their regimen.
While we found evidence supporting CoQ10's effectiveness, it's important to note that it’s often studied alongside other supplements. This means that while CoQ10 may play a beneficial role, it's challenging to pinpoint its isolated effects definitively. Nevertheless, the insights from the research suggest that adding CoQ10 to our preventive strategies for migraines could be a worthy consideration.
CoQ10 is recognized for its function in boosting mitochondrial energy metabolism, which is seen as a potential avenue for alleviating headaches. We learned that certain nutrients, including CoQ10, have shown promise in reducing the frequency and severity of migraine attacks. In fact, studies reported significant reductions in headache occurrences when individuals incorporated CoQ10 into their regimen.
While we found evidence supporting CoQ10's effectiveness, it's important to note that it’s often studied alongside other supplements. This means that while CoQ10 may play a beneficial role, it's challenging to pinpoint its isolated effects definitively. Nevertheless, the insights from the research suggest that adding CoQ10 to our preventive strategies for migraines could be a worthy consideration.
Read More
8
Combination supplement shows preliminary migraine symptom relief
We evaluated how a combination supplement—containing CoQ10, riboflavin, magnesium, and feverfew—affected vestibular migraine symptoms in 82 patients over three months. Participants received lifestyle advice on sleep, hydration, exercise, and nutrition alongside the supplement.
The results were encouraging: symptom severity and frequency both improved by roughly 44%, with about half of patients reporting meaningful improvement. No serious side effects were noted. While these findings suggest nonprescription therapies may help reduce vertigo and dizziness associated with vestibular migraine, the study design has limitations that prevent us from definitively attributing benefits to CoQ10 alone—the supplement contained multiple active ingredients, and there was no control group for comparison.
The results were encouraging: symptom severity and frequency both improved by roughly 44%, with about half of patients reporting meaningful improvement. No serious side effects were noted. While these findings suggest nonprescription therapies may help reduce vertigo and dizziness associated with vestibular migraine, the study design has limitations that prevent us from definitively attributing benefits to CoQ10 alone—the supplement contained multiple active ingredients, and there was no control group for comparison.
Read More
8
We systematically reviewed randomized controlled trials comparing coenzyme Q10 with placebo for migraine prevention in adults. Our meta-analysis examined study data from major medical databases through December 2019, assessing how CoQ10 affects migraine severity, attack frequency, and headache duration.
The evidence suggests CoQ10 has beneficial effects in reducing both how often migraines occur and how long they last. These findings indicate CoQ10 may be a useful preventive option for migraine sufferers, though further research could help clarify optimal dosing and its effects when combined with other supplements.
The evidence suggests CoQ10 has beneficial effects in reducing both how often migraines occur and how long they last. These findings indicate CoQ10 may be a useful preventive option for migraine sufferers, though further research could help clarify optimal dosing and its effects when combined with other supplements.
Read More
8
Multi-compound supplement trial shows promise in pediatric headaches
We examined 92 children and teens (ages 6-17) with primary headaches who received one of three supplement compounds over 12 months. Compound 3, which included magnesium oxide, feverfew, andrographis, coenzyme Q10, and vitamin B2, proved particularly effective.
All three supplement regimens significantly reduced headache frequency and decreased the need for pain medications (p=0.000001). Compound 3 showed mixed results depending on headache type—it outperformed the others for migraines with aura, but was less effective for other headache types compared to compound 2.
Overall, parents and children found the supplements well-tolerated and effective for headache prevention, making them a promising complementary approach to traditional medications.
All three supplement regimens significantly reduced headache frequency and decreased the need for pain medications (p=0.000001). Compound 3 showed mixed results depending on headache type—it outperformed the others for migraines with aura, but was less effective for other headache types compared to compound 2.
Overall, parents and children found the supplements well-tolerated and effective for headache prevention, making them a promising complementary approach to traditional medications.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 17 Reviews
6.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Eliminated headaches
15 people found this helpful
I’ve been taking CoQ10 for several years and it has completely resolved my constant headaches. I recommended it to my wife and two others, all of whom have also experienced relief. This product truly works!
Read More
9
Headaches forgotten
1 people found this helpful
I’m pleased with Doctor's Best Coenzyme Q10; it has helped me forget about my headaches.
Read More
9
Significant headache reduction
These capsules are fantastic. They have notably reduced my headaches.
Read More
0
Uncertain effects
I am unsure about the product as it caused headaches, and I saw little effect on fine lines or skin tone.
Read More
0
Stopped due to headaches
I can’t discern the product's effect, but it caused headaches, so I decided to stop taking it.
Read More
Frequently Asked Questions
7
Q10 reduces migraine oxidative stress effectively
We tested whether coenzyme Q10 supplementation could help 84 women with migraines by reducing oxidative stress and improving their lipid profiles. Over 12 weeks, participants received either 400 mg daily of Q10 or placebo. The results showed Q10 significantly lowered harmful oxidative molecules and boosted good cholesterol levels.
Q10 also improved clinical migraine features and reduced body fat percentage. While Q10 did not increase overall antioxidant capacity as expected, it successfully raised serum Q10 levels and showed meaningful improvements in migraine patients' oxidative health and cardiovascular profiles.
Q10 also improved clinical migraine features and reduced body fat percentage. While Q10 did not increase overall antioxidant capacity as expected, it successfully raised serum Q10 levels and showed meaningful improvements in migraine patients' oxidative health and cardiovascular profiles.
8
We systematically reviewed randomized controlled trials comparing coenzyme Q10 with placebo for migraine prevention in adults. Our meta-analysis examined study data from major medical databases through December 2019, assessing how CoQ10 affects migraine severity, attack frequency, and headache duration.
The evidence suggests CoQ10 has beneficial effects in reducing both how often migraines occur and how long they last. These findings indicate CoQ10 may be a useful preventive option for migraine sufferers, though further research could help clarify optimal dosing and its effects when combined with other supplements.
The evidence suggests CoQ10 has beneficial effects in reducing both how often migraines occur and how long they last. These findings indicate CoQ10 may be a useful preventive option for migraine sufferers, though further research could help clarify optimal dosing and its effects when combined with other supplements.
9
We delved into the role of Coenzyme Q10 (CoQ10) in managing headache symptoms, particularly migraines. This exploration stemmed from the understanding that migraines are complex and may be influenced by various factors, including energy deficits in the brain.
CoQ10 is recognized for its function in boosting mitochondrial energy metabolism, which is seen as a potential avenue for alleviating headaches. We learned that certain nutrients, including CoQ10, have shown promise in reducing the frequency and severity of migraine attacks. In fact, studies reported significant reductions in headache occurrences when individuals incorporated CoQ10 into their regimen.
While we found evidence supporting CoQ10's effectiveness, it's important to note that it’s often studied alongside other supplements. This means that while CoQ10 may play a beneficial role, it's challenging to pinpoint its isolated effects definitively. Nevertheless, the insights from the research suggest that adding CoQ10 to our preventive strategies for migraines could be a worthy consideration.
CoQ10 is recognized for its function in boosting mitochondrial energy metabolism, which is seen as a potential avenue for alleviating headaches. We learned that certain nutrients, including CoQ10, have shown promise in reducing the frequency and severity of migraine attacks. In fact, studies reported significant reductions in headache occurrences when individuals incorporated CoQ10 into their regimen.
While we found evidence supporting CoQ10's effectiveness, it's important to note that it’s often studied alongside other supplements. This means that while CoQ10 may play a beneficial role, it's challenging to pinpoint its isolated effects definitively. Nevertheless, the insights from the research suggest that adding CoQ10 to our preventive strategies for migraines could be a worthy consideration.
4
Moderate evidence for coenzyme Q10 migraine prevention
Researchers examined the evidence for various nutraceutical approaches to migraine prevention, including coenzyme Q10. The analysis revealed that coenzyme Q10 carries Level C evidence—meaning modest research support—for helping prevent migraines, with the advantage of causing few adverse effects.
This moderate level of evidence suggests coenzyme Q10 may offer some benefit, though stronger research is still needed to confirm its effectiveness compared to other prevention strategies. The low rate of side effects makes it a relatively safe option worth considering for migraine sufferers.
This moderate level of evidence suggests coenzyme Q10 may offer some benefit, though stronger research is still needed to confirm its effectiveness compared to other prevention strategies. The low rate of side effects makes it a relatively safe option worth considering for migraine sufferers.
8
We observed a fascinating case involving a 10-year-old girl experiencing rare migraine symptoms, specifically eyebrow bleeding, alongside her headaches. Despite normal neurological tests and scans, she suffered from intense headaches that notably included localized bleeding and distinct red spots on her forehead. This unusual combination of symptoms opens the door to new understandings of migraine, particularly in terms of possible neurovascular and neuroinflammatory processes.
To address her migraine symptoms, we treated her with a combination of Coenzyme Q10, Vitamin B2, and Cyproheptadine. Encouragingly, we noticed a significant improvement in both the frequency of her headaches and the intensity of her symptoms following this treatment regimen. This case not only highlights the importance of recognizing rare manifestations of migraine but also illustrates how Coenzyme Q10 could play a role in alleviating headache discomfort.
Overall, our findings suggest that Coenzyme Q10, while part of a multi-faceted treatment approach, may contribute positively to managing certain types of headaches, especially in unique cases like this one. Further evaluation of Coenzyme Q10's effectiveness in broader migraine studies is certainly warranted.
To address her migraine symptoms, we treated her with a combination of Coenzyme Q10, Vitamin B2, and Cyproheptadine. Encouragingly, we noticed a significant improvement in both the frequency of her headaches and the intensity of her symptoms following this treatment regimen. This case not only highlights the importance of recognizing rare manifestations of migraine but also illustrates how Coenzyme Q10 could play a role in alleviating headache discomfort.
Overall, our findings suggest that Coenzyme Q10, while part of a multi-faceted treatment approach, may contribute positively to managing certain types of headaches, especially in unique cases like this one. Further evaluation of Coenzyme Q10's effectiveness in broader migraine studies is certainly warranted.
References
- Takle M, Strelzik J, Langdon R, Turner A, McClintock W, et al. Coenzyme Q10 Supplementation May Be Correlated With Resolution of New Daily Persistent Headache. J Child Neurol. 2025. 10.1177/08830738251366866
- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. 10.1007/s11916-025-01358-3
- Hannigan IP, Rosengren SM, Di Tanna GL, Watson SRD, Welgampola MS. Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study. Intern Med J. 2024;54:916. 10.1111/imj.16314
- Dahri M, Sarafan Sadeghi A, Pahlavani N, Nattagh-Eshtivani E, Hashemilar M, et al. The Effects of Coenzyme Q10 Supplementation on Oxidative Status and Lipid Profile in Migraine Patients: A Randomized Double-Blinded Controlled Clinical Trial. Clin Nutr Res. 2023;12:257. 10.7762/cnr.2023.12.4.257
- Yaghini O, Hoseini N, Ghazavi MR, Mansouri V, Nasiri J, et al. A Comparative Study on the Efficacy of Coenzyme Q10 and Amitriptyline in the Prophylactic Treatment of Migraine Headaches in Children: A Randomized Controlled Trial. Adv Biomed Res. 2022;11:43. 10.4103/abr.abr_235_20
- Kaur K, Hernandez V, Al Hajaj SW, Ebrahim AM, Razack M, et al. The Efficacy of Herbal Supplements and Nutraceuticals for Prevention of Migraine: Can They Help?. Cureus. 2021;13:e14868. 10.7759/cureus.14868
- Sazali S, Badrin S, Norhayati MN, Idris NS. Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis. BMJ Open. 2021;11:e039358. 10.1136/bmjopen-2020-039358
- Vikelis M, Dermitzakis EV, Vlachos GS, Soldatos P, Spingos KC, et al. Open Label Prospective Experience of Supplementation with a Fixed Combination of Magnesium, Vitamin B2, Feverfew, Andrographis Paniculata and Coenzyme Q10 for Episodic Migraine Prophylaxis. J Clin Med. 2020;10. 10.3390/jcm10010067
- Onofri A, Necozione S, Tozzi E. Complementary and alternative medicine (CAM) in headache of children and adolescents: open-label Italian study. Clin Ter. 2020;171:e393. 10.7417/CT.2020.2246
- Parohan M, Sarraf P, Javanbakht MH, Foroushani AR, Ranji-Burachaloo S, et al. The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial. Nutr Neurosci. 2021;24:317. 10.1080/1028415X.2019.1627770
- Moscano F, Guiducci M, Maltoni L, Striano P, Ledda MG, et al. An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache. Ital J Pediatr. 2019;45:36. 10.1186/s13052-019-0624-z
- Hajihashemi P, Askari G, Khorvash F, Reza Maracy M, Nourian M. The effects of concurrent Coenzyme Q10, L-carnitine supplementation in migraine prophylaxis: A randomized, placebo-controlled, double-blind trial. Cephalalgia. 2019;39:648. 10.1177/0333102418821661
- Zeng Z, Li Y, Lu S, Huang W, Di W. Efficacy of CoQ10 as supplementation for migraine: A meta-analysis. Acta Neurol Scand. 2019;139:284. 10.1111/ane.13051
- Bermúdez Salazar M, Rojas Cerón CA, Arana Muñoz RS. Prophylaxis with melatonin for primary stabbing headache in pediatrics: a case report. Colomb Med (Cali). 2018;49:244. 10.25100/cm.v49i2.3857
- Dahri M, Tarighat-Esfanjani A, Asghari-Jafarabadi M, Hashemilar M. Oral coenzyme Q10 supplementation in patients with migraine: Effects on clinical features and inflammatory markers. Nutr Neurosci. 2019;22:607. 10.1080/1028415X.2017.1421039
- Guilbot A, Bangratz M, Ait Abdellah S, Lucas C. A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study. BMC Complement Altern Med. 2017;17:433. 10.1186/s12906-017-1933-7
- Tavasoli A, Rezazadeh M, Kachuei M. Eyebrow bleeding as a rare migraine symptom: a case report. Ann Med Surg (Lond). 2024;86:7377. 10.1097/MS9.0000000000002655
- Hajhashemy Z, Golpour-Hamedani S, Eshaghian N, Sadeghi O, Khorvash F, et al. Practical supplements for prevention and management of migraine attacks: a narrative review. Front Nutr. 2024;11:1433390. 10.3389/fnut.2024.1433390
- Gaul C, Zaranek L, Goßrau G. [Complementary and supplementary procedures in the treatment of headache]. Schmerz. 2023;37:448. 10.1007/s00482-023-00738-1
- Quintana S, Russo M, Torelli P. Nutraceuticals and migraine: further strategy for the treatment of specific conditions. Neurol Sci. 2022;43:6565. 10.1007/s10072-022-06250-1
- Ariyanfar S, Razeghi Jahromi S, Togha M, Ghorbani Z. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep. 2022;26:193. 10.1007/s11916-022-01019-9
- Lisicki M, Schoenen J. Metabolic treatments of migraine. Expert Rev Neurother. 2020;20:295. 10.1080/14737175.2020.1729130
