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SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
USERS' SCORE
Good
Based on 8 Reviews
8.7
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
9
CoQ10 enhances cognitive function
Coenzyme Q10 treatment ameliorates cognitive deficits by modulating mitochondrial functions in surgically induced menopause.
Directly addresses menopause cognition
We aimed to understand how cognitive decline occurs after menopause, particularly due to decreased ovarian function and estrogen. To explore this, we studied the effects of Coenzyme Q10 (CoQ10), a substance known for its potential health benefits, on cognitive impairment in post-menopausal mice.
After four weeks of ovariectomy, which simulates menopause, we observed significant cognitive deficits in the mice, as measured by popular tests like the Morris water maze and elevated plus maze. However, when we gave these mice CoQ10 daily for four weeks, we saw a remarkable improvement in their cognitive functions.
We also investigated the underlying reasons for this decline by looking at mitochondrial functions in the brain. Our findings revealed that the activity of several key components of the mitochondrial electron transport chain was significantly reduced in the ovariectomized mice. These changes were associated with increased oxidative stress, indicated by high levels of reactive oxygen species and protein damage.
Interestingly, CoQ10 supplementation helped mitigate these mitochondrial dysfunctions and oxidative stress, leading to improved cognitive performance in the mice. Therefore, it seems that CoQ10 has a positive effect in addressing cognitive decline related to menopause by supporting mitochondrial health and reducing oxidative stress.
After four weeks of ovariectomy, which simulates menopause, we observed significant cognitive deficits in the mice, as measured by popular tests like the Morris water maze and elevated plus maze. However, when we gave these mice CoQ10 daily for four weeks, we saw a remarkable improvement in their cognitive functions.
We also investigated the underlying reasons for this decline by looking at mitochondrial functions in the brain. Our findings revealed that the activity of several key components of the mitochondrial electron transport chain was significantly reduced in the ovariectomized mice. These changes were associated with increased oxidative stress, indicated by high levels of reactive oxygen species and protein damage.
Interestingly, CoQ10 supplementation helped mitigate these mitochondrial dysfunctions and oxidative stress, leading to improved cognitive performance in the mice. Therefore, it seems that CoQ10 has a positive effect in addressing cognitive decline related to menopause by supporting mitochondrial health and reducing oxidative stress.
Read More
8
Coenzyme Q10 shows mixed efficacy
Efficacy of 0.1% crosslinked hyaluronic acid, coenzyme Q10 and vitamin E in the management of dry eye disease in menopause patients receiving antidepressants.
Limited isolation of coenzyme Q10 effects
We explored the impact of coenzyme Q10 in a study aimed at managing dry eye disease in menopausal women undergoing antidepressant treatment. This was a thorough investigation involving sixty female participants with an average age of 63.25 years. In a double-blind, single-center setup, we compared eye drops containing crosslinked hyaluronic acid, coenzyme Q10, and vitamin E against a more traditional carmellose sodium formulation.
After two months of treatment, we discovered that the coenzyme Q10 formulation, while demonstrating positive trends, could not be isolated from other ingredients in terms of effects specifically related to menopausal symptoms. The scores from the ocular surface disease index indicated favorable results for both formulations, but we didn’t find significant advantages that could confidently highlight the standalone benefits of coenzyme Q10.
While we observed improvements in tear stability and subjective dry eye symptoms with the lower total daily dose of crosslinked hyaluronic acid eye drops, we need to acknowledge that it remains challenging to draw conclusive benefits specifically associated with coenzyme Q10 in the context of menopause.
After two months of treatment, we discovered that the coenzyme Q10 formulation, while demonstrating positive trends, could not be isolated from other ingredients in terms of effects specifically related to menopausal symptoms. The scores from the ocular surface disease index indicated favorable results for both formulations, but we didn’t find significant advantages that could confidently highlight the standalone benefits of coenzyme Q10.
While we observed improvements in tear stability and subjective dry eye symptoms with the lower total daily dose of crosslinked hyaluronic acid eye drops, we need to acknowledge that it remains challenging to draw conclusive benefits specifically associated with coenzyme Q10 in the context of menopause.
Read More
4
Menopause, HRT, coenzyme Q10 study
Effects of menopause and hormone replacement therapy on serum levels of coenzyme Q10 and other lipid-soluble antioxidants.
Limited isolated effect observed
We investigated how menopause and hormone replacement therapy (HRT) affect levels of coenzyme Q10 and other important antioxidants in women's bodies. Our study involved 50 premenopausal women, 33 healthy postmenopausal women, and 15 postmenopausal women undergoing HRT. We meticulously measured serum levels of coenzyme Q10, alpha-tocopherol, gamma-tocopherol, beta-carotene, and lycopene using high-pressure liquid chromatography.
Our findings revealed that postmenopausal women had higher levels of coenzyme Q10 and alpha-tocopherol compared to their premenopausal counterparts. However, interestingly, those on HRT experienced a significant drop in coenzyme Q10 and gamma-tocopherol, although their alpha-tocopherol levels increased. We also noted that beta-carotene, lycopene, and various lipid profiles were comparable across the groups, suggesting no significant impact from these treatments in those areas.
It appears that coenzyme Q10 could play a vital role in heart health due to its antioxidant properties and its function within the mitochondria. The decrease in coenzyme Q10 in women taking HRT raises concerns about potential increases in cardiovascular risk during menopause. Given these insights, further studies are needed to thoroughly explore the implications of HRT on antioxidant levels and cardiovascular health in postmenopausal women.
Our findings revealed that postmenopausal women had higher levels of coenzyme Q10 and alpha-tocopherol compared to their premenopausal counterparts. However, interestingly, those on HRT experienced a significant drop in coenzyme Q10 and gamma-tocopherol, although their alpha-tocopherol levels increased. We also noted that beta-carotene, lycopene, and various lipid profiles were comparable across the groups, suggesting no significant impact from these treatments in those areas.
It appears that coenzyme Q10 could play a vital role in heart health due to its antioxidant properties and its function within the mitochondria. The decrease in coenzyme Q10 in women taking HRT raises concerns about potential increases in cardiovascular risk during menopause. Given these insights, further studies are needed to thoroughly explore the implications of HRT on antioxidant levels and cardiovascular health in postmenopausal women.
Read More
Most Useful Reviews
9.5
Blood pressure relief
I have been taking blood pressure medication for three years and successfully managed it with exercise and nutritional supplements. After starting CoQ10, my blood pressure dropped by 5-10 points and remained stable. It significantly reduced gum inflammation and strengthened my teeth. At 55, my skin has become soft and hydration has improved, making it ideal for those concerned about skin and blood pressure during menopause. I encourage everyone to care for their CoQ10 and stay healthy.
Read More
9.5
Reduced pain
I didn’t expect such positive results. At 52, after starting CoQ10 alongside collagen in April 2020, I noticed muscle and joint pain diminishing within weeks. After three months, my wrinkles noticeably smoothed out, earning compliments from everyone. I believe this miracle helps combat changes associated with menopause.
Read More
8.8
Enhanced mood
Life is beautiful! Initially, I disregarded this product, but after trying it, I experienced clarity of thought, improved mood, and joy in interacting with others. I feel revitalised! This wonderful product has made me keen to maintain my regular intake. A sincere thank you to those who recommended it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
9
CoQ10 enhances cognitive function
Coenzyme Q10 treatment ameliorates cognitive deficits by modulating mitochondrial functions in surgically induced menopause.
Directly addresses menopause cognition
We aimed to understand how cognitive decline occurs after menopause, particularly due to decreased ovarian function and estrogen. To explore this, we studied the effects of Coenzyme Q10 (CoQ10), a substance known for its potential health benefits, on cognitive impairment in post-menopausal mice.
After four weeks of ovariectomy, which simulates menopause, we observed significant cognitive deficits in the mice, as measured by popular tests like the Morris water maze and elevated plus maze. However, when we gave these mice CoQ10 daily for four weeks, we saw a remarkable improvement in their cognitive functions.
We also investigated the underlying reasons for this decline by looking at mitochondrial functions in the brain. Our findings revealed that the activity of several key components of the mitochondrial electron transport chain was significantly reduced in the ovariectomized mice. These changes were associated with increased oxidative stress, indicated by high levels of reactive oxygen species and protein damage.
Interestingly, CoQ10 supplementation helped mitigate these mitochondrial dysfunctions and oxidative stress, leading to improved cognitive performance in the mice. Therefore, it seems that CoQ10 has a positive effect in addressing cognitive decline related to menopause by supporting mitochondrial health and reducing oxidative stress.
After four weeks of ovariectomy, which simulates menopause, we observed significant cognitive deficits in the mice, as measured by popular tests like the Morris water maze and elevated plus maze. However, when we gave these mice CoQ10 daily for four weeks, we saw a remarkable improvement in their cognitive functions.
We also investigated the underlying reasons for this decline by looking at mitochondrial functions in the brain. Our findings revealed that the activity of several key components of the mitochondrial electron transport chain was significantly reduced in the ovariectomized mice. These changes were associated with increased oxidative stress, indicated by high levels of reactive oxygen species and protein damage.
Interestingly, CoQ10 supplementation helped mitigate these mitochondrial dysfunctions and oxidative stress, leading to improved cognitive performance in the mice. Therefore, it seems that CoQ10 has a positive effect in addressing cognitive decline related to menopause by supporting mitochondrial health and reducing oxidative stress.
Read More
8
Coenzyme Q10 shows mixed efficacy
Efficacy of 0.1% crosslinked hyaluronic acid, coenzyme Q10 and vitamin E in the management of dry eye disease in menopause patients receiving antidepressants.
Limited isolation of coenzyme Q10 effects
We explored the impact of coenzyme Q10 in a study aimed at managing dry eye disease in menopausal women undergoing antidepressant treatment. This was a thorough investigation involving sixty female participants with an average age of 63.25 years. In a double-blind, single-center setup, we compared eye drops containing crosslinked hyaluronic acid, coenzyme Q10, and vitamin E against a more traditional carmellose sodium formulation.
After two months of treatment, we discovered that the coenzyme Q10 formulation, while demonstrating positive trends, could not be isolated from other ingredients in terms of effects specifically related to menopausal symptoms. The scores from the ocular surface disease index indicated favorable results for both formulations, but we didn’t find significant advantages that could confidently highlight the standalone benefits of coenzyme Q10.
While we observed improvements in tear stability and subjective dry eye symptoms with the lower total daily dose of crosslinked hyaluronic acid eye drops, we need to acknowledge that it remains challenging to draw conclusive benefits specifically associated with coenzyme Q10 in the context of menopause.
After two months of treatment, we discovered that the coenzyme Q10 formulation, while demonstrating positive trends, could not be isolated from other ingredients in terms of effects specifically related to menopausal symptoms. The scores from the ocular surface disease index indicated favorable results for both formulations, but we didn’t find significant advantages that could confidently highlight the standalone benefits of coenzyme Q10.
While we observed improvements in tear stability and subjective dry eye symptoms with the lower total daily dose of crosslinked hyaluronic acid eye drops, we need to acknowledge that it remains challenging to draw conclusive benefits specifically associated with coenzyme Q10 in the context of menopause.
Read More
4
Menopause, HRT, coenzyme Q10 study
Effects of menopause and hormone replacement therapy on serum levels of coenzyme Q10 and other lipid-soluble antioxidants.
Limited isolated effect observed
We investigated how menopause and hormone replacement therapy (HRT) affect levels of coenzyme Q10 and other important antioxidants in women's bodies. Our study involved 50 premenopausal women, 33 healthy postmenopausal women, and 15 postmenopausal women undergoing HRT. We meticulously measured serum levels of coenzyme Q10, alpha-tocopherol, gamma-tocopherol, beta-carotene, and lycopene using high-pressure liquid chromatography.
Our findings revealed that postmenopausal women had higher levels of coenzyme Q10 and alpha-tocopherol compared to their premenopausal counterparts. However, interestingly, those on HRT experienced a significant drop in coenzyme Q10 and gamma-tocopherol, although their alpha-tocopherol levels increased. We also noted that beta-carotene, lycopene, and various lipid profiles were comparable across the groups, suggesting no significant impact from these treatments in those areas.
It appears that coenzyme Q10 could play a vital role in heart health due to its antioxidant properties and its function within the mitochondria. The decrease in coenzyme Q10 in women taking HRT raises concerns about potential increases in cardiovascular risk during menopause. Given these insights, further studies are needed to thoroughly explore the implications of HRT on antioxidant levels and cardiovascular health in postmenopausal women.
Our findings revealed that postmenopausal women had higher levels of coenzyme Q10 and alpha-tocopherol compared to their premenopausal counterparts. However, interestingly, those on HRT experienced a significant drop in coenzyme Q10 and gamma-tocopherol, although their alpha-tocopherol levels increased. We also noted that beta-carotene, lycopene, and various lipid profiles were comparable across the groups, suggesting no significant impact from these treatments in those areas.
It appears that coenzyme Q10 could play a vital role in heart health due to its antioxidant properties and its function within the mitochondria. The decrease in coenzyme Q10 in women taking HRT raises concerns about potential increases in cardiovascular risk during menopause. Given these insights, further studies are needed to thoroughly explore the implications of HRT on antioxidant levels and cardiovascular health in postmenopausal women.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.7
9.5
Blood pressure relief
I have been taking blood pressure medication for three years and successfully managed it with exercise and nutritional supplements. After starting CoQ10, my blood pressure dropped by 5-10 points and remained stable. It significantly reduced gum inflammation and strengthened my teeth. At 55, my skin has become soft and hydration has improved, making it ideal for those concerned about skin and blood pressure during menopause. I encourage everyone to care for their CoQ10 and stay healthy.
Read More
9.5
Reduced pain
I didn’t expect such positive results. At 52, after starting CoQ10 alongside collagen in April 2020, I noticed muscle and joint pain diminishing within weeks. After three months, my wrinkles noticeably smoothed out, earning compliments from everyone. I believe this miracle helps combat changes associated with menopause.
Read More
8.8
Enhanced mood
Life is beautiful! Initially, I disregarded this product, but after trying it, I experienced clarity of thought, improved mood, and joy in interacting with others. I feel revitalised! This wonderful product has made me keen to maintain my regular intake. A sincere thank you to those who recommended it.
Read More
8.8
Fewer palpitations
Due to menopause, I experienced heart palpitations, which affected my sleep. After taking CoQ10, I noticed an improvement in my palpitations. It has made a significant difference in how I feel.
8.8
Less migraine
I took CoQ10 after researching remedies for migraines during menopause. Since taking this product, I've had fewer migraines and the severity has significantly reduced. It has been very beneficial for my wellbeing.
