Overview
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.7
USERS' SCORE
Good
Based on 5 Reviews
8.2
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
8
We explored how Coenzyme Q10 (CoQ10) supplementation affects bile acid metabolism and its potential implications for obesity. The study focused on mice fed a high-fat diet to simulate conditions related to obesity and glycolipid disorders. By utilizing advanced techniques, including Ultra-Performance Liquid Chromatography-tandem Mass Spectrometry, we assessed the impact of CoQ10 treatment.
Our findings revealed that CoQ10 not only helped reverse the decrease in serum and colonic bile acid levels associated with a high-fat diet but also altered the bile acid profile positively. We identified seventeen potential targets for CoQ10's action in bile acid metabolism, with six key targets being especially vital to the observed effects. Notably, CoQ10 showed a strong binding affinity to five of these key targets, including the farnesoid X receptor (FXR) and Takeda G-protein coupled receptor 5 (TGR5).
Through this research, we gained valuable insights into how CoQ10 can potentially regulate bile acid metabolism. These findings provide a new perspective on utilizing CoQ10 for enhancing metabolic health, particularly concerning obesity and related metabolic disorders.
Our findings revealed that CoQ10 not only helped reverse the decrease in serum and colonic bile acid levels associated with a high-fat diet but also altered the bile acid profile positively. We identified seventeen potential targets for CoQ10's action in bile acid metabolism, with six key targets being especially vital to the observed effects. Notably, CoQ10 showed a strong binding affinity to five of these key targets, including the farnesoid X receptor (FXR) and Takeda G-protein coupled receptor 5 (TGR5).
Through this research, we gained valuable insights into how CoQ10 can potentially regulate bile acid metabolism. These findings provide a new perspective on utilizing CoQ10 for enhancing metabolic health, particularly concerning obesity and related metabolic disorders.
Read More
8
Co-Q10 enhances cognitive function
We explored the impact of coenzyme Q10 (Co-Q10) on cognitive function and neuronal health in rats made obese by monosodium glutamate (MSG) exposure. This study involved forty-eight neonatal male Wistar rats divided into four groups: a control group, a group receiving MSG, and two groups treated with different dosages of Co-Q10.
The findings are impressive. Co-Q10 not only helped improve cognitive function but also showed protective effects on the hippocampus, a crucial brain region for memory. By enhancing antioxidant defenses and reducing harmful neuronal damage, Co-Q10 appears to offer a promising approach to addressing cognitive issues associated with obesity.
We conducted various tests to assess memory and learning performance, which showed notable improvements in the rats treated with Co-Q10. Additionally, we observed a significant reduction in the levels of markers associated with oxidative stress and cell damage in the hippocampus. Overall, these results suggest that Co-Q10 holds potential as a supportive treatment for cognitive deficits linked to obesity.
The findings are impressive. Co-Q10 not only helped improve cognitive function but also showed protective effects on the hippocampus, a crucial brain region for memory. By enhancing antioxidant defenses and reducing harmful neuronal damage, Co-Q10 appears to offer a promising approach to addressing cognitive issues associated with obesity.
We conducted various tests to assess memory and learning performance, which showed notable improvements in the rats treated with Co-Q10. Additionally, we observed a significant reduction in the levels of markers associated with oxidative stress and cell damage in the hippocampus. Overall, these results suggest that Co-Q10 holds potential as a supportive treatment for cognitive deficits linked to obesity.
Read More
4
We explored the effects of coenzyme Q10 (CoQ10) on obesity, particularly regarding reproductive health. To do this, we used an animal model featuring rats that were fed a cafeteria diet, which mimics unhealthy Western eating habits. This allowed us to observe how obesity impacts both metabolic and ovarian function.
After 75 days on this high-calorie diet, we divided our rats into two groups and administered oral CoQ10 to half of them for 13 days. We discovered that the cafeteria diet led to significant weight gain, along with increased blood sugar, triglycerides, and cholesterol levels. Moreover, we noted concerning changes in the ovaries, such as fewer healthy follicles and higher levels of follicular atresia and estradiol. The obese rats also experienced disruptions in their estrous cycle and a reduced ovulation rate.
Although CoQ10 did not influence the metabolic issues caused by obesity, we observed that it positively affected ovarian health. This suggests that CoQ10 might be beneficial for fertility in obese individuals who are otherwise metabolically stable. Despite its promise for reproductive improvement, it's crucial to pair CoQ10 treatment with lifestyle changes, such as a balanced diet and increased physical activity, especially for those aiming for pregnancy.
After 75 days on this high-calorie diet, we divided our rats into two groups and administered oral CoQ10 to half of them for 13 days. We discovered that the cafeteria diet led to significant weight gain, along with increased blood sugar, triglycerides, and cholesterol levels. Moreover, we noted concerning changes in the ovaries, such as fewer healthy follicles and higher levels of follicular atresia and estradiol. The obese rats also experienced disruptions in their estrous cycle and a reduced ovulation rate.
Although CoQ10 did not influence the metabolic issues caused by obesity, we observed that it positively affected ovarian health. This suggests that CoQ10 might be beneficial for fertility in obese individuals who are otherwise metabolically stable. Despite its promise for reproductive improvement, it's crucial to pair CoQ10 treatment with lifestyle changes, such as a balanced diet and increased physical activity, especially for those aiming for pregnancy.
Read More
Most Useful Reviews
7.5
Improved energy levels
27 people found this helpful
Coenzyme Q10 is a compound produced by the liver that stimulates ATP production, the body's primary energy source. Its levels decline with age, necessitating additional intake, especially for older individuals. I've taken it for five days and noticed more energy, improved mood, and enhanced productivity. I recommend this excellent supplement from Doctor's Best!
Read More
7.5
Effective dieting support
1 people found this helpful
Coenzyme Q10 has aided me in addressing obesity while improving my mood during puberty. Since starting it, along with light exercise, I’ve successfully lost weight and feel more balanced. The capsules are tasteless and easy to take, so I will keep using them!
Read More
9
Weight loss aid
I was amazed by Coenzyme Q10's effects, especially regarding weight loss and rejuvenation. It helps normalise metabolic functions and makes losing weight easier. I’ve lost more weight with it and appreciate how it improves skin texture, although the rejuvenating effects are gradual. I highly recommend it!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.7
- All Researches
9
We explored the combination of high-intensity exercise and Cuban policosanol, a natural supplement, to see how it impacts obesity and related health issues. Our study involved 17 participants with obesity, and the goal was to understand how this combination could improve their overall health in just 12 weeks.
After the program, we observed significant reductions in several key health markers. For instance, participants experienced notable drops in body mass index and waist circumference, along with improvements in blood pressure. The combination also led to a decrease in harmful cholesterol levels and an increase in the beneficial high-density lipoprotein cholesterol (HDL-C), which is great for heart health.
Interestingly, even though the serum level of coenzyme Q10 (CoQ) increased in participants, the focus of the study was primarily on the combined effects of exercise and policosanol rather than the isolated impact of CoQ itself. This means that while we saw improvements in HDL quality and functionality, and a boost in CoQ levels, we cannot definitively state that CoQ alone would have the same benefits for obesity treatment.
To sum it up, our findings indicate that engaging in a structured exercise program while taking Cuban policosanol can lead to meaningful improvements in obesity-related health markers without harming liver function or CoQ metabolism.
After the program, we observed significant reductions in several key health markers. For instance, participants experienced notable drops in body mass index and waist circumference, along with improvements in blood pressure. The combination also led to a decrease in harmful cholesterol levels and an increase in the beneficial high-density lipoprotein cholesterol (HDL-C), which is great for heart health.
Interestingly, even though the serum level of coenzyme Q10 (CoQ) increased in participants, the focus of the study was primarily on the combined effects of exercise and policosanol rather than the isolated impact of CoQ itself. This means that while we saw improvements in HDL quality and functionality, and a boost in CoQ levels, we cannot definitively state that CoQ alone would have the same benefits for obesity treatment.
To sum it up, our findings indicate that engaging in a structured exercise program while taking Cuban policosanol can lead to meaningful improvements in obesity-related health markers without harming liver function or CoQ metabolism.
Read More
8
Co-Q10 enhances cognitive function
We explored the impact of coenzyme Q10 (Co-Q10) on cognitive function and neuronal health in rats made obese by monosodium glutamate (MSG) exposure. This study involved forty-eight neonatal male Wistar rats divided into four groups: a control group, a group receiving MSG, and two groups treated with different dosages of Co-Q10.
The findings are impressive. Co-Q10 not only helped improve cognitive function but also showed protective effects on the hippocampus, a crucial brain region for memory. By enhancing antioxidant defenses and reducing harmful neuronal damage, Co-Q10 appears to offer a promising approach to addressing cognitive issues associated with obesity.
We conducted various tests to assess memory and learning performance, which showed notable improvements in the rats treated with Co-Q10. Additionally, we observed a significant reduction in the levels of markers associated with oxidative stress and cell damage in the hippocampus. Overall, these results suggest that Co-Q10 holds potential as a supportive treatment for cognitive deficits linked to obesity.
The findings are impressive. Co-Q10 not only helped improve cognitive function but also showed protective effects on the hippocampus, a crucial brain region for memory. By enhancing antioxidant defenses and reducing harmful neuronal damage, Co-Q10 appears to offer a promising approach to addressing cognitive issues associated with obesity.
We conducted various tests to assess memory and learning performance, which showed notable improvements in the rats treated with Co-Q10. Additionally, we observed a significant reduction in the levels of markers associated with oxidative stress and cell damage in the hippocampus. Overall, these results suggest that Co-Q10 holds potential as a supportive treatment for cognitive deficits linked to obesity.
Read More
8
We explored how Coenzyme Q10 (CoQ10) supplementation affects bile acid metabolism and its potential implications for obesity. The study focused on mice fed a high-fat diet to simulate conditions related to obesity and glycolipid disorders. By utilizing advanced techniques, including Ultra-Performance Liquid Chromatography-tandem Mass Spectrometry, we assessed the impact of CoQ10 treatment.
Our findings revealed that CoQ10 not only helped reverse the decrease in serum and colonic bile acid levels associated with a high-fat diet but also altered the bile acid profile positively. We identified seventeen potential targets for CoQ10's action in bile acid metabolism, with six key targets being especially vital to the observed effects. Notably, CoQ10 showed a strong binding affinity to five of these key targets, including the farnesoid X receptor (FXR) and Takeda G-protein coupled receptor 5 (TGR5).
Through this research, we gained valuable insights into how CoQ10 can potentially regulate bile acid metabolism. These findings provide a new perspective on utilizing CoQ10 for enhancing metabolic health, particularly concerning obesity and related metabolic disorders.
Our findings revealed that CoQ10 not only helped reverse the decrease in serum and colonic bile acid levels associated with a high-fat diet but also altered the bile acid profile positively. We identified seventeen potential targets for CoQ10's action in bile acid metabolism, with six key targets being especially vital to the observed effects. Notably, CoQ10 showed a strong binding affinity to five of these key targets, including the farnesoid X receptor (FXR) and Takeda G-protein coupled receptor 5 (TGR5).
Through this research, we gained valuable insights into how CoQ10 can potentially regulate bile acid metabolism. These findings provide a new perspective on utilizing CoQ10 for enhancing metabolic health, particularly concerning obesity and related metabolic disorders.
Read More
7
We set out to understand how coenzyme Q10 affects obesity, particularly when paired with simvastatin, in a well-designed study. Adult male obese Zucker rats were divided into several groups, some receiving treatment with empty nanoparticles, while others were treated with simvastatin, coenzyme Q10, or a combination of both in nanoparticles.
After six weeks of treatment, we looked at various health indicators like the lipid profiles and the balance between nitric oxide and reactive oxygen species in the heart and aorta. While all treatments lowered LDL cholesterol levels, only the combined therapy with simvastatin and coenzyme Q10 showed significant improvements in nitric oxide synthase activity and signaling pathways related to heart health.
However, coenzyme Q10 alone did not demonstrate any isolated benefits for combating obesity. Hence, while it seems to play a role in enhancing the effects of statins, it may not be effective on its own for improving outcomes in obesity.
After six weeks of treatment, we looked at various health indicators like the lipid profiles and the balance between nitric oxide and reactive oxygen species in the heart and aorta. While all treatments lowered LDL cholesterol levels, only the combined therapy with simvastatin and coenzyme Q10 showed significant improvements in nitric oxide synthase activity and signaling pathways related to heart health.
However, coenzyme Q10 alone did not demonstrate any isolated benefits for combating obesity. Hence, while it seems to play a role in enhancing the effects of statins, it may not be effective on its own for improving outcomes in obesity.
Read More
4
We explored the effects of coenzyme Q10 (CoQ10) on obesity, particularly regarding reproductive health. To do this, we used an animal model featuring rats that were fed a cafeteria diet, which mimics unhealthy Western eating habits. This allowed us to observe how obesity impacts both metabolic and ovarian function.
After 75 days on this high-calorie diet, we divided our rats into two groups and administered oral CoQ10 to half of them for 13 days. We discovered that the cafeteria diet led to significant weight gain, along with increased blood sugar, triglycerides, and cholesterol levels. Moreover, we noted concerning changes in the ovaries, such as fewer healthy follicles and higher levels of follicular atresia and estradiol. The obese rats also experienced disruptions in their estrous cycle and a reduced ovulation rate.
Although CoQ10 did not influence the metabolic issues caused by obesity, we observed that it positively affected ovarian health. This suggests that CoQ10 might be beneficial for fertility in obese individuals who are otherwise metabolically stable. Despite its promise for reproductive improvement, it's crucial to pair CoQ10 treatment with lifestyle changes, such as a balanced diet and increased physical activity, especially for those aiming for pregnancy.
After 75 days on this high-calorie diet, we divided our rats into two groups and administered oral CoQ10 to half of them for 13 days. We discovered that the cafeteria diet led to significant weight gain, along with increased blood sugar, triglycerides, and cholesterol levels. Moreover, we noted concerning changes in the ovaries, such as fewer healthy follicles and higher levels of follicular atresia and estradiol. The obese rats also experienced disruptions in their estrous cycle and a reduced ovulation rate.
Although CoQ10 did not influence the metabolic issues caused by obesity, we observed that it positively affected ovarian health. This suggests that CoQ10 might be beneficial for fertility in obese individuals who are otherwise metabolically stable. Despite its promise for reproductive improvement, it's crucial to pair CoQ10 treatment with lifestyle changes, such as a balanced diet and increased physical activity, especially for those aiming for pregnancy.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved energy levels
27 people found this helpful
Coenzyme Q10 is a compound produced by the liver that stimulates ATP production, the body's primary energy source. Its levels decline with age, necessitating additional intake, especially for older individuals. I've taken it for five days and noticed more energy, improved mood, and enhanced productivity. I recommend this excellent supplement from Doctor's Best!
Read More
7.5
Effective dieting support
1 people found this helpful
Coenzyme Q10 has aided me in addressing obesity while improving my mood during puberty. Since starting it, along with light exercise, I’ve successfully lost weight and feel more balanced. The capsules are tasteless and easy to take, so I will keep using them!
Read More
9
Weight loss aid
I was amazed by Coenzyme Q10's effects, especially regarding weight loss and rejuvenation. It helps normalise metabolic functions and makes losing weight easier. I’ve lost more weight with it and appreciate how it improves skin texture, although the rejuvenating effects are gradual. I highly recommend it!
Read More
7.5
Preventive health cure
4 people found this helpful
This Co Q10 supplement is vital for preventing numerous diseases, including obesity. The quality of this excellent dietary supplement is exceptional. I will continue to order it regularly!
Read More
7.5
Postpartum health boost
1 people found this helpful
I purchased this after childbirth to restore my health. Coenzyme Q10 is beneficial for heart diseases, reducing statin side effects, and preventing obesity. I’m pleased with the results.
Read More
Frequently Asked Questions
7.5
Improved energy levels
27 people found this helpful
Coenzyme Q10 is a compound produced by the liver that stimulates ATP production, the body's primary energy source. Its levels decline with age, necessitating additional intake, especially for older individuals. I've taken it for five days and noticed more energy, improved mood, and enhanced productivity. I recommend this excellent supplement from Doctor's Best!
7.5
Effective dieting support
1 people found this helpful
Coenzyme Q10 has aided me in addressing obesity while improving my mood during puberty. Since starting it, along with light exercise, I’ve successfully lost weight and feel more balanced. The capsules are tasteless and easy to take, so I will keep using them!
9
Weight loss aid
I was amazed by Coenzyme Q10's effects, especially regarding weight loss and rejuvenation. It helps normalise metabolic functions and makes losing weight easier. I’ve lost more weight with it and appreciate how it improves skin texture, although the rejuvenating effects are gradual. I highly recommend it!
7.5
Preventive health cure
4 people found this helpful
This Co Q10 supplement is vital for preventing numerous diseases, including obesity. The quality of this excellent dietary supplement is exceptional. I will continue to order it regularly!
7.5
Postpartum health boost
1 people found this helpful
I purchased this after childbirth to restore my health. Coenzyme Q10 is beneficial for heart diseases, reducing statin side effects, and preventing obesity. I’m pleased with the results.
References
- Erfanmanesh Z, Edalatmanesh MA, Mokhtari M. The Impact of Coenzyme Q10 on Cognitive Dysfunction, Antioxidant Defense, Cholinergic Activity, and Hippocampal Neuronal Damage in Monosodium Glutamate-Induced Obesity. Iran J Pharm Res. 2024;23:e157068. doi:10.5812/ijpr-157068
- Sarrible GB, Bazzano MV, Koutsovitis C, Bilbao MG, Da Cuña RH, et al. Effects of coenzyme q10 supplementation on metabolic and reproductive outcomes in obese rats. J Ovarian Res. 2025;18:22. doi:10.1186/s13048-025-01604-7
- Jin M, Zou T, Huang H, Chen M, Zou H, et al. The Effect of Coenzyme Q10 Supplementation on Bile Acid Metabolism: Insights from Network Pharmacology, Molecular Docking, and Experimental Validation. Mol Nutr Food Res. 2024;68:e2400147. doi:10.1002/mnfr.202400147
- Cho KH, Nam HS, Kim NY, Lee MS, Kang DJ. Combination Therapy of Cuban Policosanol (Raydel, 20 mg) and Intensive Exercise for 12 Weeks Resulted in Improvements in Obesity, Hypertension, and Dyslipidemia without a Decrease in Serum Coenzyme Q: Enhancement of Lipoproteins Quality and Antioxidant Functionality in Obese Participants. Pharmaceuticals (Basel). 2024;17. doi:10.3390/ph17010132
- Astani K, Bashiri J, Pourrazi H, Nourazar MA. Effect of high-intensity interval training and coenzyme Q10 supplementation on cardiac apoptosis in obese male rats. ARYA Atheroscler. 2022;18:1. doi:10.48305/arya.v18i0.2459
- Şaman E, Cebova M, Barta A, Koneracka M, Zavisova V, et al. Combined Therapy with Simvastatin- and Coenzyme-Q10-Loaded Nanoparticles Upregulates the Akt-eNOS Pathway in Experimental Metabolic Syndrome. Int J Mol Sci. 2022;24. doi:10.3390/ijms24010276
