Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.2
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
9
We aimed to understand how coenzyme Q10 (CoQ10) might help combat osteoporosis caused by spinal cord injuries (SCI). In our study, we induced SCI in rats by surgically transecting the spinal cord at the T10-12 level and began treating them with CoQ10 daily, starting just 12 hours after the procedure. This treatment lasted for 10 consecutive days, allowing us to evaluate its effects on bone health.
Our findings showed that CoQ10 effectively prevented the loss of bone density and mineral content typically seen in rats following SCI. We observed a notable reduction in harmful substances that damage bone, alongside an increase in protective factors. Furthermore, CoQ10 appeared to reduce inflammation in the affected rats, which is crucial since inflammation can worsen bone health.
We also examined the genetic changes associated with bone formation and found that CoQ10 backup significantly restored the balance between bone-building and bone-resorbing cells. Overall, our study suggests that CoQ10 can be a helpful intervention in mitigating osteoporosis linked to spinal cord injuries, offering hope for future treatments in similar conditions.
Our findings showed that CoQ10 effectively prevented the loss of bone density and mineral content typically seen in rats following SCI. We observed a notable reduction in harmful substances that damage bone, alongside an increase in protective factors. Furthermore, CoQ10 appeared to reduce inflammation in the affected rats, which is crucial since inflammation can worsen bone health.
We also examined the genetic changes associated with bone formation and found that CoQ10 backup significantly restored the balance between bone-building and bone-resorbing cells. Overall, our study suggests that CoQ10 can be a helpful intervention in mitigating osteoporosis linked to spinal cord injuries, offering hope for future treatments in similar conditions.
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8
We examined the effects of coenzyme Q10 (C0Q10) as a potential treatment for primary osteoporosis in a small clinical study. Even though our sample size was limited to just five participants, the preliminary results indicate that C0Q10 may have a positive impact on this complex bone disease.
It’s intriguing to consider that this agent hasn’t been previously utilized in osteoporosis therapy. We discussed possible mechanisms by which C0Q10 could work, offering insights into how it might help tackle the underlying issues associated with osteoporosis.
As our research is still ongoing, we look forward to sharing more detailed findings once the study is completed. This could represent an exciting new avenue for osteoporosis treatment that deserves further exploration.
It’s intriguing to consider that this agent hasn’t been previously utilized in osteoporosis therapy. We discussed possible mechanisms by which C0Q10 could work, offering insights into how it might help tackle the underlying issues associated with osteoporosis.
As our research is still ongoing, we look forward to sharing more detailed findings once the study is completed. This could represent an exciting new avenue for osteoporosis treatment that deserves further exploration.
Read More
9
CoQ10 mitigates hyperlipidemia-induced osteoporosis
We explored how coenzyme Q10 (CoQ10) affects osteoporosis, particularly in cases driven by high lipid levels. The study focused on mice treated with a high-fat diet, mimicking conditions that lead to hyperlipidemia-induced osteoporosis. We found that these mice exhibited elevated serum lipid levels and reduced bone formation markers. However, when we introduced CoQ10, it reversed these concerning trends.
Moreover, we observed that the protein expression of PGC-1α, which plays a vital role in mitochondrial function, was diminished in both the high-fat diet mice and bone marrow stem cells treated with oxidized low-density lipoprotein (ox-LDL). This reduction was accompanied by mitochondrial dysfunction and increased oxidative stress. Remarkably, CoQ10 was able to restore PGC-1α levels and counteract these declines, improving ATP production and decreasing harmful reactive oxygen species.
Our findings also highlighted the role of miR-130b-3p in this process. By inhibiting this microRNA, we observed a boost in PGC-1α protein levels, underscoring its importance in maintaining healthy mitochondrial function under hyperlipidemic conditions. Overall, CoQ10 shows promise in alleviating osteoporosis resulting from high lipid levels by supporting energy production and fostering a healthier balance between fat and bone cell development.
Moreover, we observed that the protein expression of PGC-1α, which plays a vital role in mitochondrial function, was diminished in both the high-fat diet mice and bone marrow stem cells treated with oxidized low-density lipoprotein (ox-LDL). This reduction was accompanied by mitochondrial dysfunction and increased oxidative stress. Remarkably, CoQ10 was able to restore PGC-1α levels and counteract these declines, improving ATP production and decreasing harmful reactive oxygen species.
Our findings also highlighted the role of miR-130b-3p in this process. By inhibiting this microRNA, we observed a boost in PGC-1α protein levels, underscoring its importance in maintaining healthy mitochondrial function under hyperlipidemic conditions. Overall, CoQ10 shows promise in alleviating osteoporosis resulting from high lipid levels by supporting energy production and fostering a healthier balance between fat and bone cell development.
Read More
Most Useful Reviews
8.8
Active preparation
Excellent! The preparation for osteoporosis and arthrosis protocols is very active, although it is generally used after the age of 35.
Read More
8.8
Optimises bone health
The product is well-packaged and cost-effective. It assists in optimising bone health and electrolyte balance and may help in reducing osteoporosis.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.2
- All Researches
9
CoQ10 mitigates hyperlipidemia-induced osteoporosis
We explored how coenzyme Q10 (CoQ10) affects osteoporosis, particularly in cases driven by high lipid levels. The study focused on mice treated with a high-fat diet, mimicking conditions that lead to hyperlipidemia-induced osteoporosis. We found that these mice exhibited elevated serum lipid levels and reduced bone formation markers. However, when we introduced CoQ10, it reversed these concerning trends.
Moreover, we observed that the protein expression of PGC-1α, which plays a vital role in mitochondrial function, was diminished in both the high-fat diet mice and bone marrow stem cells treated with oxidized low-density lipoprotein (ox-LDL). This reduction was accompanied by mitochondrial dysfunction and increased oxidative stress. Remarkably, CoQ10 was able to restore PGC-1α levels and counteract these declines, improving ATP production and decreasing harmful reactive oxygen species.
Our findings also highlighted the role of miR-130b-3p in this process. By inhibiting this microRNA, we observed a boost in PGC-1α protein levels, underscoring its importance in maintaining healthy mitochondrial function under hyperlipidemic conditions. Overall, CoQ10 shows promise in alleviating osteoporosis resulting from high lipid levels by supporting energy production and fostering a healthier balance between fat and bone cell development.
Moreover, we observed that the protein expression of PGC-1α, which plays a vital role in mitochondrial function, was diminished in both the high-fat diet mice and bone marrow stem cells treated with oxidized low-density lipoprotein (ox-LDL). This reduction was accompanied by mitochondrial dysfunction and increased oxidative stress. Remarkably, CoQ10 was able to restore PGC-1α levels and counteract these declines, improving ATP production and decreasing harmful reactive oxygen species.
Our findings also highlighted the role of miR-130b-3p in this process. By inhibiting this microRNA, we observed a boost in PGC-1α protein levels, underscoring its importance in maintaining healthy mitochondrial function under hyperlipidemic conditions. Overall, CoQ10 shows promise in alleviating osteoporosis resulting from high lipid levels by supporting energy production and fostering a healthier balance between fat and bone cell development.
Read More
9
We explored the effects of coenzyme Q10 (CoQ10) on osteoporosis, particularly in context of bone loss that results from orchiectomy—a procedure that removes the testicles. In our study with orchiectomized (ORX) mice, we supplemented some mice with CoQ10 while others did not receive the treatment.
Our findings indicated that CoQ10 supplementation could effectively prevent bone loss related to the ORX process. It worked by reducing oxidative stress and cell senescence, which are known to negatively impact bone health. Moreover, CoQ10 seemed to promote the activity of osteoblasts—cells responsible for bone formation—and inhibit osteoclasts, which break down bone tissue.
This research highlights the potential role of CoQ10 in supporting bone health and suggests it may have beneficial applications in preventing osteoporosis in people who undergo orchiectomy or experience similar conditions.
Our findings indicated that CoQ10 supplementation could effectively prevent bone loss related to the ORX process. It worked by reducing oxidative stress and cell senescence, which are known to negatively impact bone health. Moreover, CoQ10 seemed to promote the activity of osteoblasts—cells responsible for bone formation—and inhibit osteoclasts, which break down bone tissue.
This research highlights the potential role of CoQ10 in supporting bone health and suggests it may have beneficial applications in preventing osteoporosis in people who undergo orchiectomy or experience similar conditions.
Read More
9
We explored how coenzyme Q10 (CoQ10) can impact osteoporosis, particularly looking at its effects on bone health after ovariectomy in rats—a common model for studying this condition. In our investigation, we treated bone marrow stromal cells with varying concentrations of CoQ10 and measured their growth and ability to differentiate into bone-forming cells.
Our findings showed that CoQ10 significantly boosted the proliferation and differentiation of these cells, which play a crucial role in bone formation. Additionally, in rats with osteoporosis induced by surgery, CoQ10 treatment notably reduced bone resorption and increased overall bone formation, despite having no significant effect on estrogen levels, which typically impact bone health.
We noticed that CoQ10 activated a specific cellular pathway (the PTEN/PI3K/AKT pathway) that is important for bone health, as indicated by increased levels of certain proteins involved in bone growth. Overall, our research suggests that CoQ10 could be a promising treatment option for osteoporosis, promoting bone health through multiple mechanisms.
Our findings showed that CoQ10 significantly boosted the proliferation and differentiation of these cells, which play a crucial role in bone formation. Additionally, in rats with osteoporosis induced by surgery, CoQ10 treatment notably reduced bone resorption and increased overall bone formation, despite having no significant effect on estrogen levels, which typically impact bone health.
We noticed that CoQ10 activated a specific cellular pathway (the PTEN/PI3K/AKT pathway) that is important for bone health, as indicated by increased levels of certain proteins involved in bone growth. Overall, our research suggests that CoQ10 could be a promising treatment option for osteoporosis, promoting bone health through multiple mechanisms.
Read More
9
We investigated the impact of coenzyme Q10 (CoQ) on bone health by examining male Wistar rats fed lifelong diets rich in fish oil. This study aimed to understand if adding CoQ to these omega-3 fatty acid sources could help prevent osteoporosis-related bone density loss as the rats aged.
As the rats aged, we noticed a decline in bone mineral density (BMD) in those that did not receive CoQ. Interestingly, those on the CoQ-supplemented diet exhibited the highest BMD levels, suggesting a protective effect against bone mass loss. Our findings linked higher levels of oxidative stress with aging, evidenced by increased markers of oxidative damage in the absence of CoQ.
Supplementation of CoQ seemed to reduce oxidative stress, leading to improved bone health even in older rats. We believe this reduction in oxidative damage contributed to the preservation of BMD, highlighting the potential of CoQ as a beneficial addition to diets for better bone health as we age.
As the rats aged, we noticed a decline in bone mineral density (BMD) in those that did not receive CoQ. Interestingly, those on the CoQ-supplemented diet exhibited the highest BMD levels, suggesting a protective effect against bone mass loss. Our findings linked higher levels of oxidative stress with aging, evidenced by increased markers of oxidative damage in the absence of CoQ.
Supplementation of CoQ seemed to reduce oxidative stress, leading to improved bone health even in older rats. We believe this reduction in oxidative damage contributed to the preservation of BMD, highlighting the potential of CoQ as a beneficial addition to diets for better bone health as we age.
Read More
9
We aimed to understand how coenzyme Q10 (CoQ10) might help combat osteoporosis caused by spinal cord injuries (SCI). In our study, we induced SCI in rats by surgically transecting the spinal cord at the T10-12 level and began treating them with CoQ10 daily, starting just 12 hours after the procedure. This treatment lasted for 10 consecutive days, allowing us to evaluate its effects on bone health.
Our findings showed that CoQ10 effectively prevented the loss of bone density and mineral content typically seen in rats following SCI. We observed a notable reduction in harmful substances that damage bone, alongside an increase in protective factors. Furthermore, CoQ10 appeared to reduce inflammation in the affected rats, which is crucial since inflammation can worsen bone health.
We also examined the genetic changes associated with bone formation and found that CoQ10 backup significantly restored the balance between bone-building and bone-resorbing cells. Overall, our study suggests that CoQ10 can be a helpful intervention in mitigating osteoporosis linked to spinal cord injuries, offering hope for future treatments in similar conditions.
Our findings showed that CoQ10 effectively prevented the loss of bone density and mineral content typically seen in rats following SCI. We observed a notable reduction in harmful substances that damage bone, alongside an increase in protective factors. Furthermore, CoQ10 appeared to reduce inflammation in the affected rats, which is crucial since inflammation can worsen bone health.
We also examined the genetic changes associated with bone formation and found that CoQ10 backup significantly restored the balance between bone-building and bone-resorbing cells. Overall, our study suggests that CoQ10 can be a helpful intervention in mitigating osteoporosis linked to spinal cord injuries, offering hope for future treatments in similar conditions.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Active preparation
Excellent! The preparation for osteoporosis and arthrosis protocols is very active, although it is generally used after the age of 35.
Read More
8.8
Optimises bone health
The product is well-packaged and cost-effective. It assists in optimising bone health and electrolyte balance and may help in reducing osteoporosis.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Meng M, Wang J, Wang C, Zhao J, Wang H, et al. Coenzyme Q10 Protects Against Hyperlipidemia-Induced Osteoporosis by Improving Mitochondrial Function via Modulating miR-130b-3p/PGC-1α Pathway. Calcif Tissue Int. 2024;114:182. doi:10.1007/s00223-023-01161-5
- Zheng D, Cui C, Shao C, Wang Y, Ye C, et al. Coenzyme Q10 inhibits RANKL-induced osteoclastogenesis by regulation of mitochondrial apoptosis and oxidative stress in RAW264.7 cells. J Biochem Mol Toxicol. 2021;35:e22778. doi:10.1002/jbt.22778
- Wu X, Liang S, Zhu X, Wu X, Dong Z. CoQ10 suppression of oxidative stress and cell senescence increases bone mass in orchiectomized mice. Am J Transl Res. 2020;12:4314.
- Zheng D, Cui C, Yu M, Li X, Wang L, et al. Coenzyme Q10 promotes osteoblast proliferation and differentiation and protects against ovariectomy-induced osteoporosis. Mol Med Rep. 2018;17:400. doi:10.3892/mmr.2017.7907
- Varela-López A, Ochoa JJ, Llamas-Elvira JM, López-Frías M, Planells E, et al. Age-Related Loss in Bone Mineral Density of Rats Fed Lifelong on a Fish Oil-Based Diet Is Avoided by Coenzyme Q Addition. Nutrients. 2017;9. doi:10.3390/nu9020176
- Murad HA. L-Carnitine, but not coenzyme Q10, enhances the anti-osteoporotic effect of atorvastatin in ovariectomized rats. J Zhejiang Univ Sci B. 2016;17:43. doi:10.1631/jzus.B1500065
- Zhang XX, Qian KJ, Zhang Y, Wang ZJ, Yu YB, et al. Efficacy of coenzyme Q10 in mitigating spinal cord injury-induced osteoporosis. Mol Med Rep. 2015;12:3909. doi:10.3892/mmr.2015.3856
- Moon HJ, Ko WK, Jung MS, Kim JH, Lee WJ, et al. Coenzyme q10 regulates osteoclast and osteoblast differentiation. J Food Sci. 2013;78:H785. doi:10.1111/1750-3841.12116
- Neri Stagnaro M, Stagnaro S. [C0Q10 in the prevention and treatment of primary osteoporosis. Preliminary data]. Clin Ter. 1995;146:215.
