Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Moderately Good
Based on 67 Reviews
7.9
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Magnesium (from 2,000 mg magnesium lysinate glycinate chelate) (Albion®)
200 mg
48%
Top Medical Research Studies
9
We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Read More
8
This study examined how magnesium deficiency relates to depression in adults aged 20 to 60. By using the National Health and Nutrition Examination Survey data from 2005 to 2018, we analyzed the magnesium depletion score (MDS) while assessing depression through the Patient Health Questionnaire-9.
Our findings reveal a positive association: as the MDS increases, so does the likelihood of depression. Each one-unit rise in MDS raises the odds of depression. However, results varied with different MDS levels. While these results are promising, further research is necessary to understand the underlying mechanisms better.
Our findings reveal a positive association: as the MDS increases, so does the likelihood of depression. Each one-unit rise in MDS raises the odds of depression. However, results varied with different MDS levels. While these results are promising, further research is necessary to understand the underlying mechanisms better.
Read More
8
We examined the role of magnesium levels in relation to depressive symptoms through a comprehensive analysis of data from Taiwan's Nutrition and Health Survey. Involving 2,196 participants, we employed logistic and linear regression methods to assess these relationships.
Our findings revealed that higher magnesium levels correlated with fewer depressive symptoms. Interestingly, this connection was stronger in individuals with elevated C-reactive protein (CRP) levels, suggesting that inflammation influences how magnesium affects mood.
Overall, maintaining adequate magnesium levels might be beneficial, especially for those dealing with inflammation.
Our findings revealed that higher magnesium levels correlated with fewer depressive symptoms. Interestingly, this connection was stronger in individuals with elevated C-reactive protein (CRP) levels, suggesting that inflammation influences how magnesium affects mood.
Overall, maintaining adequate magnesium levels might be beneficial, especially for those dealing with inflammation.
Read More
Most Useful Reviews
9
Effective depression relief
69 people found this helpful
I take it to relieve symptoms of depression. I'm surprised by the clear effects; I had a terrible experience in psychiatry and prefer controlling my mental state with magnesium now. It’s critical not to exceed 300mg daily since I’ve read that long-term use of ineffective psychotropic medications can shorten life expectancy. I feel empowered with magnesium and find it more effective than psychosomatic treatments.
Read More
9
Positive feelings restored
33 people found this helpful
I spent many years at a psychosomatic medicine clinic for depression, but taking three tablets daily has made me feel refreshed and more positive. I stopped the psychosomatic treatments as I feel a noticeable difference with this approach. I appreciate that the ingredients are based on natural nutrients, leading to a reduced risk of side effects compared to pharmaceuticals.
Read More
9
Mood significantly improved
20 people found this helpful
I bought this product due to its reputation for aiding menopausal symptoms. It has effectively cured my depression and irritability, leaving me feeling much better. I'm amazed that a small amount of magnesium could have such a positive impact. Given my previous irritability affecting my family, this has been immensely helpful. The pills are slightly large but are manageable when chewed beforehand.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
- All Researches
9.5
Magnesium and Vitamin D effective for depression
We explored the effectiveness of magnesium coupled with vitamin D in easing depressive symptoms among individuals with long-COVID. Our study involved 60 participants suffering from mild to moderate depression, hypomagnesemia, and vitamin D deficiency.
Over four months, those who received both magnesium and vitamin D showed significant improvements in their depression scores compared to those who only took vitamin D. Specifically, a notable 73% of the magnesium group achieved significant relief, positioning this combination as a promising treatment for depression linked to long-COVID.
Mild side effects were noted but did not lead to any withdrawals, indicating the safety of this treatment option.
Over four months, those who received both magnesium and vitamin D showed significant improvements in their depression scores compared to those who only took vitamin D. Specifically, a notable 73% of the magnesium group achieved significant relief, positioning this combination as a promising treatment for depression linked to long-COVID.
Mild side effects were noted but did not lead to any withdrawals, indicating the safety of this treatment option.
Read More
9
We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Read More
8
We examined how various nutrient patterns affect depressive symptoms in older adults through a detailed study involving over 1,000 participants.
By evaluating nutrient intake and depressive symptoms over more than 15 years, we found that those with a diet high in magnesium and several other nutrients had significantly lower odds of experiencing depressive symptoms.
This suggests that nutrients, particularly magnesium, might play a crucial role in supporting mental health in older adults.
By evaluating nutrient intake and depressive symptoms over more than 15 years, we found that those with a diet high in magnesium and several other nutrients had significantly lower odds of experiencing depressive symptoms.
This suggests that nutrients, particularly magnesium, might play a crucial role in supporting mental health in older adults.
Read More
8
Magnesium deficiency correlates with depression
This study examined the relationship between magnesium deficiency, measured by the Magnesium Depletion Score (MDS), and depression among U.S. adults. We analyzed data from the National Health and Nutrition Examination Survey, focusing on those with moderate to severe depression.
Our findings revealed a significant link—higher MDS scores led to an increased risk of depression. Specifically, for each unit rise in MDS, the chance of developing depression increased by 13%. Interestingly, those with severe magnesium deficiency saw a staggering 58% rise in depression likelihood. This suggests that improving magnesium levels could be beneficial for both preventing and treating depression.
Our findings revealed a significant link—higher MDS scores led to an increased risk of depression. Specifically, for each unit rise in MDS, the chance of developing depression increased by 13%. Interestingly, those with severe magnesium deficiency saw a staggering 58% rise in depression likelihood. This suggests that improving magnesium levels could be beneficial for both preventing and treating depression.
Read More
8
This study examined how magnesium deficiency relates to depression in adults aged 20 to 60. By using the National Health and Nutrition Examination Survey data from 2005 to 2018, we analyzed the magnesium depletion score (MDS) while assessing depression through the Patient Health Questionnaire-9.
Our findings reveal a positive association: as the MDS increases, so does the likelihood of depression. Each one-unit rise in MDS raises the odds of depression. However, results varied with different MDS levels. While these results are promising, further research is necessary to understand the underlying mechanisms better.
Our findings reveal a positive association: as the MDS increases, so does the likelihood of depression. Each one-unit rise in MDS raises the odds of depression. However, results varied with different MDS levels. While these results are promising, further research is necessary to understand the underlying mechanisms better.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 67 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective depression relief
69 people found this helpful
I take it to relieve symptoms of depression. I'm surprised by the clear effects; I had a terrible experience in psychiatry and prefer controlling my mental state with magnesium now. It’s critical not to exceed 300mg daily since I’ve read that long-term use of ineffective psychotropic medications can shorten life expectancy. I feel empowered with magnesium and find it more effective than psychosomatic treatments.
Read More
9
Positive feelings restored
33 people found this helpful
I spent many years at a psychosomatic medicine clinic for depression, but taking three tablets daily has made me feel refreshed and more positive. I stopped the psychosomatic treatments as I feel a noticeable difference with this approach. I appreciate that the ingredients are based on natural nutrients, leading to a reduced risk of side effects compared to pharmaceuticals.
Read More
9
Mood significantly improved
20 people found this helpful
I bought this product due to its reputation for aiding menopausal symptoms. It has effectively cured my depression and irritability, leaving me feeling much better. I'm amazed that a small amount of magnesium could have such a positive impact. Given my previous irritability affecting my family, this has been immensely helpful. The pills are slightly large but are manageable when chewed beforehand.
Read More
7.5
Depression relief noted
17 people found this helpful
I purchased this as the initial step in treating my bipolar disorder nutritionally. I've found that my depression is relieved and my head feels clearer. Currently, even with a daily intake of five tablets, I am experiencing no side effects.
Read More
9
Immediate comfort felt
16 people found this helpful
Salvation from depression! Eye twitching or fingers twitching? Sleep problems? This is all due to a lack of magnesium! This magnesium is chelated for better absorption. I take it in conjunction with Lecithin and Omega-3. Although the tablets are large and can be hard to swallow without water, I’ve experienced a significant improvement in both my sleep and anxiety levels. I feel calm, and this magnesium effectively helps control nervous tics.
Read More
Frequently Asked Questions
7.5
Better sleep quality
5 people found this helpful
From the first day, I noticed I was getting a good night's sleep. Even waking up in the night, I could quickly fall back asleep. It also alleviated depression-like symptoms, which is why I'm giving it to my son, who deals with May blues.
9
Improved calmness
5 people found this helpful
An excellent drug! I took it after experiencing severe depression following childbirth. Within a week to ten days, sleep normalised, cramps disappeared, and I felt significantly calmer, which was crucial for me as a mother of three. The only caveat is to manage to place the pill under the tongue and swallow with ample water quickly, or the taste is rather unpleasant.
9
Improved mood
High Absorption Magnesium for depression is a great product! I’ve been taking it at night for two weeks now, along with DMAE. I used to wake up feeling very depressed, but now I find I'm waking in a better mood. I truly believe this product has made a difference!
9
Positive feelings restored
33 people found this helpful
I spent many years at a psychosomatic medicine clinic for depression, but taking three tablets daily has made me feel refreshed and more positive. I stopped the psychosomatic treatments as I feel a noticeable difference with this approach. I appreciate that the ingredients are based on natural nutrients, leading to a reduced risk of side effects compared to pharmaceuticals.
7.5
Trial success
37 people found this helpful
Wonderful results! I purchased this magnesium after hearing about its efficacy for depression. It also relieved constipation and eyelid spasms that I had for about a month. Increasing my dose led to immediate relief from spasms, and my emotional resilience to small issues has improved dramatically.
9
Immediate comfort felt
16 people found this helpful
Salvation from depression! Eye twitching or fingers twitching? Sleep problems? This is all due to a lack of magnesium! This magnesium is chelated for better absorption. I take it in conjunction with Lecithin and Omega-3. Although the tablets are large and can be hard to swallow without water, I’ve experienced a significant improvement in both my sleep and anxiety levels. I feel calm, and this magnesium effectively helps control nervous tics.
9
Effective magnesium
2 people found this helpful
I rely heavily on magnesium for my daily well-being. After trying multiple brands, I find Doctor Best's chelated magnesium lysinate glycinate to be the most effective. Its enhanced absorption has improved my sleep quality, reduced anxiety and depression, and alleviated headaches. The noticeable improvements in my overall health have prompted me to recommend this product to others. I'm grateful to have returned to this magnesium as a vital part of my health regimen.
9
Effective depression relief
69 people found this helpful
I take it to relieve symptoms of depression. I'm surprised by the clear effects; I had a terrible experience in psychiatry and prefer controlling my mental state with magnesium now. It’s critical not to exceed 300mg daily since I’ve read that long-term use of ineffective psychotropic medications can shorten life expectancy. I feel empowered with magnesium and find it more effective than psychosomatic treatments.
7.5
Helps with inflammation
2 people found this helpful
An excellent magnesium product that calms the body. It's a magnesium supplement with glycine, beneficial for relaxation, mood improvement, inflammation relief, and enhancing conditions related to depression. Magnesium glycinate is well-absorbed and should be taken at night before bed for its soothing properties. The package contains 120 capsules, each with 100mg of Magnesium Glycinate.
7.5
Depression relief noted
17 people found this helpful
I purchased this as the initial step in treating my bipolar disorder nutritionally. I've found that my depression is relieved and my head feels clearer. Currently, even with a daily intake of five tablets, I am experiencing no side effects.
8
Magnesium deficiency correlates with depression
This study examined the relationship between magnesium deficiency, measured by the Magnesium Depletion Score (MDS), and depression among U.S. adults. We analyzed data from the National Health and Nutrition Examination Survey, focusing on those with moderate to severe depression.
Our findings revealed a significant link—higher MDS scores led to an increased risk of depression. Specifically, for each unit rise in MDS, the chance of developing depression increased by 13%. Interestingly, those with severe magnesium deficiency saw a staggering 58% rise in depression likelihood. This suggests that improving magnesium levels could be beneficial for both preventing and treating depression.
Our findings revealed a significant link—higher MDS scores led to an increased risk of depression. Specifically, for each unit rise in MDS, the chance of developing depression increased by 13%. Interestingly, those with severe magnesium deficiency saw a staggering 58% rise in depression likelihood. This suggests that improving magnesium levels could be beneficial for both preventing and treating depression.
9
We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
9.5
Magnesium and Vitamin D effective for depression
We explored the effectiveness of magnesium coupled with vitamin D in easing depressive symptoms among individuals with long-COVID. Our study involved 60 participants suffering from mild to moderate depression, hypomagnesemia, and vitamin D deficiency.
Over four months, those who received both magnesium and vitamin D showed significant improvements in their depression scores compared to those who only took vitamin D. Specifically, a notable 73% of the magnesium group achieved significant relief, positioning this combination as a promising treatment for depression linked to long-COVID.
Mild side effects were noted but did not lead to any withdrawals, indicating the safety of this treatment option.
Over four months, those who received both magnesium and vitamin D showed significant improvements in their depression scores compared to those who only took vitamin D. Specifically, a notable 73% of the magnesium group achieved significant relief, positioning this combination as a promising treatment for depression linked to long-COVID.
Mild side effects were noted but did not lead to any withdrawals, indicating the safety of this treatment option.
8
We examined the role of magnesium levels in relation to depressive symptoms through a comprehensive analysis of data from Taiwan's Nutrition and Health Survey. Involving 2,196 participants, we employed logistic and linear regression methods to assess these relationships.
Our findings revealed that higher magnesium levels correlated with fewer depressive symptoms. Interestingly, this connection was stronger in individuals with elevated C-reactive protein (CRP) levels, suggesting that inflammation influences how magnesium affects mood.
Overall, maintaining adequate magnesium levels might be beneficial, especially for those dealing with inflammation.
Our findings revealed that higher magnesium levels correlated with fewer depressive symptoms. Interestingly, this connection was stronger in individuals with elevated C-reactive protein (CRP) levels, suggesting that inflammation influences how magnesium affects mood.
Overall, maintaining adequate magnesium levels might be beneficial, especially for those dealing with inflammation.
References
- Serefko A, Lachowicz-Radulska J, Szopa A, Herbet M, Czylkowska A, et al. The Novel Imipramine-Magnesium Complex Exerts Antidepressant-like Activity in Mice Subjected to the Forced Swim Test and the Tail Suspension Test. Molecules. 2025;30. doi:10.3390/molecules30030519
- Bardinet J, Pouchieu C, Chuy V, Merle B, Pellay H, et al. Association between nutrient patterns and odds of depressive symptomatology: a population-based cohort of older adults followed during 15-y. Eur J Nutr. 2025;64:88. doi:10.1007/s00394-025-03597-x
- Rodríguez-Morán M, Guerrero-Romero F, Barragán-Zuñiga J, Gamboa-Gómez CI, Weyman-Vela Y, et al. Combined oral supplementation with magnesium plus vitamin D alleviates mild to moderate depressive symptoms related to long-COVID: an open-label randomized, controlled clinical trial. Magnes Res. 2024;37:49. doi:10.1684/mrh.2024.0535
- Zhao W, Jin H. Magnesium depletion score and depression: a positive correlation among US adults. Front Public Health. 2024;12:1486434. doi:10.3389/fpubh.2024.1486434
- Carnegie RE, Zheng J, Borges MC, Jones HJ, Wade KH, et al. Micronutrients and Major Depression: A Mendelian Randomisation Study. Nutrients. 2024;16. doi:10.3390/nu16213690
- Cai Z, She J, Liu X, Li R, Guo S, et al. Associations between magnesium depletion score and depression among individuals aged 20 to 60 years. J Trace Elem Med Biol. 2024;86:127543. doi:10.1016/j.jtemb.2024.127543
- Strodl E, Bambling M, Parnam S, Ritchie G, Cramb S, et al. Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial. Sci Rep. 2024;14:20841. doi:10.1038/s41598-024-71093-z
- Hajhashemy Z, Shirani F, Askari G. Dietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies. Nutr Rev. 2025;83:217. doi:10.1093/nutrit/nuae056
- Abdelmoneam AH, Khafagy GM, Elbeh KA, Hasan MDA. Impact of Magnesium and Ferritin Deficiency on Depression Among Adolescent Students. J Prim Care Community Health. 2024;15:21501319241252570. doi:10.1177/21501319241252570
- Chou MH, Yang YK, Wang JD, Lin CY, Lin SH. Elevated C-Reactive Protein Levels Modify the Effect of Magnesium on Depressive Symptoms: A Population-Based Study. Nutrients. 2023;15. doi:10.3390/nu15071560
- Chou MH, Yang YK, Wang JD, Lin CY, Lin SH. The Association of Serum and Dietary Magnesium with Depressive Symptoms. Nutrients. 2023;15. doi:10.3390/nu15030774
- Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. doi:10.1186/s12974-023-02696-y
- Wang H, Jin M, Xie M, Yang Y, Xue F, et al. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials. J Affect Disord. 2023;323:264. doi:10.1016/j.jad.2022.11.072
- Saba S, Faizi F, Sepandi M, Nehrir B. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery. Magnes Res. 2022;35:62. doi:10.1684/mrh.2022.0503
- Abiri B, Sarbakhsh P, Vafa M. Randomized study of the effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT1 in obese women with mild to moderate depressive symptoms. Nutr Neurosci. 2022;25:2123. doi:10.1080/1028415X.2021.1945859
- Miller ES, Sakowicz A, Roy A, Wang A, Yang A, et al. Is peripartum magnesium sulfate associated with a reduction in postpartum depressive symptoms?. Am J Obstet Gynecol MFM. 2021;3:100407. doi:10.1016/j.ajogmf.2021.100407
