We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Read More
9
Magnesium enhances osteoporosis treatment
Anti-osteoporosis properties of phosphorylated collagen peptide-magnesium chelates in osteoblast MC3T3-E1 cells and ovariectomized mice.
In our exploration of osteoporosis treatment, we focused on the effects of magnesium, particularly when combined with phosphorylated collagen peptide-magnesium chelates. Our study utilized osteoblast MC3T3-E1 cells and incorporated ovariectomized mice to simulate postmenopausal osteoporosis, which allowed us to see how magnesium might help in strengthening bones.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
Read More
9
Nanopowder eggshells improve bone health
Dietary Effects of Nanopowder Eggshells on Mineral Contents, Bone Turnover Biomarkers, and Regulators of Bone Resorption in Healthy Rats and Ovariectomy-Induced Osteoporosis Rat Model.
We examined how nanopowder eggshells (NPES) could influence bone health in both healthy and ovariectomy-induced osteoporosis rats.
In our research, we found that NPES treatment significantly enhanced indicators of bone formation, like calcium and osteocalcin, particularly in healthy rats.
Additionally, in the ovariectomized group, NPES treatment helped improve levels of vital nutrients and reduced bone resorption.
Overall, our findings suggest that NPES may play a beneficial role in bettering bone health in osteoporosis models.
Read More
Most Useful Reviews
9
Important for elderly
2 people found this helpful
Today, we must fully recognise magnesium deficiency's importance, especially among the elderly. Osteoporosis poses a significant issue in this group, as insufficient magnesium intake can lead to increased bone fragility. Adequate magnesium may slow the decline in skeletal muscle mass, thus reducing osteoporosis and the risk of fractures. Thanks for the thumbs up! ❤️❤️
Read More
9
Works well daily
1 people found this helpful
This product is excellent; its magnesium component, magnesium lysine, and glycine are well-absorbed. It's affordable, and I've been taking it daily with dicalcium malate for my osteoporosis. I plan to verify its effects at the hospital in two years. I highly recommend this magnesium product.
Read More
9
Promotes bone health
Magnesium glycinate is well absorbed, helping muscle relaxation, cardiovascular health, and improved sleep quality. It supports bone health by working with calcium, making it beneficial for osteoporosis prevention.
We examined how dietary intake of magnesium, along with potassium and sodium, influences bone health, specifically focusing on osteoporosis and bone mineral density (BMD) in adults across the U.S. Our analysis was based on data from the National Health and Nutrition Examination Surveys, which spanned from 2005 to 2018, involving over 10,000 participants.
The findings revealed a positive association between higher dietary intake of potassium, magnesium, and sodium and improved BMD of the femur. This means that those who consumed more of these nutrients tended to have stronger bones. Additionally, we observed that a higher intake of these minerals was linked to a lower occurrence of osteopenia and osteoporosis.
Our study highlights how magnesium, when part of a broader nutrient intake that includes potassium and sodium, could play a significant role in maintaining bone health. While our research points to a beneficial relationship, more targeted studies are needed to definitively isolate the effects of magnesium alone on osteoporosis. Overall, this reinforces the importance of a balanced diet for bone health.
Read More
9
Magnesium improves osteoporotic bone repair
An injectable magnesium-loaded hydrogel releases hydrogen to promote osteoporotic bone repair via ROS scavenging and immunomodulation.
We delved into the use of a unique injectable hydrogel loaded with magnesium to address the challenges of repairing osteoporotic bone defects. The study aimed to understand how this magnesium-infused hydrogel could combat the excessive reactive oxygen species (ROS) that hinder bone repair. With impressive qualities such as excellent injectability and adaptability, the hydrogel can be introduced into irregular bone areas without the need for major surgery.
Once injected, the hydrogel not only transforms into a supportive scaffold but also begins to release hydrogen and magnesium ions. This release is key in reducing harmful intracellular ROS and guiding the immune response favorably by promoting macrophage polarization. We observed that this gel suppressed the formation of osteoclasts, the cells responsible for bone resorption, while simultaneously encouraging the growth of new bone cells.
Animal experiments further illuminated the effectiveness of the magnesium-loaded hydrogel, showing a remarkable ability to enhance the repair of bone defects by controlling inflammation and supporting bone formation. Overall, our findings shine a light on the potential of magnesium-based hydrogels as promising solutions for those dealing with osteoporosis-related bone damage.
Read More
9
Magnesium's role in osteoporosis therapy
Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism.
We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Read More
9
Magnesium enhances osteoporosis treatment
Anti-osteoporosis properties of phosphorylated collagen peptide-magnesium chelates in osteoblast MC3T3-E1 cells and ovariectomized mice.
In our exploration of osteoporosis treatment, we focused on the effects of magnesium, particularly when combined with phosphorylated collagen peptide-magnesium chelates. Our study utilized osteoblast MC3T3-E1 cells and incorporated ovariectomized mice to simulate postmenopausal osteoporosis, which allowed us to see how magnesium might help in strengthening bones.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
Read More
9
Calcium magnesium scaffold boosts bone repair
Novel "hot spring"-mimetic scaffolds for sequential neurovascular network reconstruction and osteoporosis reversion.
We explored a cutting-edge approach to tackle the challenges in repairing bones affected by osteoporosis. Drawing inspiration from the healing properties of hot springs, we created a unique calcium magnesium phosphate bone cement infused with manganese ions.
This innovative scaffold not only promotes the regeneration of neurovascular networks but also helps reduce harmful substances in the bone's environment. Our results indicate that this method significantly aids in bone healing, highlighting its potential for treating osteoporosis effectively.
Today, we must fully recognise magnesium deficiency's importance, especially among the elderly. Osteoporosis poses a significant issue in this group, as insufficient magnesium intake can lead to increased bone fragility. Adequate magnesium may slow the decline in skeletal muscle mass, thus reducing osteoporosis and the risk of fractures. Thanks for the thumbs up! ❤️❤️
Read More
9
Works well daily
1 people found this helpful
This product is excellent; its magnesium component, magnesium lysine, and glycine are well-absorbed. It's affordable, and I've been taking it daily with dicalcium malate for my osteoporosis. I plan to verify its effects at the hospital in two years. I highly recommend this magnesium product.
Read More
9
Promotes bone health
Magnesium glycinate is well absorbed, helping muscle relaxation, cardiovascular health, and improved sleep quality. It supports bone health by working with calcium, making it beneficial for osteoporosis prevention.
Read More
7.5
Helps osteoporosis issues
6 people found this helpful
This magnesium is excellent for sleep and has an effective impact on osteoporosis and joint issues. It's beneficial for relaxation and comfort.
Read More
7.5
Reduces joint pain
2 people found this helpful
I feel the effects of this product and purchase it repeatedly. The tablet is large, so I divide it into two while monitoring my body's response. There is hardly any taste. If taken excessively, it may cause diarrhoea, so I recommend avoiding it before heading out. The calcium addition helps prevent osteoporosis. Be mindful as too much calcium can lead to magnesium deficiency. This product effectively alleviates joint pain and body stiffness, although it is not a pain reliever.
Osteoporosis is a medical condition characterized by weakened bones, making them fragile and more prone to fractures. This condition occurs when the body loses too much bone mass, doesn't make enough bone, or a combination of both. As bones lose density, they can break more easily, often as a result of minor falls or injury. Osteoporosis is often referred to as a "silent disease" because bone loss occurs without any symptoms until a fracture occurs, often in the hip, spine, or wrist.
Risk factors for developing osteoporosis include age, gender (it’s more common in women), family history, low body weight, and certain medical conditions and medications. Lifestyle choices such as smoking, excessive alcohol consumption, and a diet low in calcium and vitamin D can also contribute to bone loss. Regular weight-bearing exercise, ensuring adequate nutrition, and, in some cases, medications can help prevent or manage osteoporosis. If you believe you may be at risk, it is important to consult with a healthcare professional for appropriate screening and intervention options.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium plays a crucial role in bone health, and its adequate intake may contribute to the prevention and management of osteoporosis. Studies have shown that magnesium is essential for the conversion of vitamin D into its active form, which in turn helps the body absorb calcium—a key mineral for maintaining strong bones. Additionally, magnesium is directly involved in bone formation and influences the activity of osteoblasts (the cells responsible for building bone) and osteoclasts (the cells that break down bone). Maintaining an appropriate level of magnesium can thus be an important factor in preserving bone density and reducing the risk of fractures in individuals with osteoporosis.
However, while incorporating magnesium into your diet may support bone health, it is important to remember that it should not be seen as a standalone treatment for osteoporosis. A balanced diet rich in multiple nutrients, including calcium and vitamin D, along with regular weight-bearing exercise, is essential for optimal bone health. If you are concerned about osteoporosis, it's advisable to consult with a healthcare provider to develop a comprehensive plan tailored to your individual needs. Magnesium supplements may be recommended for those who struggle to meet their daily intake through food sources alone, but always seek professional guidance before starting any supplementation.
Based on user reviews, the timeframe for seeing results from magnesium supplementation for osteoporosis can vary significantly from person to person. Some users like those taking magnesium alongside their osteoporosis medications report monitoring their bone health over several months to years before noticing any tangible improvements. For instance, one user indicated they would verify the supplement's effects at the hospital in two years (Read Review).
Other users noted immediate benefits in general wellness, such as improved sleep quality and reduced muscle tension, suggesting that while the long-term benefits for osteoporosis might take time, individuals might experience some positive effects relatively quickly (Read Review). Nonetheless, it is essential to approach these supplements as a component of a comprehensive treatment plan for osteoporosis, combining dietary changes, medication, and regular monitoring with healthcare professionals.
This supplement is supported by several scientific studies linking magnesium to improved bone health and osteoporosis management. Research indicates a positive relationship between higher dietary intake of magnesium and better bone mineral density (BMD), suggesting that magnesium plays a significant role in maintaining strong bones and potentially reducing the risk of osteoporosis [1]. Furthermore, clinical data show that magnesium deficiency is associated with an increased risk of osteoporosis, highlighting the importance of maintaining adequate magnesium levels [11].
Moreover, innovative therapeutic approaches utilizing magnesium, such as magnesium-infused hydrogels and bioactive glasses, have demonstrated promise in enhancing bone regeneration and repair in osteoporotic models [3], which indicates that magnesium is crucial not only in prevention but also in treatment strategies for osteoporosis. Overall, while more targeted studies are needed to fully understand the extent of magnesium's efficacy alone, current evidence suggests that magnesium can significantly contribute to bone health and may be beneficial in managing osteoporosis [2].
Users have reported various improvements in symptoms associated with magnesium supplementation, particularly in relation to osteoporosis and general wellness. Many individuals noted enhanced relaxation and better sleep quality, with products like magnesium glycinate being highlighted for their absorption and effectiveness in these areas Read Review. Several users, including those taking it alongside osteoporosis medications, indicated potential benefits in bone health and a reduction in joint pain Read Review. The product is appreciated not only for its role in preventing osteoporosis but also for contributing to improved mood and decreased irritability, especially in users who reported taking lower doses for more sensitive gastrointestinal responses Read Review.
While many users experienced positive outcomes, it’s important to note that individual results can vary. Some users, for example, found the tablets difficult to swallow and needed to cut them for easier consumption Read Review. A few also reported gastrointestinal discomfort when taking higher doses, indicating that magnesium supplementation might not suit everyone equally Read Review. Overall, while many users endorsed the merits of magnesium for osteoporosis and overall wellbeing, personal experience can greatly influence results.
Based on user reviews, combining magnesium with other supplements has been considered beneficial for managing osteoporosis. Many users reported taking magnesium alongside calcium and found this combination to support bone health effectively. For example, one user mentioned using magnesium daily with dicalcium malate, highlighting a proactive approach to their osteoporosis treatment and planning to check the results medically in the future (Read Review). Others emphasized that magnesium's role in bone health is enhanced when it's paired with calcium, reinforcing the idea that these minerals work synergistically for improved outcomes (Read Review).
Users also noted that magnesium supplementation could alleviate symptoms related to osteoporosis, such as joint and muscle pain, providing a two-fold benefit for those managing the condition (Read Review). However, some individuals expressed the importance of monitoring personal tolerance when combining magnesium with other supplements, as experiences varied widely. For instance, one user had to adjust their dosage due to gastrointestinal discomfort with the prescribed amount, illustrating that a careful approach is required when combining magnesium with other treatments (Read Review). Overall, while many users seemed to benefit from such combinations, personalized adjustments and consultations with healthcare professionals are recommended.
Users report varying dosages of magnesium for treating osteoporosis, with some finding a daily intake of 200-300 mg beneficial for their bone health. One user specifically noted improvement in sleep and decreased irritability with this dosage, emphasizing the importance of magnesium for preventing osteoporosis Read Review. Another mentioned taking magnesium alongside calcium to support their osteoporosis treatment, reinforcing the idea that balancing these minerals is crucial Read Review.
Additionally, a user highlighted the potential gastrointestinal issues when exceeding the recommended amount, advising to monitor body responses closely Read Review. Moreover, some users expressed the need to divide larger tablets to achieve the desired dose comfortably Read Review. Overall, while user experiences suggest that magnesium is essential in preventing osteoporosis, the optimal dose appears to vary, and adjustment to individual tolerance is recommended.
9
Works well daily
1 people found this helpful
This product is excellent; its magnesium component, magnesium lysine, and glycine are well-absorbed. It's affordable, and I've been taking it daily with dicalcium malate for my osteoporosis. I plan to verify its effects at the hospital in two years. I highly recommend this magnesium product.
7.5
Beneficial for joints
1 people found this helpful
This chelated product is effective, and as a yoga teacher, I take it every day for my osteoporosis and joint health. Some say it aids sleep too; I do sleep soundly, so perhaps they are right.
9
Promotes bone health
Magnesium glycinate is well absorbed, helping muscle relaxation, cardiovascular health, and improved sleep quality. It supports bone health by working with calcium, making it beneficial for osteoporosis prevention.
9
High-quality magnesium
1 people found this helpful
This brand is the best magnesium I've tried in terms of quality. As someone with fragility, I must take magnesium. It's known for alleviating joint and muscle pain and supporting bone health. Consider following Dr Karim’s work on osteoporosis for more insights.
7
Improved sleep quality
I have purchased this magnesium for a second time. I appreciate the tablet form as it allows for precise dosing from 100 mg, as not everyone needs the full daily dose of 400 mg. Since I began taking 200-300 mg daily, my sleep has improved and irritability has decreased. Low magnesium levels can lead to osteoporosis, making this supplement valuable. Its chelated form ensures high bioavailability. Overall, I highly recommend it.
6
Difficulty swallowing tablets
This magnesium seems beneficial for osteoporosis, but the tablets are too large for me to swallow without cutting them. I wish they were smaller for easier consumption.
2
Adverse side effects
3 people found this helpful
I tried magnesium for osteoporosis, but when I took the prescribed amount, I experienced abdominal pain and diarrhoea. Reducing to one tablet didn't help, suggesting it may not suit everyone.
7.5
Regular intake planned
1 people found this helpful
I'm committed to taking magnesium daily alongside my osteoporosis medication, as it's recommended to take them together with calcium. The chelated magnesium is easily absorbed, and I've had no gastrointestinal issues. I will continue to monitor my bone health.
7.5
Reduces joint pain
2 people found this helpful
I feel the effects of this product and purchase it repeatedly. The tablet is large, so I divide it into two while monitoring my body's response. There is hardly any taste. If taken excessively, it may cause diarrhoea, so I recommend avoiding it before heading out. The calcium addition helps prevent osteoporosis. Be mindful as too much calcium can lead to magnesium deficiency. This product effectively alleviates joint pain and body stiffness, although it is not a pain reliever.
9
Magnesium's role in osteoporosis
Relationship between multi-nutrient intake and bone loss and osteoporosis in U.S. adults: Findings from NHANES.
We examined how dietary intake of magnesium, along with potassium and sodium, influences bone health, specifically focusing on osteoporosis and bone mineral density (BMD) in adults across the U.S. Our analysis was based on data from the National Health and Nutrition Examination Surveys, which spanned from 2005 to 2018, involving over 10,000 participants.
The findings revealed a positive association between higher dietary intake of potassium, magnesium, and sodium and improved BMD of the femur. This means that those who consumed more of these nutrients tended to have stronger bones. Additionally, we observed that a higher intake of these minerals was linked to a lower occurrence of osteopenia and osteoporosis.
Our study highlights how magnesium, when part of a broader nutrient intake that includes potassium and sodium, could play a significant role in maintaining bone health. While our research points to a beneficial relationship, more targeted studies are needed to definitively isolate the effects of magnesium alone on osteoporosis. Overall, this reinforces the importance of a balanced diet for bone health.
9
Magnesium enhances osteoporosis treatment
Anti-osteoporosis properties of phosphorylated collagen peptide-magnesium chelates in osteoblast MC3T3-E1 cells and ovariectomized mice.
In our exploration of osteoporosis treatment, we focused on the effects of magnesium, particularly when combined with phosphorylated collagen peptide-magnesium chelates. Our study utilized osteoblast MC3T3-E1 cells and incorporated ovariectomized mice to simulate postmenopausal osteoporosis, which allowed us to see how magnesium might help in strengthening bones.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
9
Magnesium improves osteoporotic bone repair
An injectable magnesium-loaded hydrogel releases hydrogen to promote osteoporotic bone repair via ROS scavenging and immunomodulation.
We delved into the use of a unique injectable hydrogel loaded with magnesium to address the challenges of repairing osteoporotic bone defects. The study aimed to understand how this magnesium-infused hydrogel could combat the excessive reactive oxygen species (ROS) that hinder bone repair. With impressive qualities such as excellent injectability and adaptability, the hydrogel can be introduced into irregular bone areas without the need for major surgery.
Once injected, the hydrogel not only transforms into a supportive scaffold but also begins to release hydrogen and magnesium ions. This release is key in reducing harmful intracellular ROS and guiding the immune response favorably by promoting macrophage polarization. We observed that this gel suppressed the formation of osteoclasts, the cells responsible for bone resorption, while simultaneously encouraging the growth of new bone cells.
Animal experiments further illuminated the effectiveness of the magnesium-loaded hydrogel, showing a remarkable ability to enhance the repair of bone defects by controlling inflammation and supporting bone formation. Overall, our findings shine a light on the potential of magnesium-based hydrogels as promising solutions for those dealing with osteoporosis-related bone damage.
8
Magnesium's promise for osteoporosis
Honeycomb Bionic Graphene Oxide Quantum Dot/Layered Double Hydroxide Composite Nanocoating Promotes Osteoporotic Bone Regeneration via Activating Mitophagy.
In our exploration of how magnesium can help treat osteoporosis, we focused on a unique combination of materials to improve bone healing. The study investigated the use of magnesium alloys, known for their biodegradability and suitable elasticity for bone repair. However, it also incorporated graphene oxide quantum dots and layered double hydroxides to enhance the overall effect.
The results showed promise, particularly with the construction of a honeycomb-like coated structure on magnesium alloys. This innovative design helps regulate the degradation rate of magnesium, providing a conducive environment for bone regeneration. By allowing osteoblasts, the cells responsible for bone formation, to survive better and function properly, we observed that magnesium combined with these materials may effectively promote bone healing in osteoporotic patients.
Specifically, the activation of mitophagy—where damaged mitochondria in osteoblasts are cleared—was identified as a key factor in supporting osteogenesis. The improvement in bone regeneration and integration was confirmed using a rat model with femoral defects. Our findings suggest that magnesium alloys' combination with advanced materials like graphene oxide and layered double hydroxides may represent a promising approach to addressing osteoporosis-related bone defects.
References
Hu W, Feng X, Wen C. Relationship between multi-nutrient intake and bone loss and osteoporosis in U.S. adults: Findings from NHANES. Medicine (Baltimore). 2024;103:e40768. 10.1097/MD.0000000000040768
Li D, Dai D, Wang J, Zhang C. Honeycomb Bionic Graphene Oxide Quantum Dot/Layered Double Hydroxide Composite Nanocoating Promotes Osteoporotic Bone Regeneration via Activating Mitophagy. Small. 2024;20:e2403907. 10.1002/smll.202403907
Zhou H, He Z, Cao Y, Chu L, Liang B, et al. An injectable magnesium-loaded hydrogel releases hydrogen to promote osteoporotic bone repair via ROS scavenging and immunomodulation. Theranostics. 2024;14:3739. 10.7150/thno.97412
Liu L, Luo P, Wen P, Xu P. The role of magnesium in the pathogenesis of osteoporosis. Front Endocrinol (Lausanne). 2024;15:1406248. 10.3389/fendo.2024.1406248
Huang L, Cai P, Bian M, Yu J, Xiao L, et al. Injectable and high-strength PLGA/CPC loaded ALN/MgO bone cement for bone regeneration by facilitating osteogenesis and inhibiting osteoclastogenesis in osteoporotic bone defects. Mater Today Bio. 2024;26:101092. 10.1016/j.mtbio.2024.101092
Weng Z, Ye J, Cai C, Liu Z, Liu Y, et al. Inflammatory microenvironment regulation and osteogenesis promotion by bone-targeting calcium and magnesium repletion nanoplatform for osteoporosis therapy. J Nanobiotechnology. 2024;22:314. 10.1186/s12951-024-02581-7
Dai Q, Wang Z, Liu C, Chen X, Cao X. High performance injectable Mg doped bioactive glass bone cement for the regulation of osteogenic immune microenvironment. Biomater Adv. 2024;160:213864. 10.1016/j.bioadv.2024.213864
Li J, Chen Y, Zha D, Wu C, Li X, et al. Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. Lipids Health Dis. 2024;23:88. 10.1186/s12944-024-02083-3
Qin L, Liu Q, Zhang T, Tang X, Mo X, et al. Association Between Combined Polymetallic Exposure and Osteoporosis. Biol Trace Elem Res. 2024;202:3945. 10.1007/s12011-023-04002-6
Ma T, Guan Y, Feng J, Yang Y, Chen J, et al. Osteogenic effect of magnesium oxychloride cement modified with phytic acid and loaded with strontium ranelate. Biomater Res. 2023;27:128. 10.1186/s40824-023-00474-8
Zhang C, Du B, Deng G, Zhang S, Yu T, et al. Anti-osteoporosis properties of phosphorylated collagen peptide-magnesium chelates in osteoblast MC3T3-E1 cells and ovariectomized mice. Chin Med J (Engl). 2024;137:1762. 10.1097/CM9.0000000000002877
Zhao Y, Liu J, Hu L, Yao X, Tu R, et al. Novel "hot spring"-mimetic scaffolds for sequential neurovascular network reconstruction and osteoporosis reversion. Biomaterials. 2025;320:123191. 10.1016/j.biomaterials.2025.123191
Al-Garawi ZS, Al-Qaisi AHI, Al-Shamari KA, Öztürkkan FE, Necefoğlu H. The utility of Hibiscus sabdariffa L. to prepare metal oxides NPs for clinical application on osteoporosis supported by theoretical study. Bioprocess Biosyst Eng. 2024;47:753. 10.1007/s00449-024-03012-5
Düğer H, Uçan B, Çalışkan M, Bostan H, Demirci T, et al. Hypomagnesemia may be associated with symptomatic disease in patients with primary hyperparathyroidism. Endocrine. 2024;83:466. 10.1007/s12020-023-03577-3
Han H, Chen S, Wang X, Jin J, Li X, et al. Association of the composite dietary antioxidant index with bone mineral density in the United States general population: data from NHANES 2005-2010. J Bone Miner Metab. 2023;41:631. 10.1007/s00774-023-01438-7
Zhu Y, Jia G, Yang Y, Weng J, Liu S, et al. Biomimetic Porous Magnesium Alloy Scaffolds Promote the Repair of Osteoporotic Bone Defects in Rats through Activating the Wnt/β-Catenin Signaling Pathway. ACS Biomater Sci Eng. 2023;9:3435. 10.1021/acsbiomaterials.2c01097
Fouhy LE, Mangano KM, Zhang X, Hughes BD, Tucker KL, et al. Association between a Calcium-to-Magnesium Ratio and Osteoporosis among Puerto Rican Adults. J Nutr. 2023;153:2642. 10.1016/j.tjnut.2023.05.009
Xie Y, Bao Z, Wang Z, Du D, Chen G, et al. Magnesium Ascorbyl Phosphate Promotes Bone Formation Via CaMKII Signaling. J Bone Miner Res. 2023;38:1015. 10.1002/jbmr.4820
Salama RHM, Ali SS, Salama THM, Almged MA, Alsanory TA, et al. Dietary Effects of Nanopowder Eggshells on Mineral Contents, Bone Turnover Biomarkers, and Regulators of Bone Resorption in Healthy Rats and Ovariectomy-Induced Osteoporosis Rat Model. Appl Biochem Biotechnol. 2023;195:5034. 10.1007/s12010-022-04038-9