Last update
5/25/2025

Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 19 Researches
8.2
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.7
Supplement Facts
Serving Size:  2 Tablets
Amount Per Serving
%DV
Magnesium (from 2,000 mg magnesiumlysinate glycinate chelate) (Albion®)
200 mg
48%

Top Medical Research Studies

9
Magnesium's role in osteoporosis therapy
We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.

Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.

In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.

Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Read More
9
Magnesium enhances osteoporosis treatment
In our exploration of osteoporosis treatment, we focused on the effects of magnesium, particularly when combined with phosphorylated collagen peptide-magnesium chelates. Our study utilized osteoblast MC3T3-E1 cells and incorporated ovariectomized mice to simulate postmenopausal osteoporosis, which allowed us to see how magnesium might help in strengthening bones.

We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.

However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
Read More
9
Nanopowder eggshells improve bone health
We examined how nanopowder eggshells (NPES) could influence bone health in both healthy and ovariectomy-induced osteoporosis rats.

In our research, we found that NPES treatment significantly enhanced indicators of bone formation, like calcium and osteocalcin, particularly in healthy rats.

Additionally, in the ovariectomized group, NPES treatment helped improve levels of vital nutrients and reduced bone resorption.

Overall, our findings suggest that NPES may play a beneficial role in bettering bone health in osteoporosis models.
Read More

Most Useful Reviews

9
Important for elderly
2 people found this helpful
Today, we must fully recognise magnesium deficiency's importance, especially among the elderly. Osteoporosis poses a significant issue in this group, as insufficient magnesium intake can lead to increased bone fragility. Adequate magnesium may slow the decline in skeletal muscle mass, thus reducing osteoporosis and the risk of fractures. Thanks for the thumbs up! ❤️❤️
Read More
9
Works well daily
1 people found this helpful
This product is excellent; its magnesium component, magnesium lysine, and glycine are well-absorbed. It's affordable, and I've been taking it daily with dicalcium malate for my osteoporosis. I plan to verify its effects at the hospital in two years. I highly recommend this magnesium product.
Read More
9
Promotes bone health
Magnesium glycinate is well absorbed, helping muscle relaxation, cardiovascular health, and improved sleep quality. It supports bone health by working with calcium, making it beneficial for osteoporosis prevention.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 19 Researches
8.2
  • All Researches
9
Magnesium's role in osteoporosis
We examined how dietary intake of magnesium, along with potassium and sodium, influences bone health, specifically focusing on osteoporosis and bone mineral density (BMD) in adults across the U.S. Our analysis was based on data from the National Health and Nutrition Examination Surveys, which spanned from 2005 to 2018, involving over 10,000 participants.

The findings revealed a positive association between higher dietary intake of potassium, magnesium, and sodium and improved BMD of the femur. This means that those who consumed more of these nutrients tended to have stronger bones. Additionally, we observed that a higher intake of these minerals was linked to a lower occurrence of osteopenia and osteoporosis.

Our study highlights how magnesium, when part of a broader nutrient intake that includes potassium and sodium, could play a significant role in maintaining bone health. While our research points to a beneficial relationship, more targeted studies are needed to definitively isolate the effects of magnesium alone on osteoporosis. Overall, this reinforces the importance of a balanced diet for bone health.
Read More
9
Magnesium improves osteoporotic bone repair
We delved into the use of a unique injectable hydrogel loaded with magnesium to address the challenges of repairing osteoporotic bone defects. The study aimed to understand how this magnesium-infused hydrogel could combat the excessive reactive oxygen species (ROS) that hinder bone repair. With impressive qualities such as excellent injectability and adaptability, the hydrogel can be introduced into irregular bone areas without the need for major surgery.

Once injected, the hydrogel not only transforms into a supportive scaffold but also begins to release hydrogen and magnesium ions. This release is key in reducing harmful intracellular ROS and guiding the immune response favorably by promoting macrophage polarization. We observed that this gel suppressed the formation of osteoclasts, the cells responsible for bone resorption, while simultaneously encouraging the growth of new bone cells.

Animal experiments further illuminated the effectiveness of the magnesium-loaded hydrogel, showing a remarkable ability to enhance the repair of bone defects by controlling inflammation and supporting bone formation. Overall, our findings shine a light on the potential of magnesium-based hydrogels as promising solutions for those dealing with osteoporosis-related bone damage.
Read More
9
Magnesium's role in osteoporosis therapy
We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.

Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.

In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.

Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Read More
9
Magnesium enhances osteoporosis treatment
In our exploration of osteoporosis treatment, we focused on the effects of magnesium, particularly when combined with phosphorylated collagen peptide-magnesium chelates. Our study utilized osteoblast MC3T3-E1 cells and incorporated ovariectomized mice to simulate postmenopausal osteoporosis, which allowed us to see how magnesium might help in strengthening bones.

We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.

However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
Read More
9
Calcium magnesium scaffold boosts bone repair
We explored a cutting-edge approach to tackle the challenges in repairing bones affected by osteoporosis. Drawing inspiration from the healing properties of hot springs, we created a unique calcium magnesium phosphate bone cement infused with manganese ions.

This innovative scaffold not only promotes the regeneration of neurovascular networks but also helps reduce harmful substances in the bone's environment. Our results indicate that this method significantly aids in bone healing, highlighting its potential for treating osteoporosis effectively.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 17 Reviews
7.7
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Important for elderly
2 people found this helpful
Today, we must fully recognise magnesium deficiency's importance, especially among the elderly. Osteoporosis poses a significant issue in this group, as insufficient magnesium intake can lead to increased bone fragility. Adequate magnesium may slow the decline in skeletal muscle mass, thus reducing osteoporosis and the risk of fractures. Thanks for the thumbs up! ❤️❤️
Read More
9
Works well daily
1 people found this helpful
This product is excellent; its magnesium component, magnesium lysine, and glycine are well-absorbed. It's affordable, and I've been taking it daily with dicalcium malate for my osteoporosis. I plan to verify its effects at the hospital in two years. I highly recommend this magnesium product.
Read More
9
Promotes bone health
Magnesium glycinate is well absorbed, helping muscle relaxation, cardiovascular health, and improved sleep quality. It supports bone health by working with calcium, making it beneficial for osteoporosis prevention.
Read More
7.5
Helps osteoporosis issues
6 people found this helpful
This magnesium is excellent for sleep and has an effective impact on osteoporosis and joint issues. It's beneficial for relaxation and comfort.
Read More
7.5
Reduces joint pain
2 people found this helpful
I feel the effects of this product and purchase it repeatedly. The tablet is large, so I divide it into two while monitoring my body's response. There is hardly any taste. If taken excessively, it may cause diarrhoea, so I recommend avoiding it before heading out. The calcium addition helps prevent osteoporosis. Be mindful as too much calcium can lead to magnesium deficiency. This product effectively alleviates joint pain and body stiffness, although it is not a pain reliever.
Read More

Frequently Asked Questions

9
Works well daily
1 people found this helpful
This product is excellent; its magnesium component, magnesium lysine, and glycine are well-absorbed. It's affordable, and I've been taking it daily with dicalcium malate for my osteoporosis. I plan to verify its effects at the hospital in two years. I highly recommend this magnesium product.
7.5
Beneficial for joints
1 people found this helpful
This chelated product is effective, and as a yoga teacher, I take it every day for my osteoporosis and joint health. Some say it aids sleep too; I do sleep soundly, so perhaps they are right.
9
Promotes bone health
Magnesium glycinate is well absorbed, helping muscle relaxation, cardiovascular health, and improved sleep quality. It supports bone health by working with calcium, making it beneficial for osteoporosis prevention.
9
High-quality magnesium
1 people found this helpful
This brand is the best magnesium I've tried in terms of quality. As someone with fragility, I must take magnesium. It's known for alleviating joint and muscle pain and supporting bone health. Consider following Dr Karim’s work on osteoporosis for more insights.
7
Improved sleep quality
I have purchased this magnesium for a second time. I appreciate the tablet form as it allows for precise dosing from 100 mg, as not everyone needs the full daily dose of 400 mg. Since I began taking 200-300 mg daily, my sleep has improved and irritability has decreased. Low magnesium levels can lead to osteoporosis, making this supplement valuable. Its chelated form ensures high bioavailability. Overall, I highly recommend it.
6
Difficulty swallowing tablets
This magnesium seems beneficial for osteoporosis, but the tablets are too large for me to swallow without cutting them. I wish they were smaller for easier consumption.
2
Adverse side effects
3 people found this helpful
I tried magnesium for osteoporosis, but when I took the prescribed amount, I experienced abdominal pain and diarrhoea. Reducing to one tablet didn't help, suggesting it may not suit everyone.
7.5
Regular intake planned
1 people found this helpful
I'm committed to taking magnesium daily alongside my osteoporosis medication, as it's recommended to take them together with calcium. The chelated magnesium is easily absorbed, and I've had no gastrointestinal issues. I will continue to monitor my bone health.
7.5
Reduces joint pain
2 people found this helpful
I feel the effects of this product and purchase it repeatedly. The tablet is large, so I divide it into two while monitoring my body's response. There is hardly any taste. If taken excessively, it may cause diarrhoea, so I recommend avoiding it before heading out. The calcium addition helps prevent osteoporosis. Be mindful as too much calcium can lead to magnesium deficiency. This product effectively alleviates joint pain and body stiffness, although it is not a pain reliever.
9
Magnesium's role in osteoporosis
We examined how dietary intake of magnesium, along with potassium and sodium, influences bone health, specifically focusing on osteoporosis and bone mineral density (BMD) in adults across the U.S. Our analysis was based on data from the National Health and Nutrition Examination Surveys, which spanned from 2005 to 2018, involving over 10,000 participants.

The findings revealed a positive association between higher dietary intake of potassium, magnesium, and sodium and improved BMD of the femur. This means that those who consumed more of these nutrients tended to have stronger bones. Additionally, we observed that a higher intake of these minerals was linked to a lower occurrence of osteopenia and osteoporosis.

Our study highlights how magnesium, when part of a broader nutrient intake that includes potassium and sodium, could play a significant role in maintaining bone health. While our research points to a beneficial relationship, more targeted studies are needed to definitively isolate the effects of magnesium alone on osteoporosis. Overall, this reinforces the importance of a balanced diet for bone health.
9
Magnesium enhances osteoporosis treatment
In our exploration of osteoporosis treatment, we focused on the effects of magnesium, particularly when combined with phosphorylated collagen peptide-magnesium chelates. Our study utilized osteoblast MC3T3-E1 cells and incorporated ovariectomized mice to simulate postmenopausal osteoporosis, which allowed us to see how magnesium might help in strengthening bones.

We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.

However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
9
Magnesium improves osteoporotic bone repair
We delved into the use of a unique injectable hydrogel loaded with magnesium to address the challenges of repairing osteoporotic bone defects. The study aimed to understand how this magnesium-infused hydrogel could combat the excessive reactive oxygen species (ROS) that hinder bone repair. With impressive qualities such as excellent injectability and adaptability, the hydrogel can be introduced into irregular bone areas without the need for major surgery.

Once injected, the hydrogel not only transforms into a supportive scaffold but also begins to release hydrogen and magnesium ions. This release is key in reducing harmful intracellular ROS and guiding the immune response favorably by promoting macrophage polarization. We observed that this gel suppressed the formation of osteoclasts, the cells responsible for bone resorption, while simultaneously encouraging the growth of new bone cells.

Animal experiments further illuminated the effectiveness of the magnesium-loaded hydrogel, showing a remarkable ability to enhance the repair of bone defects by controlling inflammation and supporting bone formation. Overall, our findings shine a light on the potential of magnesium-based hydrogels as promising solutions for those dealing with osteoporosis-related bone damage.
8
Magnesium's promise for osteoporosis
In our exploration of how magnesium can help treat osteoporosis, we focused on a unique combination of materials to improve bone healing. The study investigated the use of magnesium alloys, known for their biodegradability and suitable elasticity for bone repair. However, it also incorporated graphene oxide quantum dots and layered double hydroxides to enhance the overall effect.

The results showed promise, particularly with the construction of a honeycomb-like coated structure on magnesium alloys. This innovative design helps regulate the degradation rate of magnesium, providing a conducive environment for bone regeneration. By allowing osteoblasts, the cells responsible for bone formation, to survive better and function properly, we observed that magnesium combined with these materials may effectively promote bone healing in osteoporotic patients.

Specifically, the activation of mitophagy—where damaged mitochondria in osteoblasts are cleared—was identified as a key factor in supporting osteogenesis. The improvement in bone regeneration and integration was confirmed using a rat model with femoral defects. Our findings suggest that magnesium alloys' combination with advanced materials like graphene oxide and layered double hydroxides may represent a promising approach to addressing osteoporosis-related bone defects.

References

  1. Hu W, Feng X, Wen C. Relationship between multi-nutrient intake and bone loss and osteoporosis in U.S. adults: Findings from NHANES. Medicine (Baltimore). 2024;103:e40768. 10.1097/MD.0000000000040768
  2. Li D, Dai D, Wang J, Zhang C. Honeycomb Bionic Graphene Oxide Quantum Dot/Layered Double Hydroxide Composite Nanocoating Promotes Osteoporotic Bone Regeneration via Activating Mitophagy. Small. 2024;20:e2403907. 10.1002/smll.202403907
  3. Zhou H, He Z, Cao Y, Chu L, Liang B, et al. An injectable magnesium-loaded hydrogel releases hydrogen to promote osteoporotic bone repair via ROS scavenging and immunomodulation. Theranostics. 2024;14:3739. 10.7150/thno.97412
  4. Liu L, Luo P, Wen P, Xu P. The role of magnesium in the pathogenesis of osteoporosis. Front Endocrinol (Lausanne). 2024;15:1406248. 10.3389/fendo.2024.1406248
  5. Huang L, Cai P, Bian M, Yu J, Xiao L, et al. Injectable and high-strength PLGA/CPC loaded ALN/MgO bone cement for bone regeneration by facilitating osteogenesis and inhibiting osteoclastogenesis in osteoporotic bone defects. Mater Today Bio. 2024;26:101092. 10.1016/j.mtbio.2024.101092
  6. Weng Z, Ye J, Cai C, Liu Z, Liu Y, et al. Inflammatory microenvironment regulation and osteogenesis promotion by bone-targeting calcium and magnesium repletion nanoplatform for osteoporosis therapy. J Nanobiotechnology. 2024;22:314. 10.1186/s12951-024-02581-7
  7. Dai Q, Wang Z, Liu C, Chen X, Cao X. High performance injectable Mg doped bioactive glass bone cement for the regulation of osteogenic immune microenvironment. Biomater Adv. 2024;160:213864. 10.1016/j.bioadv.2024.213864
  8. Li J, Chen Y, Zha D, Wu C, Li X, et al. Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. Lipids Health Dis. 2024;23:88. 10.1186/s12944-024-02083-3
  9. Qin L, Liu Q, Zhang T, Tang X, Mo X, et al. Association Between Combined Polymetallic Exposure and Osteoporosis. Biol Trace Elem Res. 2024;202:3945. 10.1007/s12011-023-04002-6
  10. Ma T, Guan Y, Feng J, Yang Y, Chen J, et al. Osteogenic effect of magnesium oxychloride cement modified with phytic acid and loaded with strontium ranelate. Biomater Res. 2023;27:128. 10.1186/s40824-023-00474-8
  11. Zhang C, Du B, Deng G, Zhang S, Yu T, et al. Anti-osteoporosis properties of phosphorylated collagen peptide-magnesium chelates in osteoblast MC3T3-E1 cells and ovariectomized mice. Chin Med J (Engl). 2024;137:1762. 10.1097/CM9.0000000000002877
  12. Zhao Y, Liu J, Hu L, Yao X, Tu R, et al. Novel "hot spring"-mimetic scaffolds for sequential neurovascular network reconstruction and osteoporosis reversion. Biomaterials. 2025;320:123191. 10.1016/j.biomaterials.2025.123191
  13. Al-Garawi ZS, Al-Qaisi AHI, Al-Shamari KA, Öztürkkan FE, Necefoğlu H. The utility of Hibiscus sabdariffa L. to prepare metal oxides NPs for clinical application on osteoporosis supported by theoretical study. Bioprocess Biosyst Eng. 2024;47:753. 10.1007/s00449-024-03012-5
  14. Düğer H, Uçan B, Çalışkan M, Bostan H, Demirci T, et al. Hypomagnesemia may be associated with symptomatic disease in patients with primary hyperparathyroidism. Endocrine. 2024;83:466. 10.1007/s12020-023-03577-3
  15. Han H, Chen S, Wang X, Jin J, Li X, et al. Association of the composite dietary antioxidant index with bone mineral density in the United States general population: data from NHANES 2005-2010. J Bone Miner Metab. 2023;41:631. 10.1007/s00774-023-01438-7
  16. Zhu Y, Jia G, Yang Y, Weng J, Liu S, et al. Biomimetic Porous Magnesium Alloy Scaffolds Promote the Repair of Osteoporotic Bone Defects in Rats through Activating the Wnt/β-Catenin Signaling Pathway. ACS Biomater Sci Eng. 2023;9:3435. 10.1021/acsbiomaterials.2c01097
  17. Fouhy LE, Mangano KM, Zhang X, Hughes BD, Tucker KL, et al. Association between a Calcium-to-Magnesium Ratio and Osteoporosis among Puerto Rican Adults. J Nutr. 2023;153:2642. 10.1016/j.tjnut.2023.05.009
  18. Xie Y, Bao Z, Wang Z, Du D, Chen G, et al. Magnesium Ascorbyl Phosphate Promotes Bone Formation Via CaMKII Signaling. J Bone Miner Res. 2023;38:1015. 10.1002/jbmr.4820
  19. Salama RHM, Ali SS, Salama THM, Almged MA, Alsanory TA, et al. Dietary Effects of Nanopowder Eggshells on Mineral Contents, Bone Turnover Biomarkers, and Regulators of Bone Resorption in Healthy Rats and Ovariectomy-Induced Osteoporosis Rat Model. Appl Biochem Biotechnol. 2023;195:5034. 10.1007/s12010-022-04038-9
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