We conducted a study to see how coenzyme Q10 (CoQ10) supplementation impacts migraine symptoms and inflammation. This randomized double-blind trial involved 45 non-menopausal women with episodic migraines.
Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.
Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
Read More
8
CoQ10 shows promise for migraines
Efficacy of CoQ10 as supplementation for migraine: A meta-analysis.
We investigated whether coenzyme Q10 (CoQ10) could help reduce migraines. By examining five studies with 346 participants, we learned that CoQ10 may not significantly cut down on the number of attacks or their severity.
However, it appears to decrease the number of migraine days and duration each month. This suggests that while CoQ10 may not be a cure-all, it could help those suffering from migraines find some relief. Further research will be necessary to confirm these findings.
Read More
8
Co-Q10 potentially benefits migraine patients
The Effects of Coenzyme Q10 Supplementation on Oxidative Status and Lipid Profile in Migraine Patients: A Randomized Double-Blinded Controlled Clinical Trial.
We investigated how Coenzyme Q10 (Co-Q10) affects migraine symptoms in a well-structured clinical trial. Over the course of 12 weeks, 84 women aged 18 to 50 diagnosed with episodic migraines participated in a randomized, double-blind study, where they received either Co-Q10 (400 mg/day) or a placebo.
Upon analyzing the results, we observed some promising outcomes. Participants who took Co-Q10 experienced a significant reduction in malondialdehyde (MDA) levels, an indicator of oxidative stress. Additionally, there was a noteworthy increase in high-density lipoprotein cholesterol (HDL-C) levels, which is beneficial for overall heart health. We also noted a decrease in body fat percentage among those receiving Co-Q10.
However, while some improvements were documented, Co-Q10 did not show a significant effect on total antioxidant capacity or other lipid profile measures like low-density lipoprotein cholesterol and triglycerides. Therefore, while Co-Q10 may hold potential for enhancing certain health aspects in migraine sufferers, its overall impact on migraine management and other related parameters remains mixed.
Read More
Most Useful Reviews
9
Effective migraine relief
5 people found this helpful
Amazing! I had almost lost all hope until I decided to try CoQ10. It has significantly reduced the frequency of my migraine attacks; it's miraculous and a lifesaver. I take one capsule every morning without any side effects or unpleasant taste. I believe bioperine enhances the effect of CoQ10. If you are struggling with migraines and feel you've exhausted options, I strongly recommend trying CoQ10. It may change your life!
Read More
9
Improves migraine symptoms
3 people found this helpful
CoQ10 works well for migraines. Rapid depletion can occur with intense exercise, stress, surgeries, and statin use. It’s crucial to stabilise CoQ10 levels as low levels are linked to various conditions. Taking CoQ10, especially with statins, is vital as it shows promising results for migraines, significantly improving their frequency and intensity. The effects become noticeable only after a month of consistent use, and it's best absorbed with food.
Read More
9
Tremendous relief
1 people found this helpful
Great value. I’ve taken this product for years, and it tremendously reduces both the frequency and severity of my migraines. I highly recommend this brand as it's much cheaper than others.
The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial.
We explored how the combination of nano-curcumin and coenzyme Q10 (CoQ10) affects migraine symptoms and patients' quality of life. In a double-blind, placebo-controlled study involving 100 participants, we assessed the impacts on headache frequency, severity, and duration over eight weeks.
Our findings were promising: the group taking both nano-curcumin and CoQ10 showed significant improvements compared to those receiving the placebo or single supplements alone. Remarkably, this combination enhanced migraine-specific scores without any reported side effects. Overall, it highlights the potential benefits of these supplements in managing migraine.
Read More
9
CoQ10 and L-carnitine aid migraines
The effects of concurrent Coenzyme Q10, L-carnitine supplementation in migraine prophylaxis: A randomized, placebo-controlled, double-blind trial.
We explored the impact of Coenzyme Q10 in combination with L-carnitine on migraine symptoms in a well-structured trial involving 56 participants aged 20-40. Over eight weeks, subjects received these supplements or a placebo.
Our findings show a substantial improvement in migraine-related aspects, including a decrease in headache severity, duration, and frequency, alongside lower serum lactate levels. This suggests that these supplements could be beneficial for those suffering from migraines.
Read More
9
CoQ10 improves migraine symptoms
Oral coenzyme Q10 supplementation in patients with migraine: Effects on clinical features and inflammatory markers.
We conducted a study to see how coenzyme Q10 (CoQ10) supplementation impacts migraine symptoms and inflammation. This randomized double-blind trial involved 45 non-menopausal women with episodic migraines.
Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.
Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
Read More
9
Favorable outcomes in migraine prevention
A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study.
We explored the effects of a daily supplement containing coenzyme Q10, feverfew, and magnesium on migraine prevention. In our observational study, which included adult migraine sufferers, participants took the supplement for three months after a one-month baseline phase.
Results revealed a significant reduction in migraine days, dropping from an average of 4.9 days to 1.3 days by the third month. Additionally, 75% of participants experienced at least a 50% reduction in migraine frequency.
The treatment was well tolerated and also appeared to improve anxiety and depressive symptoms, enhancing overall quality of life.
Read More
9
CoQ10 helps children’s migraines
Nutraceuticals safety and efficacy in migraine without aura in a population of children affected by neurofibromatosis type I.
We aimed to explore how a nutraceutical combination of Ginkgolide B, Coenzyme Q10, Riboflavin, and Magnesium could help children with neurofibromatosis type 1 manage migraine without aura. Over six months, 18 school-aged children took this supplement twice a day and kept journals tracking their migraine symptoms.
Remarkably, we observed significant reductions in frequency, intensity, duration, and overall migraine-related disability. Our findings reveal that this nutraceutical blend may effectively alleviate migraine symptoms for these children, marking a promising step forward in managing headaches associated with NF1.
Amazing! I had almost lost all hope until I decided to try CoQ10. It has significantly reduced the frequency of my migraine attacks; it's miraculous and a lifesaver. I take one capsule every morning without any side effects or unpleasant taste. I believe bioperine enhances the effect of CoQ10. If you are struggling with migraines and feel you've exhausted options, I strongly recommend trying CoQ10. It may change your life!
Read More
9
Improves migraine symptoms
3 people found this helpful
CoQ10 works well for migraines. Rapid depletion can occur with intense exercise, stress, surgeries, and statin use. It’s crucial to stabilise CoQ10 levels as low levels are linked to various conditions. Taking CoQ10, especially with statins, is vital as it shows promising results for migraines, significantly improving their frequency and intensity. The effects become noticeable only after a month of consistent use, and it's best absorbed with food.
Read More
9
Tremendous relief
1 people found this helpful
Great value. I’ve taken this product for years, and it tremendously reduces both the frequency and severity of my migraines. I highly recommend this brand as it's much cheaper than others.
Read More
9
Effective against migraines
Great antioxidants! They are very effective in reducing migraine headache attacks and increase cerebral blood flow.
Read More
6
Helpful with migraines
Good product! I use it for my migraines; so far, it’s effective. It’s easy to swallow and has no unpleasant taste, although I'm feeling a bit dizzy, which I hope will pass.
Read More
Frequently Asked Questions
Migraine is a neurological condition characterized by recurrent and often debilitating headaches, typically accompanied by a variety of symptoms such as nausea, vomiting, and heightened sensitivity to light and sound. These headaches can be pulsing or throbbing in nature and are usually localized to one side of the head, although they can occur on both sides. Migraines can last anywhere from a few hours to several days and can significantly interfere with daily activities. Many individuals also experience an "aura," which can include visual disturbances like flashing lights or blind spots, as a precursor to the actual headache.
While the exact cause of migraines is not fully understood, they are thought to be linked to changes in brain activity and environmental factors, along with genetics. Various triggers can precipitate a migraine attack, including stress, hormonal changes, certain foods, and sleep disturbances. Treatment options vary and can include prescription medications, over-the-counter pain relief, lifestyle changes, and preventive strategies. If you suffer from migraines, it's essential to consult with a healthcare professional to develop a tailored management plan suited to your symptoms and needs.
Coenzyme Q10, often abbreviated as CoQ10, is a naturally occurring antioxidant that is found in the cells of the body. It plays a crucial role in the production of energy within mitochondria, which are the powerhouses of our cells. CoQ10 is important for maintaining cellular energy levels and overall health, as it assists in the conversion of food into energy. Additionally, it helps protect cells from oxidative damage, which is linked to various conditions such as heart disease and aging.
As a dietary supplement, CoQ10 is popular for its potential benefits, including promoting heart health, improving energy levels, and supporting cognitive function. It's particularly beneficial for individuals who are taking statin medications, as these drugs can lower natural CoQ10 levels in the body. While more research is needed to determine its efficacy fully, many users have reported positive experiences. If you’re considering adding CoQ10 to your supplement routine, it’s best to consult with a healthcare professional to determine the appropriate dosage and ensure it fits your health needs.
Coenzyme Q10 (CoQ10) has gained attention as a potential supplement for managing migraines, and some studies suggest it may offer benefits. Research indicates that CoQ10 could help reduce the frequency and intensity of migraine attacks. This antioxidant plays a vital role in energy production within cells, and it is thought that improving mitochondrial function may alleviate some migraine symptoms. In clinical studies, participants taking CoQ10 have reported fewer migraine days and a decrease in the use of pain-relief medications, making it a promising option for those who experience migraines.
However, while the results are encouraging, it’s important to note that more comprehensive research is needed to establish the effectiveness of CoQ10 definitively. Additionally, the optimal dosage and the duration of supplementation for maximum benefits remain unclear. Before adding CoQ10 to your regimen, it’s advisable to consult with a healthcare professional, especially if you’re currently taking medications or have underlying health conditions. They can provide personalized guidance and help monitor any potential interactions or side effects.
Based on user reviews, the timeline for seeing results from CoQ10 for migraine relief typically spans about a month. One reviewer highlights that the effects become noticeable only after a month of consistent use, emphasizing the importance of stability in CoQ10 levels, particularly for those on statin medications Read Review. Another user asserts that the supplement has significantly reduced the frequency of their migraine attacks, indicating that it can be a game changer for those who have struggled with migraines Read Review.
Coenzyme Q10 (CoQ10) has garnered attention as a potential supplement for migraine management, supported by several studies suggesting its effectiveness. Research categorizes it with Level C evidence, implying some beneficial effects in preventing migraines, though the data is not overwhelmingly strong [1]. Notably, some clinical trials have indicated that CoQ10 supplementation can lead to a reduction in migraine frequency and intensity, particularly in those with lower baseline levels of this nutrient [26]. Additionally, a study involving children demonstrated CoQ10's long-term efficacy comparable to traditional migraine medications, with a significantly favorable side effect profile [24].
Despite the positive findings, it's essential to note that the evidence surrounding CoQ10 is still evolving. Many studies call for further rigorous trials to establish its precise role in migraine prevention, as well as to clarify its effectiveness in comparison to other treatments [19]. While CoQ10 might be a valuable option for individuals seeking alternatives to conventional migraine therapies, it's crucial to approach its use as part of a broader treatment strategy, ideally under the guidance of a healthcare professional, to ensure a comprehensive approach to managing migraines [22].
Users report a notable improvement in migraine symptoms after taking CoQ10. Many have experienced a significant reduction in the frequency of their migraine attacks, with one user describing the supplement as "miraculous" and a "lifesaver" after feeling hopeless about their condition Read Review. Another reviewer stresses the importance of stabilizing CoQ10 levels, especially for those on statin medications, indicating that consistent use can lead to improved outcomes over time Read Review.
In addition to frequency reduction, users also note improvements in the overall intensity of migraine symptoms. One review mentions that CoQ10 is effective not just in lowering the number of attacks but also in enhancing cerebral blood flow, which is beneficial for those suffering from migraines Read Review. However, it's worth noting that individual experiences can vary, and while many have found relief, others, like one user, mentioned feeling some dizziness, which may need monitoring Read Review. Overall, the anecdotal experiences suggest that CoQ10 could be a promising option for those seeking migraine relief.
Based on user reviews, there are positive reports regarding the combination of CoQ10 with other supplements for managing migraines. One individual suggests that taking CoQ10 alongside bioperine may enhance its effects, highlighting the potential for synergistic benefits when combined with specific supplements Read Review. This aligns with the broader trend observed among users who note improvements in migraine frequency and intensity when using CoQ10, particularly for those who are also on statin medications, as the latter can deplete CoQ10 levels rapidly Read Review.
Moreover, users have noted that antioxidants are effective in reducing migraine attacks and may work well in conjunction with CoQ10 to further enhance cerebral blood flow, which is beneficial for those suffering from migraines Read Review. Although many find success with these combinations, it's essential for users to monitor their individual responses, as one reviewer mentioned experiencing dizziness, which underscores the importance of a personalized approach to supplement regimens Read Review.
Based on current research, the optimal dose of Coenzyme Q10 (CoQ10) for the prevention of migraines appears to be around 400 mg per day. In a well-structured clinical trial involving women with episodic migraines, this dosage led to significant reductions in oxidative stress and improvements in specific health markers. Participants reported a decrease in migraine frequency, which suggests that consistent supplementation could help those suffering from this condition [21].
While the evidence surrounding CoQ10 is promising, it's important to note that many studies call for further research to firmly establish its effectiveness and optimal dosing strategies. Using CoQ10 as a part of a broader treatment strategy, possibly in combination with other supplements, also shows potential benefits [24]. However, individuals seeking to explore CoQ10 for migraine management are encouraged to consult with their healthcare provider to tailor the approach based on personal health needs.
9
Improves migraine symptoms
3 people found this helpful
CoQ10 works well for migraines. Rapid depletion can occur with intense exercise, stress, surgeries, and statin use. It’s crucial to stabilise CoQ10 levels as low levels are linked to various conditions. Taking CoQ10, especially with statins, is vital as it shows promising results for migraines, significantly improving their frequency and intensity. The effects become noticeable only after a month of consistent use, and it's best absorbed with food.
9
Effective migraine relief
5 people found this helpful
Amazing! I had almost lost all hope until I decided to try CoQ10. It has significantly reduced the frequency of my migraine attacks; it's miraculous and a lifesaver. I take one capsule every morning without any side effects or unpleasant taste. I believe bioperine enhances the effect of CoQ10. If you are struggling with migraines and feel you've exhausted options, I strongly recommend trying CoQ10. It may change your life!
9
Effective against migraines
Great antioxidants! They are very effective in reducing migraine headache attacks and increase cerebral blood flow.
6
Helpful with migraines
Good product! I use it for my migraines; so far, it’s effective. It’s easy to swallow and has no unpleasant taste, although I'm feeling a bit dizzy, which I hope will pass.
7
CoQ10 shows limited migraine effectiveness
Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur.
We explored the effectiveness of Coenzyme Q10 (CoQ10) in preventing migraines. The findings suggest that CoQ10 has limited evidence supporting its use, classified as Level C. This means that while some patients may benefit, the overall results are not strong enough to warrant a confident recommendation. Importantly, adverse side effects appear low, making it a relatively safe option. However, we must approach it with care, looking at other proven alternatives for migraine prevention.
4
Coenzyme Q10 and migraine research
The Role of Metabolism in Migraine Pathophysiology and Susceptibility.
We explored the potential role of coenzyme Q10 as a treatment option for migraines, particularly against the backdrop of mitochondrial dysfunction. This condition suggests that individuals with migraines may experience an imbalance between energy supply and demand in their brains. Through our examination of existing trials, we noted that some studies have found promising results for coenzyme Q10, especially among those who had lower levels of this nutrient before treatment.
However, it's important to be candid about the study’s limitations. Many of these trials lacked proper control groups or sufficient sample sizes to draw more conclusive results. Although the initial findings are intriguing, more rigorous research is needed to verify whether coenzyme Q10 can genuinely make a difference for migraine sufferers.
Overall, we recognize the potential that coenzyme Q10 holds as an adjunctive therapy for migraines, particularly as part of a personalized approach that considers individual nutrient deficiencies. By focusing on tailored treatments, we may pave the way for more effective management of migraines in the future.
8
Coenzyme Q10 shows promise in migraine
A Comparative Study on the Efficacy of Coenzyme Q10 and Amitriptyline in the Prophylactic Treatment of Migraine Headaches in Children: A Randomized Controlled Trial.
We explored the use of coenzyme Q10 as a preventive treatment for migraine headaches in children aged 5 to 15. Conducted as a randomized controlled trial with 72 participants, we aimed to compare how effectively coenzyme Q10 works against a commonly used medication, amitriptyline. Both treatments were assessed for their impact on the frequency, duration, and severity of migraines, as well as improvements in children's quality of life.
Our findings revealed that coenzyme Q10 offered encouraging long-term benefits for managing migraines, showing notable efficacy particularly over extended periods. While amitriptyline responded more quickly, the side effects were more pronounced in children taking this medication. Interestingly, after three months of treatment, both groups exhibited similar clinical outcomes and enhancements in quality of life.
Overall, we determined that coenzyme Q10 could serve as a viable alternative for migraine prophylaxis, given its favorable side effect profile and comparable effectiveness to traditional treatments like amitriptyline.
We explored the potential benefits of Coenzyme Q10 (CoQ10) as a treatment for migraines, diving into several studies that highlighted its role in managing this challenging condition. Research indicated that oxidative stress could play a part in migraines, and CoQ10, known for its antioxidant properties, seemed an interesting candidate to investigate.
Although the effectiveness of CoQ10 for migraine relief is not yet firmly established, some preliminary short-term studies suggest that it might offer some benefits. Among various studies, we noticed that combining CoQ10 with other treatments made it difficult to isolate its specific effects, highlighting a need for further research.
Our findings suggest that while there’s promise in CoQ10 as a migraine remedy, more comprehensive and controlled studies are essential to truly understand its potential and effectiveness. As of now, the scientific community continues to call for prospective research with larger sample sizes and longer follow-ups to clarify these initial observations.
4
CoQ10's potential for migraines
Involvement of Coenzyme Q10 in Various Neurodegenerative and Psychiatric Diseases.
We explored the role of coenzyme Q10, or CoQ10, in managing migraines. This important molecule is widely known for its energy-producing and antioxidant properties, which have drawn attention to its potential benefits for neurological conditions, including migraines.
The research indicates that CoQ10 may serve as a protective agent for the nervous system. Its role in energy metabolism could be particularly beneficial for those suffering from migraines, as energy deficits in brain cells are often linked to migraine attacks. By helping to stabilize mitochondrial function, CoQ10 might reduce the frequency or severity of migraine episodes.
While the precise outcomes of various studies on CoQ10 and migraine treatment can vary, many health professionals see promise in this supplement. However, more comprehensive studies are needed to fully establish its effectiveness specifically for migraine relief, particularly in comparison to other treatments.
Overall, CoQ10 shows potential, but it's important to consult with a healthcare provider to understand its use better as part of a larger migraine management strategy.
8
Co-Q10 potentially benefits migraine patients
The Effects of Coenzyme Q10 Supplementation on Oxidative Status and Lipid Profile in Migraine Patients: A Randomized Double-Blinded Controlled Clinical Trial.
We investigated how Coenzyme Q10 (Co-Q10) affects migraine symptoms in a well-structured clinical trial. Over the course of 12 weeks, 84 women aged 18 to 50 diagnosed with episodic migraines participated in a randomized, double-blind study, where they received either Co-Q10 (400 mg/day) or a placebo.
Upon analyzing the results, we observed some promising outcomes. Participants who took Co-Q10 experienced a significant reduction in malondialdehyde (MDA) levels, an indicator of oxidative stress. Additionally, there was a noteworthy increase in high-density lipoprotein cholesterol (HDL-C) levels, which is beneficial for overall heart health. We also noted a decrease in body fat percentage among those receiving Co-Q10.
However, while some improvements were documented, Co-Q10 did not show a significant effect on total antioxidant capacity or other lipid profile measures like low-density lipoprotein cholesterol and triglycerides. Therefore, while Co-Q10 may hold potential for enhancing certain health aspects in migraine sufferers, its overall impact on migraine management and other related parameters remains mixed.
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Sazali S, Badrin S, Norhayati MN, Idris NS. Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis. BMJ Open. 2021;11:e039358. 10.1136/bmjopen-2020-039358
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Parohan M, Sarraf P, Javanbakht MH, Foroushani AR, Ranji-Burachaloo S, et al. The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial. Nutr Neurosci. 2021;24:317. 10.1080/1028415X.2019.1627770
Moscano F, Guiducci M, Maltoni L, Striano P, Ledda MG, et al. An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache. Ital J Pediatr. 2019;45:36. 10.1186/s13052-019-0624-z
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Hajihashemi P, Askari G, Khorvash F, Reza Maracy M, Nourian M. The effects of concurrent Coenzyme Q10, L-carnitine supplementation in migraine prophylaxis: A randomized, placebo-controlled, double-blind trial. Cephalalgia. 2019;39:648. 10.1177/0333102418821661
Zeng Z, Li Y, Lu S, Huang W, Di W. Efficacy of CoQ10 as supplementation for migraine: A meta-analysis. Acta Neurol Scand. 2019;139:284. 10.1111/ane.13051
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Guilbot A, Bangratz M, Ait Abdellah S, Lucas C. A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study. BMC Complement Altern Med. 2017;17:433. 10.1186/s12906-017-1933-7
Shoeibi A, Olfati N, Soltani Sabi M, Salehi M, Mali S, et al. Effectiveness of coenzyme Q10 in prophylactic treatment of migraine headache: an open-label, add-on, controlled trial. Acta Neurol Belg. 2017;117:103. 10.1007/s13760-016-0697-z
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Tavasoli A, Rezazadeh M, Kachuei M. Eyebrow bleeding as a rare migraine symptom: a case report. Ann Med Surg (Lond). 2024;86:7377. 10.1097/MS9.0000000000002655
Hajhashemy Z, Golpour-Hamedani S, Eshaghian N, Sadeghi O, Khorvash F, et al. Practical supplements for prevention and management of migraine attacks: a narrative review. Front Nutr. 2024;11:1433390. 10.3389/fnut.2024.1433390
Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Espada-Rubio S, Agúndez JAG. Oxidative Stress and Migraine. Mol Neurobiol. 2024;61:8344. 10.1007/s12035-024-04114-7
Hannigan IP, Rosengren SM, Di Tanna GL, Watson SRD, Welgampola MS. Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study. Intern Med J. 2024;54:916. 10.1111/imj.16314
Dahri M, Sarafan Sadeghi A, Pahlavani N, Nattagh-Eshtivani E, Hashemilar M, et al. The Effects of Coenzyme Q10 Supplementation on Oxidative Status and Lipid Profile in Migraine Patients: A Randomized Double-Blinded Controlled Clinical Trial. Clin Nutr Res. 2023;12:257. 10.7762/cnr.2023.12.4.257
Ebrahimi A, Kamyab A, Hosseini S, Ebrahimi S, Ashkani-Esfahani S. Involvement of Coenzyme Q10 in Various Neurodegenerative and Psychiatric Diseases. Biochem Res Int. 2023;2023:5510874. 10.1155/2023/5510874
Stearns SA, Xun H, Haddad A, Rinkinen J, Bustos VP, et al. Therapeutic Options for Migraines in the Microsurgical Patient: A Scoping Review. Plast Reconstr Surg. 2024;153:988e. 10.1097/PRS.0000000000010861
Yaghini O, Hoseini N, Ghazavi MR, Mansouri V, Nasiri J, et al. A Comparative Study on the Efficacy of Coenzyme Q10 and Amitriptyline in the Prophylactic Treatment of Migraine Headaches in Children: A Randomized Controlled Trial. Adv Biomed Res. 2022;11:43. 10.4103/abr.abr_235_20
Ariyanfar S, Razeghi Jahromi S, Togha M, Ghorbani Z. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep. 2022;26:193. 10.1007/s11916-022-01019-9
Grech O, Mollan SP, Wakerley BR, Fulton D, Lavery GG, et al. The Role of Metabolism in Migraine Pathophysiology and Susceptibility. Life (Basel). 2021;11. 10.3390/life11050415
Kaur K, Hernandez V, Al Hajaj SW, Ebrahim AM, Razack M, et al. The Efficacy of Herbal Supplements and Nutraceuticals for Prevention of Migraine: Can They Help?. Cureus. 2021;13:e14868. 10.7759/cureus.14868
Vikelis M, Dermitzakis EV, Vlachos GS, Soldatos P, Spingos KC, et al. Open Label Prospective Experience of Supplementation with a Fixed Combination of Magnesium, Vitamin B2, Feverfew, Andrographis Paniculata and Coenzyme Q10 for Episodic Migraine Prophylaxis. J Clin Med. 2020;10. 10.3390/jcm10010067
Onofri A, Necozione S, Tozzi E. Complementary and alternative medicine (CAM) in headache of children and adolescents: open-label Italian study. Clin Ter. 2020;171:e393. 10.7417/CT.2020.2246