Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.5
USERS' SCORE
Good
Based on 5 Reviews
8.5
Supplement Facts
Serving Size: 1 Veggie Softgel
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
300 mg
Black Pepper Ext. (Piper nigrum)(fruit)(standardized to contain 95% Piperine)(BioPerine®)
5 mg

Top Medical Research Studies

We conducted a study to see how coenzyme Q10 (CoQ10) supplementation impacts migraine symptoms and inflammation. This randomized double-blind trial involved 45 non-menopausal women with episodic migraines.

Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.

Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
Read More
We investigated whether coenzyme Q10 (CoQ10) could help reduce migraines. By examining five studies with 346 participants, we learned that CoQ10 may not significantly cut down on the number of attacks or their severity.

However, it appears to decrease the number of migraine days and duration each month. This suggests that while CoQ10 may not be a cure-all, it could help those suffering from migraines find some relief. Further research will be necessary to confirm these findings.
Read More
8
Co-Q10 potentially benefits migraine patients
We investigated how Coenzyme Q10 (Co-Q10) affects migraine symptoms in a well-structured clinical trial. Over the course of 12 weeks, 84 women aged 18 to 50 diagnosed with episodic migraines participated in a randomized, double-blind study, where they received either Co-Q10 (400 mg/day) or a placebo.

Upon analyzing the results, we observed some promising outcomes. Participants who took Co-Q10 experienced a significant reduction in malondialdehyde (MDA) levels, an indicator of oxidative stress. Additionally, there was a noteworthy increase in high-density lipoprotein cholesterol (HDL-C) levels, which is beneficial for overall heart health. We also noted a decrease in body fat percentage among those receiving Co-Q10.

However, while some improvements were documented, Co-Q10 did not show a significant effect on total antioxidant capacity or other lipid profile measures like low-density lipoprotein cholesterol and triglycerides. Therefore, while Co-Q10 may hold potential for enhancing certain health aspects in migraine sufferers, its overall impact on migraine management and other related parameters remains mixed.
Read More

Most Useful Reviews

9
Effective migraine relief
5 people found this helpful
Amazing! I had almost lost all hope until I decided to try CoQ10. It has significantly reduced the frequency of my migraine attacks; it's miraculous and a lifesaver. I take one capsule every morning without any side effects or unpleasant taste. I believe bioperine enhances the effect of CoQ10. If you are struggling with migraines and feel you've exhausted options, I strongly recommend trying CoQ10. It may change your life!
Read More
9
Improves migraine symptoms
3 people found this helpful
CoQ10 works well for migraines. Rapid depletion can occur with intense exercise, stress, surgeries, and statin use. It’s crucial to stabilise CoQ10 levels as low levels are linked to various conditions. Taking CoQ10, especially with statins, is vital as it shows promising results for migraines, significantly improving their frequency and intensity. The effects become noticeable only after a month of consistent use, and it's best absorbed with food.
Read More
9
Tremendous relief
1 people found this helpful
Great value. I’ve taken this product for years, and it tremendously reduces both the frequency and severity of my migraines. I highly recommend this brand as it's much cheaper than others.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.5
  • All Researches
9
We explored how the combination of nano-curcumin and coenzyme Q10 (CoQ10) affects migraine symptoms and patients' quality of life. In a double-blind, placebo-controlled study involving 100 participants, we assessed the impacts on headache frequency, severity, and duration over eight weeks.

Our findings were promising: the group taking both nano-curcumin and CoQ10 showed significant improvements compared to those receiving the placebo or single supplements alone. Remarkably, this combination enhanced migraine-specific scores without any reported side effects. Overall, it highlights the potential benefits of these supplements in managing migraine.
Read More
9
CoQ10 and L-carnitine aid migraines
We explored the impact of Coenzyme Q10 in combination with L-carnitine on migraine symptoms in a well-structured trial involving 56 participants aged 20-40. Over eight weeks, subjects received these supplements or a placebo.

Our findings show a substantial improvement in migraine-related aspects, including a decrease in headache severity, duration, and frequency, alongside lower serum lactate levels. This suggests that these supplements could be beneficial for those suffering from migraines.
Read More
We conducted a study to see how coenzyme Q10 (CoQ10) supplementation impacts migraine symptoms and inflammation. This randomized double-blind trial involved 45 non-menopausal women with episodic migraines.

Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.

Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
Read More
9
Favorable outcomes in migraine prevention
We explored the effects of a daily supplement containing coenzyme Q10, feverfew, and magnesium on migraine prevention. In our observational study, which included adult migraine sufferers, participants took the supplement for three months after a one-month baseline phase.

Results revealed a significant reduction in migraine days, dropping from an average of 4.9 days to 1.3 days by the third month. Additionally, 75% of participants experienced at least a 50% reduction in migraine frequency.

The treatment was well tolerated and also appeared to improve anxiety and depressive symptoms, enhancing overall quality of life.
Read More
9
CoQ10 helps children’s migraines
We aimed to explore how a nutraceutical combination of Ginkgolide B, Coenzyme Q10, Riboflavin, and Magnesium could help children with neurofibromatosis type 1 manage migraine without aura. Over six months, 18 school-aged children took this supplement twice a day and kept journals tracking their migraine symptoms.

Remarkably, we observed significant reductions in frequency, intensity, duration, and overall migraine-related disability. Our findings reveal that this nutraceutical blend may effectively alleviate migraine symptoms for these children, marking a promising step forward in managing headaches associated with NF1.
Read More

User Reviews

USERS' SCORE
Good
Based on 5 Reviews
8.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Effective migraine relief
5 people found this helpful
Amazing! I had almost lost all hope until I decided to try CoQ10. It has significantly reduced the frequency of my migraine attacks; it's miraculous and a lifesaver. I take one capsule every morning without any side effects or unpleasant taste. I believe bioperine enhances the effect of CoQ10. If you are struggling with migraines and feel you've exhausted options, I strongly recommend trying CoQ10. It may change your life!
Read More
9
Improves migraine symptoms
3 people found this helpful
CoQ10 works well for migraines. Rapid depletion can occur with intense exercise, stress, surgeries, and statin use. It’s crucial to stabilise CoQ10 levels as low levels are linked to various conditions. Taking CoQ10, especially with statins, is vital as it shows promising results for migraines, significantly improving their frequency and intensity. The effects become noticeable only after a month of consistent use, and it's best absorbed with food.
Read More
9
Tremendous relief
1 people found this helpful
Great value. I’ve taken this product for years, and it tremendously reduces both the frequency and severity of my migraines. I highly recommend this brand as it's much cheaper than others.
Read More
9
Effective against migraines
Great antioxidants! They are very effective in reducing migraine headache attacks and increase cerebral blood flow.
Read More
6
Helpful with migraines
Good product! I use it for my migraines; so far, it’s effective. It’s easy to swallow and has no unpleasant taste, although I'm feeling a bit dizzy, which I hope will pass.
Read More

Frequently Asked Questions

9
Improves migraine symptoms
3 people found this helpful
CoQ10 works well for migraines. Rapid depletion can occur with intense exercise, stress, surgeries, and statin use. It’s crucial to stabilise CoQ10 levels as low levels are linked to various conditions. Taking CoQ10, especially with statins, is vital as it shows promising results for migraines, significantly improving their frequency and intensity. The effects become noticeable only after a month of consistent use, and it's best absorbed with food.
9
Effective migraine relief
5 people found this helpful
Amazing! I had almost lost all hope until I decided to try CoQ10. It has significantly reduced the frequency of my migraine attacks; it's miraculous and a lifesaver. I take one capsule every morning without any side effects or unpleasant taste. I believe bioperine enhances the effect of CoQ10. If you are struggling with migraines and feel you've exhausted options, I strongly recommend trying CoQ10. It may change your life!
9
Effective against migraines
Great antioxidants! They are very effective in reducing migraine headache attacks and increase cerebral blood flow.
6
Helpful with migraines
Good product! I use it for my migraines; so far, it’s effective. It’s easy to swallow and has no unpleasant taste, although I'm feeling a bit dizzy, which I hope will pass.
7
CoQ10 shows limited migraine effectiveness
We explored the effectiveness of Coenzyme Q10 (CoQ10) in preventing migraines. The findings suggest that CoQ10 has limited evidence supporting its use, classified as Level C. This means that while some patients may benefit, the overall results are not strong enough to warrant a confident recommendation. Importantly, adverse side effects appear low, making it a relatively safe option. However, we must approach it with care, looking at other proven alternatives for migraine prevention.
We explored the potential role of coenzyme Q10 as a treatment option for migraines, particularly against the backdrop of mitochondrial dysfunction. This condition suggests that individuals with migraines may experience an imbalance between energy supply and demand in their brains. Through our examination of existing trials, we noted that some studies have found promising results for coenzyme Q10, especially among those who had lower levels of this nutrient before treatment.

However, it's important to be candid about the study’s limitations. Many of these trials lacked proper control groups or sufficient sample sizes to draw more conclusive results. Although the initial findings are intriguing, more rigorous research is needed to verify whether coenzyme Q10 can genuinely make a difference for migraine sufferers.

Overall, we recognize the potential that coenzyme Q10 holds as an adjunctive therapy for migraines, particularly as part of a personalized approach that considers individual nutrient deficiencies. By focusing on tailored treatments, we may pave the way for more effective management of migraines in the future.
8
Coenzyme Q10 shows promise in migraine
We explored the use of coenzyme Q10 as a preventive treatment for migraine headaches in children aged 5 to 15. Conducted as a randomized controlled trial with 72 participants, we aimed to compare how effectively coenzyme Q10 works against a commonly used medication, amitriptyline. Both treatments were assessed for their impact on the frequency, duration, and severity of migraines, as well as improvements in children's quality of life.

Our findings revealed that coenzyme Q10 offered encouraging long-term benefits for managing migraines, showing notable efficacy particularly over extended periods. While amitriptyline responded more quickly, the side effects were more pronounced in children taking this medication. Interestingly, after three months of treatment, both groups exhibited similar clinical outcomes and enhancements in quality of life.

Overall, we determined that coenzyme Q10 could serve as a viable alternative for migraine prophylaxis, given its favorable side effect profile and comparable effectiveness to traditional treatments like amitriptyline.
We explored the potential benefits of Coenzyme Q10 (CoQ10) as a treatment for migraines, diving into several studies that highlighted its role in managing this challenging condition. Research indicated that oxidative stress could play a part in migraines, and CoQ10, known for its antioxidant properties, seemed an interesting candidate to investigate.

Although the effectiveness of CoQ10 for migraine relief is not yet firmly established, some preliminary short-term studies suggest that it might offer some benefits. Among various studies, we noticed that combining CoQ10 with other treatments made it difficult to isolate its specific effects, highlighting a need for further research.

Our findings suggest that while there’s promise in CoQ10 as a migraine remedy, more comprehensive and controlled studies are essential to truly understand its potential and effectiveness. As of now, the scientific community continues to call for prospective research with larger sample sizes and longer follow-ups to clarify these initial observations.
We explored the role of coenzyme Q10, or CoQ10, in managing migraines. This important molecule is widely known for its energy-producing and antioxidant properties, which have drawn attention to its potential benefits for neurological conditions, including migraines.

The research indicates that CoQ10 may serve as a protective agent for the nervous system. Its role in energy metabolism could be particularly beneficial for those suffering from migraines, as energy deficits in brain cells are often linked to migraine attacks. By helping to stabilize mitochondrial function, CoQ10 might reduce the frequency or severity of migraine episodes.

While the precise outcomes of various studies on CoQ10 and migraine treatment can vary, many health professionals see promise in this supplement. However, more comprehensive studies are needed to fully establish its effectiveness specifically for migraine relief, particularly in comparison to other treatments.

Overall, CoQ10 shows potential, but it's important to consult with a healthcare provider to understand its use better as part of a larger migraine management strategy.
8
Co-Q10 potentially benefits migraine patients
We investigated how Coenzyme Q10 (Co-Q10) affects migraine symptoms in a well-structured clinical trial. Over the course of 12 weeks, 84 women aged 18 to 50 diagnosed with episodic migraines participated in a randomized, double-blind study, where they received either Co-Q10 (400 mg/day) or a placebo.

Upon analyzing the results, we observed some promising outcomes. Participants who took Co-Q10 experienced a significant reduction in malondialdehyde (MDA) levels, an indicator of oxidative stress. Additionally, there was a noteworthy increase in high-density lipoprotein cholesterol (HDL-C) levels, which is beneficial for overall heart health. We also noted a decrease in body fat percentage among those receiving Co-Q10.

However, while some improvements were documented, Co-Q10 did not show a significant effect on total antioxidant capacity or other lipid profile measures like low-density lipoprotein cholesterol and triglycerides. Therefore, while Co-Q10 may hold potential for enhancing certain health aspects in migraine sufferers, its overall impact on migraine management and other related parameters remains mixed.

References

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  2. Sazali S, Badrin S, Norhayati MN, Idris NS. Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis. BMJ Open. 2021;11:e039358. 10.1136/bmjopen-2020-039358
  3. Lisicki M, Schoenen J. Metabolic treatments of migraine. Expert Rev Neurother. 2020;20:295. 10.1080/14737175.2020.1729130
  4. Parohan M, Sarraf P, Javanbakht MH, Foroushani AR, Ranji-Burachaloo S, et al. The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial. Nutr Neurosci. 2021;24:317. 10.1080/1028415X.2019.1627770
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  6. Parohan M, Sarraf P, Javanbakht MH, Ranji-Burachaloo S, Djalali M. Effect of coenzyme Q10 supplementation on clinical features of migraine: a systematic review and dose-response meta-analysis of randomized controlled trials. Nutr Neurosci. 2020;23:868. 10.1080/1028415X.2019.1572940
  7. Hajihashemi P, Askari G, Khorvash F, Reza Maracy M, Nourian M. The effects of concurrent Coenzyme Q10, L-carnitine supplementation in migraine prophylaxis: A randomized, placebo-controlled, double-blind trial. Cephalalgia. 2019;39:648. 10.1177/0333102418821661
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  21. Dahri M, Sarafan Sadeghi A, Pahlavani N, Nattagh-Eshtivani E, Hashemilar M, et al. The Effects of Coenzyme Q10 Supplementation on Oxidative Status and Lipid Profile in Migraine Patients: A Randomized Double-Blinded Controlled Clinical Trial. Clin Nutr Res. 2023;12:257. 10.7762/cnr.2023.12.4.257
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  23. Stearns SA, Xun H, Haddad A, Rinkinen J, Bustos VP, et al. Therapeutic Options for Migraines in the Microsurgical Patient: A Scoping Review. Plast Reconstr Surg. 2024;153:988e. 10.1097/PRS.0000000000010861
  24. Yaghini O, Hoseini N, Ghazavi MR, Mansouri V, Nasiri J, et al. A Comparative Study on the Efficacy of Coenzyme Q10 and Amitriptyline in the Prophylactic Treatment of Migraine Headaches in Children: A Randomized Controlled Trial. Adv Biomed Res. 2022;11:43. 10.4103/abr.abr_235_20
  25. Ariyanfar S, Razeghi Jahromi S, Togha M, Ghorbani Z. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep. 2022;26:193. 10.1007/s11916-022-01019-9
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