Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.7
USERS' SCORE
Good
Based on 6 Reviews
8.6
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin C (as ascorbic acid)
40 mg
44%
Thiamin (as thiamin HCl)
60 mg
5000%
Riboflavin (as riboflavin and riboflavin-5-phosphate)
75 mg
5769%
Niacin (as niacinamide and niacin)
50 mg
313%
Vitamin B6 (from pyridoxine HCl and pyridoxal-5-phosphate)
50 mg
2941%
Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt) (Quatrefolic®)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41677%
Biotin
600 mcg
2000%
Pantothenic Acid (as d-calcium pantothenate)
100 mg
2000%
Top Medical Research Studies
9
In our review and meta-analysis, we sought to understand how Vitamin B2 supplementation influences migraines. By examining nine studies with over 670 participants, we found that taking 400 mg of Vitamin B2 daily for three months significantly reduced the frequency, duration, and pain intensity of migraine attacks.
Our analysis revealed that Vitamin B2 wasn't just a minor help; it truly made a difference in managing migraine symptoms. This suggests a potential alternative to traditional pharmaceuticals, offering hope for migraine sufferers looking for effective prevention options.
Our analysis revealed that Vitamin B2 wasn't just a minor help; it truly made a difference in managing migraine symptoms. This suggests a potential alternative to traditional pharmaceuticals, offering hope for migraine sufferers looking for effective prevention options.
Read More
9
We conducted a retrospective observational study involving 42 children and adolescents, aged six to 18, to assess the effectiveness of riboflavin in managing migraines.
Participants saw significant improvements, with fewer headache days per month and reduced headache intensity and duration after starting riboflavin.
Additionally, we found a decrease in reliance on acute medications and missed school days related to migraines, suggesting riboflavin is a safe and beneficial option for young migraine sufferers.
Participants saw significant improvements, with fewer headache days per month and reduced headache intensity and duration after starting riboflavin.
Additionally, we found a decrease in reliance on acute medications and missed school days related to migraines, suggesting riboflavin is a safe and beneficial option for young migraine sufferers.
Read More
8
We analyzed the role of vitamin B2, or riboflavin, in preventing migraines for adults. Our findings indicate that riboflavin is recommended for migraine prevention, though pediatric use lacks evidence.
While the adverse events associated with riboflavin are minimal, we noted that other nutraceuticals show varying levels of support for migraine treatment. Most notably, magnesium is also recommended for prevention and treatment, while coenzyme Q10 has limited evidence.
However, we observed that some supplements, like feverfew, require caution due to safety uncertainties. Overall, riboflavin stands out as a viable option for adults seeking relief from migraines.
While the adverse events associated with riboflavin are minimal, we noted that other nutraceuticals show varying levels of support for migraine treatment. Most notably, magnesium is also recommended for prevention and treatment, while coenzyme Q10 has limited evidence.
However, we observed that some supplements, like feverfew, require caution due to safety uncertainties. Overall, riboflavin stands out as a viable option for adults seeking relief from migraines.
Read More
Most Useful Reviews
10
Migraine-free benefit
56 people found this helpful
FOLATE HELPED STOP MIGRAINES. Since beginning supplements about 40 days ago, I've not had a migraine. I previously experienced ten migraines from March to May, with the last two eight days apart.
Read More
9
Life-changing experience
35 people found this helpful
This made a world of difference for me! If you're feeling low and suffer from migraines daily, you should try this. I researched and found that a lack of this nutrient can lead to various problems. After my first pill, I felt better and now hardly get migraines. I’ve had only two since starting, and I’ve stopped taking Excedrin entirely. I highly recommend this before considering antidepressants or anxiety medications.
Read More
7.5
Less frequent migraines
Vitamin B Complex provides the optimal combination and dosage at a fair price. I had been searching for a suitable complex, as prescribed by my doctor, to combat migraines and chose this one. After taking it, my migraines have become less frequent.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.7
- All Researches
9
In our review and meta-analysis, we sought to understand how Vitamin B2 supplementation influences migraines. By examining nine studies with over 670 participants, we found that taking 400 mg of Vitamin B2 daily for three months significantly reduced the frequency, duration, and pain intensity of migraine attacks.
Our analysis revealed that Vitamin B2 wasn't just a minor help; it truly made a difference in managing migraine symptoms. This suggests a potential alternative to traditional pharmaceuticals, offering hope for migraine sufferers looking for effective prevention options.
Our analysis revealed that Vitamin B2 wasn't just a minor help; it truly made a difference in managing migraine symptoms. This suggests a potential alternative to traditional pharmaceuticals, offering hope for migraine sufferers looking for effective prevention options.
Read More
9
We conducted a retrospective observational study involving 42 children and adolescents, aged six to 18, to assess the effectiveness of riboflavin in managing migraines.
Participants saw significant improvements, with fewer headache days per month and reduced headache intensity and duration after starting riboflavin.
Additionally, we found a decrease in reliance on acute medications and missed school days related to migraines, suggesting riboflavin is a safe and beneficial option for young migraine sufferers.
Participants saw significant improvements, with fewer headache days per month and reduced headache intensity and duration after starting riboflavin.
Additionally, we found a decrease in reliance on acute medications and missed school days related to migraines, suggesting riboflavin is a safe and beneficial option for young migraine sufferers.
Read More
8
We analyzed the role of vitamin B2, or riboflavin, in preventing migraines for adults. Our findings indicate that riboflavin is recommended for migraine prevention, though pediatric use lacks evidence.
While the adverse events associated with riboflavin are minimal, we noted that other nutraceuticals show varying levels of support for migraine treatment. Most notably, magnesium is also recommended for prevention and treatment, while coenzyme Q10 has limited evidence.
However, we observed that some supplements, like feverfew, require caution due to safety uncertainties. Overall, riboflavin stands out as a viable option for adults seeking relief from migraines.
While the adverse events associated with riboflavin are minimal, we noted that other nutraceuticals show varying levels of support for migraine treatment. Most notably, magnesium is also recommended for prevention and treatment, while coenzyme Q10 has limited evidence.
However, we observed that some supplements, like feverfew, require caution due to safety uncertainties. Overall, riboflavin stands out as a viable option for adults seeking relief from migraines.
Read More
8
Vitamin B12 and magnesium effective
We set out to investigate whether combining vitamin B12, magnesium, and high-intensity interval training (HIIT) could help reduce migraine symptoms. In a randomized, placebo-controlled trial with 60 participants, we split them into four groups to assess various interventions over two months. Our findings showed that the combination of B12, magnesium, and regular exercise had significant benefits in reducing migraine pain and inflammation. This suggests that a synergistic approach could effectively improve migraine management.
Read More
8
We examined the potential benefits of vitamin B6, folate, and B12 for treating migraines, particularly migraine with aura (MA). Our systematic literature search gathered 12 studies, revealing that while these vitamins didn't significantly help with acute migraines, B6 showed promise when used preventively alongside folate and B12 in adults with MA. However, folate alone didn’t perform better than a placebo. Unfortunately, data on migraine without aura (MO) in both adults and children were limited, emphasizing the need for more rigorous studies.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
Migraine-free benefit
56 people found this helpful
FOLATE HELPED STOP MIGRAINES. Since beginning supplements about 40 days ago, I've not had a migraine. I previously experienced ten migraines from March to May, with the last two eight days apart.
Read More
9
Life-changing experience
35 people found this helpful
This made a world of difference for me! If you're feeling low and suffer from migraines daily, you should try this. I researched and found that a lack of this nutrient can lead to various problems. After my first pill, I felt better and now hardly get migraines. I’ve had only two since starting, and I’ve stopped taking Excedrin entirely. I highly recommend this before considering antidepressants or anxiety medications.
Read More
7.5
Less frequent migraines
Vitamin B Complex provides the optimal combination and dosage at a fair price. I had been searching for a suitable complex, as prescribed by my doctor, to combat migraines and chose this one. After taking it, my migraines have become less frequent.
Read More
7.5
Symptom relief
Decent! I use it to relieve migraine symptoms.
Read More
6
Fewer headaches
I typically suffer from severe migraine headaches. However, I have been taking B vitamins, which supposedly improve the situation. It seems the frequency of my headaches has decreased, but I am still assessing its effectiveness. The size is convenient for swallowing.
Read More
Frequently Asked Questions
7.5
Less frequent migraines
Vitamin B Complex provides the optimal combination and dosage at a fair price. I had been searching for a suitable complex, as prescribed by my doctor, to combat migraines and chose this one. After taking it, my migraines have become less frequent.
6
Fewer headaches
I typically suffer from severe migraine headaches. However, I have been taking B vitamins, which supposedly improve the situation. It seems the frequency of my headaches has decreased, but I am still assessing its effectiveness. The size is convenient for swallowing.
0
Not recommended
3 people found this helpful
Not satisfied. I used it daily, which was wrong as I took too high a dose, causing me a headache, diarrhoea, and overall tiredness. After some time, I tried a pill and got a migraine, so I decided to stop taking it. I won't use it again.
References
- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. doi:10.1007/s11916-025-01358-3
- Li H, Krall JR, Frankenfeld C, Slavin M. Nutritional intake of riboflavin (vitamin B2) and migraine: a cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES) 2001-2004. Nutr Neurosci. 2023;26:1068. doi:10.1080/1028415X.2022.2126760
- Li D, Guo Y, Xia M, Zhang J, Zang W. Dietary intake of thiamine and riboflavin in relation to severe headache or migraine: A cross-sectional survey. Headache. 2022;62:1133. doi:10.1111/head.14384
- Liu H, Wang L, Chen C, Dong Z, Yu S. Association between Dietary Niacin Intake and Migraine among American Adults: National Health and Nutrition Examination Survey. Nutrients. 2022;14. doi:10.3390/nu14153052
- Matin H, Taghian F, Chitsaz A. Artificial intelligence analysis to explore synchronize exercise, cobalamin, and magnesium as new actors to therapeutic of migraine symptoms: a randomized, placebo-controlled trial. Neurol Sci. 2022;43:4413. doi:10.1007/s10072-021-05843-6
- Chen YS, Lee HF, Tsai CH, Hsu YY, Fang CJ, et al. Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis. Nutr Neurosci. 2022;25:1801. doi:10.1080/1028415X.2021.1904542
- Das R, Qubty W. Retrospective Observational Study on Riboflavin Prophylaxis in Child and Adolescent Migraine. Pediatr Neurol. 2021;114:5. doi:10.1016/j.pediatrneurol.2020.09.009
- Yamanaka G, Suzuki S, Takeshita M, Go S, Morishita N, et al. Effectiveness of low-dose riboflavin as a prophylactic agent in pediatric migraine. Brain Dev. 2020;42:523. doi:10.1016/j.braindev.2020.04.002
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. doi:10.1111/ane.13251
- Togha M, Razeghi Jahromi S, Ghorbani Z, Martami F, Seifishahpar M. Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study. Headache. 2019;59:1492. doi:10.1111/head.13618
- Askari G, Nasiri M, Mozaffari-Khosravi H, Rezaie M, Bagheri-Bidakhavidi M, et al. The effects of folic acid and pyridoxine supplementation on characteristics of migraine attacks in migraine patients with aura: A double-blind, randomized placebo-controlled, clinical trial. Nutrition. 2017;38:74. doi:10.1016/j.nut.2017.01.007
- Thompson DF, Saluja HS. Prophylaxis of migraine headaches with riboflavin: A systematic review. J Clin Pharm Ther. 2017;42:394. doi:10.1111/jcpt.12548
- Prakash S, Kumar Singh A, Rathore C. Chronic Migraine Responding to Intravenous Thiamine: A Report of Two Cases. Headache. 2016;56:1204. doi:10.1111/head.12838
- Namazi N, Heshmati J, Tarighat-Esfanjani A. Supplementation with Riboflavin (Vitamin B2) for Migraine Prophylaxis in Adults and Children: A Review. Int J Vitam Nutr Res. 2015;85:79. doi:10.1024/0300-9831/a000225
- Gaul C, Diener HC, Danesch U. Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial. J Headache Pain. 2015;16:516. doi:10.1186/s10194-015-0516-6
